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Cited by 40Thyroid Disorders and TreatmentsThyroid and Parathyroid SurgeryAdrenal Hormones and Disorders

Plasma Norepinephrine Kinetics, Dopamine-β-Hydroxylase, and Chromogranin-A, in Hypothyroid Patients before and following Replacement Therapy*

POLIKAR, RALF, KENNEDY, BRIAN, ZIEGLER, MICHAEL, O'CONNOR, DANIEL T., SMITH, JOHANA, NICOD, PASCAL·1990·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem-70-1-277
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Abstract

Whether the increased plasma norepinephrine level reported in hypothyroidism is the result of impaired norepinephrine (NE) clearance or increased NE release by nerve terminals is unknown. We, therefore, measured plasma NE levels and clearance in 11 hypothyroid patients before [T4 index, 41.2 +/- 7.7 nmol/L (mean +/- SEM); TSH, 71.4 +/- 23.0 mU/L] and 4 +/- 0.5 months after thyroid replacement (T4 index, 136.4 +/- 24.4 nmol/L; TSH, 3.2 +/- 1.2 mU/L) and in 8 healthy volunteers. Plasma dopamine-beta-hydroxylase and chromogranin-A, which are coreleased with NE by sympathetic nerve endings, were also measured. Plasma NE was higher in the hypothyroid (2.37 +/- 0.24 nmol/L) than in the euthyroid state (1.86 +/- 0.24 nmol/L; P less than 0.02) or in the controls (1.87 +/- 0.27 nmol/L). Plasma clearance of NE, however, was not affected after thyroid replacement (hypothyroid, 2.08 +/- 0.31 L/min; euthyroid, 1.94 +/- 0.21 L/min; controls, 1.86 +/- 0.15 L/min). There was no significant change in plasma dopamine-beta-hydroxylase (hypothyroid, 720 +/- 139 nmol/mL.h; euthyroid, 553 +/- 97 nmol/mL.h) or plasma chromogranin-A (hypothyroid, 48.9 +/- 7.1 ng/mL; euthyroid, 42.9 +/- 5.3 ng/mL) after thyroid replacement. We conclude that the increased plasma NE in hypothyroid patients is not due to a change in plasma clearance, but is more likely secondary to increased NE release.

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Crossref · 10.1210/jcem-70-1-277

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Authors
POLIKAR, R., KENNEDY, B., ZIEGLER, M., O'CONNOR, D. T., SMITH, J., & NICOD, P.
Affiliations
University of California San Diego Medical Center (US)
ORCID
ZIEGLER, MICHAEL
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1990-01
Volume
70
Issue
1
Pages
277-281
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem-70-1-277
OpenAlex
W2131523884
Semantic Scholar
461bbc521cf4f82e9452389ff17482f92324ae4a
Cited by
40
References
23
Citations by year
2020: 1 · 2019: 2 · 2015: 1 · 2014: 1 · 2013: 2
FWCI
0.90
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS (submittedVersion)
  • SERVAL (Université de Lausanne) (submittedVersion)
Funders
  • National Institutes of Health (5r01hl035924-06)
  • National Heart, Lung, and Blood Institute (HL 35924)
  • National Center for Research Resources (MO1 RR00827, M01RR000827)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
hypothyroidism, plasma norepinephrine, norepinephrine clearance, noradrenaline release, thyroid hormone replacement, dopamine beta-hydroxylase, chromogranin A, sympathetic nervous system, thyroid hormones
MeSH terms
Adult, Aged, Chromogranins, Dopamine beta-Hydroxylase, Female, Half-Life, Humans, Hypothyroidism, Male, Metabolic Clearance Rate, Middle Aged, Nerve Endings, Nerve Tissue Proteins, Norepinephrine, Thyrotropin, Thyroxine, Chromogranin A

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