The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Pituitary Size in Depression*
Abstract
Magnetic resonance images centered at the pituitary stalk were used to measure pituitary gland size in 19 patients with major depression compared with that in age- and sex-matched controls. Depressed patients had significantly greater pituitary cross-sectional area (P = 0.0009) and volume (P = 0.007) than the controls. This difference was particularly prominent in elderly depressed patients compared to elderly controls. These results provide the first demonstration of structural alterations in the pituitary gland in major depression.
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“For example Krishnan et al. (1991) showed that MRI-based measures of cross-sectional area and volume of the pituitary were increased (by 34 and 41%, respectively) in depressives versus controls.”
From Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression (2008) · cites this paper as Krishnan et al. (1991)
Citations
Cites
Carroll, B. J. (1981) · Archives of General Psychiatry · doi:10.1001/archpsyc.1981.01780260017001 · Cited by 2,243
Nemeroff, C. B., Widerlöv, E., Bissette, G., Walléus, H., Karlsson, I., Eklund, K., Kilts, C. D., Loosen, P. T., & Vale, W. (1984) · Science · doi:10.1126/science.6334362 · Cited by 1,485
Self-citationPsychiatric implications of basic and clinical studies with corticotropin-releasing factor.
Gold, P., Chrousos, G., Kellner, C., Post, R., Roy, A., Augerinos, P., Schulte, H., Oldfield, E., & Loriaux, D. (1984) · American Journal of Psychiatry · doi:10.1176/ajp.141.5.619 · Cited by 460
Development and aging of brain midline structures: assessment with MR imaging.
Hayakawa, K., Konishi, Y., MATSUDA, T., Kuriyama, M., Konishi, K., Yamashita, K., Okumura, R., & Hamanaka, D. (1989) · Radiology · doi:10.1148/radiology.172.1.2740500 · Cited by 168
Westlund, K. N., Aguilera, G., & Childs, G. V. (1985) · Endocrinology · doi:10.1210/endo-116-1-439 · Cited by 99
Blunting of ACTH response to human CRH in depressed patients is avoided by metyrapone pretreatment
von Bardeleben, U., Stalla, G. K., Müller, O. A., & Holsboer, F. (1988) · Biological Psychiatry · doi:10.1016/0006-3223(88)90254-5 · Cited by 81
Lisansky, J. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810070067011 · Cited by 72
Doraiswamy, P. M., Krishnan, K. R. R., Figiel, G. S., Husain, M. M., Boyko, O. B., Rockwell, W. J. K., & Ellinwood, E. H. (1990) · Biological Psychiatry · doi:10.1016/0006-3223(90)90628-f · Cited by 68
Self-citationMagnetic Resonance Imaging of Pituitary and Parasellar Abnormalities
Chakeres, D. W., Curtin, A., & Ford, G. (1989) · Radiologic Clinics of North America · doi:10.1016/s0033-8389(22)00875-2 · Cited by 65
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Drevets, W. C., Price, J. L., & Furey, M. L. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0189-x · Cited by 2,241
“For example Krishnan et al. (1991) showed that MRI-based measures of cross-sectional area and volume of the pituitary were increased (by 34 and 41%, respectively) in depressives versus controls.”
BackgroundResultNeurocircuitry of Mood Disorders
Price, J. L., & Drevets, W. C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.104 · Cited by 1,606
The role of corticotropin-releasing factor in depression and anxiety disorders
Arborelius, L., Owens, M., Plotsky, P., & Nemeroff, C. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1600001 · Cited by 1,378
Self-citationNeuroimaging studies of mood disorders
Drevets, W. C. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01020-9 · Cited by 1,334
The stress system in the human brain in depression and neurodegeneration
Swaab, D. F., Bao, A.-M., & Lucassen, P. J. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2005.03.003 · Cited by 984
Metadata
- Authors
- KRISHNAN, K. R. R., DORAISWAMY, P. M., LURIE, S. N., FIGIEL, G. S., HUSAIN, M. M., BOYKO, O. B., ELLINWOOD, E. H., & NEMEROFF, C. B.
- Affiliations
- Duke University (US)
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1991-02
- Volume
- 72
- Issue
- 2
- Pages
- 256-259
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2051225255
- Cited by
- 232
- References
- 9
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 3 · 2022: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 5 · 2015: 7 · 2014: 7 · 2013: 4 · 2012: 6
- FWCI
- 4.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh044716-06)
- National Institute of Mental Health (R01MH042088, MH-44716, MH 40159, MH42088)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Keywords
- major depressive disorder, pituitary volume, pituitary stalk, brain structural changes, geriatric depression, neuroimaging of depression
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Depressive Disorder, Female, Humans, Magnetic Resonance Imaging, Middle Aged, Pituitary Gland
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