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Cited by 139Thyroid Disorders and TreatmentsGrowth Hormone and Insulin-like Growth FactorsAdrenal Hormones and Disorders

Effects of acute and chronic interleukin-6 administration on thyroid hormone metabolism in humans.

Stouthard, J M, van der Poll, T, Endert, E, Bakker, P J, Veenhof, C H, Sauerwein, H P, Romijn, J A·1994·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.79.5.7962327
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Abstract

Cytokines, such as tumor necrosis factor-alpha and interleukin-1 beta (IL-1 beta), alter thyroid hormone metabolism, and may be involved in the pathogenesis of the euthyroid sick syndrome. Both cytokines also induce the production of IL-6. To assess whether IL-6 itself modulates thyroid hormone metabolism, we studied the acute and chronic effects of recombinant human IL-6 (rhIL-6) on thyroid hormone concentrations in patients with renal cell cancer. In the first study protocol, plasma thyroid hormone concentrations were measured during a 4-h infusion of rhIL-6 (150 micrograms) or, on another day, during infusion of saline (control; n = 8). There were no effects of rhIL-6 infusion on T4, free T4, or thyroid hormone-binding index. However, rhIL-6 induced a significant decrease in the plasma concentrations of TSH (P < 0.001) and T3 (P < 0.001) compared with those in the control study, associated with an increase in rT3 concentrations (P < 0.001). In the second study, a dose of 150 micrograms rhIL-6 was administered sc for 42 consecutive days (n = 8). Weekly assessment of thyroid hormone and TSH concentrations showed a decrease in the T3 concentration (P < 0.001) and a transient increase in rT3 (P < 0.01) and free T4 concentrations (P < 0.01). There were no changes in T4 concentrations during chronic administration of rhIL-6. It is concluded that IL-6 induces major changes in thyroid hormone metabolism and may be another pathogenetic factor in the euthyroid sick syndrome.

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Crossref · 10.1210/jcem.79.5.7962327

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  • In human volunteers, short-term infusion of IL-6 induces decreased serum TSH concentrations, but daily injections over 42 days only cause a modest decrease in T3 and a transient increase in rT3 and free T4.

    “In human volunteers, short-term infusion of IL-6 induces decreased serum TSH concentrations, but daily injections over 42 days only cause a modest decrease in T3 and a transient increase in rT3 and free T4 [54].”

    From An update on non-thyroidal illness syndrome (2021) · cites this paper as [54]

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Authors
Stouthard, J. M., van der Poll, T., Endert, E., Bakker, P. J., Veenhof, C. H., Sauerwein, H. P., & Romijn, J. A.
Affiliations
Amsterdam UMC Location University of Amsterdam (NL)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1994-11
Volume
79
Issue
5
Pages
1342-1346
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.79.5.7962327
OpenAlex
W2083039315
Cited by
139
References
2
Citations by year
2026: 2 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 2 · 2020: 6 · 2019: 3 · 2018: 2 · 2017: 6 · 2016: 6 · 2015: 5 · 2014: 7 · 2013: 6 · 2012: 1
FWCI
7.04
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
interleukin-6, thyroid hormone metabolism, recombinant human interleukin-6, thyroid-stimulating hormone, triiodothyronine, reverse T3, free thyroxine, low T3 syndrome, cytokines, renal cell carcinoma
MeSH terms
Carcinoma, Renal Cell, Dose-Response Relationship, Drug, Female, Humans, Kidney Neoplasms, Male, Middle Aged, Recombinant Proteins, Thyroid Gland, Thyrotropin, Thyroxine, Triiodothyronine, Interleukin-6

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