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Cited by 132Thyroid Disorders and TreatmentsHeart Failure Treatment and ManagementHormonal and reproductive studies

The role of thyroid hormone in the pathophysiology of heart failure: clinical evidence

Galli, E., Pingitore, A., Iervasi, G.·2010·Heart Failure Reviews
DOI 10.1007/s10741-008-9126-6
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Abstract

Thyroid hormone (TH) has a fundamental role in cardiovascular homeostasis in both physiological and pathological conditions, influencing cardiac contractility, heart rate (HR), diastolic function and systemic vascular resistance (SVR) through genomic and non-genomic mediated effects. In heart failure (HF) the main alteration of thyroid function is referred to as "low-triiodothyronine (T3) syndrome" (LT3S) characterized by decreased total serum T3 and free T3 (fT3) with normal levels of thyroxine (T4) and thyrotropin (TSH). Even if commonly interpreted as an adaptive factor, LT3S may have potential negative effects, contributing to the progressive deterioration of cardiac function and myocardial remodeling in HF and representing a powerful predictor of mortality in HF patients. All these observations, together with the early evidence of the benefits of T3 administration in HF patients indicate that placebo-controlled prospective studies are now needed to better define the safety and prognostic effects of chronic treatment with synthetic TH in HF.

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Crossref · 10.1007/s10741-008-9126-6

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  • Low thyroid hormone levels increase systemic vascular resistance and induce endothelial dysfunction by reducing nitric oxide availability.

    “Low thyroid hormone levels also increase systemic vascular resistance and induce endothelial dysfunction by reducing nitric oxide availability.37,38,39”

    From Association of subclinical hypothyroidism and cardiovascular disease with mortality (2020) · cites this paper as [39]

  • Low triiodothyronine syndrome occurs in 15% to 30% of patients with heart failure, with incidence varying by clinical severity.

    “In the clinical setting, the most frequent alteration of TH metabolism is the low T 3 syndrome that occurs in 15% to 30% of patients with HF, with the incidence changing in relation to the clinical severity of the disease.”

    From Thyroid Hormones and Cardiovascular Function and Diseases (2018) · cites this paper as [129]

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Authors
Galli, E., Pingitore, A., & Iervasi, G.
Affiliations
  • University of Pisa (IT)
  • Istituto di Fisiologia Clinica (IT)
Corresponding author
Iervasi, G.
ORCID
Venue
Heart Failure Reviews
Publisher
Springer Science and Business Media LLC
Published
2008-12-27
Volume
15
Issue
2
Pages
155-169
ISSN
  • 1382-4147 (ISSN-L)
  • 1573-7322
DOI
10.1007/s10741-008-9126-6
OpenAlex
W2062044444
Cited by
132
References
147
Citations by year
2025: 3 · 2024: 6 · 2023: 8 · 2022: 8 · 2021: 13 · 2020: 12 · 2019: 5 · 2018: 6 · 2017: 6 · 2016: 5 · 2015: 12 · 2014: 11 · 2013: 10 · 2012: 8
FWCI
4.51
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Heart Failure Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
thyroid hormones, heart failure, low triiodothyronine syndrome, free triiodothyronine, cardiac contractility, diastolic function, systemic vascular resistance, heart rate, cardiac remodeling, mortality prediction, cardiovascular homeostasis
MeSH terms
Heart Failure, Humans, Hypothyroidism, Prognosis, Thyroid Hormones, Triiodothyronine, Ventricular Function, Ventricular Remodeling

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