The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Neutralization of TNF does not influence endotoxininduced changes in thyroid hormone metabolism in humans
Abstract
To determine the role of tumor necrosis factor (TNF) in endotoxin-induced changes in plasma thyroid hormone and thyroid-stimulating hormone (TSH) concentrations, 24 healthy postabsorptive humans were studied on a control study day ( n= 6), after infusion of a recombinant TNF receptor IgG fusion protein (TNFR:Fc; 6 mg/m 2; n = 6) after intravenous injection of endotoxin (2 ng/kg; n = 6), or after administration of endotoxin with TNFR:Fc ( n = 6). Administration of TNFR:Fc alone did not affect thyroid hormone or TSH levels when compared with the control day. Endotoxin induced a transient rise in plasma TNF activity (1.5 h: 219 ± 42 pg/ml), which was completely prevented by TNFR:Fc ( P < 0.05). After endotoxin administration, plasmal-thyroxine (T 4), free T 4, 3,5,3′-triiodothyronine (T 3), and TSH were lower and 3,3′,5′-triiodothyronine was higher than on the control day (all P < 0.05). Coinfusion of TNFR:Fc with endotoxin did not influence these endotoxin-induced changes. Our results suggest that endogenous TNF does not play an important role in the alterations in plasma thyroid hormone and TSH concentrations induced by mild endotoxemia in healthy humans.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Infusion of TNFα in humans alters serum T3, TSH and rT3, while blocking TNFα by a recombinant TNF receptor-IgG fusion protein does not prevent these changes.
“The same holds true for TNFα, as infusion of this cytokine in humans alters serum T3, TSH and rT3, while blocking TNFα by a recombinant TNF receptor-IgG fusion protein does not prevent these changes [57].”
From An update on non-thyroidal illness syndrome (2021) · cites this paper as [57]
Citations
Cites
Biologic basis for interleukin-1 in disease.
Dinarello, C. (1996) · Blood · doi:10.1182/blood.v87.6.2095.bloodjournal8762095 · Cited by 4,344
Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
Tracey, K. J., Fong, Y., Hesse, D. G., Manogue, K. R., Lee, A. T., Kuo, G. C., Lowry, S. F., & Cerami, A. (1987) · Nature · doi:10.1038/330662a0 · Cited by 2,448 · cited 1×
“Endogenous TNF has been implicated as an important mediator of LPS-induced host responses (26, 29, 30).”
BackgroundSelf-citationAlterations in thyroid function in patients with systemic illness: the euthyroid sick syndrome
WARTOFSKY, L., & BURMAN, K. D. (1982) · Endocrine Reviews · doi:10.1210/edrv-3-2-164 · Cited by 916
Mohler, K. M., Torrance, D., Smith, C., Goodwin, R., Stremler, K. E., Fung, V., Madani, H., & Widmer, M. B. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.3.1548 · Cited by 832
Tumor Necrosis Factor: A Putative Mediator of the Sick Euthyroid Syndrome in Man*
POLL, T. V. D., ROMIJN, J. A., WIERSINGA, W. M., & SAUERWEIN, H. P. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-71-6-1567 · Cited by 270
van der Poll, T., & Lowry, S. F. (1995) · Shock · doi:10.1097/00024382-199501000-00001 · Cited by 231
Self-citationSuppression of Thyrotropin in the Low-Thyroxine State of Severe Nonthyroidal Illness
WEHMANN, R. E., Gregerman, R. I., Burns, W. H., Saral, R., & Santos, G. W. (1985) · New England Journal of Medicine · doi:10.1056/nejm198502283120904 · Cited by 224
Suffredini, A. F., Reda, D., Banks, S. M., Tropea, M., Agosti, J. M., & Miller, R. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.10.5038 · Cited by 205
Self-citationEvans, T. J., Moyes, D. L., Carpenter, A., Martin, R., Loetscher, H., Lesslauer, W., & Cohen, J. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.6.2173 · Cited by 174
Pang, X.-P., Hershman, J. M., Mirell, C. J., & Pekary, A. E. (1989) · Endocrinology · doi:10.1210/endo-125-1-76 · Cited by 162
van der Poll, T., Levi, M. M., van Deventer, S. J. H., Cate, H. T., Haagmans, B. L., Biemond, B. J., Buller, H. R., Hack, C. E., & ten Cate, J. W. (1994) · Blood · doi:10.1182/blood.v83.2.446.bloodjournal832446 · Cited by 158
Sato, K., Satoh, T., SHIZUME, K., Ozawa, M., Han, D. C., IMAMURA, H., Tsushima, T., Demura, H., KANAJI, Y., Ito, Y., et al. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-70-6-1735 · Cited by 150
van der Poll, T., Coyle, S. M., Levi, M. M., Jansen, P. M., Dentener, M. A., Barbosa, K., Buurman, W. A., Hack, C. E., ten Cate, J. W., Agosti, J. M., et al. (1997) · PubMed · doi:10.1182/blood.v89.10.3727 · Cited by 147
Self-citationEffects of acute and chronic interleukin-6 administration on thyroid hormone metabolism in humans.
Stouthard, J. M., van der Poll, T., Endert, E., Bakker, P. J., Veenhof, C. H., Sauerwein, H. P., & Romijn, J. A. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.5.7962327 · Cited by 139
Self-citationDecreased Nocturnal Surge of Thyrotropin in Nonthyroidal Illness*
Romijn, J. A., & Wiersinga, W. M. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-70-1-35 · Cited by 119
PANG, X.-P., HERSHMAN, J. M., CHUNG, M., & PEKARY, A. E. (1989) · Endocrinology · doi:10.1210/endo-125-4-1783 · Cited by 116
Effects of Tumor Necrosis Factor-α/Cachectin on Thyroid Hormone Metabolism in Mice*
Ozawa, M., Sato, K., Han, D. C., Kawakami, M., Tsushima, T., & SHIZUME, K. (1988) · Endocrinology · doi:10.1210/endo-123-3-1461 · Cited by 116
Boelen, A., Maas, M. A., Lowik, C. W., Platvoet, M. C., & Wiersinga, W. M. (1996) · Endocrinology · doi:10.1210/endo.137.12.8940342 · Cited by 108
Wiersinga, W. M., & CHOPRA, I. J. (1982) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(82)84024-x · Cited by 100
PEKARY, A. E., Hershman, J. M., & Berg, L. (1998) · Endocrinology · doi:10.1210/endo.139.2.5760 · Cited by 92
van der Poll, T., Van Zee, K. J., Endert, E., Coyle, S. M., Stiles, D. M., Pribble, J. P., Catalano, M. A., Moldawer, L. L., & Lowry, S. F. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.4.7714108 · Cited by 85
Self-citationAcute effects of interferon-alpha administration on thyroid hormone metabolism in healthy men
Corssmit, E. P. M., Heyligenberg, R., Endert, E., Sauerwein, H. P., & Romijn, J. A. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.11.7593416 · Cited by 82
Self-citationTang, K. T., Braverman, L. E., & DeVito, W. J. (1995) · Endocrinology · doi:10.1210/endo.136.3.7867596 · Cited by 66
Buscema, M., Todd, I., DEUSS, U., HAMMOND, L. J., Mirakian, R. M., Pujol‐Borrell, R., & Bottazzo, G. F. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-69-2-433 · Cited by 58
Rasmussen, Å. K., Kayser, L., Feldt‐Rasmussen, U., & Bendtzen, K. (1994) · Journal of Endocrinology · doi:10.1677/joe.0.1430359 · Cited by 57
Pekary, A. E., Berg, L., Santini, F., CHOPRA, I. J., & Hershman, J. M. (1994) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(94)90256-9 · Cited by 55
Thyroid hormone metabolism in nonthyroidal illness
Wiersinga, W. M., & Boelen, A. (1996) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/00060793-199610000-00011 · Cited by 44
Detection of in vivo production of tumour necrosis factor-alpha by human thyroid epithelial cells.
Zheng, R., Abney, E. R., Chu, C., Field, M., Maini, R. N., Lamb, J. R., & Feldmann, M. (1992) · PubMed Central · Cited by 42
van der Poll, T., Coyle, S. M., Kumar, A., Barbosa, K., Agosti, J. M., & Lowry, S. F. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.3.1490 · Cited by 41
Self-citationSuppression of Rat Thyrotroph and Thyroid Cell Function by Tumor Necrosis Factor-α
Pang, X.-P., YOSHIMURA, M., & Hershman, J. M. (1993) · Thyroid · doi:10.1089/thy.1993.3.325 · Cited by 39
PEKARY, A. E., Levin, S. R., Johnson, D. G., Berg, L., & Hershman, J. M. (1997) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1997.17.185 · Cited by 37
Tumor necrosis factor-α decreases thyrotropin-induced 5′-deiodinase activity in FRTL-5 thyroid cells
Ongphiphadhanakul, B., Fang, S. L., Tang, K., Patwardhan, N. A., & Braverman, L. E. (1994) · European Journal of Endocrinology · doi:10.1530/eje.0.1300502 · Cited by 33
The mechanism of action of tumour necrosis factor-α and interleukin 1 on FRTL-5 rat thyroid cells
Pang, X.-P., Hershman, J. M., Smith, V., PEKARY, A. E., & Sugawara, M. (1990) · European Journal of Endocrinology · doi:10.1530/acta.0.1230203 · Cited by 31
Biological Responses to Endotoxin in Humans1
van der Poll, T., & Lowry, S. F. (2015) · Progress in surgery · doi:10.1159/000424018 · Cited by 13
Self-citationSphingomyelinase and Phospholipase A 2 Regulate Type I Deiodinase Expression in FRTL-5 Cells
Pekary, A. E., CHOPRA, I. J., Berg, L., & Hershman, J. M. (1997) · Thyroid · doi:10.1089/thy.1997.7.647 · Cited by 12
Action of tumor necrosis factor-alpha on thyroid cells.
Hershman, J. M., & Pang, X.-P. (1994) · PubMed · Cited by 2
Flagged first, then by citations
Research works printed but not linked: 8
- Corssmit E. P. M., 1995, J. Clin. Endocrinol. Metab., 80, 3140
- Hershman J. M., 1993, Trans. Am. Clin. Climatol. Assoc., 105, 131
- Stouthard J. M. L., 1994, J. Clin. Endocrinol. Metab., 79, 1342
- Van der Poll T., 1997, Blood, 89, 3727
- Van der Poll T., 1994, Blood, 83, 446, 10.1182/blood.V83.2.446.446 · DOI
- Van der Poll T., 1995, Shock, 3, 1
- Van der Poll T., 1995, J. Clin. Endocrinol. Metab., 80, 1341
- Zheng R. Q. H., 1992, Immunology, 75, 456
Cited by
Sorted by citations
Thyroid Hormones, Oxidative Stress, and Inflammation
Mancini, A., Segni, C. D., Raimondo, S., Olivieri, G., Silvestrini, A., Meucci, E., & Currò, D. (2016) · Mediators of Inflammation · doi:10.1155/2016/6757154 · Cited by 558
An update on non-thyroidal illness syndrome
Fliers, E., & Boelen, A. (2021) · Journal of Endocrinological Investigation · doi:10.1007/s40618-020-01482-4 · Cited by 218
De Groot, L. J. (2006) · Critical Care Clinics · doi:10.1016/j.ccc.2005.10.001 · Cited by 188
A potential role of activated NF-κB in the pathogenesis of euthyroid sick syndrome
Nagaya, T., Fujieda, M., Otsuka, G., Yang, J.-P., Okamoto, T., & Seo, H. (2000) · Journal of Clinical Investigation · doi:10.1172/jci7771 · Cited by 107
Chen, D. L., Rosenbluth, D., Mintun, M. A., & Schuster, D. P. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01429.2005 · Cited by 80
Thyroid Hormones in Critical Illness
Maiden, M. J., & Torpy, D. J. (2019) · Critical Care Clinics · doi:10.1016/j.ccc.2018.11.012 · Cited by 76
Euthyroid Sick Syndrome and the Role of Cytokines
Papanicolaou, D. A. (2000) · Reviews in Endocrine and Metabolic Disorders · doi:10.1023/a:1010060303031 · Cited by 72
Experimental Human Endotoxemia: A Model of the Systemic Inflammatory Response Syndrome?
Calvano, S. E., & Coyle, S. M. (2012) · Surgical Infections · doi:10.1089/sur.2012.155 · Cited by 57
Self-citationThe Dynamic Neuroendocrine Response to Critical Illness
Langouche, L., & den Berghe, G. V. (2006) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2006.09.007 · Cited by 54
Anterior pituitary function in critical illness
Téblick, A., Langouche, L., & Van den Berghe, G. (2019) · Endocrine Connections · doi:10.1530/ec-19-0318 · Cited by 52
Effect of Inflammation on Molecular Targets and Drug Transporters
Hanafy, S., El‐Kadi, A. O. S., & Jamali, F. (2012) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/j30300 · Cited by 37
Effect of endotoxin challenge on hepatic 5′-deiodinase activity in cattle
Kahl, S., Elsasser, T. H., & Blum, J. W. (2000) · Domestic Animal Endocrinology · doi:10.1016/s0739-7240(99)00069-7 · Cited by 31
DeGroot, L. J. (2010) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00089-5 · Cited by 23
Hypothalamic–pituitary hormones during critical illness
Langouche, L., & den Berghe, G. V. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-59602-4.00008-3 · Cited by 23
Endotoxn-induced nonthyroidal illness in dogs
Panciera, D. L., Ritchey, J. W., & Ward, D. L. (2003) · American Journal of Veterinary Research · doi:10.2460/ajvr.2003.64.229 · Cited by 21
Bik, W., Wolińska‐Witort, E., Chmielowska, M., Baranowska-Bik, A., Rusiecka-Kuczalek, E., & Baranowska, B. (2004) · NeuroImmunoModulation · doi:10.1159/000080145 · Cited by 21
Non-Thyroidal Illness: Physiopathology and Clinical Implications
Mancini, A., Raimondo, S., Di, C., Persano, M., & Pontecorvi, A. (2013) · InTech eBooks · doi:10.5772/55644 · Cited by 6
The Dynamic Neuroendocrine Response to Critical Illness
Langouche, L., & den Berghe, G. V. (2008) · Humana Press eBooks · doi:10.1007/978-1-60327-177-6_8 · Cited by 5
Hans, V., Lenzlinger, P. M., Joller‐Jemelka, H. I., Morganti-Kossmann, M. C., & Kossmann, T. (2005) · European Journal of Trauma · doi:10.1007/s00068-005-2068-y · Cited by 3
Skvortsova, V. I., Platonova, I. A., Васильевна, Т. Т., Volkovenko, O. V., Demidova, L. I., & Ostrovtsev, I. V. (2004) · Neuroscience and Behavioral Physiology · doi:10.1023/b:neab.0000042653.86706.2a · Cited by 3
Endocrine System in Acute Kidney Injury
Sabatino, A., Ceresini, G., Marina, M., & Fiaccadori, E. (2019) · Springer eBooks · doi:10.1007/978-3-319-97765-2_23 · Cited by 2
Hormonal synchronization of lipopolysaccharide-induced hypothermic response in rats.
Polat, H., Mamuk, S., & Akarsu, E. S. (2013) · PubMed · doi:10.3275/8945 · Cited by 1
Thyroidal Changes During Critical Illness
Langouche, L., & den Berghe, G. V. (2016) · Springer eBooks · doi:10.1007/978-3-319-27687-8_11 · Cited by 1
Corder, N. L. B., Flatland, B., Fry, M. M., Sun, X., Fecteau, K. A., & Giori, L. (2019) · PeerJ · doi:10.7717/peerj.7468 · Cited by 1
Endocrinology in the critically ill
Vervenne, H. B. V. K., & den Berghe, G. V. (2011) · doi:10.1093/med/9780199235292.003.0177 · Cited by 1
Koenig, R. J. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-4745-2.00020-1
Sajdel, E. M., Biały, M., & Zabielski, R. (2016) · Contemporary clinical neuroscience · doi:10.1007/978-1-4939-3737-0_4
Metadata
- Authors
- van der Poll, T., Endert, E., Coyle, S. M., Agosti, J. M., & Lowry, S. F.
- Affiliations
- Division of Surgical Sciences, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey 08903;
- Amsterdam UMC Location University of Amsterdam (NL)
- University of Medicine and Dentistry of New Jersey (US)
- Immune Tolerance Network (US)
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 1999-02-01
- Volume
- 276
- Issue
- 2
- Pages
- R357-R362
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2116555527
- Cited by
- 27
- References
- 36
- Citations by year
- 2020: 1 · 2019: 4 · 2016: 3 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Funders
- National Institute of General Medical Sciences (GM-34695)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Keywords
- TNF-α, endotoxin, endotoxemia, thyroid hormone metabolism, thyroid-stimulating hormone, thyroxine, triiodothyronine
- MeSH terms
- Adult, Endotoxins, Euthyroid Sick Syndromes, Humans, Immunoglobulin G, Immunoglobulin Fc Fragments, Injections, Intravenous, Lipopolysaccharides, Male, Recombinant Fusion Proteins, Thyroid Hormones, Thyrotropin, Thyroxine, Triiodothyronine, Triiodothyronine, Reverse, Tumor Necrosis Factor-alpha, Receptors, Tumor Necrosis Factor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
