The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The individual responsiveness to growth hormone (GH) treatment in GH- deficient adults is dependent on the level of GH-binding protein, body mass index, age, and gender
Abstract
The aim of the present trial was to study the individual responsiveness to GH treatment in terms of body composition and to search for possible predictors of the response in GH-deficient adults. Sixty-eight patients (44 men and 24 women) with a mean age of 44.3 (1.2) yr and verified GH deficiency participated in a 2-phase treatment trial with an initial randomized, double blind, placebo-controlled, 6-month period, followed by an open treatment period, thereby ensuring all patients 12 months of GH treatment. Recombinant human GH was administered sc daily at bedtime, with a target dose of 12 micrograms/kg x day. GHBP was measured by ligand-mediated immunofunctional assay, and serum insulin-like growth factor I (IGF-I) was determined by RIA after acid-ethanol extraction, using a truncated IGF-I analog as the radioligand. Lean body mass (LBM) and body fat (BF) were determined by dual energy x-ray absorptiometry, and total body water (TBW) was determined by bioelectrical impedance. During the placebo control period, serum IGF-I,LBM, and TBW increased (P < 0.001), whereas BF decreased (P < 0.001) and serum GHBP was unchanged in the group treated with GH compared with the patients treated with placebo. After 12 months of GH treatment, the individual changes in BF ranged from -12.5 to 4.3 kg and from -4.5 to 10.1 kg in LBM. Age (P < 0.05) and baseline GHBP level (P < 0.01) were inversely correlated with the increase in LBM. The GH-induced increment in IGF-I and TBW was greater in men…
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Muscle strength improvement is sustained for at least 10 years.
“Muscle strength improvement is sustained for at least 10 years (168).”
From Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline (2016) · cites this paper as [168]
Lean body mass improves by up to 7% during the first year of GH replacement.
“while lean body mass improves by up to 7% during the first year of GH replacement (167,168).”
From Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline (2016) · cites this paper as [168]
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WEISSBERGER, A. J., HO, K. K. Y., & LAZARUS, L. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-72-2-374 · Cited by 514
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Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline
Fleseriu, M., Hashim, I. A., Karavitaki, N., Melmed, S., Murad, M. H., Salvatori, R., & Samuels, M. H. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2118 · Cited by 945
Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review
Carroll, P. V., Christ the members of Growth Hormon, E. R., Bengtsson, B. Å., Carlsson, L., Christiansen, J. S., Clemmons, D., Hintz, R., Ho, K., Laron, Z., Sizonenko, P., et al. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.2.4594 · Cited by 822
Self-citationEndocrine Control of Body Composition in Infancy, Childhood, and Puberty
Veldhuis, J. D., Roemmich, J. N., Richmond, E. J., Rogol, A. D., Lovejoy, J. C., Sheffield-Moore, M., Mauras, N., & Bowers, C. Y. (2005) · Endocrine Reviews · doi:10.1210/er.2003-0038 · Cited by 452
Maison, P., Griffin, S., Nicoue-Beglah, M., Haddad, N., Balkau, B., & Chanson, P. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030840 · Cited by 362
Drake, W. M., Rodríguez‐Arnao, J., Weaver, J. U., James, I. T., Coyte, D., Spector, T. D., Besser, G. M., & Monson, J. P. (2001) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2001.01246.x · Cited by 76
Filipsson, H., & Johannsson, G. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-0319 · Cited by 50
Self-citationSex-steroid control of the aging somatotropic axis
Veldhuis, J. D., Erickson, D., Iranmanesh, A., Miles, J. M., & Bowers, C. Y. (2005) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2005.07.006 · Cited by 30
Christiansen, J. J., Fisker, S., Gravholt, C. H., Bennett, P., Svenstrup, B., Andersen, M., Feldt-Rasmussen, U., Christiansen, J. S., & Jørgensen, J. O. L. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.01898 · Cited by 16
Metadata
- Authors
- Johannsson, G., Bjarnason, R., Bramnert, M., Carlsson, L. M., Degerblad, M., Manhem, P., Rośen, T., Thorén, M., & Bengtsson, B. A.
- Affiliations
- Sahlgrenska University Hospital (SE)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1996-04
- Volume
- 81
- Issue
- 4
- Pages
- 1575-1581
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2153909093
- Cited by
- 197
- References
- 1
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 2 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 4 · 2012: 6
- FWCI
- 12.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Keywords
- growth hormone deficiency, individual treatment response, GH-binding protein, insulin-like growth factor I, body composition, lean body mass, fat mass, total body water, predictors of treatment response, sex differences, age effects, body mass index
- MeSH terms
- Adipose Tissue, Adult, Age Factors, Body Water, Carrier Proteins, Child, Double-Blind Method, Female, Follow-Up Studies, Humans, Insulin-Like Growth Factor I, Male, Pituitary Diseases, Pituitary Neoplasms, Placebos, Recombinant Proteins, Regression Analysis, Sex Characteristics, Growth Hormone, Absorptiometry, Photon, Body Mass Index, Age of Onset
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