Sex-steroid control of the aging somatotropic axis

The Somatomedin Hypothesis: 2001

Roith, D. L., Bondy, C. A., Yakar, S., Liu, J., & Butler, A. A. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.1.0419 · Cited by 1,258 · see citing works

Pathophysiology of the Neuroregulation of Growth Hormone Secretion in Experimental Animals and the Human*

Giustina, A., & Veldhuis, J. D. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.6.0353 · Cited by 1,253 · see citing works

Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations

HO, K. Y., EVANS, W. S., BLIZZARD, R. M., VELDHUIS, J. D., MERRIAM, G. R., SAMOJLIK, E., FURLANETTO, R., ROGOL, A. D., KAISER, D. L., & THORNER, M. O. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-1-51 · Cited by 921 · see citing works

Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men

IRANMANESH, A., LIZARRALDE, G., & VELDHUIS, J. D. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-5-1081 · Cited by 672 · see citing works

Age-related change in the twenty-four-hour spontaneous secretion of growth hormone

FINKELSTEIN, J. W., ROFFWARG, H. P., BOYAR, R. M., KREAM, J., & HELLMAN, L. (1972) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-35-5-665 · Cited by 640 · see citing works

Low Serum Insulin-Like Growth Factor I Is Associated With Increased Risk of Ischemic Heart Disease: A Population-Based Case-Control Study

Juul, A., Scheike, T., Davidsen, M., Gyllenborg, J., & Jørgensen, T. (2002) · Circulation · doi:10.1161/01.cir.0000027563.44593.cc · Cited by 640 · see citing works

Neuroendocrine Control of Growth Hormone Secretion

Müller, E. E., Locatelli, V., & Cocchi, D. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.2.511 · Cited by 631 · see citing works

The Influence of Age on the 24-Hour Integrated Concentration of Growth Hormone in Normal Individuals*

Zadik, Z., CHALEW, A., McCarter, R., Meistas, M. T., & Kowarski, A. A. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-60-3-513 · Cited by 596 · see citing works

Pathophysiology of the Neuroregulation of Growth Hormone Secretion in Experimental Animals and the Human

Giustina, A. (1998) · Endocrine Reviews · doi:10.1210/er.19.6.717 · Cited by 489 · see citing works

Effects of Estrogen and Sex Difference on Secretion of Human Growth Hormone1

FRANTZ, A. G., & RABKIN, M. T. (1965) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-25-11-1470 · Cited by 467 · see citing works

Endocrine Control of Body Composition in Infancy, Childhood, and Puberty

Veldhuis, J. D., Roemmich, J. N., Richmond, E. J., Rogol, A. D., Lovejoy, J. C., Sheffield-Moore, M., Mauras, N., & Bowers, C. Y. (2005) · Endocrine Reviews · doi:10.1210/er.2003-0038 · Cited by 452 · see citing works

Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis

Lichtenwalner, R. J., Forbes, M. E., Bennett, S. A., Lynch, C. D., Sonntag, W. E., & Riddle, D. R. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00378-5 · Cited by 428 · see citing works

Differential impact of age, sex steroid hormones, and obesity on basal versus pulsatile growth hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay

Veldhuis, J. D., Liem, A. Y., South, S. A., WELTMAN, A. L., Weltman, J. Y., Clemmons, D., Abbott, R. D., Mulligan, T., Johnson, M. L., & Pincus, S. M. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.11.7593428 · Cited by 385 · see citing works

The prospective association of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-1 levels with all cause and cardiovascular disease mortality in older adults: the Rancho Bernardo Study

Laughlin, G. A., Barrett-Connor, E., Criqui, M. H., & Kritz-Silverstein, D. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030967 · Cited by 374 · see citing works

Older males secrete luteinizing hormone and testosterone more irregularly, and jointly more asynchronously, than younger males

Pincus, S. M., Mulligan, T., Iranmanesh, A., Gheorghiu, S., Godschalk, M., & Veldhuis, P. P. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.14100 · Cited by 337 · see citing works

Growth Hormone Treatment of Abdominally Obese Men Reduces Abdominal Fat Mass, Improves Glucose and Lipoprotein Metabolism, and Reduces Diastolic Blood Pressure1

Johannsson, G., Mårin, P., Lönn, L., Ottosson, M., Stenlöf, K., Björntorp, P. A., Sjöström, L., & Bengtsson, B. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.3.3809 · Cited by 336 · see citing works

A Low Dose of Ghrelin Stimulates Growth Hormone (GH) Release Synergistically with GH-Releasing Hormone in Humans

Hataya, Y., Akamizu, T., Takaya, K., Kanamoto, N., Ariyasu, H., Saijo, M., Moriyama, K., Shimatsu, A., Kojima, M., Kangawa, K., et al. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.9.8002 · Cited by 293 · see citing works

An amplitude-specific divergence in the pulsatile mode of growth hormone (GH) secretion underlies the gender difference in mean GH concentrations in men and premenopausal women.

van den Berg, G., Veldhuis, J. D., Frölich, M., & Roelfsema, F. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.7.8675561 · Cited by 293 · see citing works

The Somatomedin Hypothesis: 2001

Roith, D. L. (2001) · Endocrine Reviews · doi:10.1210/er.22.1.53 · Cited by 271 · see citing works

Growth hormone treatment improves serum lipids and lipoproteins in adults with growth hormone deficiency

Cuneo, R. C., Salomon, F., Watts, G. F., Hesp, R., & Sönksen, P. H. (1993) · Metabolism · doi:10.1016/0026-0495(93)90145-e · Cited by 252 · see citing works

Growth Hormone Treatment of Abdominally Obese Men Reduces Abdominal Fat Mass, Improves Glucose and Lipoprotein Metabolism, and Reduces Diastolic Blood Pressure

Johannsson, G. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.3.727 · Cited by 230 · see citing works

Estrogen and Testosterone, But Not a Nonaromatizable Androgen, Direct Network Integration of the Hypothalamo-Somatotrope (Growth Hormone)-Insulin-Like Growth Factor I Axis in the Human: Evidence from Pubertal Pathophysiology and Sex-Steroid Hormone Replacement1

Veldhuis, J. D., Metzger, D. L., MARTHA, P. M., Mauras, N., Kerrigan, J. R., Keenan, B. S., Rogol, A. D., & Pincus, S. M. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.10.4317 · Cited by 225 · see citing works

Enhanced basal and disorderly growth hormone secretion distinguish acromegalic from normal pulsatile growth hormone release.

Hartman, M. L., Pincus, S. M., Johnson, M. L., Matthews, D., Faunt, L. M., Vance, M. L., Thorner, M. O., & Veldhuis, J. D. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117446 · Cited by 220 · see citing works

Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity.

Shuto, Y., Shibasaki, T., Otagiri, A., Kuriyama, H., Ohata, H., Tamura, H., Kamegai, J., Sugihara, H., Oikawa, S., & Wakabayashi, I. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0213300 · Cited by 220 · see citing works

Relationship between age, percentage body fat, fitness, and 24-hour growth hormone release in healthy young adults: effects of gender

WELTMAN, A. L., Weltman, J. Y., Hartman, M. L., Abbott, R. D., Rogol, A. D., Evans, W. S., & Veldhuis, J. D. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.3.8126124 · Cited by 199 · see citing works

The individual responsiveness to growth hormone (GH) treatment in GH- deficient adults is dependent on the level of GH-binding protein, body mass index, age, and gender

Johannsson, G., Bjarnason, R. G., Bramnert, M., Carlsson, L. M. S., Degerblad, M., Manhem, P., Rosén, T., Thoren, M., & Bengtsson, B. ‐. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.4.8636370 · Cited by 199 · see citing works

Pulsatile growth hormone release in normal women during the menstrual cycle

Faria, A. C. S., Bekenstein, L. W., Booth, R., Vaccaro, V. A., Asplin, C. M., Veldhuls, J. D., Thorner, M. O., & Evans, W. S. (1992) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1992.tb02270.x · Cited by 193 · see citing works

Acute and Chronic Estrogen Effects upon Serum Somatomedin Activity, Growth Hormone, and Prolactin in Man

Wiedemann, E., Schwartz, E., & FRANTZ, A. G. (1976) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-42-5-942 · Cited by 187 · see citing works

Activation of the somatotropic axis by testosterone in adult males: evidence for the role of aromatization

Weissberger, A. J., & Ho, K. K. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.76.6.8501143 · Cited by 185 · see citing works

Two Years of Growth Hormone (GH) Treatment Increase Isometric and Isokinetic Muscle Strength in GH-Deficient Adults

Johannsson, G., Grimby, G., Sunnerhagen, K. S., & Bengtsson, B. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.9.4204 · Cited by 172 · see citing works

Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth.

Low, M. J., Otero-Corchon, V., Parlow, A. F., Ramirez, J. L., Kumar, U., Patel, Y. C., & Rubinstein, M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11941 · Cited by 163 · see citing works

Gender and Sexual Maturation-Dependent Contrasts in the Neuroregulation of Growth Hormone Secretion in Prepubertal and Late Adolescent Males and Females--A General Clinical Research Center-Based Study

Veldhuis, J. D., Roemmich, J. N., & Rogol, A. D. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.7.6697 · Cited by 155 · see citing works

Estrogen receptor blockade with tamoxifen diminishes growth hormone secretion in boys: evidence for a stimulatory role of endogenous estrogens during male adolescence.

Metzger, D. L., & Kerrigan, J. R. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.2.8045971 · Cited by 152 · see citing works

A feedback-controlled ensemble model of the stress-responsive hypothalamo-pituitary-adrenal axis.

Keenan, D. M., Licinio, J., & Veldhuis, J. D. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051624198 · Cited by 145 · see citing works

Low basal and persistent pulsatile growth hormone secretion are revealed in normal and hyposomatotropic men studied with a new ultrasensitive chemiluminescence assay.

Iranmanesh, A., Grisso, B., & Veldhuis, J. D. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.3.8126122 · Cited by 137 · see citing works

Gender difference in insulin-like growth factor I response to growth hormone (GH) treatment in GH-deficient adults: role of sex hormone replacement

Span, J. P. T., Pieters, G. F. F. M., Sweep, C. G. J., Hermus, A. R. M. M., & Smals, A. G. H. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.3.6463 · Cited by 132 · see citing works

Estrogen and Testosterone, But Not a Nonaromatizable Androgen, Direct Network Integration of the Hypothalamo-Somatotrope (Growth Hormone)-Insulin-Like Growth Factor I Axis in the Human: Evidence from Pubertal Pathophysiology and Sex-Steroid Hormone Replacement

Veldhuis, J. D. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.10.3414 · Cited by 132 · see citing works

Growth hormone secretion pattern is an independent regulator of growth hormone actions in humans

Jaffe, C. A., Turgeon, D. K., Lown, K. S., DeMott-Friberg, R., & Watkins, P. B. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00513.2001 · Cited by 128 · see citing works

Altered Neuroregulation of GH Secretion in Viscerally Obese Premenopausal Women

Pijl, H., Langendonk, J. G., Burggraaf, J., Frölich, M., Cohen, A. F., Veldhuis, J. D., & Meinders, A. E. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.11.8061 · Cited by 125 · see citing works

Long-Term Improvement of Quality of Life During Growth Hormone (GH) Replacement Therapy in Adults with GH Deficiency, as Measured by Questions on Life Satisfaction-Hypopituitarism (QLS-H)

Rosilio, M., Blum, W. F., Edwards, D. J., Shavrikova, E. P., Valle, D., Lamberts, S. W. J., Erfurth, E. M., Webb, S. M., Ross, R. J. M., Chihara, K., et al. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030134 · Cited by 121 · see citing works

Insulin-Like Growth Factor I and Growth Hormone (GH) Treatment in GH-Deficient Humans: Differential Effects on Protein, Glucose, Lipid, and Calcium Metabolism1

Mauras, N., O'Brien, K. O., Welch, S., Rini, A., Helgeson, K., Vieira, N. E., & Yergey, A. L. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.4.6541 · Cited by 117 · see citing works

Interaction of insulin-like growth factor-I and estradiol signaling pathways on hypothalamic neuronal differentiation

Dueñas, M., Torres‐Alemán, I., Naftolin, F. N., & García‐Segura, L. M. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00142-x · Cited by 114 · see citing works

Differential Effects of Growth Hormone and Insulin-Like Growth Factor I on Colony Formation of Epiphyseal Chondrocytes in Suspension Culture in Rats of Different Ages*

Lindahl, A. H., Isgaard, J., Carlsson, L. M. S., & Isaksson, O. G. P. (1987) · Endocrinology · doi:10.1210/endo-121-3-1061 · Cited by 114 · see citing works

Genomic Structure and Transcriptional Regulation of the Human Growth Hormone Secretagogue Receptor1

Petersenn, S., Rasch, A. C., Penshorn, M., Beil, F. U., & Schulte, H. M. (2001) · Endocrinology · doi:10.1210/endo.142.6.8184 · Cited by 114 · see citing works

Increased Pulsatile, But Not Basal, Growth Hormone Secretion Rates and Plasma Insulin-Like Growth Factor I Levels during the Periovulatory Interval in Normal Women

Ovesen, P., Vahl, N., Fisker, S., Veldhuis, J. D., Christiansen, J. S., & Jørgensen, J. O. L. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.5.4761 · Cited by 113 · see citing works

A Paradoxical Gender Dissociation within the Growth Hormone/Insulin-Like Growth Factor I Axis during Protracted Critical Illness1

den Berghe, G. V., Baxter, R. C., Weekers, F., Wouters, P. J., Bowers, C. Y., & Veldhuis, J. D. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.1.6316 · Cited by 106 · see citing works

Maturation of the Regulation of Growth Hormone Secretion in Young Males with Hypogonadotropic Hypogonadism Pharmacologically Exposed to Progressive Increments in Serum Testosterone1

Giustina, A., Scalvini, T., Tassi, C., Desenzani, P., Poiesi, C., Wehrenberg, W. B., Rogol, A. D., & Veldhuis, J. D. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.4.3871 · Cited by 99 · see citing works

The role of sexual steroids in the modulation of growth hormone (GH) secretion in humans.

Devesa, J., Lois, N., Arce, V., Diaz, M. J., Lima, L., & Tresguerres, J. A. F. (1991) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(91)90179-9 · Cited by 98 · see citing works

Unequal impact of short-term testosterone repletion on the somatotropic axis of young and older men.

Gentili, A., Mulligan, T., Godschalk, M., Clore, J., Patrie, J., Iranmanesh, A., & Veldhuis, J. D. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.2.8222 · Cited by 98 · see citing works

Physiological control of pituitary hormone secretory-burst mass, frequency, and waveform: a statistical formulation and analysis

Keenan, D. M., Roelfsema, F., Biermasz, N. R., & Veldhuis, J. D. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00195.2003 · Cited by 96 · see citing works

The effect of one-year cross-sex hormonal treatment on bone metabolism and serum insulin-like growth factor-1 in transsexuals

van Kesteren, P. J. M., Lips, P. T. A. M., Devillé, W. L. J. M., Popp‐Snijders, C., Asscheman, H., Megens, J. A. J., & Gooren, L. J. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.6.8964856 · Cited by 94 · see citing works

Unequal impact of age, percentage body fat, and serum testosterone concentrations on the somatotrophic, IGF-I, and IGF-binding protein responses to a three-day intravenous growth hormone-releasing hormone pulsatile infusion in men

Iranmanesh, A., South, S. A., Liem, A. Y., Clemmons, D. R., Thorner, M. O., WELTMAN, A. L., & Veldhuis, J. D. (1998) · European Journal of Endocrinology · doi:10.1530/eje.0.1390059 · Cited by 88 · see citing works

Short-Term Estradiol Supplementation Augments Growth Hormone (GH) Secretory Responsiveness to Dose-Varying GH-Releasing Peptide Infusions in Healthy Postmenopausal Women

Anderson, S. M., Shah, N., Evans, W. S., Patrie, J. T., Bowers, C. Y., & Veldhuis, J. D. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7240 · Cited by 83 · see citing works

The GH-releasing effect of ghrelin, a natural GH secretagogue, is only blunted by the infusion of exogenous somatostatin in humans.

Di Vito, L., Broglio, F., Benso, A., Gottero, C., Prodam, F., Papotti, M., Muccioli, G., Dieguez, C., Casanueva, F. F., Deghenghi, R., et al. (2002) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2002.01530.x · Cited by 83 · see citing works

The Growth Hormone Response to Hexarelin in Children: Reproducibility and Effect of Sex Steroids1

Loche, S., Colao, A., Cappa, M., BELLONE, J., Aimaretti, G., Farello, G., Faedda, A., Lombardi, G., Deghenghi, R., & Ghigo, E. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.3.3795 · Cited by 82 · see citing works

Actions of estrogen on pulsatile, nyctohemeral, and entropic modes of growth hormone secretion

Shah, N., Evans, W. S., & Veldhuis, J. D. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.5.r1351 · Cited by 82 · see citing works

Effects of Recombinant Human Insulin-Like Growth Factor I (IGF-I) Therapy on the Growth Hormone-IGF System of a Patient with a Partial IGF-I Gene Deletion

Camacho‐Hübner, C., Woods, K. A., Miraki‐Moud, F., Hindmarsh, P. C., Clark, A., Hansson, Y., Johnston, A. E., Baxter, R. C., & Savage, M. O. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.5.5649 · Cited by 75 · see citing works

Hormonal Relationships During the Menstrual Cycle

Yen, S. S. C. (1970) · JAMA · doi:10.1001/jama.1970.03170090029006 · Cited by 75 · see citing works

Maturation of the Regulation of Growth Hormone Secretion in Young Males with Hypogonadotropic Hypogonadism Pharmacologically Exposed to Progressive Increments in Serum Testosterone

Giustina, A. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.4.1210 · Cited by 74 · see citing works

Reconstruction of <i>in vivo</i> time-evolving neuroendocrine dose–response properties unveils admixed deterministic and stochastic elements

Keenan, D. M., Alexander, S., Irvine, C. H. G., Clarke, I., Scott, C., Turner, A., Tilbrook, A. J., Canny, B. J., & Veldhuis, J. D. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0300619101 · Cited by 70 · see citing works

A construct of interactive feedback control of the GH axis in the male

Farhy, L. S., Straume, M., Johnson, M. L., Kovatchev, B. P., & Veldhuis, J. D. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.1.r38 · Cited by 70 · see citing works

Lowering Total Plasma Insulin-Like Growth Factor I Concentrations by Way of a Novel, Potent, and Selective Growth Hormone (GH) Receptor Antagonist, Pegvisomant (B2036-Peg), Augments the Amplitude of GH Secretory Bursts and Elevates Basal/Nonpulsatile GH Release in Healthy Women and Men1

Veldhuis, J. D., Bidlingmaier, M., Anderson, S. M., Wu, Z., & Strasburger, C. J. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.7.7656 · Cited by 68 · see citing works

Short-Term Modulation of the Androgen Milieu Alters Pulsatile, But Not Exercise- or Growth Hormone (GH)-Releasing Hormone-Stimulated GH Secretion in Healthy Men: Impact of Gonadal Steroid and GH Secretory Changes on Metabolic Outcomes¹

Fryburg, D. A., Weltman, A., Jahn, L. A., Weltman, J. Y., Samojlik, E., Hintz, R. L., & Veldhuis, J. D. (1997) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jcem.82.11.4379 · Cited by 64 · see citing works

Defective Hypothalamic Growth Hormone (GH)-Releasing Hormone Activity May Contribute to Declining GH Secretion with Age in Man1

Uberti, E. C. D., Ambrosio, M. R., Cella, S. G., Margutti, A., Trasforini, G., Rigamonti, A. E., Petrone, E., & Müller, E. E. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.9.4216 · Cited by 61 · see citing works

Sustained elevation of pulsatile growth hormone (GH) secretion and insulin-like growth factor I (IGF-I), IGF-binding protein-3 (IGFBP-3), and IGFBP-5 concentrations during 30-day continuous subcutaneous infusion of GH-releasing peptide-2 in older men and women.

Bowers, C. Y., Granda, R., Mohan, S., Kuipers, J., Baylink, D., & Veldhuis, J. D. (2004) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2003-031799 · Cited by 57 · see citing works

Insulin-Like Growth Factor I and Growth Hormone (GH) Treatment in GH-Deficient Humans: Differential Effects on Protein, Glucose, Lipid, and Calcium Metabolism

Mauras, N. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.4.1686 · Cited by 57 · see citing works

Short-Term Estradiol Replacement in Postmenopausal Women Selectively Mutes Somatostatin’s Dose-Dependent Inhibition of Fasting Growth Hormone Secretion1

Bray, M. J., Vick, T. M., Shah, N., Anderson, S. M., Rice, L., Iranmanesh, A., Evans, W. S., & Veldhuis, J. D. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.7.7647 · Cited by 56 · see citing works

Putative GH pulse renewal: periventricular somatostatinergic control of an arcuate-nuclear somatostatin and GH-releasing hormone oscillator

Farhy, L. S., & Veldhuis, J. D. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00473.2003 · Cited by 55 · see citing works

Age-related Variations in the Neuroendocrine Control, More Than Impaired Receptor Sensitivity, Cause The Reduction in the GH-releasing Activity of GHRPs in Human Aging

Arvat, E., Ceda, G. P., Vito, L. D., Ramunni, J., Gianotti, L., Broglio, F., Deghenghi, R., & Ghigo, E. (1998) · Pituitary · doi:10.1023/a:1009970909015 · Cited by 54 · see citing works

Endocrine and Metabolic Effects of Long-Term Administration of[ Nle27]Growth Hormone-Releasing Hormone-(1–29)-NH2in Age-Advanced Men and Women1

Khorram, O., Laughlin, G. A., & Yen, S. S. C. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.5.3943 · Cited by 54 · see citing works

Low basal and persistent pulsatile growth hormone secretion are revealed in normal and hyposomatotropic men studied with a new ultrasensitive chemiluminescence assay

Iranmanesh, A. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.78.3.526 · Cited by 54 · see citing works

A Paradoxical Gender Dissociation within the Growth Hormone/Insulin-Like Growth Factor I Axis during Protracted Critical Illness

den Berghe, G. V. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.1.183 · Cited by 51 · see citing works

Tripartite Neuroendocrine Activation of the Human Growth Hormone (GH) Axis in Women by Continuous 24-Hour GH-Releasing Peptide Infusion: Pulsatile, Entropic, and Nyctohemeral Mechanisms1

Shah, N., Evans, W. S., Bowers, C. Y., & Veldhuis, J. D. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.6.5687 · Cited by 50 · see citing works

E2 Supplementation Selectively Relieves GH’s Autonegative Feedback on GH-Releasing Peptide-2-Stimulated GH Secretion

Anderson, S. M., Wideman, L., Patrie, J. T., Weltman, A., Bowers, C. Y., & Veldhuis, J. D. (2001) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jcem.86.12.8076 · Cited by 50 · see citing works

Joint pituitary-hypothalamic and intrahypothalamic autofeedback construct of pulsatile growth hormone secretion

Farhy, L. S., & Veldhuis, J. D. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00086.2003 · Cited by 50 · see citing works

Lowering Total Plasma Insulin-Like Growth Factor I Concentrations by Way of a Novel, Potent, and Selective Growth Hormone (GH) Receptor Antagonist, Pegvisomant (B2036-Peg), Augments the Amplitude of GH Secretory Bursts and Elevates Basal/Nonpulsatile GH Release in Healthy Women and Men

Veldhuis, J. D. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.7.3304 · Cited by 50 · see citing works

Unequal autonegative feedback by GH models the sexual dimorphism in GH secretory dynamics

Farhy, L. S., Straume, M., Johnson, M. L., Kovatchev, B. P., & Veldhuis, J. D. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00407.2001 · Cited by 49 · see citing works

The impact of dose and route of estrogen administration on the somatotropic axis in normal women.

Lissett, C. A., & Shalet, S. M. (2003) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2003-022036 · Cited by 48 · see citing works

Estradiol supplementation enhances submaximal feed-forward drive of growth hormone (GH) secretion by recombinant human GH-releasing hormone-1,44-amide in a putatively somatostatin-withdrawn milieu.

Veldhuis, J. D., Evans, W. S., & Bowers, C. Y. (2003) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2003-030410 · Cited by 46 · see citing works

Genomic Structure and Transcriptional Regulation of the Human Growth Hormone Secretagogue Receptor

Petersenn, S. (2001) · Endocrinology · doi:10.1210/en.142.6.2649 · Cited by 46 · see citing works

Aging effects on growth hormone receptor binding in the brain

Nyberg, F. (1997) · Experimental Gerontology · doi:10.1016/s0531-5565(96)00170-2 · Cited by 41 · see citing works

Defective Hypothalamic Growth Hormone (GH)-Releasing Hormone Activity May Contribute to Declining GH Secretion with Age in Man

Uberti, E. C. D. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.9.2885 · Cited by 41 · see citing works

Short-Term Estradiol Replacement in Postmenopausal Women Selectively Mutes Somatostatin's Dose-Dependent Inhibition of Fasting Growth Hormone Secretion

Bray, M. J. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.7.3143 · Cited by 40 · see citing works

Estradiol Supplementation in Postmenopausal Women Doubles Rebound-Like Release of Growth Hormone (GH) Triggered by Sequential Infusion and Withdrawal of Somatostatin: Evidence that Estrogen Facilitates Endogenous GH-Releasing Hormone Drive

Veldhuis, J. D., Anderson, S. M., Patrie, J. T., & Bowers, C. Y. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031291 · Cited by 39 · see citing works

Effects of Aging and Estradiol Supplementation on GH Axis Dynamics in Women

Lieman, H., Adel, T. E., Forst, C., Hagen, S. V., & Santoro, N. F. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.8.7751 · Cited by 39 · see citing works

Continuous 24-Hour Intravenous Infusion of Recombinant Human Growth Hormone (GH)-Releasing Hormone-(1–44)-Amide Augments Pulsatile, Entropic, and Daily Rhythmic GH Secretion in Postmenopausal Women Equally in the Estrogen-Withdrawn and Estrogen-Supplemented States1

Evans, W. S., Anderson, S. M., Hull, L. T., Azimi, P., Bowers, C. Y., & Veldhuis, P. P. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7195 · Cited by 39 · see citing works

The insulin‐like growth factor‐I generation test: peripheral responsiveness to growth hormone is not decreased with ageing

Lissett, C. A., & Shalet, S. M. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01703.x · Cited by 37 · see citing works

Oral Estradiol Administration Modulates Continuous Intravenous Growth Hormone (GH)-Releasing Peptide-2-Driven GH Secretion in Postmenopausal Women

Shah, N., Evans, W. S., Bowers, C. Y., & Veldhuis, J. D. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.8.6729 · Cited by 36 · see citing works

Impact of Estradiol Supplementation on Dual Peptidyl Drive of GH Secretion in Postmenopausal Women

Veldhuis, J. D., Evans, W. S., & Bowers, C. Y. (2002) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jcem.87.2.8251 · Cited by 36 · see citing works

Short-Term Modulation of the Androgen Milieu Alters Pulsatile, But Not Exercise- or Growth Hormone (GH)-Releasing Hormone-Stimulated GH Secretion in Healthy Men: Impact of Gonadal Steroid and GH Secretory Changes on Metabolic Outcomes

Fryburg, D. A. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.11.3710 · Cited by 36 · see citing works

The Growth Hormone Response to Hexarelin in Children: Reproducibility and Effect of Sex Steroids

Loche, S. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.3.861 · Cited by 35 · see citing works

Estradiol supplementation modulates growth hormone (GH) secretory-burst waveform and recombinant human insulin-like growth factor-I-enforced suppression of endogenously driven GH release in postmenopausal women.

Veldhuis, J. D., Anderson, S. M., Kok, P., Iranmanesh, A., Frystyk, J., Ørskov, H., & Keenan, D. M. (2004) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2003-031482 · Cited by 34 · see citing works

The IGF‐I response to very low rhGH doses is preserved in human ageing

Arvat, E., Ceda, G. P., Ramunni, J., et al. (1998) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1998.00613.x · Cited by 32 · see citing works

Endocrine and Metabolic Effects of Long-Term Administration of [Nle27]Growth Hormone-Releasing Hormone-(1-29)-NH2 in Age-Advanced Men and Women

Khorram, O. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.5.1472 · Cited by 31 · see citing works

Sex-Steroid Modulation of Growth Hormone (GH) Secretory Control: Three-Peptide Ensemble Regulation Under Dual Feedback Restraint by GH and IGF-I

Veldhuis, J. D., & Bowers, C. Y. (2003) · Endocrine · doi:10.1385/endo:22:1:25 · Cited by 28 · see citing works

Testosterone Blunts Feedback Inhibition of Growth Hormone Secretion by Experimentally Elevated Insulin-Like Growth Factor-I Concentrations

Veldhuis, J. D., Anderson, S. M., Iranmanesh, A., & Bowers, C. Y. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1303 · Cited by 27 · see citing works

Interactive Regulation of Postmenopausal Growth Hormone Insulin-Like Growth Factor Axis by Estrogen and Growth Hormone-Releasing Peptide-2

Veldhuis, J. D., Evans, W. S., Bowers, C. Y., & Anderson, S. M. (2001) · Endocrine · doi:10.1385/endo:14:1:045 · Cited by 27 · see citing works

Dual secretagogue drive of burst-like growth hormone secretion in postmenopausal compared with premenopausal women studied under an experimental estradiol clamp.

Erickson, D., Keenan, D. M., Mielke, K., Bradford, K., Bowers, C. Y., Miles, J. M., & Veldhuis, J. D. (2004) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2004-0424 · Cited by 26 · see citing works

Peak and trough growth hormone (GH) concentrations influence growth and serum insulin like growth factor‐1 (IGF‐1) concentrations in short children

Achermann, J. C., Brook, C. G. D., Robinson, I. C. A. F., Matthews, D. R., & Hindmarsh, P. C. (1999) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1999.tb03945.x · Cited by 25 · see citing works

Contributions of gender and systemic estradiol and testosterone concentrations to maximal secretagogue drive of burst-like growth hormone secretion in healthy middle-aged and older adults

Veldhuis, J. D., Patrie, J. T., Brill, K. T., Weltman, J. Y., Mueller, E. E., Bowers, C. Y., & Weltman, A. (2004) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2004-0644 · Cited by 25 · see citing works

Sustained Growth Hormone (GH) and Insulin-Like Growth Factor I Responses to Prolonged High-Dose Twice-Daily GH-Releasing Hormone Stimulation in Middle-Aged and Older Men

Veldhuis, J. D., Patrie, J. T., Frick, K., Weltman, J. Y., & WELTMAN, A. L. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0430 · Cited by 25 · see citing works

Continuous 24-Hour Intravenous Infusion of Recombinant Human Growth Hormone (GH)-Releasing Hormone-(1-44)-Amide Augments Pulsatile, Entropic, and Daily Rhythmic GH Secretion in Postmenopausal Women Equally in the Estrogen-Withdrawn and Estrogen-Supplemented States

Evans, W. S. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.2.700 · Cited by 25 · see citing works

Growth Hormone and the Acquisition of Bone Mass

Johannsson, G., & Bengtsson, B.-Å. (2009) · Hormone Research · doi:10.1159/000191332 · Cited by 22 · see citing works

Acromegalic features in growth hormore (GH)‐deficient patients after long‐term GH therapy

Carvalho, L. R. S., de Faria, M. E. J., Osório, M. G. F., et al. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01899.x · Cited by 21 · see citing works

Contrasting Negative-Feedback Control of Endogenously Driven and Exercise-Stimulated Pulsatile Growth Hormone Secretion in Women and Men

Veldhuis, J. D., Patrie, J. T., Wideman, L., Patterson, M., Weltman, J. Y., & WELTMAN, A. L. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031081 · Cited by 21 · see citing works

Tripartite Neuroendocrine Activation of the Human Growth Hormone (GH) Axis in Women by Continuous 24-Hour GH-Releasing Peptide Infusion: Pulsatile, Entropic, and Nyctohemeral Mechanisms

Shah, N. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.6.2140 · Cited by 20 · see citing works

Rethink about growth-hormone therapy for critically ill patients

Bengtsson, B.-Å. (1999) · The Lancet · doi:10.1016/s0140-6736(99)00330-x · Cited by 18 · see citing works

Short-Term Testosterone Supplementation Relieves Growth Hormone Autonegative Feedback in Men

Veldhuis, J. D., Evans, W. S., Iranmanesh, A., WELTMAN, A. L., & Bowers, C. Y. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031017 · Cited by 16 · see citing works

Enhancement of the peripheral sensitivity to growth hormone in adults with GH deficiency

Aimaretti, G., Fanciulli, G., Bellone, S., Maccario, M., Arvat, E., Delitala, G., Camanni, F., & Ghigo, E. (2001) · European Journal of Endocrinology · doi:10.1530/eje.0.1450267 · Cited by 13 · see citing works

Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications

Pataky, M. W., Young, W. F., & Nair, K. S. (2021) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.07.033 · Cited by 207 · see citing works

Endocrine alterations in response to calorie restriction in humans

Redman, L. M., & Ravussin, E. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.10.014 · Cited by 54 · see citing works

Failure of Growth Hormone (GH) to Feed Back at the Level of the Pituitary to Alter the Response of the Somatotrophs to GH-Releasing Factor*

Kraicer, J., Lussier, B., Moor, B. C., et al. (1988) · Endocrinology · doi:10.1210/endo-122-4-1511 · Cited by 39 · see citing works

EFFECT OF GROWTH HORMONE ON GROWTH IN HYPOPHYSECTOMIZED-PANCREATECTOMIZEDRATS

Scow, R. O. (1957) · Endocrinology · doi:10.1210/endo-61-5-582 · Cited by 23 · see citing works

HORMONE-SULPHATASE RELATIONSHIPS

PULKKINEN, M. O., & Hakkarainen, H. (1965) · European Journal of Endocrinology · doi:10.1530/acta.0.0480313 · Cited by 4 · see citing works

THE ROLE OF GROWTH HORMONE IN CALORIGENESIS AND THYROID FUNCTION1

Evans, E. S., Simpson, M. E., & Evans, H. M. (1958) · Endocrinology · doi:10.1210/endo-63-6-836 · Cited by 25 · see citing works

Studies on Rat Pituitary Homografts. II. Effects of Thyrotropin-Releasing Hormone on in Vitro Biosynthesis and Release of Growth Hormone and Prolactin*

GIANNATTASIO, G., Zanini, A., Panerai, A. E., et al. (1979) · Endocrinology · doi:10.1210/endo-104-1-237 · Cited by 17 · see citing works