The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Expression of Functional Leptin Receptors in the Human Ovary1
Abstract
The size of body fat stores is known to influence fertility, indicating a link between adipose tissue and the reproductive system. Studies in mice have identified the adipocyte-derived hormone, leptin (Ob protein), as a possible mediator of this effect. The aim of this study was to investigate the possibility that leptin may have direct effects on the human ovary. To probe this hypothesis we first analyzed the expression of leptin receptors in the human ovary. Transcripts encoding both the long and short isoforms of the leptin receptor were present in human granulosa cells and thecal cells; however, the short isoforms were expressed at much higher levels. Immunoreactive leptin was present in follicular fluid at levels similar to those found in serum. ob gene expression, however, was undetectable in the ovary, as determined by reverse transcription-PCR, whereas it was easily detected in adipose tissue. To determine whether leptin could induce a biological response in ovarian cells, we examined the effect of leptin on estradiol production in cultured granulosa cells. Leptin (100 ng/mL) inhibited LH (0.1 ng/mL)-stimulated estradiol production. In contrast, leptin had no effect on estradiol production in the absence of LH. In conclusion, this study has demonstrated that the leptin receptor is expressed in the human ovary, that leptin is present in follicular fluid, and that leptin can induce a biological response in ovarian cells. These results suggest that leptin may have a direct effect on the human ovary.
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Citations
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Cited by
Leptin in the regulation of immunity, inflammation, and hematopoiesis
Fantuzzi, G., & Faggioni, R. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.68.4.437 · Cited by 980
The Insulin-Related Ovarian Regulatory System in Health and Disease
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The Role of Leptin in Human Obesity and Disease: A Review of Current Evidence
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Leptin and reproduction: a review
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Leptin's Actions on the Reproductive Axis: Perspectives and Mechanisms
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Metadata
- Authors
- Karlsson, C., Lindell, K., Svensson, E., Bergh, C., Lind, P., Billig, H., Carlsson, L. M. S., & Carlsson, B.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1997-12-01
- Volume
- 82
- Issue
- 12
- Pages
- 4144-4148
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2082296248
- Cited by
- 362
- References
- 9
- FWCI
- 19.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Karlsson, C., Lindell, K., Svensson, E., Bergh, C., Lind, P., Billig, H., Carlsson, L. M. S., & Carlsson, B. (1997). Expression of Functional Leptin Receptors in the Human Ovary1. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem.82.12.4446
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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