Cited by 974Sleep and Wakefulness ResearchObstructive Sleep Apnea ResearchSleep and Work-Related Fatigue

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Elevation of Plasma Cytokines in Disorders of Excessive Daytime Sleepiness: Role of Sleep Disturbance and Obesity

Vgontzas, Alexandros N., Papanicolaou, Dimitris A., Bixler, Edward O., Kales, Anthony, Tyson, Kathy, Chrousos, George P.·1997·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem.82.5.3950

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Abstract

Excessive daytime sleepiness (EDS) and fatigue are frequent symptoms in the general population and the chief complaint of the majority of patients at Sleep Disorders Centers. There is evidence that the inflammatory cytokines tumor necrosis factor-alpha (TNF alpha), interleukin-1beta (IL-1beta), and IL-6 are involved in physiological sleep regulation and that their administration to humans is associated with sleepiness and fatigue. To explore whether plasma levels of TNF alpha, IL-1beta, and IL-6 are elevated in patients with EDS, we measured morning plasma levels of TNF alpha, IL-1beta, and IL-6 in 12 sleep apneics, 11 narcoleptics, 8 idiopathic hypersomniacs, and 10 normal controls. TNF alpha was significantly elevated in sleep apneics and narcoleptics compared to that in normal controls (P < 0.001 and P = 0.001, respectively). Plasma IL-1beta concentrations were not different between sleep disorder patients and controls, whereas IL-6 was markedly and significantly elevated in sleep apneics compared to that in normal controls (P = 0.028). The primary factor influencing TNF alpha values was the degree of nocturnal sleep disturbance, whereas the primary determinant for IL-6 levels was the body mass index. Our findings suggest that TNF alpha and IL-6 might play a significant role in mediating sleepiness and fatigue in disorders of EDS in humans.

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Rechtschaffen, A. (1968) · Medical Entomology and Zoology · Cited by 11,772
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Hypertension and associated metabolic abnormalities–the role of insulin resistance and the sympathoadrenal system.
Reaven, G. M., Lithell, H., & Landsberg, L. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602083340607 · Cited by 1,435
Altered regulation of IL-6 production with normal aging. Possible linkage to the age-associated decline in dehydroepiandrosterone and its sulfated derivative
Daynes, R. A., Araneo, B. A., Ershler, W. B., Maloney, C., Li, G. Z., & Ryu, S. Y. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.12.5219 · Cited by 1,264
Prevalence of sleep disorders in the Los Angeles metropolitan area
Bixler, E. O., Kales, A., Soldatos, C. R., Kales, J. D., & Healey, S. (1979) · American Journal of Psychiatry · doi:10.1176/ajp.136.10.1257 · Cited by 889
Self-citation
Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans.
Mastorakos, G., Chrousos, G. P., & Weber, J. S. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.6.8263159 · Cited by 591
Self-citation
Sleep Apnea and Sleep Disruption in Obese Patients
Vgontzas, A. N. (1994) · Archives of Internal Medicine · doi:10.1001/archinte.1994.00420150073007 · Cited by 470
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Urinary Catecholamines Before and After Tracheostomy in Patients with Obstructive Sleep Apnea and Hypertension
Fletcher, E. C., MILLER, J. F., Schaaf, J. W., & Fletcher, J. G. (1987) · SLEEP · doi:10.1093/sleep/10.1.35 · Cited by 313
The relationship of interleukin-1 and immune functions to sleep in humans.
Moldofsky, H., Lue, F. A., Eisen, J. S., Keystone, E., & Gorczynski, R. M. (1986) · Psychosomatic Medicine · doi:10.1097/00006842-198605000-00001 · Cited by 229
Exercise stimulates interleukin-6 secretion: inhibition by glucocorticoids and correlation with catecholamines
Papanicolaou, D. A., Petrides, J. S., Tsigos, C., Bina, S., Kalogeras, K. T., Wilder, R. L., Gold, P. W., Deuster, P. A., & Chrousos, G. P. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.271.3.e601 · Cited by 226
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Poitou, C., Coupaye, M., Laaban, J.-P., Coussieu, C., Bedel, J., Bouillot, J., Basdevant, A., Clément, K., & Oppert, J. (2006) · Obesity Surgery · doi:10.1381/096089206778870111 · Cited by 30
Sleep and the Immune System
Opp, M. R., Jan Born, A., & Irwin, M. R. (2007) · Elsevier eBooks · doi:10.1016/b978-012088576-3/50034-4 · Cited by 29
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Yao, M., Tachibana, N., Okura, M., Ikeda, A., Tanigawa, T., Yamagishi, K., Sato, S., Shimamoto, T., & Iso, H. (2006) · SLEEP · doi:10.1093/sleep/29.5.661 · Cited by 29
Plasma concentrations of tumor necrosis factor‐α (TNF‐α) and soluble TNF receptors in patients with bulimia nervosa
Nakai, Y., Hamagaki, S., Takagi, R., Taniguchi, A., & Kurimoto, F. (2000) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2000.01091.x · Cited by 29
Glyceroneogenesis is inhibited through HIV protease inhibitor-induced inflammation in human subcutaneous but not visceral adipose tissue
Leroyer, S., Vatier, C., Kadiri, S., Quette, J., Chapron, C., Capeau, J., & Antoine, B. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m000869 · Cited by 28
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The evaluation of adenotonsillectomy on TNF-α and IL-6 levels in obese children with obstructive sleep apnea
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Belfki, H., Ali, S. B., Bougatef, S., Ahmed, D. B., Haddad, N., Jmal, A., Abdennebi, M., & Romdhane, H. B. (2011) · Inflammation · doi:10.1007/s10753-011-9361-1 · Cited by 28
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Sangal, R. B. (2012) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.2270 · Cited by 28
Defining common outcome metrics used in obstructive sleep apnea
Al-Shawwa, B. A., Badi, A. N., Goldberg, A. N., & Woodson, B. T. (2008) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2008.07.008 · Cited by 29
Precision Medicine: The Role of the MSIDS Model in Defining, Diagnosing, and Treating Chronic Lyme Disease/Post Treatment Lyme Disease Syndrome and Other Chronic Illness: Part 2
Horowitz, R. I., & Freeman, P. (2018) · Healthcare · doi:10.3390/healthcare6040129 · Cited by 25
Serum and Plasma Tumor Necrosis Factor Alpha Levels in Individuals with Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression
Imani, M. M., Sadeghi, M., Khazaie, H., Emami, M., Bahmani, D. S., & Brand, S. (2020) · Life · doi:10.3390/life10060087 · Cited by 28
Lifestyle modification and endothelial function in obese subjects
Hamdy, O. (2005) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.3.2.231 · Cited by 28
Review of clinical and psychobiological dimensions of the chronic fatigue syndrome: differentiation from depression and contribution of sleep dysfunctions
Fischler, B. (1999) · Sleep Medicine Reviews · doi:10.1016/s1087-0792(99)90020-5 · Cited by 28
Metabolic syndrome and sleep apnea.
Kostoglou‐Athanassiou, I., & Athanassiou, P. (2008) · PubMed Central · Cited by 28
Interactions between and Shared Molecular Mechanisms of Diabetic Peripheral Neuropathy and Obstructive Sleep Apnea in Type 2 Diabetes Patients
Shen, H., Zhao, J., Liu, Y., & Sun, G. (2018) · Journal of Diabetes Research · doi:10.1155/2018/3458615 · Cited by 28
Sleep Duration and Diabetic Kidney Disease
Tan, N. Y. Q., Chan, J. C., Cheng, C., Wong, T. Y., & Sabanayagam, C. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00808 · Cited by 27
Impaired sleep quality is associated with concurrent elevations in inflammatory markers: are post-menopausal women at greater risk?
D’Antono, B., & Bouchard, V. (2019) · Biology of Sex Differences · doi:10.1186/s13293-019-0250-x · Cited by 28
Sleep Apnea and Sudden Cardiac Death
Blackwell, J., Walker, M., Stafford, P. L., Estrada, S., Adabağ, S., & Kwon, Y. (2019) · Circulation Reports · doi:10.1253/circrep.cr-19-0085 · Cited by 29
Bidirectional association between alopecia areata and sleep disorders: a population-based cohort study in Taiwan
Dai, Y., Tai, Y., Chen, C., Chang, Y.-T., Chen, T., & Chen, M. (2020) · Sleep Medicine · doi:10.1016/j.sleep.2020.06.015 · Cited by 27
Oxidative Stress in Obstructive Sleep Apnea Syndrome: Putative Pathways to Hearing System Impairment
Mastino, P., Rosati, D., de Soccio, G., Romeo, M., Pentangelo, D., Venarubea, S., Fiore, M., Meliante, P. G., Petrella, C., Barbato, C., et al. (2023) · Antioxidants · doi:10.3390/antiox12071430 · Cited by 30
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Sleep Disordered Breathing in Four Resource-Limited Settings in Peru: Prevalence, Risk Factors, and Association with Chronic Diseases
CRONICAS Cohort Study Group, Schwartz, N. G., Rattner, A., Schwartz, A. R., Mokhlesi, B., Gilman, R. H., Bernabé‐Ortiz, A., Miranda, J. J., & Checkley, W. (2015) · SLEEP · doi:10.5665/sleep.4988 · Cited by 25
Sleep Apnea and Hypertension
Hahn, P. Y., & Somers, V. K. (2007) · Elsevier eBooks · doi:10.1016/b978-0-323-03961-1.50079-9 · Cited by 27
Linkage and association of the CA repeat polymorphism of the IL6 gene, obesity-related phenotypes, and bone mineral density (BMD) in two independent Caucasian populations
Huang, Q.-Y., Shen, H., Deng, H.-Y., Conway, T., Davies, K. M., Li, J., Recker, R. R., & Deng, H. (2003) · Journal of Human Genetics · doi:10.1007/s10038-003-0053-z · Cited by 27
Objective Daytime Napping is Associated with Disease Severity and Inflammation in Patients with Mild to Moderate Dementia1
Basta, M., Koutentaki, E., Vgontzas, A. N., Zaganas, I. V., Vogiatzi, E., Gouna, G., Bourbouli, M., Panagiotakis, S. H., Kapetanaki, S., Fernández‐Mendoza, J., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-190483 · Cited by 26
Self-citation
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Urbanik, D., Martynowicz, H., Mazur, G. J., Poręba, R., & Gać, P. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9030836 · Cited by 27
Cellular mechanisms in intermittent hypoxia-induced cardiac damage in vivo
Han, Q., Yeung, S. C., Ip, M., & Mak, J. (2013) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-013-0294-z · Cited by 26
Sleep Apnea and Metabolic Dysfunction: Cause or Co-Relation?
Aurora, R. N., & Punjabi, N. M. (2007) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2007.03.006 · Cited by 27
What can blood biomarkers tell us about cardiovascular risk in obstructive sleep apnea?
Freitas, I. G. D. A., de Bruin, P. F. C., Bittencourt, L., de Bruin, V. M. S., & Tufik, S. B. (2015) · Sleep And Breathing · doi:10.1007/s11325-015-1143-9 · Cited by 26
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Tanabe, T., Rozycki, H. J., Kanoh, S., & Rubin, B. K. (2012) · Expert Review of Respiratory Medicine · doi:10.1586/ers.12.67 · Cited by 27
Acute modafinil exposure reduces daytime sleepiness in abstinent methamphetamine-dependent volunteers
Mahoney, J., Jackson, B. J., Kalechstein, A., Garza, R. D. L., Chang, L. C., & Newton, T. (2012) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001805 · Cited by 25
Proinflammatory Cytokines, Mood, and Sleep in Interepisode Bipolar Disorder and Insomnia: A Pilot Study With Implications for Psychosocial Interventions
Dolsen, E. A., Soehner, A. M., & Harvey, A. G. (2017) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000529 · Cited by 27
Elevation of serum TNF-α levels in mild and moderate Alzheimer patients with daytime sleepiness
Chen, R., Yin, Y., Zhao, Z., Huang, L., Huang, S., Zhuang, J., Wu, H., Peng, H., & Li, P. (2012) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2011.12.015 · Cited by 26
JCS 2023 Guideline on Diagnosis and Treatment of Sleep Disordered Breathing in Cardiovascular Disease
Kasai, T., Kohno, T., Shimizu, W., Ando, S., Joho, S., Osada, N., Kato, M., Kario, K., Shiina, K., Tamura, A., et al. (2024) · Circulation Journal · doi:10.1253/circj.cj-23-0489 · Cited by 25
Cytokine production from peripheral blood mononuclear cells and polymorphonuclear leukocytes in patients studied for suspected obstructive sleep apnea
Guasti, L., Marino, F., Cosentino, M., Maroni, L., Maresca, A. M., Colombo, F., Maio, R. C., Castiglioni, L., Saporiti, F., Loraschi, A., et al. (2009) · Sleep And Breathing · doi:10.1007/s11325-009-0315-x · Cited by 25
Relationships between Obstructive Sleep Apnea Syndrome, Continuous Positive Airway Pressure Treatment, and Inflammatory Cytokines
Doğan, F., Yosunkaya, Ş., Okur, H. K., & Can, Ü. (2014) · Sleep Disorders · doi:10.1155/2014/518920 · Cited by 25
Adipocytokines in obstructive sleep apnea: A systematic review and meta-analysis
Janmohammadi, P., Raeisi, T., Zarei, M., Nejad, M. M., Karimi, R., Mirali, Z., Zafary, R., & Alizadeh, S. (2023) · Respiratory Medicine · doi:10.1016/j.rmed.2023.107122 · Cited by 25
A randomized, subject and rater-blinded, placebo-controlled trial of dimethyl fumarate for obstructive sleep apnea
Braley, T. J., Huber, A. K., Segal, B. M., Kaplish, N., Saban, R., Washnock-Schmid, J. M., & Chervin, R. D. (2018) · SLEEP · doi:10.1093/sleep/zsy109 · Cited by 25
Anemia of aging and obstructive sleep apnea
Khan, A. M., Ashizawa, S., Hlebowicz, V., & Appel, D. W. (2010) · Sleep And Breathing · doi:10.1007/s11325-010-0326-7 · Cited by 25
Association between Systemic Inflammation and Obstructive Sleep Apnea in Men with or at Risk for HIV Infection
Brigham, E. P., Patil, S. P., Jacobson, L. P., Margolick, J. B., Godfrey, R., Johnson, J. R., Johnson, L., Reynolds, S. M., Schwartz, A. R., Smith, P. L., et al. (2013) · Antiviral Therapy · doi:10.3851/imp2745 · Cited by 25
Body fat and C-reactive protein levels in healthy non-obese men
Bo, M., Raspo, S., Morra, F., Isaia, G., Cassader, M., Fabris, F., & Poli, L. (2004) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/s0939-4753(04)80012-7 · Cited by 25
Obstructive Sleep Apnea-Associated Intermittent Hypoxia-Induced Immune Responses in Males, Pregnancies, and Offspring
Song, R., Baker, T. L., Watters, J. J., & Kumar, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031852 · Cited by 25
Molecular mechanism of tumour necrosis factor alpha regulates hypocretin (orexin) expression, sleep and behaviour
Zhan, S., Che, P., Zhao, X., Li, N., Ding, Y., Liu, J., Li, S., Ding, K., Han, L. K., Huang, Z., et al. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14566 · Cited by 24
Sleep Apnea Determines Soluble TNF-α Receptor 2 Response to Massive Weight Loss
Pallayová, M., Steele, K. E., Magnuson, T. H., Schweitzer, M., Smith, P. L., Patil, S. P., Bevans‐Fonti, S., Polotsky, V. Y., & Schwartz, A. R. (2011) · Obesity Surgery · doi:10.1007/s11695-011-0359-4 · Cited by 24
Identification of differentially expressed genes in subcutaneous adipose tissue from subjects with familial combined hyperlipidemia
Eurlings, P. M. H., Kallen, C., Geurts, J. M. W., Kouwenberg, P., Boeckx, W. D., & de Bruin, T. W. (2002) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)30467-3 · Cited by 24
Sleepiness in Cognitively Unimpaired Older Adults Is Associated With CSF Biomarkers of Inflammation and Axonal Integrity
Carvalho, D. Z., Louis, E. K. S., Przybelski, S. A., Morgenthaler, T. I., Machulda, M. M., Boeve, B. F., Petersen, R. C., Jack, C. R., Graff‐Radford, J., Vemuri, P., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.930315 · Cited by 25
Pharmacotherapy of obstructive sleep apnea
Lin, C. M., Huang, Y. S., & Guilleminault, C. (2012) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2012.666525 · Cited by 23
[The obstructive sleep apnoea syndrome in obesity: a conspirator in the shadow].
Salvador, J., Iriarte, J., Silva, C., Ambrosi, J. G., Caballero, A., & Frühbeck, G. (2004) · PubMed · Cited by 23
Neurally Mediated Hypotension In Fatigued Gulf War Veterans: A Preliminary Report
Kator, S., Wonnett, J. A., Pappas, B. L., Davis, S. D., & Sall, J. (2000) · The American Journal of the Medical Sciences · doi:10.1016/s0002-9629(15)40694-9 · Cited by 23
The vascular micromilieu in obstructive sleep apnoea
Schulz, R. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00022905 · Cited by 23
Tumor Necrosis Factor-α Expression in Uvular Tissues Differs Between Snorers and Apneic Patients
Loubaki, L., Jacques, É., Semlali, A., Biardel, S., Chakir, J., & Sériès, F. (2008) · CHEST Journal · doi:10.1378/chest.08-0886 · Cited by 23
Cobalamin Used in Chronic Fatigue Syndrome Therapy Is a Nitric Oxide Scavenger
Pall, M. L. (2000) · Journal of Chronic Fatigue Syndrome · doi:10.1300/j092v08n02_04 · Cited by 23
Obesity, Senescence, and Senolytics
Chaib, S., Tchkonia, T., & Kirkland, J. L. (2021) · Handbook of Experimental Pharmacology · doi:10.1007/164_2021_555 · Cited by 22
Short-term effect of multilevel surgery on adipokines and pro-inflammatory cytokines in patients with obstructive sleep apnea
Eun, Y., Kim, M. G., Kwon, K. H., Shin, S. Y., Cho, J. S., & Kim, S. W. (2010) · Acta Oto-Laryngologica · doi:10.3109/00016489.2010.495134 · Cited by 23
Understanding the Metabolic Syndrome: A Modeling Perspective
Khoo, M. C. K., Oliveira, F., & Cheng, L. (2012) · IEEE Reviews in Biomedical Engineering · doi:10.1109/rbme.2012.2232651 · Cited by 24
Risk factors for, and prevalence of, sleep apnoea in cardiac rehabilitation facilities in Germany: The Reha-Sleep registry
Skobel, E. C., Kamke, W., Bönner, G., Alt, B., Purucker, H.-C., Schwaab, B., Einwang, H.-P., Schröder, K., Langheim, E., Völler, H., et al. (2014) · European Journal of Preventive Cardiology · doi:10.1177/2047487314537916 · Cited by 22
Obstructive Sleep Apnea Treatment and Atrial Fibrillation: A Need for Definitive Evidence
Nalliah, C. J., Sanders, P., & Kalman, J. M. (2016) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.12981 · Cited by 23
HPA Axis and Sleep
Nicolaides, N. C., Vgontzas, A. N., Kritikou, I., & Chrousos, G. P. (2016) · Europe PMC (PubMed Central) · Cited by 22
Self-citation
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Tosun, A., Köktürk, O., Karataş, G. K., Çiftçi, T. U., & Sepici, V. (2008) · Clinics · doi:10.1590/s1807-59322008000500010 · Cited by 22
Neuroimmunology of Disordered Sleep in Depression and Alcoholism
Irwin, M. R. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00338-4 · Cited by 22
Effect of weight loss on inflammation in patients with mild obstructive sleep apnea
Sahlman, J., Seppä, J., Herder, C., Peltonen, M., PEUHKURINEN, K. J., Gylling, H., Vanninen, E. J., Tukiainen, H. O., Punnonen, K. R. A., Partinen, M., et al. (2010) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.10.007 · Cited by 22
A Comparison of the Long‐Term Outcome and Effects of Surgery or Continuous Positive Airway Pressure on Patients with Obstructive Sleep Apnea Syndrome
Lin, S., Chen, N., Li, H., Fang, T., Huang, C., Tsai, Y., & Lee, C. (2006) · The Laryngoscope · doi:10.1097/01.mlg.0000217242.16814.da · Cited by 22
Relationship between the Serum Concentrations of C-reactive Protein and Parameters of Adiposity and Insulin Resistance in Patients with Type 2 Diabetes Mellitus
Iwasaki, T., Nakajima, A., Yoneda, M., & Terauchi, Y. (2006) · Endocrine Journal · doi:10.1507/endocrj.k05-133 · Cited by 22
Aging and Adiposity—Focus on Biological Females at Midlife and Beyond
Rehman, A., Lathief, S., Charoenngam, N., & Pal, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052972 · Cited by 24
Sleep apnea modifies the long‐term impact of surgically induced weight loss on cardiac function and inflammation
Kardassis, D., Grote, L., Sjöström, L., Hedner, J. A., & Karason, K. (2013) · Obesity · doi:10.1002/oby.20115 · Cited by 21
Inflammatory markers in palatine tonsils of children with obstructive sleep apnea syndrome
Chen, V. G., da Fonseca, V. M. G., do Amaral, J. B., Camargo-Kosugi, C. M., Moreira, G. A., Kosugi, E. M., & Fujita, R. R. (2018) · Brazilian Journal of Otorhinolaryngology · doi:10.1016/j.bjorl.2018.08.001 · Cited by 21
Obesity and COVID-19
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Insomnia disorders are associated with increased cardiometabolic disturbances and death risks from cardiovascular diseases in psychiatric patients treated with weight-gain-inducing psychotropic drugs: results from a Swiss cohort
Laaboub, N., Dubath, C., Ranjbar, S., Sibailly, G., Grosu, C., Piras, M., Délessert, D., Richard-Lepouriel, H., Ansermot, N., Crettol, S., et al. (2022) · BMC Psychiatry · doi:10.1186/s12888-022-03983-3 · Cited by 22
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Authors: Vgontzas, A. N., Papanicolaou, D. A., Bixler, E. O., Kales, A., Tyson, K., & Chrousos, G. P.
Affiliations: Pennsylvania State University (US)
National Institutes of Health (US)
Corresponding author: Vgontzas, Alexandros N.
ORCID: Vgontzas, Alexandros N.
Chrousos, George P.
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 1997-05
Volume: 82
Issue: 5
Pages: 1313-1316
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem.82.5.3950
OpenAlex: W1975319022
Cited by: 974
References: 22
Citations by year: 2026: 10 · 2025: 23 · 2024: 24 · 2023: 24 · 2022: 32 · 2021: 33 · 2020: 25 · 2019: 24 · 2018: 23 · 2017: 23 · 2016: 29 · 2015: 40 · 2014: 42 · 2013: 38 · 2012: 46
FWCI: 11.57
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: excessive daytime sleepiness, plasma cytokines, TNF-α, IL-1β, interleukin-6, sleep apnea, narcolepsy, idiopathic hypersomnia, sleep disorders, obesity, body mass index, fatigue, inflammation
MeSH terms: Adult, Female, Humans, Disorders of Excessive Somnolence, Interleukin-1, Male, Narcolepsy, Obesity, Sleep Apnea Syndromes, Sleep Wake Disorders, Tumor Necrosis Factor-alpha, Interleukin-6, Body Mass Index, Cytokines

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Elevation of Plasma Cytokines in Disorders of Excessive Daytime Sleepiness: Role of Sleep Disturbance and Obesity

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