Cited by 974Sleep and Wakefulness ResearchObstructive Sleep Apnea ResearchSleep and Work-Related Fatigue

The DOI matches its Crossref record; 21 of the 22 references it cites were found in a registry or an index.

Elevation of Plasma Cytokines in Disorders of Excessive Daytime Sleepiness: Role of Sleep Disturbance and Obesity

Vgontzas, Alexandros N., Papanicolaou, Dimitris A., Bixler, Edward O., Kales, Anthony, Tyson, Kathy, Chrousos, George P.·1997·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem.82.5.3950

Open this paper in CoChat — free account

Abstract

Excessive daytime sleepiness (EDS) and fatigue are frequent symptoms in the general population and the chief complaint of the majority of patients at Sleep Disorders Centers. There is evidence that the inflammatory cytokines tumor necrosis factor-alpha (TNF alpha), interleukin-1beta (IL-1beta), and IL-6 are involved in physiological sleep regulation and that their administration to humans is associated with sleepiness and fatigue. To explore whether plasma levels of TNF alpha, IL-1beta, and IL-6 are elevated in patients with EDS, we measured morning plasma levels of TNF alpha, IL-1beta, and IL-6 in 12 sleep apneics, 11 narcoleptics, 8 idiopathic hypersomniacs, and 10 normal controls. TNF alpha was significantly elevated in sleep apneics and narcoleptics compared to that in normal controls (P < 0.001 and P = 0.001, respectively). Plasma IL-1beta concentrations were not different between sleep disorder patients and controls, whereas IL-6 was markedly and significantly elevated in sleep apneics compared to that in normal controls (P = 0.028). The primary factor influencing TNF alpha values was the degree of nocturnal sleep disturbance, whereas the primary determinant for IL-6 levels was the body mass index. Our findings suggest that TNF alpha and IL-6 might play a significant role in mediating sleepiness and fatigue in disorders of EDS in humans.

Integrity signals

Registry

Crossref · 10.1210/jcem.82.5.3950

Cites

21 of 21 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A manual for standardized terminology, techniques and scoring system for sleep stages in human subjects
Rechtschaffen, A. (1968) · Medical Entomology and Zoology · Cited by 11,772
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Hypertension and associated metabolic abnormalities–the role of insulin resistance and the sympathoadrenal system.
Reaven, G. M., Lithell, H., & Landsberg, L. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602083340607 · Cited by 1,435
Altered regulation of IL-6 production with normal aging. Possible linkage to the age-associated decline in dehydroepiandrosterone and its sulfated derivative
Daynes, R. A., Araneo, B. A., Ershler, W. B., Maloney, C., Li, G. Z., & Ryu, S. Y. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.12.5219 · Cited by 1,264
Prevalence of sleep disorders in the Los Angeles metropolitan area
Bixler, E. O., Kales, A., Soldatos, C. R., Kales, J. D., & Healey, S. (1979) · American Journal of Psychiatry · doi:10.1176/ajp.136.10.1257 · Cited by 889
Self-citation
Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans.
Mastorakos, G., Chrousos, G. P., & Weber, J. S. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.6.8263159 · Cited by 591
Self-citation
Sleep Apnea and Sleep Disruption in Obese Patients
Vgontzas, A. N. (1994) · Archives of Internal Medicine · doi:10.1001/archinte.1994.00420150073007 · Cited by 470
Self-citation
Urinary Catecholamines Before and After Tracheostomy in Patients with Obstructive Sleep Apnea and Hypertension
Fletcher, E. C., MILLER, J. F., Schaaf, J. W., & Fletcher, J. G. (1987) · SLEEP · doi:10.1093/sleep/10.1.35 · Cited by 313
The relationship of interleukin-1 and immune functions to sleep in humans.
Moldofsky, H., Lue, F. A., Eisen, J. S., Keystone, E., & Gorczynski, R. M. (1986) · Psychosomatic Medicine · doi:10.1097/00006842-198605000-00001 · Cited by 229
Exercise stimulates interleukin-6 secretion: inhibition by glucocorticoids and correlation with catecholamines
Papanicolaou, D. A., Petrides, J. S., Tsigos, C., Bina, S., Kalogeras, K. T., Wilder, R. L., Gold, P. W., Deuster, P. A., & Chrousos, G. P. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.271.3.e601 · Cited by 226
Self-citation

Flagged first, then by citations

Show all 22 references

1 of the 22 references couldn’t be matched to a known paper.

Sorted by citations

Items 301–400 of 974

Sleep Duration and Excessive Daytime Sleepiness Are Associated with Obesity Independent of Diet and Physical Activity
Maugeri, A., Medina‐Inojosa, J. R., Kunzová, Š., Agodi, A., Barchitta, M., Sochor, O., López-Jiménez, F. A., Geda, Y. E., & Vinciguerra, M. (2018) · Nutrients · doi:10.3390/nu10091219 · Cited by 79
Microvascular Endothelial Dysfunction in Obstructive Sleep Apnea Is Caused by Oxidative Stress and Improved by Continuous Positive Airway Pressure Therapy
Buchner, N. J., Quack, I., Woznowski, M., Stähle, C., Wenzel, U. O., & Rump, L. C. (2011) · Respiration · doi:10.1159/000323266 · Cited by 74
Sleep disturbances in adults with arthritis: Prevalence, mediators, and subgroups at greatest risk. Data from the 2007 National Health Interview Survey
Louie, G. H., Tektonidou, M. G., Caban-Martinez, A. J., & Ward, M. M. (2010) · Arthritis Care & Research · doi:10.1002/acr.20362 · Cited by 73
Sleep and inflammatory bowel disease: exploring the relationship between sleep disturbances and inflammation.
Kinnucan, J. A. R., Rubin, D. T., & Ali, T. (2013) · Europe PMC (PubMed Central) · Cited by 73
Obstructive sleep apnea and coronary artery disease
Lüthje, L., & Andreas, S. (2007) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.08.002 · Cited by 72
Body Mass Index (BMI) as a First-Line Screening Criterion for Detection of Excessive Daytime Sleepiness Among Professional Drivers
Dagan, Y., Doljansky, J. T., Green, A., & Weiner, A. (2006) · Traffic Injury Prevention · doi:10.1080/15389580500412994 · Cited by 72
Inflammation accelerates atherosclerotic processes in obstructive sleep apnea syndrome (OSAS)
Quercioli, A., Mach, F., & Montecucco, F. (2010) · Sleep And Breathing · doi:10.1007/s11325-010-0338-3 · Cited by 72
Quintessential Risk Factors: Their Role in Promoting Cognitive Dysfunction and Alzheimer’s Disease
Daulatzai, M. A. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0854-6 · Cited by 70
Sleep deprivation, sleep apnea and cardiovascular diseases
Levy, P. A. (2011) · Frontiers in Bioscience-Elite · doi:10.2741/521 · Cited by 70
Effects of weight loss on visceral and abdominal subcutaneous adipose tissue blood-flow and insulin-mediated glucose uptake in healthy obese subjects
Viljanen, A. P. M., Läutamaki, R., Järvisalo, M. J., Parkkola, R. K., Huupponen, R., Lehtimäki, T. J., Rönnemaa, T., Raitakari, O. T., Iozzo, P., & Nuutila, P. (2008) · Annals of Medicine · doi:10.1080/07853890802446754 · Cited by 70
Exhaled pH, exhaled nitric oxide, and induced sputum cellularity in obese patients with obstructive sleep apnea syndrome
Carpagnano, G. E., Spanevello, A., Sabato, R., Depalo, A., Turchiarelli, V., & Barbaro, M. P. F. (2007) · Translational research · doi:10.1016/j.trsl.2007.09.004 · Cited by 70
Interleukin-6 Regulates the Expression of Hypothalamic Neuropeptides Involved in Body Weight in a Gender-Dependent Way
Señarís, R. M., Trujillo‐Güiza, M. L., Navia, B., Comes, G., Ferrer, B., Giralt, M., & Hidalgo, J. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02158.x · Cited by 70
Long-term exercise training decreases interleukin-6 (IL-6) serum levels in subjects with impaired glucose tolerance: effect of the −174G/C variant in IL-6 gene
Oberbach, A., Lehmann, S., Kirsch, K., Krist, J., Sonnabend, M., Linke, A., Tönjes, A., Stümvoll, M., Blüher, M., & Kovacs, P. L. (2008) · European Journal of Endocrinology · doi:10.1530/eje-08-0220 · Cited by 69
Vedolizumab Therapy Is Associated with an Improvement in Sleep Quality and Mood in Inflammatory Bowel Diseases
Stevens, B. W., Borren, N. Z., Velonias, G., Conway, G. M., Cleland, T., Andrews, E., Khalili, H., Garber, J. G., Xavier, R. J., Yajnik, V., et al. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4356-2 · Cited by 68
Structural equation modeling of sleep apnea, inflammation, and metabolic dysfunction in children
Waters, K. A., Mast, B. T., VELLA, S., Eva, R. C. D., O'Brien, L. M., Bailey, S., Tam, C. S., Wong, M., & Baur, L. A. (2007) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2007.00614.x · Cited by 69
The phenotype and genotype of adult obstructive sleep apnoea/hypopnoea syndrome
Riha, R. L., Gislasson, T., & Diefenbach, K. (2009) · European Respiratory Journal · doi:10.1183/09031936.00151008 · Cited by 70
Sleep and Glucose Intolerance/Diabetes Mellitus
Ip, M., & Mokhlesi, B. (2007) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2006.12.002 · Cited by 67
Excessive daytime sleepiness: an emerging marker of cardiovascular risk
Bock, J. M., Covassin, N., & Somers, V. K. (2022) · Heart · doi:10.1136/heartjnl-2021-319596 · Cited by 72
The Effect of Surgical Treatment of Obstructive Sleep Apnea Syndrome on the Plasma TNF-.ALPHA. Levels
Kataoka, T., Enomoto, F., Kim, R., Yokoi, H., Fujimori, M., Sakai, Y., Ando, I., Ichikawa, G., & Ikeda, K. (2004) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.204.267 · Cited by 67
Plasma IL‐6 concentration is inversely related to insulin sensitivity, and acute‐phase proteins associate with glucose and lipid metabolism in healthy subjects
Heliövaara, M. K., Teppo, A. M., Karonen, S. ‐., Tuominen, J. A., & Ebeling, P. R. (2004) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2004.00463.x · Cited by 65
Innate immune mechanisms linking non-esterified fatty acids and respiratory disease
Wood, L. G., Scott, H. A., Garg, M. L., & Gibson, P. G. (2008) · Progress in Lipid Research · doi:10.1016/j.plipres.2008.10.001 · Cited by 67
Asthma, Body Mass Index, and C-Reactive Protein Among US Adults
Ford, E. S. (2003) · Journal of Asthma · doi:10.1081/jas-120023497 · Cited by 65
Exhaled breath condensate cytokine level as a diagnostic tool for obstructive sleep apnea syndrome
Li, Y., Chongsuvivatwong, V., Geater, A. F., & Liu, A. (2008) · Sleep Medicine · doi:10.1016/j.sleep.2007.11.013 · Cited by 64
Neuroscience-driven discovery and development of sleep therapeutics
Dresler, M., Spoormaker, V. I., Beitinger, P., Czisch, M., Kimura, M., Steiger, A., & Holsboer, F. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.10.012 · Cited by 63
Genes for normal sleep and sleep disorders
Tafti, M., Maret, S., & Dauvilliers, Y. A. (2005) · Annals of Medicine · doi:10.1080/07853890500372047 · Cited by 66
Relationship between sleep‐disordered breathing and markers of systemic inflammation in women from the general population
Svensson, M., Venge, P., Janson, C., & Lindberg, E. (2011) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2011.00946.x · Cited by 63
Production of Inflammatory Mediators by Monocytes in Patients with Obstructive Sleep Apnea Syndrome
Tamaki, S., Yamauchi, M., Fukuoka, A., Makinodan, K., Koyama, N., Tomoda, K., Yoshikawa, M., & Kimura, H. (2009) · Internal Medicine · doi:10.2169/internalmedicine.48.2366 · Cited by 63
Obstructive sleep apnea and the risk of autoimmune diseases: A longitudinal population-based study
Kang, J., & Lin, H. (2012) · Sleep Medicine · doi:10.1016/j.sleep.2012.03.002 · Cited by 63
Inflammatory Markers in Middle-Aged Obese Subjects: Does Obstructive Sleep Apnea Syndrome Play a Role?
Steiropoulos, P., Παπάνας, Ν., Nena, E., Antoniadou, M., Serasli, E., Papoti, S., Hatzizisi, O., Kyriazis, G., Τzouvelekis, Α., Maltezos, E. S., et al. (2010) · Mediators of Inflammation · doi:10.1155/2010/675320 · Cited by 66
Obstructive Sleep Apnea and Coronary Artery Disease: From Pathophysiology to Clinical Implications
Torres-Alba, F. D., Gemma, D., Armada-Romero, E., Rey-Blas, J. R., de Sá, E. L., & Lopez-Sendon, J. L. (2013) · Pulmonary Medicine · doi:10.1155/2013/768064 · Cited by 64
Influence of Obesity and Bariatric Surgery on the Periodontal Condition
Pataro, A. L., Costa, F. O., Cortelli, S. C., Cortelli, J. R., Souza, A. C. D., de Abreu, M. H. N. G., Girundi, M. G., & Costa, J. E. (2011) · Journal of Periodontology · doi:10.1902/jop.2011.100782 · Cited by 62
Excessive Daytime Sleepiness is Associated with Increased Health Care Utilization Among Patients Referred for Assessment of OSA
Ronksley, P. E., Hemmelgarn, B. R., Heitman, S. J., Ward, F. W., Ghali, W. A., Manns, B., Faris, P., & Tsai, W. H. (2011) · SLEEP · doi:10.1093/sleep/34.3.363 · Cited by 62
Exhaled NO and iNOS expression in sputum cells of healthy, obese and OSA subjects
Depalo, A., Carpagnano, G. E., Spanevello, A., Sabato, R., Cagnazzo, M. G., Gramiccioni, C., & Barbaro, M. P. F. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01875.x · Cited by 61
Melancholic and atypical subtypes of depression represent distinct pathophysiological entities: CRH, neural circuits, and the diathesis for anxiety and depression
Gold, P. W., & Chrousos, G. P. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.5 · Cited by 61
Self-citation
Sleep quality and disease activity in patients with inflammatory bowel disease: a systematic review and meta-analysis
Hao, G., Zhu, B., li, Y., Wang, P., Li, L., & Hou, L. (2020) · Sleep Medicine · doi:10.1016/j.sleep.2020.08.032 · Cited by 60
Correlates of excessive daytime sleepiness in obstructive sleep apnea: Results from the nationwide SESAR cohort including 34,684 patients
Ulander, M., Hedner, J. A., Stillberg, G., Sunnergren, O., & Grote, L. (2022) · Journal of Sleep Research · doi:10.1111/jsr.13690 · Cited by 60
Sleep Is Increased By Weight Gain and Decreased By Weight Loss in Mice
Guan, Z., Vgontzas, A. N., Bixler, E. O., & Fang, J. (2008) · SLEEP · doi:10.1093/sleep/31.5.627 · Cited by 61
Self-citation
Sleep Apnea and its Association with the Stress System, Inflammation, Insulin Resistance and Visceral Obesity
Trakada, G., Chrousos, G. P., Pejovic, S., & Vgontzas, A. N. (2007) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2007.04.003 · Cited by 67
Self-citation
Glass capillary based microfluidic ELISA for rapid diagnostics
Tan, X., Oo, M. K. K., Gong, Y., Li, Y., Zhu, H., & Fan, X. (2017) · The Analyst · doi:10.1039/c7an00523g · Cited by 60
Immune Function, Pain, and Psychological Stress in Patients Undergoing Spinal Surgery
Starkweather, A. R., Witek‐Janusek, L., Nockels, R. P., Peterson, J., & Mathews, H. L. (2006) · Spine · doi:10.1097/01.brs.0000231795.85409.87 · Cited by 59
CPAP Treatment and Cardiovascular Prevention
Javaheri, S., Martínez‐García, M. Á., & Campos‐Rodríguez, F. (2019) · CHEST Journal · doi:10.1016/j.chest.2019.04.092 · Cited by 59
Obstructive Sleep Apnea and Hypertension: a Critical Review
Mohsenin, V. (2014) · Current Hypertension Reports · doi:10.1007/s11906-014-0482-4 · Cited by 59
Severity of obstructive sleep apnea is associated with elevated plasma fibrinogen in otherwise healthy patients
Shamsuzzaman, A., Amin, R. S., Calvin, A. D., Davison, D. E., & Somers, V. K. (2014) · Sleep And Breathing · doi:10.1007/s11325-014-0938-4 · Cited by 62
Airway inflammation in patients affected by obstructive sleep apnea
Sabato, R., Guido, P., Salerno, F. G., Resta, O., Spanevello, A., & Barbaro, M. P. F. (2016) · Monaldi Archives for Chest Disease · doi:10.4081/monaldi.2006.572 · Cited by 58
Plasma Levels of Tumor Necrosis Factor α and Soluble Tumor Necrosis Factor Receptors in Patients With Narcolepsy
Himmerich, H. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.16.1739 · Cited by 58
Obesity hypoventilation syndrome
BaHammam, A. S., & Dabal, L. A. (2009) · Annals of Thoracic Medicine · doi:10.4103/1817-1737.49411 · Cited by 57
An IL-6 link between obesity and cancer
Ghosh, S. (2013) · Frontiers in Bioscience · doi:10.2741/e628 · Cited by 57
Preliminary Evidence of Increased Pain and Elevated Cytokines in Fibromyalgia Patients with Defective Growth Hormone Response to Exercise
Ross, R. L., Jones, K., Bennett, R., Ward, R. L., Druker, B., & Wood, L. (2010) · Open Immunology Journal · doi:10.2174/1874226201003010009 · Cited by 58
The associations of adiposity, physical activity and inflammation with fatigue in older adults
Valentine, R. J., Woods, J. A., McAuley, E., Dantzer, R., & Evans, E. M. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.06.002 · Cited by 57
Sleep disorders in morbid obesity
Akinnusi, M. E., Saliba, R. G., Porhomayon, J., & El-Solh, A. (2011) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2011.10.016 · Cited by 57
Drug disease interactions: role of inflammatory mediators in disease and variability in drug response.
Kulmatycki, K. M., & Jamali, F. (2005) · PubMed · Cited by 58
Neurotoxic Saboteurs: Straws that Break the Hippo’s (Hippocampus) Back Drive Cognitive Impairment and Alzheimer’s Disease
Daulatzai, M. A. (2013) · Neurotoxicity Research · doi:10.1007/s12640-013-9407-2 · Cited by 56
Atrial fibrillation in obstructive sleep apnea
Goyal, S. (2013) · World Journal of Cardiology · doi:10.4330/wjc.v5.i6.157 · Cited by 56
Hypercapnia is a Key Correlate of EEG Activation and Daytime Sleepiness in Hypercapnic Sleep Disordered Breathing Patients
Wang, D., Piper, A. J., Yee, B. J., WONG, K. K. H., Kim, J.-W., D'Rozario, A. L., Rowsell, L., Dijk, D., & Grunstein, R. R. (2014) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.3700 · Cited by 56
Evaluation of the Association of Sleep Apnea-Related Systemic Inflammation with CRP, ESR, and Neutrophil-to-Lymphocyte Ratio
Çankaya, S. (2015) · Medical Science Monitor · doi:10.12659/msm.893175 · Cited by 59
Cytokine changes after surgical treatment of obstructive sleep apnoea syndrome
Constantinidis, J., Ereliadis, S., Angouridakis, N., Konstantinidis, I., Vital, V., & Angouridaki, C. (2008) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-008-0627-7 · Cited by 57
Cancer-Related Fatigue
Gerber, L. H. (2016) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/j.pmr.2016.08.004 · Cited by 58
Plasma C-reactive protein levels and their relationship to anthropometric and lipid characteristics among children
Wu, D., Chu, N., Shen, M., & Chang, J. (2003) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(02)00519-x · Cited by 56
Association between tumor necrosis factor alpha and obstructive sleep apnea in adults: a meta-analysis update
Cao, Y., Song, Y., Ning, P., Zhang, L., Wu, S., Quan, J., & Li, Q. (2020) · BMC Pulmonary Medicine · doi:10.1186/s12890-020-01253-0 · Cited by 55
TNFα G308A polymorphism is associated with resilience to sleep deprivation-induced psychomotor vigilance performance impairment in healthy young adults
Satterfield, B. C., Wisor, J. P., Field, S. A., Schmidt, M. A., & Dongen, H. P. A. V. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.12.009 · Cited by 59
Effects of long-term continuous positive airway pressure on body composition and IGF1
Münzer, T., Hegglin, A., Stannek, T., Schoch, O. D., Korte, W. C., Büche, D., Schmid, C., & Hürny, C. (2010) · European Journal of Endocrinology · doi:10.1530/eje-09-0919 · Cited by 56
Tumor necrosis factor alpha is a promising circulating biomarker for the development of obstructive sleep apnea syndrome: a meta-analysis
Qing-sheng, L., & Zheng, X. (2017) · Oncotarget · doi:10.18632/oncotarget.15203 · Cited by 55
In vivo and in vitro immune variables in patients with narcolepsy and HLA-DR2 matched controls
Hinze‐Selch, D., Wetter, T. C., Zhang, Y., Lu, H. C., Albert, E. D., Mullington, J. M., Wekerle, H., Holsboer, F., & Pollmächer, T. (1998) · Neurology · doi:10.1212/wnl.50.4.1149 · Cited by 55
Sleep Disorders and Psoriasis: An Update
Halioua, B., Chelli, C., Misery, L., Taïeb, J., & TAIEB, C. (2022) · Acta Dermato Venereologica · doi:10.2340/actadv.v102.1991 · Cited by 59
Obesity and Respiratory Diseases in Childhood
Fiorino, E. K., & Brooks, L. J. (2009) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2009.05.010 · Cited by 54
Biomarkers to Improve Diagnosis and Monitoring of Obstructive Sleep Apnea Syndrome: Current Status and Future Perspectives
Archontogeorgis, K., Nena, E., Παπάνας, Ν., & Steiropoulos, P. (2014) · Pulmonary Medicine · doi:10.1155/2014/930535 · Cited by 54
How is Your Sleep: A Neglected Topic for Health Care Screening
Sorscher, A. J. (2008) · The Journal of the American Board of Family Medicine · doi:10.3122/jabfm.2008.02.070167 · Cited by 53
Effects of i.c.v. administration of interleukin-1 on sleep and body temperature of interleukin-6-deficient mice
Olivadoti, M. D., & Opp, M. R. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.02.008 · Cited by 53
Anti‐aging effects of caloric restriction: Involvement of neuroendocrine adaptation by peripheral signaling
Chiba, T., Yamaza, H., Higami, Y., & Shimokawa, I. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10211 · Cited by 53
Tumor necrosis factor-alpha regulates the Hypocretin system via mRNA degradation and ubiquitination
Zhan, S., Cai, G., Zheng, A., Wang, Y., Jia, J., Fang, H., Yang, Y., Hu, M., & Ding, Q. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.11.003 · Cited by 52
TIME-DEPENDENT INHIBITORY EFFECT OF LIPOPOLYSACCHARIDE INJECTION ONPER1ANDPER2GENE EXPRESSION IN THE MOUSE HEART AND LIVER
Yamamura, Y., Yano, I., Kudo, T., & Shibata, S. (2010) · Chronobiology International · doi:10.3109/07420521003769111 · Cited by 53
Idiopathic Hypersomnia
Bassetti, C. L., & Dauvilliers, Y. A. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4160-6645-3.00086-4 · Cited by 51
Self-reported and actigraphic short sleep duration in older adults
Miner, B., Stone, K. L., Zeitzer, J. M., Han, L., Doyle, M., Blackwell, T., Gill, T. M., Redeker, N. S., Hajduk, A. M., & Yaggi, H. K. (2021) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.9584 · Cited by 51
Gender differences in the association of sleep apnea and inflammation
Gaines, J., Vgontzas, A. N., Fernández‐Mendoza, J., Kritikou, I., Basta, M., & Bixler, E. O. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.11.013 · Cited by 50
Self-citation
Fatigue in primary biliary cirrhosis
Abbas, G., Jorgensen, R. A., & Lindor, K. D. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.62 · Cited by 51
Interleukin-6 levels fluctuate with the light–dark cycle in the brain and peripheral tissues in rats
Guan, Z., Vgontzas, A. N., Omori, T., Peng, X., Bixler, E. O., & Fang, J. (2005) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2005.01.005 · Cited by 50
Self-citation
Sleep Apnea and Hypertension
Seravalle, G., & Grassi, G. M. (2021) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-021-00484-4 · Cited by 58
The Neuroendocrinology of Stress
Kaltsas, G., Chrousos, G. P., & Sternberg, E. M. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511546396.013 · Cited by 51
Self-citation
The nose, upper airway, and obstructive sleep apnea
Wilhelm, C. P., deShazo, R. D., Tamanna, S., Ullah, M. I., & Skipworth, L. B. (2015) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2015.06.011 · Cited by 51
Impact of cytokine in type 1 narcolepsy: Role of pandemic H1N1 vaccination ?
Lecendreux, M., Libri, V., Jaussent, I., Mottez, E., Lopez, R., Lavault, S., Régnault, A., Arnulf, I., & Dauvilliers, Y. A. (2015) · Journal of Autoimmunity · doi:10.1016/j.jaut.2015.03.003 · Cited by 50
Obstructive Sleep Breathing Disorders
Au, C. T., & Li, A. M. (2009) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2008.10.012 · Cited by 50
Cerebrospinal Fluid and Plasma Leptin Measurements: Covariability with Dopamine and Cortisol in Fasting Humans
Hagan, M. M., Havel, P. J., Seeley, R. J., Woods, S. C., Ekhator, N. N., Baker, D. G., Hill, K. K., Wortman, M. D., Miller, A. H., Gingerich, R. L., et al. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.10.6034 · Cited by 50
Lack of Benefit of Continuous Positive Airway Pressure on Lung Function in Patients with Overlap Syndrome
O’Brien, A., & Whitman, K. (2005) · Lung · doi:10.1007/s00408-005-2551-6 · Cited by 49
Abnormal Cytokine and Adrenocortical Hormone Regulation in Myotonic Dystrophy
Johansson, Å., Carlström, K., Åhrén, B., Cederquist, K., Krylborg, E., Forsberg, H., & Olsson, T. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.9.6794 · Cited by 48
Sleep Disruption Worsens Seizures: Neuroinflammation as a Potential Mechanistic Link
Bonilla‐Jaime, H., Zeleke, H., Rojas, A., & Espinosa‐García, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212531 · Cited by 53
Gamma-aminobutyric acid (GABA) receptor mediates suanzaorentang, a traditional Chinese herb remedy, -induced sleep alteration
Yi, P.-L., Tsai, C., Chen, Y.-C., & Chang, F. (2006) · Journal of Biomedical Science · doi:10.1007/s11373-006-9137-z · Cited by 48
Sleep Disordered Breathing, Fatigue, and Sleepiness in HIV-Infected and -Uninfected Men
Patil, S. P., Brown, T. T., Jacobson, L. P., Margolick, J. B., Laffan, A. M., Johnson, L., Godfrey, R., Johnson, J. R., Reynolds, S. M., Schwartz, A. R., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099258 · Cited by 48
Maternal snoring during pregnancy is associated with enhanced fetal erythropoiesis – a preliminary study
Tauman, R., Many, A., Deutsch, V. R., Arvas, S., Ascher-Landsberg, J., Greenfeld, M., & Sivan, Y. (2011) · Sleep Medicine · doi:10.1016/j.sleep.2010.09.005 · Cited by 48
Blood biomarkers of endocrine, immune, inflammatory, and metabolic systems in obstructive sleep apnea
Fleming, W. E., Ferouz-Colborn, A. S., Samoszuk, M. K., Azad, A., Lu, J., Riley, J. S., Cruz, A. B., Podolak, S., Clark, D. J., Bray, K. R., et al. (2016) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2016.05.005 · Cited by 48
Sleep Disturbances in MCI and AD: Neuroinflammation as a Possible Mediating Pathway
Pak, V. M., Onen, S. ‐., Bliwise, D. L., Kutner, N. G., Russell, K. L., & Onen, F. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00069 · Cited by 53
Bariatric surgery and its impact on sleep architecture, sleep-disordered breathing, and metabolism
Pannain, S., & Mokhlesi, B. (2010) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.07.007 · Cited by 48
New frontiers in pharmacologic obstructive sleep apnea treatment: A narrative review
Schütz, S. G., Dunn, A., Braley, T. J., Pitt, B., & Shelgikar, A. V. (2021) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2021.101473 · Cited by 47
The causal associations of altered inflammatory proteins with sleep duration, insomnia and daytime sleepiness
Zhang, Y., Zhao, W., Liu, K., Chen, Z., Fei, Q., Ahmad, N., & Yi, M. (2023) · SLEEP · doi:10.1093/sleep/zsad207 · Cited by 52
The daily variation in sleepiness and its relation to the preceding sleep episode—a prospective study across 42 days of normal living
Åkerstedt, T., Axelsson, J., Lekander, M., Orsini, N., & Kecklund, G. (2012) · Journal of Sleep Research · doi:10.1111/jsr.12014 · Cited by 47
Wheat gluten intake increases weight gain and adiposity associated with reduced thermogenesis and energy expenditure in an animal model of obesity
Freire, R. H., Fernandes, L. R., da Silva, R. B., Coelho, B. S., Araújo, L. P., Ribeiro, L. S., Andrade, J. M. O., Lima, P. M. A., Araújo, R. S., Santos, S. H. S., et al. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.204 · Cited by 47
Genetics of sleep and sleep disorders
Franken, P. (2003) · Frontiers in bioscience · doi:10.2741/1084 · Cited by 47
Sleep disordered breathing in chronic stroke survivors. A study of the long term follow-up of the SCOPES cohort using home based polysomnography
Cadilhac, D. A.-M., Thorpe, R. D., Pearce, D. C., Barnes, M., Rochford, P. D., Tarquinio, N., Davis, S. M., Donnan, G. A., & Pierce, R. J. (2005) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2004.08.014 · Cited by 48
DNA polymorphism-diet-cofactor-development hypothesis and the gene-teratogen model for schizophrenia and other developmental disorders
Johnson, W. G. (1999) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19990820)88:4 · Cited by 33
Poor sleep quality is associated with worse self-rated health in long sleep duration but not short sleep duration
Andréasson, A., Axelsson, J., Bosch, J. A., & Balter, L. J. T. (2021) · Sleep Medicine · doi:10.1016/j.sleep.2021.10.028 · Cited by 50
Sleepiness, inflammation and oxidative stress markers in middle-aged males with obstructive sleep apnea without metabolic syndrome: a cross-sectional study
Andaku, D. K., D’Almeida, V., Carneiro, G., Hix, S., Tufik, S., & Togeiro, S. M. (2015) · Respiratory Research · doi:10.1186/s12931-015-0166-x · Cited by 46

Authors: Vgontzas, A. N., Papanicolaou, D. A., Bixler, E. O., Kales, A., Tyson, K., & Chrousos, G. P.
Affiliations: Pennsylvania State University (US)
National Institutes of Health (US)
Corresponding author: Vgontzas, Alexandros N.
ORCID: Vgontzas, Alexandros N.
Chrousos, George P.
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 1997-05
Volume: 82
Issue: 5
Pages: 1313-1316
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem.82.5.3950
OpenAlex: W1975319022
Cited by: 974
References: 22
Citations by year: 2026: 10 · 2025: 23 · 2024: 24 · 2023: 24 · 2022: 32 · 2021: 33 · 2020: 25 · 2019: 24 · 2018: 23 · 2017: 23 · 2016: 29 · 2015: 40 · 2014: 42 · 2013: 38 · 2012: 46
FWCI: 11.57
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: excessive daytime sleepiness, plasma cytokines, TNF-α, IL-1β, interleukin-6, sleep apnea, narcolepsy, idiopathic hypersomnia, sleep disorders, obesity, body mass index, fatigue, inflammation
MeSH terms: Adult, Female, Humans, Disorders of Excessive Somnolence, Interleukin-1, Male, Narcolepsy, Obesity, Sleep Apnea Syndromes, Sleep Wake Disorders, Tumor Necrosis Factor-alpha, Interleukin-6, Body Mass Index, Cytokines

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Elevation of Plasma Cytokines in Disorders of Excessive Daytime Sleepiness: Role of Sleep Disturbance and Obesity

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks