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The Transforming Growth Factor-β Superfamily Cytokine Macrophage Inhibitory Cytokine-1 Is Present in High Concentrations in the Serum of Pregnant Women1
Open accessAbstract
Macrophage inhibitory cytokine-1 (MIC-1) is a recently described divergent member of the transforming growth factor-β superfamily. MIC-1 transcription up-regulation is associated with macrophage activation, and this observation led to its cloning. Northern blots indicate that MIC-1 is also present in human placenta. A sensitive sandwich enzyme-linked immunosorbent assay for the quantification of MIC-1 was developed and used to examine the role of this cytokine in pregnancy. High levels of MIC-1 are present in the sera of pregnant women. The level rises substantially with progress of gestation. MIC-1 can also be detected, in large amounts, in amniotic fluid and placental extracts. In addition, the BeWo placental trophoblastic cell line was found to constitutively express the MIC-1 transcript and secrete large amounts of MIC-1. These findings suggest that the placental trophoblast is a major source of the MIC-1 present in maternal serum and amniotic fluid. We suggest that MIC-1 may promote fetal survival by suppressing the production of maternally derived proinflammatory cytokines within the uterus.
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Research works printed but not linked: 28
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Cytokines, Prostaglandins and Parturition—A Review
Keelan, J. A., Blumenstein, M., Helliwell, R. J. A., Sato, T. A., Marvin, K. W., & Mitchell, M. D. (2003) · Placenta · doi:10.1053/plac.2002.0948 · Cited by 606
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Metadata
- Authors
- Moore, A. G., Brown, D. A., Fairlie, W. D., Bauskin, A. R., Brown, P. K., Munier, M. L. C., Russell, P. K., Salamonsen, L. A., Wallace, E. M., & Breit, S. N.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2000-12-01
- Volume
- 85
- Issue
- 12
- Pages
- 4781-4788
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2061054042
- Cited by
- 180
- References
- 0
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Moore, A. G., Brown, D. A., Fairlie, W. D., Bauskin, A. R., Brown, P. K., Munier, M. L. C., Russell, P. K., Salamonsen, L. A., Wallace, E. M., & Breit, S. N. (2000). The Transforming Growth Factor-β Superfamily Cytokine Macrophage Inhibitory Cytokine-1 Is Present in High Concentrations in the Serum of Pregnant Women1. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem.85.12.7007
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