CoChat
Sign Up
Cited by 17Diabetes Management and ResearchDiabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

Effect of short-term glucose control on glycemic thresholds for epinephrine and hypoglycemic symptoms

Burge, Mark R., Sobhy, Taher A., Qualls, Clifford R., Schade, David S.·2001·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.86.11.7993
Open this paper in CoChat — free account

Abstract

Hypoglycemia is the principal barrier to achieving target glucose goals in type 2 diabetes. The effect of short-term improvement in glycemic control on plasma glucose thresholds for symptomatic and hormonal responses to hypoglycemia in type 2 diabetes is not known. We hypothesized that the thresholds for these events would be increased by 1 wk of improved glycemic control in elderly patients with type 2 diabetes. Ten elderly patients with type 2 diabetes were admitted for an 8-d inpatient protocol. All subjects underwent insulin-induced hypoglycemia on days 2 (preglucose control) and 8 (postglucose control). Between days 2 and 8, subjects received intensive diabetes management to improve their glycemic control. Timed blood glucose profiles were obtained daily during the week before and during admission. Plasma glucose, counterregulatory hormones, and hypoglycemic symptoms were assessed at baseline and every 10 min during the hypoglycemic studies. Mean blood glucose concentrations were significantly reduced by intensive diabetes management from 9.8 +/- 3.7 mmol/liter to 7.7 +/- 3.3 mmol/liter (P < 0.001). The plasma glucose threshold for epinephrine release during insulin-induced hypoglycemia was significantly increased by intensive management from a glucose concentration of 3.7 +/- 0.5 mmol/liter at baseline to 3.1 +/- 0.3 mmol/liter after intensive management (P < 0.05). The plasma glucose threshold for hypoglycemic symptoms was also increased by intensive therapy from a glucose concentration of 5.3 +/- 1.2 to 3.3 +/- 0.6 mmol/liter (P = 0.003). These rapid changes may increase the risk for severe hypoglycemia in type 2 diabetes and limit the ability of physicians to rapidly correct hyperglycemia in elderly type 2 diabetes patients.

Integrity signals

Registry

Crossref · 10.1210/jcem.86.11.7993

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Intensification of glycemic control in elderly patients is associated with an increased reduction in the plasma glucose thresholds for epinephrine release and for the appearance of hypoglycemia.

    “The intensi fi cation of glycemic control in the elderly patient is associated with an increased reduction in the plasma glucose thresholds for epinephrine release and for the appearance of hypoglycemia (56).”

    From Hypoglycemia and Diabetes: A Report of a Workgroup of the American Diabetes Association and The Endocrine Society (2013) · cites this paper as [56]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Burge, M. R., Sobhy, T. A., Qualls, C. R., & Schade, D. S.
Affiliations
University of New Mexico (US)
Corresponding author
Burge, Mark R.
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2001-11
Volume
86
Issue
11
Pages
5471-5478
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.86.11.7993
OpenAlex
W2046503730
Cited by
17
References
38
Citations by year
2026: 1 · 2014: 1 · 2013: 2
FWCI
0.92
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Deutsches Krebsforschungszentrum
  • National Institutes of Health (5k23dk002680-03)
  • National Institute of Diabetes and Digestive and Kidney Diseases (1-K23-DK02680-01)
  • National Center for Research Resources (5M01-RR00997, M01RR000997)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
type 2 diabetes, hypoglycemia, glycemic control, intensive diabetes management, insulin-induced hypoglycemia, epinephrine secretion, hypoglycemic symptoms, counterregulatory hormones, elderly patients
MeSH terms
Aged, Blood Glucose, Diabetes Mellitus, Type 2, Epinephrine, Female, Glyburide, Glycated Hemoglobin, Humans, Hydrocortisone, Hypoglycemia, Hypoglycemic Agents, Insulin, Male, Middle Aged, Body Mass Index

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review