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Cited by 205Growth Hormone and Insulin-like Growth FactorsNutrition and Health in AgingHormonal and reproductive studies

The DOI matches its Crossref record; 27 of the 28 references it cites were found in a registry or an index.

Association of IGF-I Levels with Muscle Strength and Mobility in Older Women

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Cappola, Anne R., Bandeen-Roche, Karen, Wand, Gary S., Volpato, Stefano, Fried, Linda P.·2001·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.86.9.7868
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Abstract

The functional consequences of the age-associated decline in IGF-I are unknown. We hypothesized that low IGF-I levels in older women would be associated with poor muscle strength and mobility. We assessed this question in a population representative of the full spectrum of health in the community, obtaining serum IGF-I levels from women aged 70-79 yr, enrolled in the Women's Health and Aging Study I or II. Cross-sectional analyses were performed using 617 women with IGF-I levels drawn within 90 d of measurement of outcomes. After adjustment for age, there was an association between IGF-I and knee extensor strength (P = 0.004), but not anthropometry or other strength measures. We found a positive relationship between IGF-I levels and walking speed for IGF-I levels below 50 microg/liter (P < 0.001), but no relationship above this threshold. A decline in IGF-I level was associated with self-reported difficulty in mobility tasks. All findings were attenuated after multivariate adjustment. In summary, in a study population including frail and healthy older women, low IGF-I levels were associated with poor knee extensor muscle strength, slow walking speed, and self-reported difficulty with mobility tasks. These findings suggest a role for IGF-I in disability as well as a potential target population for interventions to raise IGF-I levels.

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Crossref · 10.1210/jcem.86.9.7868

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Metadata

Authors
Cappola, A. R., Bandeen-Roche, K., Wand, G. S., Volpato, S., & Fried, L. P.
Affiliations
  • Johns Hopkins University (US)
  • Department of Biostatistics, Johns Hopkins School of Hygiene and Public Health (K.B.-R.), Baltimore, Maryland 21205
  • National Institutes of Health (US)
Corresponding author
Cappola, Anne R.
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2001-09-01
Volume
86
Issue
9
Pages
4139-4146
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.86.9.7868
OpenAlex
W2082560483
Cited by
205
References
28
Citations by year
2026: 1 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 9 · 2021: 4 · 2020: 11 · 2019: 8 · 2018: 9 · 2017: 9 · 2016: 4 · 2015: 8 · 2014: 8 · 2013: 14 · 2012: 13
FWCI
5.28
Type
journal article
Language
en
Open access
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
  • Columbia Academic Commons (Columbia University)
Funders
  • Johns Hopkins University
  • Quest Diagnostics
  • National Institute on Aging (N01AG12112, R01 AG11703, R01AG011703)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
insulin-like growth factor I, muscle strength, quadriceps strength, mobility (physical function), walking speed, older women, functional disability, aging, Women's Health and Aging Study
MeSH terms
Activities of Daily Living, Aged, Aging, Body Composition, Body Weight, Cross-Sectional Studies, Female, Humans, Insulin-Like Growth Factor I, Psychomotor Performance, Muscle, Skeletal, Hand Strength, Phlebotomy, Human Growth Hormone

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