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Association of IGF-I Levels with Muscle Strength and Mobility in Older Women
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The functional consequences of the age-associated decline in IGF-I are unknown. We hypothesized that low IGF-I levels in older women would be associated with poor muscle strength and mobility. We assessed this question in a population representative of the full spectrum of health in the community, obtaining serum IGF-I levels from women aged 70-79 yr, enrolled in the Women's Health and Aging Study I or II. Cross-sectional analyses were performed using 617 women with IGF-I levels drawn within 90 d of measurement of outcomes. After adjustment for age, there was an association between IGF-I and knee extensor strength (P = 0.004), but not anthropometry or other strength measures. We found a positive relationship between IGF-I levels and walking speed for IGF-I levels below 50 microg/liter (P < 0.001), but no relationship above this threshold. A decline in IGF-I level was associated with self-reported difficulty in mobility tasks. All findings were attenuated after multivariate adjustment. In summary, in a study population including frail and healthy older women, low IGF-I levels were associated with poor knee extensor muscle strength, slow walking speed, and self-reported difficulty with mobility tasks. These findings suggest a role for IGF-I in disability as well as a potential target population for interventions to raise IGF-I levels.
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“The weak observational association between low circulating IGF-1 and some, but not other, measures of weak muscle strength and limited mobility among older women may reflect general age-associated debility rather than any specific hormonal effects (173).”
From Circulating Testosterone as the Hormonal Basis of Sex Differences in Athletic Performance (2018) · cites this paper as [173]
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Cites
A questionnaire for the assessment of leisure time physical activities
Taylor, H. L., Jacobs, D. R., Schucker, B., Knudsen, J., Leon, A. S., & Debacker, G. (1978) · Journal of Chronic Diseases · doi:10.1016/0021-9681(78)90058-9 · Cited by 1,848
Effects of Human Growth Hormone in Men over 60 Years Old
Rudman, D. R., Feller, A. G., Nagraj, H. S., Gergans, G. A., Lalitha, P. Y., Goldberg, A. F., Schlenker, R. A., Cohn, L., Rudman, I. W., & Mattson, D. E. (1990) · New England Journal of Medicine · doi:10.1056/nejm199007053230101 · Cited by 1,545
Human growth hormone and human aging
CORPAS, E., HARMAN, S. M., & BLACKMAN, M. R. (1993) · Endocrine Reviews · doi:10.1210/edrv-14-1-20 · Cited by 911
Heymsfield, S. B., McManus, C., Smith, J. L., Stevens, V. L., & Nixon, D. (1982) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/36.4.680 · Cited by 825
Rutherford, G., Skinner, C. J., Holt, D., & Smith, T. M. F. (1991) · Journal of the Royal Statistical Society Series C (Applied Statistics) · doi:10.2307/2347535 · Cited by 750
Evidence for a non-linear relationship between leg strength and gait speed
BUCHNER, D. M., LARSON, E. B., WAGNER, E. H., KOEPSELL, T. D., & DE LATEUR, B. J. (1996) · Age and Ageing · doi:10.1093/ageing/25.5.386 · Cited by 542
The Women's Health and Aging Study: Health and Social Characteristics of Older Women with Disability
Guralnik, J. M., Fried, L. P., Simonsick, E. M., Kasper, J. D., & Lafferty, M. E. (1995) · PsycEXTRA Dataset · doi:10.1037/e306362003-001 · Cited by 504
Preclinical mobility disability predicts incident mobility disabilityin older women
Fried, L. P., Bandeen‐Roche, K., Chaves, P. H. M., & Johnson, B. A. (2000) · The Journals of Gerontology Series A · doi:10.1093/gerona/55.1.m43 · Cited by 483
Growth Hormone Replacement in Healthy Older Men Improves Body Composition but Not Functional Ability
Papadakis, M. A., Grady, D., Black, D., Tierney, M. J., Gooding, G. A. W., Schambelan, M., & Grunfeld, C. (1996) · Annals of Internal Medicine · doi:10.7326/0003-4819-124-8-199604150-00002 · Cited by 474
Wegman, E. J., & Wright, I. W. (1983) · Journal of the American Statistical Association · doi:10.1080/01621459.1983.10477977 · Cited by 339
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Makary, M. A., Segev, D. L., Pronovost, P. J., Syin, D., Bandeen-Roche, K., Patel, P., Takenaga, R., Devgan, L., Holzmueller, C. G., Tian, J., et al. (2010) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2010.01.028 · Cited by 2,184
Newman, A. B., Kupelian, V., Visser, M., Simonsick, E. M., Goodpaster, B. H., Kritchevsky, S. B., Tylavsky, F. A., Rubin, S. M., Harris, T. B., & on Behalf of the Health, A. A. B. C. S. I. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.1.72 · Cited by 1,692
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Rolland, Y., Czerwinski, S., van Kan, G. A., Morley, J. E., Cesari, M., Onder, G., Woo, J., Baumgartner, R., Pillard, F., Boirie, Y., et al. (2008) · The Journal of nutrition, health and aging · doi:10.1007/bf02982704 · Cited by 1,071
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Stenholm, S., Harris, T. B., Rantanen, T., Visser, M., Kritchevsky, S. B., & Ferrucci, L. (2008) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e328312c37d · Cited by 1,070
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Volpato, S., Bianchi, L., Cherubini, A., Landi, F., Maggio, M. G., Savino, E., Bandinelli, S., Ceda, G. P., Guralnik, J. M., Zuliani, G., et al. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt149 · Cited by 307
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Leng, S. X., Cappola, A. R., Andersen, R. E., Blackman, M. R., Koenig, K., Blair, M., & Walston, J. D. (2004) · Aging Clinical and Experimental Research · doi:10.1007/bf03324545 · Cited by 270
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Metadata
- Authors
- Cappola, A. R., Bandeen-Roche, K., Wand, G. S., Volpato, S., & Fried, L. P.
- Affiliations
- Johns Hopkins University (US)
- Department of Biostatistics, Johns Hopkins School of Hygiene and Public Health (K.B.-R.), Baltimore, Maryland 21205
- National Institutes of Health (US)
- Corresponding author
- Cappola, Anne R.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2001-09-01
- Volume
- 86
- Issue
- 9
- Pages
- 4139-4146
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2082560483
- Cited by
- 205
- References
- 28
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 9 · 2021: 4 · 2020: 11 · 2019: 8 · 2018: 9 · 2017: 9 · 2016: 4 · 2015: 8 · 2014: 8 · 2013: 14 · 2012: 13
- FWCI
- 5.28
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Columbia Academic Commons (Columbia University)
- Funders
- Johns Hopkins University
- Quest Diagnostics
- National Institute on Aging (N01AG12112, R01 AG11703, R01AG011703)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- insulin-like growth factor I, muscle strength, quadriceps strength, mobility (physical function), walking speed, older women, functional disability, aging, Women's Health and Aging Study
- MeSH terms
- Activities of Daily Living, Aged, Aging, Body Composition, Body Weight, Cross-Sectional Studies, Female, Humans, Insulin-Like Growth Factor I, Psychomotor Performance, Muscle, Skeletal, Hand Strength, Phlebotomy, Human Growth Hormone
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