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Weight Loss Reduces Interleukin-18 Levels in Obese Women
Abstract
Obesity is associated with an increased risk of developing atherosclerosis, which may be mediated, at least in part, by increased secretion of proinflammatory cytokines by adipose tissue. We examined the hypothesis that circulating levels of IL-18 were elevated in obese women and would be reduced by weight loss. In a sample of 40 obese (body mass index, 36.4 +/- 3.1 kg/m(2)) women we found that plasma IL-18 levels were higher than in 40 normal weight control women (P < 0.01) and were positively associated with body weight (r = 0.46; P < 0.01) and visceral fat (waist to hip ratio; r = 0.39; P < 0.01). Caloric restriction-induced weight loss (> or = 10% of original weight) over 1 yr reduced IL-18 levels from 247 (204/309) to 147 (111/210) pg/ml (medians and 25%/75%; P < 0.01), positively associated with changes in body mass index and waist to hip ratio. In obese women, IL-18 levels are associated with body weight and abdominal fat deposition; weight loss is an important intervention to reduce IL-18 levels. IL-18 may be a novel cytokine operating in human obesity.
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“Abdominal obesity is a risk factor for type 2 diabetes, hypertension, dyslipidaemia and CVD (50) , and also probably obesityassociated hepatic diseases (non-alcoholic fatty liver disease and non-alcoholic steatohepatitis).”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [50]
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Metadata
- Authors
- Esposito, K., Pontillo, A., Ciotola, M., Di Palo, C., Grella, E., Nicoletti, G., & Giugliano, D.
- Affiliations
- University of Campania "Luigi Vanvitelli" (IT)
- Corresponding author
- Esposito, Katherine
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2002-08
- Volume
- 87
- Issue
- 8
- Pages
- 3864-3866
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2139613376
- Cited by
- 254
- References
- 24
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 10 · 2023: 3 · 2022: 10 · 2021: 9 · 2020: 12 · 2019: 5 · 2018: 11 · 2017: 9 · 2016: 8 · 2015: 7 · 2014: 13 · 2013: 13 · 2012: 8
- FWCI
- 11.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
- Funders
- Università degli Studi di Napoli Federico II
- Seconda Università degli Studi di Napoli
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- IL-18, obesity, weight loss, caloric restriction, visceral fat, waist-to-hip ratio, inflammatory cytokines, adipose tissue, atherosclerosis risk, obese women
- MeSH terms
- Adult, Blood Glucose, Female, Humans, Insulin, Cholesterol, HDL, Cholesterol, LDL, Obesity, Triglycerides, Weight Loss, Interleukin-18
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