Cited by 254Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityAdipose Tissue and Metabolism

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Weight Loss Reduces Interleukin-18 Levels in Obese Women

Esposito, Katherine, Pontillo, Alessandro, Ciotola, Myriam, Di Palo, Carmen, Grella, Elisa, Nicoletti, Gianfranco, Giugliano, Dario·2002·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem.87.8.8781

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Abstract

Obesity is associated with an increased risk of developing atherosclerosis, which may be mediated, at least in part, by increased secretion of proinflammatory cytokines by adipose tissue. We examined the hypothesis that circulating levels of IL-18 were elevated in obese women and would be reduced by weight loss. In a sample of 40 obese (body mass index, 36.4 +/- 3.1 kg/m(2)) women we found that plasma IL-18 levels were higher than in 40 normal weight control women (P < 0.01) and were positively associated with body weight (r = 0.46; P < 0.01) and visceral fat (waist to hip ratio; r = 0.39; P < 0.01). Caloric restriction-induced weight loss (> or = 10% of original weight) over 1 yr reduced IL-18 levels from 247 (204/309) to 147 (111/210) pg/ml (medians and 25%/75%; P < 0.01), positively associated with changes in body mass index and waist to hip ratio. In obese women, IL-18 levels are associated with body weight and abdominal fat deposition; weight loss is an important intervention to reduce IL-18 levels. IL-18 may be a novel cytokine operating in human obesity.

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Additional file 1 of Changes in tubular biomarkers with dietary intervention and metformin in patients with autosomal dominant polycystic kidney disease: a post-hoc analysis of two clinical trials
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Additional file 3 of Changes in tubular biomarkers with dietary intervention and metformin in patients with autosomal dominant polycystic kidney disease: a post-hoc analysis of two clinical trials
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Additional file 2 of Changes in tubular biomarkers with dietary intervention and metformin in patients with autosomal dominant polycystic kidney disease: a post-hoc analysis of two clinical trials
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Authors: Esposito, K., Pontillo, A., Ciotola, M., Di Palo, C., Grella, E., Nicoletti, G., & Giugliano, D.
Affiliations: University of Campania "Luigi Vanvitelli" (IT)
Corresponding author: Esposito, Katherine
ORCID: Esposito, Katherine
Giugliano, Dario
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2002-08
Volume: 87
Issue: 8
Pages: 3864-3866
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem.87.8.8781
OpenAlex: W2139613376
Cited by: 254
References: 24
Citations by year: 2026: 2 · 2025: 3 · 2024: 10 · 2023: 3 · 2022: 10 · 2021: 9 · 2020: 12 · 2019: 5 · 2018: 11 · 2017: 9 · 2016: 8 · 2015: 7 · 2014: 13 · 2013: 13 · 2012: 8
FWCI: 11.88
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
Funders: Università degli Studi di Napoli Federico II
Seconda Università degli Studi di Napoli
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: IL-18, obesity, weight loss, caloric restriction, visceral fat, waist-to-hip ratio, inflammatory cytokines, adipose tissue, atherosclerosis risk, obese women
MeSH terms: Adult, Blood Glucose, Female, Humans, Insulin, Cholesterol, HDL, Cholesterol, LDL, Obesity, Triglycerides, Weight Loss, Interleukin-18

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Weight Loss Reduces Interleukin-18 Levels in Obese Women

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