The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Estrogen Receptor (ER)-β Reduces ERα-Regulated Gene Transcription, Supporting a “Ying Yang” Relationship between ERα and ERβ in Mice
Open accessAbstract
Estrogen is of importance for the regulation of adult bone metabolism. The aim of the present study was to determine the role of estrogen receptor-β (ERβ) in vivo on global estrogen-regulated transcriptional activity in bone. The effect of estrogen in bone of ovariectomized mice was determined using microarray analysis including 9400 genes. Most of the genes (95% = 240 genes) that were increased by estrogen in wild-type (WT) mice were also increased by estrogen in ERβ-inactivated mice. Interestingly, the average stimulatory effect of estrogen on the mRNA levels of these genes was 85% higher in ERβ-inactivated than in WT mice, demonstrating that ERβ reduces estrogen receptor-α (ERα)-regulated gene transcription in bone. The average stimulatory effect of estrogen on estrogen-regulated bone genes in ERα-inactivated mice was intermediate between that seen in WT and ERαβ double-inactivated mice. Thus, ERβ inhibits ERα-mediated gene transcription in the presence of ERα, whereas, in the absence of ERα, it can partially replace ERα. In conclusion, our in vivo data indicate that an important physiological role of ERβ is to modulate ERα-mediated gene transcription supporting a “Ying Yang” relationship between ERα and ERβ in mice.
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Cites
A role for estrogen receptor β in the regulation of growth of the ventral prostate
Weihua, Z., Mäkelä, S., Andersson, L. C., Salmi, S., Saji, S., Webster, J. I., Jensen, E. V., Nilsson, S., Warner, M., & Gustafsson, J.-Å. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111150898 · Cited by 440
Self-citation
Cited by
Gillies, G. E., & McArthur, S. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002071 · Cited by 733
Vanderschueren, D., Vandenput, L., Boonen, S., Lindberg, M. K., Bouillon, R., & Ohlsson, C. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0003 · Cited by 717
Self-citationLoss of ERβ expression as a common step in estrogen-dependent tumor progression
Bardin, A., Boulle, N., Lazennec, G., Vignon, F., & Pujol, P. (2004) · Endocrine-Related Cancer · doi:10.1677/erc.1.00800 · Cited by 417
Sex Steroid Actions in Male Bone
Vanderschueren, D., Laurent, M. R., Claessens, F., Gielen, E., Lagerquist, M. K., Vandenput, L., Börjesson, A. E., & Ohlsson, C. (2014) · Endocrine Reviews · doi:10.1210/er.2014-1024 · Cited by 327
Self-citationRole of estrogen receptor alpha and beta expression and signaling on cognitive function during aging
Foster, T. C. (2012) · Hippocampus · doi:10.1002/hipo.20935 · Cited by 231
Metadata
- Authors
- Lindberg, M. K., Movérare, S., Skrtic, S., Gao, H., Dahlman-Wright, K., Gustafsson, J.-A., & Ohlsson, C.
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2003-02-01
- Volume
- 17
- Issue
- 2
- Pages
- 203-208
- ISSN
- 0888-8809 (ISSN-L)
- 1944-9917
- OpenAlex
- W2154937055
- Cited by
- 479
- References
- 1
- FWCI
- 18.75
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lindberg, M. K., Movérare, S., Skrtic, S., Gao, H., Dahlman-Wright, K., Gustafsson, J.-A., & Ohlsson, C. (2003). Estrogen Receptor (ER)-β Reduces ERα-Regulated Gene Transcription, Supporting a “Ying Yang” Relationship between ERα and ERβ in Mice. Molecular Endocrinology. https://doi.org/10.1210/me.2002-0206
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