The DOI matches its Crossref record; 117 of the 117 references it cites were found in a registry or an index.
Genomic Targets of Nuclear Estrogen Receptors
Open accessAbstract
Estrogen influences the physiology of many target tissues in both women and men. The long-term effects of estrogen are mediated predominantly by nuclear estrogen receptors (ERs) functioning as DNA-binding transcription factors. Tissue-specific responses to estrogen therefore result from regulation of different sets of genes. However, it remains perplexing as to what regulatory sequence contexts specify distinct genomic responses. First, this review classifies estrogen response sequences in mammalian target genes. Of note, around one third of known human target genes associate only indirectly with ER, through intermediary transcription factor(s). Then, computational approaches are presented both for refining direct ER-binding sites and for formulating hypotheses regarding the overall genomic expression pattern. Surprisingly, limited evolutionary conservation of specific estrogen-responsive sites is observed between human and mouse. Finally, consideration of the cellular functions of regulated human genes suggests links between particular biological roles and specific types of estrogen response elements, although with the important caveat that only a restricted set of target genes is available. These analyses support the view that specific, hormone-driven gene expression programs can result from the interplay of environmental and cellular cues with the distinct types of estrogen-response sequences.
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1 retracted
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RetractedThe Human Genome Browser at UCSC
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Initial sequencing and comparative analysis of the mouse genome
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The coregulator exchange in transcriptional functions of nuclear receptors
Glass, C. K., & Rosenfeld, M. G. (2000) · Genes & Development · doi:10.1101/gad.14.2.121 · Cited by 2,233
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Detecting Subtle Sequence Signals: a Gibbs Sampling Strategy for Multiple Alignment
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Cofactor Dynamics and Sufficiency in Estrogen Receptor–Regulated Transcription
Shang, Y., Hu, X., DiRenzo, J., Lazar, M. A., & Brown, M. (2000) · Cell · doi:10.1016/s0092-8674(00)00188-4 · Cited by 1,657
Nuclear Hormone Receptors and Gene Expression
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DNA binding sites: representation and discovery
Stormo, G. D. (2000) · Bioinformatics · doi:10.1093/bioinformatics/16.1.16 · Cited by 1,502
Combinatorial Control of Gene Expression by Nuclear Receptors and Coregulators
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Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses
Vandenberg, L. N., Colborn, T., Hayes, T. B., Heindel, J. J., Jacobs, D. R., Lee, D.-H., Shioda, T., Soto, A. M., vom Saal, F. S., Welshons, W. V., et al. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1050 · Cited by 3,209
Hamilton, K. J., Hewitt, S. C., Arao, Y., & Korach, K. S. (2017) · Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2016.12.005 · Cited by 336
The contributions of oxytocin and vasopressin pathway genes to human behavior
Ebstein, R. P., Knafo, A., Mankuta, D., Chew, S. H., & Lai, P. S. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.014 · Cited by 283
Intrinsically disordered proteins play diverse roles in cell signaling
Bondos, S. E., Dunker, A. K., & Uversky, V. N. (2022) · Cell Communication and Signaling · doi:10.1186/s12964-022-00821-7 · Cited by 222
The Hair Follicle as an Estrogen Target and Source
Ohnemus, U., Uenalan, M., Inzunza, J., Gustafsson, J.-A., & Paus, R. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0020 · Cited by 205
Metadata
- Authors
- O’Lone, R., Frith, M. C., Karlsson, E. K., & Hansen, U.
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2004-08
- Volume
- 18
- Issue
- 8
- Pages
- 1859-1875
- ISSN
- 0888-8809 (ISSN-L)
- 1944-9917
- OpenAlex
- W2052306492
- Cited by
- 441
- References
- 117
- FWCI
- 10.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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