Cited by 284Neuroendocrine regulation and behaviorNeurotransmitter Receptor Influence on BehaviorSexual Differentiation and Disorders

The contributions of oxytocin and vasopressin pathway genes to human behavior

Ebstein, Richard P., Knafo, Ariel, Mankuta, David, Chew, Soo Hong, Lai, Poh San·2012·Hormones and Behavior

Abstract

Arginine vasopressin (AVP) and oxytocin (OXT) are social hormones and mediate affiliative behaviors in mammals and as recently demonstrated, also in humans. There is intense interest in how these simple nonapeptides mediate normal and abnormal behavior, especially regarding disorders of the social brain such as autism that are characterized by deficits in social communication and social skills. The current review examines in detail the behavioral genetics of the first level of human AVP-OXT pathway genes including arginine vasopressin 1a receptor (AVPR1a), oxytocin receptor (OXTR), AVP (AVP-neurophysin II [NPII]) and OXT (OXT neurophysin I [NPI]), oxytocinase/vasopressinase (LNPEP), ADP-ribosyl cyclase (CD38) and arginine vasopressin 1b receptor (AVPR1b). Wherever possible we discuss evidence from a variety of research tracks including molecular genetics, imaging genomics, pharmacology and endocrinology that support the conclusions drawn from association studies of social phenotypes and detail how common polymorphisms in AVP-OXT pathway genes contribute to the behavioral hard wiring that enables individual Homo sapiens to interact successfully with conspecifics. This article is part of a Special Issue entitled Oxytocin, Vasopressin, and Social Behavior.

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Crossref · 10.1016/j.yhbeh.2011.12.014

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  • Genetic studies of SNPs in the OTR gene provide evidence for involvement of the OTR in various social behaviors in humans, and potential sex-specific effects on human social behavior.

    “Genetic studies of single nucleotide polymorphisms (SNPs) in the OTR gene provide evidence for the involvement of the OTR in various social behaviors in humans (for reviews see Meyer-Lindenberg et al., 2011; Ebstein et al., 2012), and potential sex-specific effects on human social behavior.”

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Authors
Ebstein, R. P., Knafo, A., Mankuta, D., Chew, S. H., & Lai, P. S.
Affiliations
  • National University of Singapore (SG)
  • Hebrew University of Jerusalem (IL)
Corresponding author
Ebstein, Richard P.
Venue
Hormones and Behavior
Publisher
Elsevier BV
Published
2012-03
Volume
61
Issue
3
Pages
359-379
ISSN
0018-506X (ISSN-L)
OpenAlex
W2085830161
Cited by
283
References
311
Citations by year
2026: 4 · 2025: 8 · 2024: 10 · 2023: 8 · 2022: 8 · 2021: 13 · 2020: 14 · 2019: 13 · 2018: 28 · 2017: 28 · 2016: 31 · 2015: 33 · 2014: 43 · 2013: 35 · 2012: 7
FWCI
3.44
Type
journal article
Language
en
Open access
closed
Locations
  • Hormones and Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • National University of Singapore (submittedVersion)
Funders
  • National University of Singapore
  • Ministry of Education - Singapore
  • John Templeton Foundation
  • AGA Research Foundation
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Keywords
oxytocin, vasopressin, social behavior, autism spectrum disorder, AVPR1A, oxytocin receptor, neurophysin II, neurophysin I, CD38, AVPR1B, genetic polymorphism, social brain
MeSH terms
Animals, Autistic Disorder, Dancing, Feeding Behavior, Humans, Music, Oxytocin, Retinoids, Social Behavior, Vasopressins, Gene Expression, Receptors, Vasopressin, Receptors, Oxytocin, Microsatellite Repeats, Substance-Related Disorders, Polymorphism, Single Nucleotide, Genomics, ADP-ribosyl Cyclase 1

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