The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A Crucial Role for the Vitamin D Receptor in Experimental Inflammatory Bowel Diseases
Abstract
The active form of vitamin D (1,25D3) suppressed the development of animal models of human autoimmune diseases including experimental inflammatory bowel disease (IBD). The vitamin D receptor (VDR) is required for all known biologic effects of vitamin D. Here we show that VDR deficiency (knockout, KO) resulted in severe inflammation of the gastrointestinal tract in two different experimental models of IBD. In the CD45RB transfer model of IBD, CD4+/CD45RBhigh T cells from VDR KO mice induced more severe colitis than wild-type CD4+/CD45RBhigh T cells. The second model of IBD used was the spontaneous colitis that develops in IL-10 KO mice. VDR/IL-10 double KO mice developed accelerated IBD and 100% mortality by 8 wk of age. At 8 wk of age, all of the VDR and IL-10 single KO mice were healthy. Rectal bleeding was observed in every VDR/IL-10 KO mouse. Splenocytes from the VDR/IL-10 double KO mice cells transferred IBD symptoms. The severe IBD in VDR/IL-10 double KO mice is a result of the immune system and not a result of altered calcium homeostasis, or gastrointestinal tract function. The data establishes an essential role for VDR signaling in the regulation of inflammation in the gastrointestinal tract.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The aging immune system: primer and prospectus
Miller, R. A. (1996) · Science · doi:10.1126/science.273.5271.70 · Cited by 1,165 · cited 1×
“-host disease (23), aging (24), and tumor development (25).”
BackgroundPowrie, F., Leach, M. W., Mauze, S., Caddie, L. B., & Coffman, R. L. (1993) · International Immunology · doi:10.1093/intimm/5.11.1461 · Cited by 1,078
Cited by
Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice
Bouillon, R., Carmeliet, G., Verlinden, L., van Etten, E., Verstuyf, A., Luderer, H. F., Lieben, L., Mathieu, C., & Demay, M. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0004 · Cited by 1,783
Epidemiology and risk factors for IBD
Ananthakrishnan, A. N. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.34 · Cited by 1,741
Vitamin D and the intracrinology of innate immunity
Hewison, M. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.02.013 · Cited by 230
Norval, M., Cullen, A. P., de Gruijl, F. R., Longstreth, J., Takizawa, Y., Lucas, R. M., Noonan, F. P., & van der Leun, J. C. (2007) · Photochemical & Photobiological Sciences · doi:10.1039/b700018a · Cited by 199
Vitamin D receptor is required to control gastrointestinal immunity in IL-10 knockout mice
Froicu, M., Zhu, Y., & Cantorna, M. T. (2006) · Immunology · doi:10.1111/j.1365-2567.2005.02290.x · Cited by 128
Self-citation
Metadata
- Authors
- Froicu, M., Weaver, V., Wynn, T. A., McDowell, M. A., Welsh, J. E., & Cantorna, M. T.
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2003-12-01
- Volume
- 17
- Issue
- 12
- Pages
- 2386-2392
- ISSN
- 0888-8809 (ISSN-L)
- 1944-9917
- OpenAlex
- W2121484716
- Cited by
- 407
- References
- 2
- FWCI
- 5.36
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A Crucial Role for the Vitamin D Receptor in Experimental Inflammatory Bowel Diseases. https://app.cochat.ai/papers/10.1210/me.2003-0281
- The paper
- Froicu, M., Weaver, V., Wynn, T. A., McDowell, M. A., Welsh, J. E., & Cantorna, M. T. (2003). A Crucial Role for the Vitamin D Receptor in Experimental Inflammatory Bowel Diseases. Molecular Endocrinology. https://doi.org/10.1210/me.2003-0281
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
