Cited by 184Retinoids in leukemia and cellular processesProtein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancer

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Rapid, Nongenomic Actions of Retinoic Acid on Phosphatidylinositol-3-Kinase Signaling Pathway Mediated by the Retinoic Acid Receptor

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Masiá, Susana, Alvarez, Susana, de Lera, Angel R., Barettino, Domingo·2007·Molecular Endocrinology

DOI 10.1210/me.2007-0062

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Abstract

Retinoic acid (RA) treatment of SH-SY5Y neuroblastoma cells results in activation of phosphatidylinositol-3-kinase (PI3K) signaling pathway, and this activation is required for RA-induced differentiation. Here we show that RA activates PI3K and ERK1/2 MAPK signaling pathways through a rapid, nongenomic mechanism that does not require new gene transcription or newly synthesized proteins. Activation of PI3K by RA appears to involve the classical nuclear receptor, retinoic acid receptor (RAR), on the basis of the pharmacological profile of the activation, loss, and gain of function experiments with mouse embryo fibroblast-RAR(alpha beta gamma)(L-/L-) null cells, and the physical association between liganded RAR and PI3K activity. The association of RAR with the two subunits of PI3K was differentially regulated by the ligand. Immunoprecipitation experiments performed in SH-SY5Y cells showed stable association between RARalpha and p85, the regulatory subunit of PI3K, independently of the presence of RA. In contrast, ligand administration increased the association of p110, the catalytic subunit of PI3K, to this complex. The intracellular localization of RAR proved to be relevant for PI3K activation. A chimerical RAR fusing c-Src myristylation domain to the N terminus of RARalpha (Myr-RARalpha) was targeted to plasma membrane. Transfection of Myr-RARalpha to mouse embryo fibroblast-RAR(alpha beta gamma)(L-/L-) null cells and COS-7 cells results in strong activation of the PI3K signaling pathway, although both in the absence as well in the presence of RA. Our results support a mechanism in which ligand binding to RAR would play a major role in the assembly and intracellular location of a signaling complex involving RAR and the subunits of PI3K.

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Activation of Phosphatidylinositol 3-Kinase/Akt Pathway by Androgen through Interaction of p85α, Androgen Receptor, and Src
Sun, M., Yang, L., Feldman, R. I., Sun, X.-M., Bhalla, K. N., Jove, R., Nicosia, S. V., & Cheng, J. Q. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306295200 · Cited by 175
Retracted
Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface
Brown, D. A., & Rose, J. K. (1992) · Cell · doi:10.1016/0092-8674(92)90189-j · Cited by 2,921
Production of high-titer helper-free retroviruses by transient transfection.
Pear, W. S., Nolan, G. P., Scott, M. L., & Baltimore, D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8392 · Cited by 2,267
Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line
Morgenstern, J. P., & Land, H. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.12.3587 · Cited by 2,099
Treatment of High-Risk Neuroblastoma with Intensive Chemotherapy, Radiotherapy, Autologous Bone Marrow Transplantation, and 13-cis-Retinoic Acid
Matthay, K. K., Villablanca, J. G., Seeger, R. C., Stram, D. O., Harris, R. E., Ramsay, N. K. C., Swift, P. S., Shimada, H., Black, C. T., Brodeur, G. M., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199910143411601 · Cited by 1,891
Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase
Simoncini, T., Hafezi‐Moghadam, A., Brazil, D. P., Ley, K. F., Chin, W. W., & Liao, J. K. (2000) · Nature · doi:10.1038/35035131 · Cited by 1,436
Principles for modulation of the nuclear receptor superfamily
Gronemeyer, H., Gustafsson, J.-Å., & Laudet, V. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1551 · Cited by 1,285
Cellular Function of Phosphoinositide 3-Kinases: Implications for Development, Immunity, Homeostasis, and Cancer
Katso, R., Okkenhaug, K., Ahmadi, K., White, S., Timms, J. F., & Waterfield, M. D. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.615 · Cited by 1,234
Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors
Kousteni, S., Bellido, T., Plotkin, L. I., O’Brien, C. A., Bodenner, D., Li, H., Han, K., Gregorio, G. B. D., Katzenellenbogen, J. A., Katzenellenbogen, B. S., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00268-9 · Cited by 1,163
Cell Membrane and Nuclear Estrogen Receptors (ERs) Originate from a Single Transcript: Studies of ER and ER Expressed in Chinese Hamster Ovary Cells
Razandi, M., Pedram, A., Greene, G. L., & Levin, E. R. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.2.0239 · Cited by 1,075

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Nagl, F., Schönhofer, K., Seidler, B., Mages, J., Allescher, H., Schmid, R. M., Schneider, G., & Saur, D. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00034.2009 · Cited by 29
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Barceinas, R. S. Q., García-Regalado, A., Aréchaga-Ocampo, E., Villegas‐Sepúlveda, N., & la Rosa, C. H. G.-D. (2015) · BioMed Research International · doi:10.1155/2015/404368 · Cited by 28
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Jiang, M., Meng, J., Zeng, F., Qing, H., Hook, G., HOOK, V. Y. H., Wu, Z., & Ni, J. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15032 · Cited by 28
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Larangé, A., Takazawa, I., Kakugawa, K., Thiault, N., Ngoi, S., Olive, M. E., Iwaya, H., Seguin, L., Vicente-Suarez, I., Bécart, S., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.07.017 · Cited by 27
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Ruiz, A., Dror, E., Handschin, C., Furrer, R., Pérez‐Schindler, J., Bachmann, C., Treves, S., & Zorzato, F. (2018) · Scientific Reports · doi:10.1038/s41598-017-18844-3 · Cited by 26
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Chebaro, Y., Amal, I., Rochel, N., Rochette-Egly, C., Stote, R. H., & Dejaegere, A. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003012 · Cited by 25
RARα supports the development of Langerhans cells and langerin-expressing conventional dendritic cells
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Non-canonical retinoid signaling in neural development, regeneration and synaptic function
Piazza, A., Carlone, R. L., & Spencer, G. E. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1371135 · Cited by 24
The p85α regulatory subunit of PI3K mediates cAMP-PKA and retinoic acid biological effects on MCF7 cell growth and migration
Coppa, A. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1383 · Cited by 23
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Ramos, V. D. M., Zanotto‐Filho, A., Pasquali, M. A. D. B., Klafke, K., Gasparotto, J., Dunkley, P. R., Gelain, D. P., & Moreira, J. C. F. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9506-6 · Cited by 23
EPA/DHA and Vitamin A Supplementation Improves Spatial Memory and Alleviates the Age-related Decrease in Hippocampal RXRγ and Kinase Expression in Rats
Létondor, A., Buaud, B., Vaysse, C., Richard, E., Layé, S., Pallet, V., & Alfos, S. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00103 · Cited by 23
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Maugeri, G., D’Amico, A. G., Rasà, D. M., Reitano, R., Saccone, S., Federico, C., Parenti, R., Magro, G. G., & D’Agata, V. (2016) · Genes & Cancer · doi:10.18632/genesandcancer.94 · Cited by 22
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Laserna, E. J., Valero, M. L., Sanz, L., del Pino, M. M. S., Calvete, J. J., & Barettino, D. (2009) · Molecular Endocrinology · doi:10.1210/me.2009-0165 · Cited by 21
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Youn, H., Kim, E., & Um, S. (2013) · Cancer Letters · doi:10.1016/j.canlet.2012.12.019 · Cited by 21
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Higgins, S., Wong, S. H. X., Richner, M., Rowe, C. L., Newgreen, D. F., Werther, G. A., & Russo, V. C. (2009) · Endocrinology · doi:10.1210/en.2008-1797 · Cited by 21
Retinoic acid–induced survival effects in SH‐SY5Y neuroblastoma cells
Waetzig, V., Haeusgen, W., Andres, C., Frehse, S., Reinecke, K., Bruckmueller, H., Böhm, R., Herdegen, T., & Cascorbi, I. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27885 · Cited by 21
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Redfern, C. P. F. (2020) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2020.02.002 · Cited by 23
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Taylor, E., & Heyland, A. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111468 · Cited by 22
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Laursen, K. B., & Gudas, L. J. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.001951 · Cited by 20
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Brossaud, J., Roumes, H., Moisan, M., Pallet, V., Redonnet, A., & Corcuff, J. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12192 · Cited by 22
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Tian, X., An, R., Luo, Y., Li, M., Xu, L., & Dong, Z. (2019) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2019.04.017 · Cited by 20
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Santos, D. L., & Payan‐Carreira, R. (2019) · CRC Press eBooks · doi:10.1201/9780429244216 · Cited by 18

Authors: Masiá, S., Alvarez, S., de Lera, A. R., & Barettino, D.
Affiliations: Biology of Hormone Action Unit (S.M., D.B.). Department of Molecular and Cellular Pathology and Therapy, Instituto de Biomedicina de Valencia [Consejo Superior de Investigaciones Cientificas (CSIC)], E-46010 Valencia, Spain;
Universidade de Vigo (S.A., A.R.d.L.), Departamento de Química Orgánica, Facultad de Ciencias, E-36200 Vigo, Spain
Consejo Superior de Investigaciones Científicas (ES)
Corresponding author: Barettino, Domingo
Venue: Molecular Endocrinology
Publisher: The Endocrine Society
Published: 2007-10-01
Volume: 21
Issue: 10
Pages: 2391-2402
ISSN: 0888-8809 (ISSN-L)
1944-9917
DOI: 10.1210/me.2007-0062
OpenAlex: W2015219861
Cited by: 184
References: 67
Citations by year: 2026: 3 · 2025: 6 · 2024: 8 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 9 · 2019: 16 · 2018: 12 · 2017: 5 · 2016: 13 · 2015: 11 · 2014: 16 · 2013: 15 · 2012: 11
FWCI: 5.01
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Molecular Endocrinology (publishedVersion)
PubMed (publishedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, other-oa)
Funders: European Commission
Generalitat Valenciana
European Regional Development Fund
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords: retinoic acid, non-genomic signaling, retinoic acid receptor, phosphatidylinositol 3-kinase, PI3K signaling, ERK signaling, neuronal differentiation, SH-SY5Y cells, p85 regulatory subunit, p110 catalytic subunit, RARα, subcellular localization
MeSH terms: Retinoic Acid Receptor alpha, Humans, Tretinoin, Signal Transduction, Receptors, Retinoic Acid, Phosphatidylinositol 3-Kinases, Mitogen-Activated Protein Kinase 1, Cell Line, Tumor, Mitogen-Activated Protein Kinase 3

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Rapid, Nongenomic Actions of Retinoic Acid on Phosphatidylinositol-3-Kinase Signaling Pathway Mediated by the Retinoic Acid Receptor

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