Hepatic metabolism of retinoids and disease associations

Liver fibrosis

Bataller, R., & Brenner, D. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24282 · Cited by 4,958 · see citing works

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

Friedman, S. L. (2008) · Physiological Reviews · doi:10.1152/physrev.00013.2007 · Cited by 2,842 · see citing works

Primary liver cancer: Worldwide incidence and trends

Bosch, F. X., Ribes, J., Díaz, M., & Clèries, R. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.09.011 · Cited by 2,473 · see citing works

Molecular Regulation of Hepatic Fibrosis, an Integrated Cellular Response to Tissue Injury

Friedman, S. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.4.2247 · Cited by 2,090 · see citing works

Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid)

Warrell, R. P., Frankel, S. R., Miller, W. H., Scheinberg, D. A., Itri, L. M., Hittelman, W. N., Vyas, R. C., Andreeff, M., Tafuri, A., Jakubowski, A. A., et al. (1991) · New England Journal of Medicine · doi:10.1056/nejm199105163242002 · Cited by 1,248 · see citing works

The retinoids—Biology, chemistry and medicine

(1996) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(97)80793-5 · Cited by 1,188 · see citing works

Retinoic Acid Synthesis and Signaling during Early Organogenesis

Duester, G. (2008) · Cell · doi:10.1016/j.cell.2008.09.002 · Cited by 1,098 · see citing works

Gene expression regulation by retinoic acid

Balmer, J. E., & Blomhoff, R. (2002) · Journal of Lipid Research · doi:10.1194/jlr.r100015-jlr200 · Cited by 1,039 · see citing works

The Retinoids-Biology, Chemistry and Medicine

Wolf, G. (1994) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/60.5.796a · Cited by 1,005 · see citing works

Nongenomic actions of steroid hormones

Lösel, R., & Wehling, M. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1009 · Cited by 980 · see citing works

Overview of retinoid metabolism and function

Blomhoff, R., & Blomhoff, H. K. (2006) · Journal of Neurobiology · doi:10.1002/neu.20242 · Cited by 948 · see citing works

Retinol-binding protein: the transport protein for vitamin A in human plasma

Kanai, M., Raz, A., & Goodman, D. S. (1968) · Journal of Clinical Investigation · doi:10.1172/jci105889 · Cited by 899 · see citing works

The promise of retinoids to fight against cancer

Altucci, L., & Gronemeyer, H. (2001) · Nature Reviews Cancer · doi:10.1038/35106036 · Cited by 773 · see citing works

History, Heterogeneity, Developmental Biology, and Functions of Quiescent Hepatic Stellate Cells

Geerts, A. (2001) · Seminars in Liver Disease · doi:10.1055/s-2001-17550 · Cited by 740 · see citing works

Prevention of Second Primary Tumors by an Acyclic Retinoid, Polyprenoic Acid, in Patients with Hepatocellular Carcinoma

Muto, Y., Moriwaki, H., Ninomiya, M., Adachi, S., Saito, A. M., Takasaki, K., Tanaka, T., Tsurumi, K., Okuno, M., Tomita, E., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199606133342402 · Cited by 667 · see citing works

PLASMA LIPID TRANSFER PROTEINS

Tall, A. R. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.001315 · Cited by 639 · see citing works

Alcohol and hepatocellular carcinoma

Morgan, T. R. M., Mandayam, S., & Jamal, M. M. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.09.020 · Cited by 631 · see citing works

Families of retinoid dehydrogenases regulating vitamin A function: Production of visual pigment and retinoic acid

Duester, G. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01497.x · Cited by 570 · see citing works

Focus on hepatocellular carcinoma

Bruix, J., Boix, L., Sala, M., & Llovet, J. M. (2004) · Cancer Cell · doi:10.1016/s1535-6108(04)00058-3 · Cited by 569 · see citing works

Vitamin A metabolism: An update

D’Ambrosio, D. N., Clugston, R. D., & Blaner, W. S. (2011) · Nutrients · doi:10.3390/nu3010063 · Cited by 562 · see citing works

Impaired retinal function and vitamin A availability in mice lacking retinol‐binding protein

Quadro, L., Blaner, W. S., Salchow, D. J., Vogel, S., Piantedosi, R., Gouras, P., Freeman, S., Cosma, M. P., Colantuoni, V., & Gottesman, M. E. (1999) · The EMBO Journal · doi:10.1093/emboj/18.17.4633 · Cited by 506 · see citing works

Hepatic uptake of chylomicron remnants

Cooper, A. D. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34932-4 · Cited by 499 · see citing works

International Union of Pharmacology. LXIII. Retinoid X receptors

Germain, P., Chambon, P., Eichele, G., Evans, R. M., Lazar, M. A., Leid, M., De Lera, A. R., Lotan, R., Mangelsdorf, D. J., & Gronemeyer, H. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.4.7 · Cited by 496 · see citing works

Vitamin A metabolism: new perspectives on absorption, transport, and storage

Blomhoff, R., Green, M. H., Green, J. B., Berg, T., & Norum, K. R. (1991) · Physiological Reviews · doi:10.1152/physrev.1991.71.4.951 · Cited by 447 · see citing works

Hepatic stellate cell lipid droplets: A specialized lipid droplet for retinoid storage

Blaner, W. S., O'Byrne, S. M., Wongsiriroj, N., Kluwe, J., D'Ambrosio, D. M., Jiang, H., Schwabe, R. F., Hillman, E. M. C., Piantedosi, R., & Libien, J. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2008.11.001 · Cited by 444 · see citing works

cDNA Cloning of Human Retinoic Acid-metabolizing Enzyme (hP450RAI) Identifies a Novel Family of Cytochromes P450 (CYP26)*

White, J. A., Beckett-Jones, B., Guo, Y.-D., Dilworth, F., Bonasoro, J., Jones, G., & Petkovich, M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18538 · Cited by 412 · see citing works

Structure of a complex of two plasma proteins: transthyretin and retinol-binding protein

Monaco, H. L., Rizzi, M., & Coda, A. (1995) · Science · doi:10.1126/science.7754382 · Cited by 410 · see citing works

Retinoic acid biosynthesis and metabolism

Napoli, J. L. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.9.8801182 · Cited by 378 · see citing works

Hepatic Vitamin A Depletion in Alcoholic Liver Injury

Leo, M. A., & Lieber, C. S. (1982) · New England Journal of Medicine · doi:10.1056/nejm198209023071006 · Cited by 345 · see citing works

From carrot to clinic: an overview of the retinoic acid signaling pathway

Theodosiou, M., Laudet, V., & Schubert, M. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0268-z · Cited by 329 · see citing works

Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormone

Episkopou, V, Maeda, S., Nishiguchi, S., Shimada, K., Gaitanaris, G. A., Gottesman, M. E., & Robertson, E. J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.6.2375 · Cited by 325 · see citing works

Cellular retinol‐binding protein I is essential for vitamin A homeostasis

Ghyselinck, N. B., Båvik, C., Sapin, V., Mark, M. P., Bonnier, D., Hindelang, C., Dierich, A., Nilsson, C. B., Håkansson, H., Sauvant, P., et al. (1999) · The EMBO Journal · doi:10.1093/emboj/18.18.4903 · Cited by 319 · see citing works

Retinoids and retinoid-binding protein expression in rat adipocytes.

Tsutsumi, C., Okuno, M., Tannous, L., Piantedosi, R., Allan, M., Goodman, D. S., & Blaner, W. S. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)46017-6 · Cited by 317 · see citing works

Cellular Retinoid-Binding Proteins

Ong, D. E. (1987) · Archives of Dermatology · doi:10.1001/archderm.1987.01660360140026 · Cited by 308 · see citing works

Direct Channeling of Retinoic Acid between Cellular Retinoic Acid-Binding Protein II and Retinoic Acid Receptor Sensitizes Mammary Carcinoma Cells to Retinoic Acid-Induced Growth Arrest

Budhu, A. S., & Noy, N. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.8.2632-2641.2002 · Cited by 296 · see citing works

Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT)

O'Byrne, S. M., Wongsiriroj, N., Libien, J., Vogel, S., Goldberg, I. J., Baehr, W., Palczewski, K., & Blaner, W. S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507924200 · Cited by 296 · see citing works

The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters

Yen, C. E., Monetti, M., Burri, B. J., & Farese, R. V. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500036-jlr200 · Cited by 280 · see citing works

Retinoic acid receptors and cancers

Soprano, D. R., Qin, P., & Soprano, K. J. (2004) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.24.012003.132407 · Cited by 270 · see citing works

Plasma Retinol-Binding Protein

Goodman, D. S. (1984) · Elsevier eBooks · doi:10.1016/b978-0-12-658102-7.50008-7 · Cited by 268 · see citing works

Mechanisms of digestion and absorption of dietary vitamin A

Harrison, E. H. (2005) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.25.050304.092614 · Cited by 262 · see citing works

CMO1 Deficiency Abolishes Vitamin A Production from β-Carotene and Alters Lipid Metabolism in Mice

Hessel, S., Eichinger, A., Isken, A., Amengual, J., Hunzelmann, S., Hoeller, U., Elste, V., Hunziker, W., Goralczyk, R., Oberhauser, V., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706763200 · Cited by 259 · see citing works

Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all- <i>trans</i> -retinoic acid metabolism

White, J. A., Ramshaw, H., Taimi, M., Stangle, W., Zhang, A., Everingham, S., Creighton, S., Tam, S.-P., Jones, G., & Petkovich, M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.120161397 · Cited by 248 · see citing works

Cytosolic retinoid dehydrogenases govern ubiquitous metabolism of retinol to retinaldehyde followed by tissue-specific metabolism to retinoic acid

Duester, G., Mic, F. A., & Molotkov, A. (2003) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(02)00204-1 · Cited by 243 · see citing works

Medium-chain and short-chain dehydrogenases/reductases in retinoid metabolism

Parés, X., Farrés, J., Kedishvili, N., & Duester, G. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8591-3 · Cited by 242 · see citing works

Mice deficient in cellular retinoic acid binding protein II (CRABPII) or in both CRABPI and CRABPII are essentially normal

Lampron, C., Rochette‐Egly, C., Gorry, P., Dollé, P., Mark, M. P., Lufkin, T., LeMeur, M., & Chambon, P. (1995) · Development · doi:10.1242/dev.121.2.539 · Cited by 226 · see citing works

A novel human cytochrome P450, CYP26C1, involved in metabolism of 9-cis and all-trans isomers of retinoic acid

Taimi, M., Helvig, C., Wisniewski, J., Ramshaw, H., White, J., Amad, M., Korczak, B., & Petkovich, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m308337200 · Cited by 211 · see citing works

The role of CYP26 enzymes in retinoic acid clearance

Thatcher, J. E., & Isoherranen, N. (2009) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425250903032681 · Cited by 201 · see citing works

In vivo uptake of chylomicron [3H]retinyl ester by rat liver: evidence for retinol transfer from parenchymal to nonparenchymal cells.

Blomhoff, R., Helgerud, P., Rasmussen, M., Berg, T., & Norum, K. R. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.23.7326 · Cited by 190 · see citing works

Alcoholic liver disease: new insights into mechanisms and preventative strategies

Stewart, S. F., Jones, D. E., & Day, C. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)02096-2 · Cited by 187 · see citing works

Rapid, Nongenomic Actions of Retinoic Acid on Phosphatidylinositol-3-Kinase Signaling Pathway Mediated by the Retinoic Acid Receptor

Masiá, S., Alvarez, S., de Lera, A. R., & Barettino, D. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0062 · Cited by 184 · see citing works

Disruption of the lecithin:retinol acyltransferase gene makes mice more susceptible to Vitamin A deficiency

Liu, L., & Gudas, L. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509643200 · Cited by 181 · see citing works

Differential interaction of lecithin-retinol acyltransferase with cellular retinol binding proteins

Herr, F. M., & Ong, D. E. (1992) · Biochemistry · doi:10.1021/bi00144a014 · Cited by 178 · see citing works

Tumor necrosis factor and interleukin 1 decrease RXRα, PPARα, PPARγ, LXRα, and the coactivators SRC-1, PGC-1α, and PGC-1β in liver cells

Kim, M. S., Sweeney, T. R., Shigenaga, J. K., Chui, L. G., Moser, A., Grunfeld, C., & Feingold, K. R. (2007) · Metabolism · doi:10.1016/j.metabol.2006.10.007 · Cited by 168 · see citing works

Retinoids, retinoid-binding proteins, and retinyl palmitate hydrolase distributions in different types of rat liver cells.

Blaner, W. S., Hendriks, H., Brouwer, A., Leeuw, A. M. D., Knook, D. L., & Goodman, D. S. (1985) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34272-3 · Cited by 161 · see citing works

Malnutrition in end stage liver disease: Recommendations and nutritional support

Tsiaousi, E., Hatzitolios, A. I., Trygonis, S., & Savopoulos, C. G. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2008.05369.x · Cited by 159 · see citing works

Postprandial plasma vitamin A metabolism in humans: A reassessment of the use of plasma retinyl esters as markers for intestinally derived chylomicrons and their remnants

Krasinski, S. D., Cohn, J. S., Russell, R. M., & Schaefer, E. J. (1990) · Metabolism · doi:10.1016/0026-0495(90)90249-c · Cited by 151 · see citing works

Vitamin A‐Storing Cells (Stellate Cells)

Senoo, H., Kojima, N., & Sato, M. (2007) · Vitamins and hormones · doi:10.1016/s0083-6729(06)75006-3 · Cited by 149 · see citing works

Retinol esterification by rat liver microsomes. Evidence for a fatty acyl coenzyme A: retinol acyltransferase.

Ross, A. C. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34945-7 · Cited by 146 · see citing works

Postprandial lipoproteins and atherosclerosis

Kenneth, C.-W. Y. (2001) · Frontiers in bioscience · doi:10.2741/yu · Cited by 145 · see citing works

Storage of vitamin A in extrahepatic stellate cells in normal rats

Nagy, N. E., Holven, K. B., Roos, N., Senoo, H., Kojima, N., Norum, K. R., & Blomhoff, R. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37232-1 · Cited by 144 · see citing works

Nutritional assessment in various stages of liver cirrhosis

Roongpisuthipong, C., Sobhonslidsuk, A., Nantiruj, K., & Songchitsomboon, S. (2001) · Nutrition · doi:10.1016/s0899-9007(01)00626-8 · Cited by 143 · see citing works

Retinoic acid receptor α dominant negative form causes steatohepatitis and liver tumors in transgenic mice

Yanagitani, A., Yamada, S., Yasui, S., Shimomura, T., Murai, R., Murawaki, Y., Hashiguchi, K., Kanbe, T., Saeki, T., Ichiba, M., et al. (2004) · Hepatology · doi:10.1002/hep.20335 · Cited by 141 · see citing works

Signaling pathways in retinoid chemoprevention and treatment of cancer

Niles, R. M. (2004) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2004.05.020 · Cited by 141 · see citing works

Retinol-binding protein messenger RNA levels in the liver and in extrahepatic tissues of the rat.

Soprano, D. R., Soprano, K. J., & Goodman, D. S. (1986) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38843-x · Cited by 140 · see citing works

The control of morphogen signalling: Regulation of the synthesis and catabolism of retinoic acid in the developing embryo

Reijntjes, S., Blentic, A., Gale, E. A., & Maden, M. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.06.019 · Cited by 137 · see citing works

Biochemical Basis for Depressed Serum Retinol Levels in Transthyretin-deficient Mice

van Bennekum, A. M., Wei, S., Gamble, M. V., Vogel, S., Piantedosi, R., Gottesman, M., Episkopou, V., & Blaner, W. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008091200 · Cited by 136 · see citing works

Ethanol enhances retinoic acid metabolism into polar metabolites in rat liver via induction of cytochrome P4502E1

Liu, C., Russell, R. M., Seitz, H. K., & Wang, X. D. (2001) · Gastroenterology · doi:10.1053/gast.2001.20877 · Cited by 136 · see citing works

Pharmacological and rAAV Gene Therapy Rescue of Visual Functions in a Blind Mouse Model of Leber Congenital Amaurosis

Batten, M. L., Imanishi, Y., Tu, D. C., Doan, T., Zhu, L., Pang, J., Glushakova, L., Moise, A. R., Baehr, W., Van Gelder, R. N., et al. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020333 · Cited by 134 · see citing works

Newly administered [3H]retinol is transferred from hepatocytes to stellate cells in liver for storage

Blomhoff, R., Holte, K., Næss, L., & Berg, T. (1984) · Experimental Cell Research · doi:10.1016/0014-4827(84)90713-4 · Cited by 134 · see citing works

Diabetes and liver disease: An ominous association

Moscatiello, S., Manini, R., & Marchesini, G. (2006) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2006.08.004 · Cited by 129 · see citing works

Plasma Retinol-Binding Protein

Choi, S. (2017) · Springer eBooks · doi:10.1007/978-3-319-67199-4_102946 · Cited by 128 · see citing works

Biosynthesis, Absorption, and Hepatic Metabolism of Retinol

Goodman, D. S., & Blaner, W. S. (1984) · Elsevier eBooks · doi:10.1016/b978-0-12-658102-7.50007-5 · Cited by 127 · see citing works

Understanding the physiological role of retinol-binding protein in vitamin A metabolism using transgenic and knockout mouse models

Quadro, L., Hamberger, L., Colantuoni, V., Gottesman, M. E., & Blaner, W. S. (2003) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(03)00038-4 · Cited by 127 · see citing works

Mouse Retinal Dehydrogenase 4 (RALDH4), Molecular Cloning, Cellular Expression, and Activity in 9-cis-Retinoic Acid Biosynthesis in Intact Cells

Lin, M., Zhang, M., Abraham, M., Smith, S. M., & Napoli, J. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211417200 · Cited by 127 · see citing works

Regulation of Hepatic Retinol Metabolism: Perspectives from Studies on Vitamin A Status

Ross, A. C., & Zolfaghari, R. (2004) · Journal of Nutrition · doi:10.1093/jn/134.1.269s · Cited by 126 · see citing works

The Molecular Basis of Retinoid Absorption

Wongsiriroj, N., Piantedosi, R., Palczewski, K., Goldberg, I. J., Johnston, T. P., Li, E., & Blaner, W. S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800777200 · Cited by 126 · see citing works

Studies on the Metabolism of Retinol and Retinol-binding Protein in Transthyretin-deficient Mice Produced by Homologous Recombination

Wei, S., Episkopou, V., Piantedosi, R., Maeda, S., Shimada, K., Gottesman, M. E., & Blaner, W. S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.2.866 · Cited by 123 · see citing works

Growth inhibition of human hepatoma cells by acyclic retinoid is associated with induction of p21(CIP1) and inhibition of expression of cyclin D1.

Suzui, M., Masuda, M., Lim, J. T. E., Albanese, C., Pestell, R. G., & Weinstein, I. B. (2002) · PubMed · Cited by 122 · see citing works

Biochemical characteristics of isolated rat liver stellate cells

Yamada, M., Blaner, W. S., Soprano, D. R., Dixon, J. L., Kjeldbye, H. M., & Goodman, D. S. (1987) · Hepatology · doi:10.1002/hep.1840070609 · Cited by 122 · see citing works

Absence of hepatic stellate cell retinoid lipid droplets does not enhance hepatic fibrosis but decreases hepatic carcinogenesis

Kluwe, J., Wongsiriroj, N., Troeger, J. S., Gwak, G., Dapito, D. H., Pradère, J., Jiang, H., Siddiqi, M., Piantedosi, R., O’Byrne, S. M., et al. (2011) · Gut · doi:10.1136/gut.2010.209551 · Cited by 121 · see citing works

Untitled work

(2001) · PubMed · Cited by 120 · see citing works

Vitamin A regulation of gene expression: molecular mechanism of a prototype gene

McGrane, M. M. (2007) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.10.006 · Cited by 115 · see citing works

4-Hydroxyretinoic Acid, a Novel Substrate for Human Liver Microsomal UDP-glucuronosyltransferase(s) and Recombinant UGT2B7

Samokyszyn, V. M., Gall, W. E., Zawada, G., Freyaldenhoven, M. A., Chen, G., Mackenzie, P. I., Tephly, T. R., & Radominska-p, A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.10.6908 · Cited by 113 · see citing works

A multicompartmental model of vitamin A kinetics in rats with marginal liver vitamin A stores.

Green, M. H., Uhl, L., & Green, J. B. (1985) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34310-8 · Cited by 106 · see citing works

Generating gradients of retinoic acid in the chick embryo: <i>Cyp26C1</i> expression and a comparative analysis of the Cyp26 enzymes

Reijntjes, S., Gale, E., & Maden, M. (2004) · Developmental Dynamics · doi:10.1002/dvdy.20025 · Cited by 106 · see citing works

Effects of dietary retinoid and triglyceride on the lipid composition of rat liver stellate cells and stellate cell lipid droplets

Moriwaki, H., Blaner, W. S., Piantedosi, R., & Goodman, D. S. (1988) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38430-3 · Cited by 104 · see citing works

Diacylglycerol acyltranferase 1 anti-sense oligonucleotides reduce hepatic fibrosis in mice with nonalcoholic steatohepatitis

Yamaguchi, K., Yang, L., McCall, S. J., Huang, J., Yu, X. X., Pandey, S., Bhanot, S., Monia, B. P., Li, Y.-X., & Diehl, A. M. (2007) · Hepatology · doi:10.1002/hep.21988 · Cited by 102 · see citing works

Differential modulation of rat hepatic stellate phenotype by natural and synthetic retinoids

Hellemans, K., Verbuyst, P., Quartier, E., Schuit, F., Rombouts, K., Chandraratna, R. A. S., Schuppan, D., & Geerts, A. (2004) · Hepatology · doi:10.1002/hep.20015 · Cited by 102 · see citing works

Cholate-independent retinyl ester hydrolysis. Stimulation by Apo-cellular retinol-binding protein.

Boerman, M. H. E. M., & Napoli, J. L. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54565-8 · Cited by 99 · see citing works

Acyl coenzyme A dependent retinol esterification by acyl coenzyme A:diacylglycerol acyltransferase 1

Orland, M. D., Anwar, K., Cromley, D., Chu, C.-H., Chen, L., Billheimer, J. T., Hussain, M. M., & Cheng, D. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.09.003 · Cited by 97 · see citing works

Prediagnostic Level of Serum Retinol in Relation to Reduced Risk of Hepatocellular Carcinoma

Yuan, J., Gao, Y., Ong, C. N., Ross, R. K., & Yu, M. C. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj104 · Cited by 93 · see citing works

Alcohol, vitamin A, and cancer

Wang, X. (2005) · Alcohol · doi:10.1016/j.alcohol.2005.04.006 · Cited by 91 · see citing works

Biosynthesis, Absorption, Metabolism and Transport of Retinoids

Vogel, S., Gamble, M. V., & Blaner, W. S. (1999) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-58483-1_2 · Cited by 90 · see citing works

Retinyl Ester Hydrolysis and Retinol Efflux from BFC-1β Adipocytes

Wei, S., Lai, K., Patel, S., Piantedosi, R., Shen, H., Colantuoni, V., Kraemer, F. B., & Blaner, W. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.22.14159 · Cited by 89 · see citing works

Restoration of retinoic acid concentration supresses ethanol-enhanced c-Jun expression and hepatocyte proliferation in rat liver

Chung, J. (2001) · Carcinogenesis · doi:10.1093/carcin/22.8.1213 · Cited by 89 · see citing works

Differential role of ethanol and acetaldehyde in the induction of oxidative stress in HEP G2 cells: Effect on transcription factors AP-1 and NF-κB

Román, J., Colell, A., Blasco, C., Caballería, J., Parés, A. R., Rodés, J., & Fernández-Checa, J. C. (1999) · Hepatology · doi:10.1002/hep.510300623 · Cited by 86 · see citing works

Studies of vitamin A metabolism in mouse model systems

Gottesman, M. E., Quadro, L., & Blaner, W. S. (2001) · BioEssays · doi:10.1002/bies.1059 · Cited by 82 · see citing works

Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids

Marill, J., Capron, C., Idres, N., & Chabot, G. G. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00925-x · Cited by 81 · see citing works

Retinoic acid metabolism

Petkovich, M. P. (2001) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2001.113715 · Cited by 78 · see citing works

Megalin-Mediated Reuptake of Retinol in the Kidneys of Mice Is Essential for Vitamin A Homeostasis

Raila, J., Willnow, T. E., & Schweigert�, F. J. (2005) · Journal of Nutrition · doi:10.1093/jn/135.11.2512 · Cited by 75 · see citing works

Vitamin A: recent advances in the biotransformation, transport, and metabolism of retinoids

Ross, A. C., Zolfaghari, R., & Weisz, J. (2001) · Current Opinion in Gastroenterology · doi:10.1097/00001574-200103000-00015 · Cited by 74 · see citing works

Low serum retinol levels are associated with hepatocellular carcinoma in patients with chronic liver disease

Newsome, P. N., Beldon, I., Moussa, Y. I., Delahooke, T., Poulopoulos, G., Hayes, P. C., & Plevris, J. N. (2000) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2000.00849.x · Cited by 74 · see citing works

Retinol metabolism in rats with low vitamin A status: a compartmental model

Lewis, K., Green, M. H., Green, J., & Zech, L. A. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42338-7 · Cited by 74 · see citing works

Genetic analysis of expression profile involved in retinoid metabolism in non‐alcoholic fatty liver disease

Ashla, A. A., Hoshikawa, Y., Tsuchiya, H., Hashiguchi, K., Enjoji, M., Nakamuta, M., Taketomi, A., Maehara, Y., Shomori, K., Kurimasa, A., et al. (2010) · Hepatology Research · doi:10.1111/j.1872-034x.2010.00646.x · Cited by 73 · see citing works

The role of extrahepatic retinol binding protein in the mobilization of retinoid stores

Quadro, L., Blaner, W. S., Hamberger, L., Novikoff, P. M., Vogel, S., Piantedosi, R., Gottesman, M. E., & Colantuoni, V. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400137-jlr200 · Cited by 72 · see citing works

Nuclear Receptors and Inflammatory Diseases

Wang, K., & Wan, Y. Y. (2008) · Experimental Biology and Medicine · doi:10.3181/0708-mr-231 · Cited by 72 · see citing works

Hepatotoxicity of alcohol‐induced polar retinol metabolites involves apoptosis via loss of mitochondrial membrane potential

Dan, Z., Popov, Y. V., Patsenker, E., Preimel, D., Liu, C., Wang, X., Seitz, H. K., Schuppan, D., & Stickel, F. (2005) · The FASEB Journal · doi:10.1096/fj.04-2809fje · Cited by 70 · see citing works

Oncogenic Potential of Retinoic Acid Receptor-γ in Hepatocellular Carcinoma

Yan, T., Wu, H., Zhang, H., Lu, N., Ye, P., Yu, F.-H., Zhou, H., Li, W., Cao, X., Lin, Y., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2968 · Cited by 69 · see citing works

Phosphorylation of retinoid X receptor suppresses its ubiquitination in human hepatocellular carcinoma

Adachi, S., Okuno, M., Matsushima‐Nishiwaki, R., Takano, Y., Kojima, S., Friedman, S. L., Moriwaki, H., & Okano, Y. (2002) · Hepatology · doi:10.1053/jhep.2002.31164 · Cited by 68 · see citing works

Cloning of a rat cDNA encoding retinol dehydrogenase isozyme type III

Chai, X., Zhai, Y. W., & Napoli, J. L. (1996) · Gene · doi:10.1016/0378-1119(95)00833-0 · Cited by 67 · see citing works

Prevention of Second Primary Tumors by an Acyclic Retinoid in Patients with Hepatocellular Carcinoma

Takai, K., Okuno, M., Yasuda, I., Matsushima‐Nishiwaki, R., Uematsu, T., Tsurumi, H., Shiratori, Y., Muto, Y., & Moriwaki, H. (2005) · Intervirology · doi:10.1159/000082093 · Cited by 67 · see citing works

Retinoid‐binding proteins in the cerebellum and choroid plexus and their relationship to regionalized retinoic acid synthesis and degradation

Yamamoto, M., Dräger, U. C., Ong, D. E., & McCaffery, P. J. A. (1998) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1998.2570344.x · Cited by 65 · see citing works

Molecular mechanism for growth suppression of human hepatocellular carcinoma cells by acyclic retinoid

Matsushima‐Nishiwaki, R., Okuno, M., Takano, Y., Kojima, S., Friedman, S. L., & Moriwaki, H. (2003) · Carcinogenesis · doi:10.1093/carcin/bgg090 · Cited by 65 · see citing works

Apoptosis in Human Hepatoma Cell Line Induced by 4,5-Didehydro geranylgeranoic Acid (Acyclic Retinoid) via Down-Regulation of Transforming Growth Factor-α

Nakamura, N., Shidoji, Y., Moriwaki, H., & Muto, Y. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0188 · Cited by 64 · see citing works

Cellular Retinol–Binding Protein–1 in Hepatocellular Carcinoma Correlates With β–Catenin, Ki–67 Index, and Patient Survival

Schmitt-Graeff, A. H., Ertelt-Heitzmann, V., Allgaier, H., Koelble, K., Olschewski, M., Nitschke, R., Bochaton‐Piallat, M., Gabbiani, G., & Blum, H. E. (2003) · Hepatology · doi:10.1053/jhep.2003.50321 · Cited by 62 · see citing works

Transfer of retinol from parenchymal to stellate cells in liver is mediated by retinol-binding protein.

Blomhoff, R., Berg, T., & Norum, K. R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.10.3455 · Cited by 61 · see citing works

Transfer of retinol-binding protein from HepG2 human hepatoma cells to cocultured rat stellate cells.

Senoo, H., Smeland, S., Malaba, L. C., Bjerknes, T., Stang, E., Roos, N., Berg, T., Norum, K. R., & Blomhoff, R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.8.3616 · Cited by 61 · see citing works

NF-κB, JNK, and TLR Signaling Pathways in Hepatocarcinogenesis

Maeda, S. (2010) · Gastroenterology Research and Practice · doi:10.1155/2010/367694 · Cited by 59 · see citing works

Retinoic acid inhibits hepatic Jun N-terminal kinase-dependent signaling pathway in ethanol-fed rats

Chung, J., Chavez, P. R. G., Russell, R. M., & Wang, X. (2002) · Oncogene · doi:10.1038/sj.onc.1205023 · Cited by 59 · see citing works

Muscle Expression of Human Retinol-binding Protein (RBP)

Quadro, L., Blaner, W. S., Hamberger, L., Gelder, R. N. V., Vogel, S., Piantedosi, R., Gouras, P., Colantuoni, V., & Gottesman, M. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205046200 · Cited by 58 · see citing works

Acyclic Retinoid Inhibits Diethylnitrosamine-Induced Liver Tumorigenesis in Obese and Diabetic C57BLKS/J- +Lepr db /+Lepr db Mice

Shimizu, M., Sakai, H., Shirakami, Y., Iwasa, J., Yasuda, Y., Kubota, M., Takai, K., Tsurumi, H., Tanaka, T., & Moriwaki, H. (2010) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-10-0163 · Cited by 54 · see citing works

Prevention of cervical intraepithelial neoplasia and cervical cancer

Meyskens, F. L., & Manetta, A. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.6.1417s · Cited by 52 · see citing works

Hepatic uptake and metabolism of chylomicron retinyl esters: probable role of plasma membrane/endosomal retinyl ester hydrolases

Harrison, E. H., Gad, M. Z., & Ross, A. C. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39737-6 · Cited by 52 · see citing works

Use of Model‐Based Compartmental Analysis to Study Vitamin A Kinetics and Metabolism

Cifelli, C. J., Green, J. B., & Green, M. H. (2007) · Vitamins and hormones · doi:10.1016/s0083-6729(06)75007-5 · Cited by 51 · see citing works

Carotenoids and Retinoids

(2005) · AOCS Publishing eBooks · doi:10.1201/9781439822371 · Cited by 51 · see citing works

Chlormethiazole Treatment Prevents Reduced Hepatic Vitamin A Levels in Ethanol-Fed Rats

Liu, C., Chung, J., Seitz, H. K., Russell, R. M., & Wang, X. (2002) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02474.x · Cited by 51 · see citing works

Expression of carboxylesterase and lipase genes in rat liver cell-types

Mello, T., Nakatsuka, A., Fears, S. L., Davis, W. I., Tsukamoto, H., BOSRON, W. F., & Sanghani, S. P. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.07.024 · Cited by 50 · see citing works

Studies on the in vivo transfer to retinoids from parenchymal to stellate cells in rat liver

Blaner, W. S., Dixon, J. L., Moriwaki, H., MARTINO, R. A., Stein, O., Stein, Y., & Goodman, D. S. (1987) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1987.tb11058.x · Cited by 49 · see citing works

Alteration of a single amino acid residue in retinoic acid receptor causes dominant-negative phenotype.

Saitou, M., Narumiya, S., & Kakizuka, A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32280-9 · Cited by 48 · see citing works

Retinoids in liver fibrosis and cancer

Okuno, M. (2002) · Frontiers in bioscience · doi:10.2741/a775 · Cited by 47 · see citing works

Acyclic retinoid inhibits human hepatoma cell growth by suppressing fibroblast growth factor-mediated signaling pathways

Shao, R., Otsuka, M., Kato, N., Taniguchi, H., Hoshida, Y., Moriyama, M., Kawabe, T., & Omata, M. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.09.077 · Cited by 45 · see citing works

Serum retinol and risk of hepatocellular carcinoma in patients with child-Pugh class A cirrhosis

Clemente, C., Elba, S., Buongiorno, G., Berloco, P. B., Guerra, V., & Leo, A. D. (2002) · Cancer Letters · doi:10.1016/s0304-3835(01)00843-6 · Cited by 45 · see citing works

An acyclic retinoid, NIK-333, inhibits N-diethylnitrosamine-induced rat hepatocarcinogenesis through suppression of TGF- expression and cell proliferation

Kagawa, M. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh093 · Cited by 42 · see citing works

Enrichment of Nur77 Mediated by Retinoic Acid Receptor β Leads to Apoptosis of Human Hepatocellular Carcinoma Cells Induced by Fenretinide and Histone Deacetylase Inhibitors §Δ

Yang, H., Qi, Z., & Wan, Y. Y. (2010) · Hepatology · doi:10.1002/hep.24101 · Cited by 42 · see citing works

Successful Treatment of Relapse of Acute Promyelocytic Leukemia with a New Synthetic Retinoid, Am80

Takeshita, A., Shibata, Y., Shinjo, K., Yanagi, M., Tobita, T., Ohnishi, K., Miyawaki, S., Shudo, K., & Ohno, R. (1996) · Annals of Internal Medicine · doi:10.7326/0003-4819-124-10-199605150-00006 · Cited by 42 · see citing works

Neutral and acid retinyl ester hydrolases associated with rat liver microsomes: relationships to microsomal cholesteryl ester hydrolases

Gad, M. Z., & Harrison, E. (1991) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42056-5 · Cited by 39 · see citing works

Acyclic retinoid activates retinoic acid receptor beta and induces transcriptional activation of p21(CIP1) in HepG2 human hepatoma cells.

Suzui, M., Shimizu, M., Masuda, M., Lim, J. T. E., Yoshimi, N., & Weinstein, I. B. (2004) · PubMed · Cited by 39 · see citing works

Acyclic retinoid activates retinoic acid receptor β and induces transcriptional activation of p21CIP1 in HepG2 human hepatoma cells

Suzui, M., Shimizu, M., Masuda, M., Lim, J. T. E., Yoshimi, N., & Weinstein, I. B. (2004) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.309.3.3 · Cited by 37 · see citing works

Retinoid binding-proteins redirect retinoid metabolism: biosynthesis and metabolism of retinoic acid

Napoli, J. L. (1997) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.1997.0164 · Cited by 36 · see citing works

A Marginal Vitamin A Status Alters the Distribution of Vitamin A among Parenchymal and Stellate Cells in Rat Liver

Batres, R. O., & Olson, J. A. (1987) · Journal of Nutrition · doi:10.1093/jn/117.5.874 · Cited by 36 · see citing works

Use of the deuterated-retinol-dilution technique to assess total-body vitamin A stores of adult volunteers consuming different amounts of vitamin A

Haskell, M. J., Mazumder, R. N., Peerson, J. M., Jones, A. D., Wahed, M. A., Mahalanabis, D., & Brown, K. H. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.5.874 · Cited by 35 · see citing works

Novel aspects of vitamin A metabolism in the dog: distribution of lipoprotein retinyl esters in vitamin A-deprived and cholesterol-fed animals

Wilson, D. E., Hejazi, J., Elstad, N. L., Ing-Fong, C., Gleeson, J. M., & Iverius, P. (1987) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(87)90047-6 · Cited by 34 · see citing works

Liver-specific cytochrome P450 CYP2C22 is a direct target of retinoic acid and a retinoic acid-metabolizing enzyme in rat liver

Qian, L., Zolfaghari, R., & Ross, A. C. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m002840 · Cited by 34 · see citing works

In vivo biosynthesis of retinoic acid from beta-carotene involves and excentric cleavage pathway in ferret intestine

Hébuterne, X., Wang, X.-D., Smith, D. E., Tang, G., & Russell, R. M. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37592-1 · Cited by 34 · see citing works

A Unique Cytoplasmic Localization of Retinoic Acid Receptor-γ and Its Regulations

Han, Y.-H., Zhou, H., Kim, J. H., Yan, T., Lee, K.-H., Wu, H., Lin, F., Lu, N., Liu, J., Zeng, J.-Z., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.007708 · Cited by 33 · see citing works

Lipases and Carboxylesterases: Possible Roles in the Hepatic Utilization of Vitamin A

Harrison, E. H. (2000) · Journal of Nutrition · doi:10.1093/jn/130.2.340s · Cited by 33 · see citing works

Nuclear Retinoid Receptors and Mechanisms of Action

Piedrafita, F. J., & Pfahl, M. (1999) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-58483-1_5 · Cited by 33 · see citing works

Hepatic Synthesis, Maturation and Complex Formation between Retinol-Binding Protein and Transthyretin

Gaetani, S., Bellovino, D., Apreda, M., & Devirgiliis, C. (2002) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2002.211 · Cited by 33 · see citing works

Untitled work

(2001) · PubMed · Cited by 33 · see citing works

Retinoyl β-Glucuronide: A Biologically Active Interesting Retinoid

Barua, A. B., & Sidell, N. (2004) · Journal of Nutrition · doi:10.1093/jn/134.1.286s · Cited by 32 · see citing works

Experimental and kinetic methods for studying vitamin A dynamics in vivo

Green, M. H., & Green, J. B. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)90035-y · Cited by 32 · see citing works

Overexpression of retinoic acid receptor alpha in hepatocellular carcinoma.

Sano, K., Takayama, T., Murakami, K., Saiki, I., & Makuuchi, M. (2003) · PubMed · Cited by 31 · see citing works

Dietary Retinoic Acid Alters Vitamin A Kinetics in Both the Whole Body and in Specific Organs of Rats with Low Vitamin A Status

Cifelli, C. J., Green, J. B., & Green, M. H. (2005) · Journal of Nutrition · doi:10.1093/jn/135.4.746 · Cited by 30 · see citing works

The Paired Deuterated Retinol Dilution Technique Can Be Used to Estimate the Daily Vitamin A Intake Required to Maintain a Targeted Whole Body Vitamin A Pool Size in Men,

Haskell, M. J., Jamil, K. A.-H., Peerson, J. M., Wahed, M. A., & Brown, K. H. (2011) · Journal of Nutrition · doi:10.3945/jn.110.133124 · Cited by 30 · see citing works

Acyclic retinoid in the chemoprevention of hepatocellular carcinoma (Review)

Kojima, S., Okuno, M., Matsushima‐Nishiwaki, R., Friedman, S., & Moriwaki, H. (2004) · International Journal of Oncology · doi:10.3892/ijo.24.4.797 · Cited by 30 · see citing works

Ferrets (Mustela putoius furo) Inefficiently Convert β-Carotene to Vitamin A

Lederman, J. D., Overton Katrina, M., Hofmann Nicolle, E., Moore Billy, J., Jesse, T. W., & Erdman John, W. (1998) · Journal of Nutrition · doi:10.1093/jn/128.2.271 · Cited by 29 · see citing works

Retinoids and Alcohol-Related Carcinogenesis

Wang, X. (2003) · Journal of Nutrition · doi:10.1093/jn/133.1.287s · Cited by 28 · see citing works

Hepatic effects of a methionine–choline-deficient diet in hepatocyte RXRα-null mice

Gyamfi, M. A., Tanaka, Y., He, L., Klaassen, C. D., & Wan, Y. Y. (2008) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2008.09.022 · Cited by 27 · see citing works

Esterase 22 and beta-glucuronidase hydrolyze retinoids in mouse liver

Schreiber, R., Taschler, U., Wolinski, H., Seper, A., Tamegger, S. N., Graf, M. E., Kohlwein, S. D., Haemmerle, G., Zimmermann, R., Zechner, R., et al. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m000950 · Cited by 27 · see citing works

Biomarker and animal models for assessment of retinoid efficacy in cancer chemoprevention

Niles, R. M. (2007) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2007.00685.x · Cited by 27 · see citing works

Development of a Compartmental Model Describing the Dynamics of Vitamin A Metabolism in Men

von Reinersdorff, D., Green, M. H., & Green, J. B. (1998) · Advances in experimental medicine and biology · doi:10.1007/978-1-4899-1959-5_13 · Cited by 26 · see citing works

Transduction of antisense cyclin D1 using two-step gene transfer inhibits the growth of rat hepatoma cells.

Uto, H., Ido, A., Moriuchi, A., Onaga, Y., Nagata, K., Onaga, M., Tahara, Y., Hori, T., Hirono, S., Hayashi, K., et al. (2001) · PubMed · Cited by 26 · see citing works

Quantitative and Conceptual Contributions of Mathematical Modeling to Current Views on Vitamin a Metabolism, Biochemistry, and Nutrition

Green, M. H., & Green, J. B. (1996) · Advances in food and nutrition research · doi:10.1016/s1043-4526(08)60018-2 · Cited by 25 · see citing works

Lack of Secretion of Retinyl Ester by Livers of Normal and Cholesterol-Fed Rabbits

Thompson, K. H., Hughes, L. B., & Zilversmit, D. B. (1983) · Journal of Nutrition · doi:10.1093/jn/113.10.1995 · Cited by 22 · see citing works

Possible Role of Endogenous Retinoid (Vitamin A) Toxicity in the Pathophysiology of Primary Biliary Cirrhosis

Erickson, J. M., & Mawson, A. R. (2000) · Journal of Theoretical Biology · doi:10.1006/jtbi.2000.2102 · Cited by 19 · see citing works

Mathematical Modeling in Nutrition and the Health Sciences

Novotny, J. A., Boston, R., & Green, M. H. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-9019-8 · Cited by 18 · see citing works

3, 4-Didehydroretinol Kinetics Differ during Lactation in Sows on a Retinol Depletion Regimen and the Serum:Milk 3, 4-Didehydroretinol:Retinol Ratios Are Correlated1–3

Surles, R. L., Hutson, P. R., Valentine, A. R., Mills, J. P., & Tanumihardjo, S. A. (2011) · Journal of Nutrition · doi:10.3945/jn.110.131904 · Cited by 13 · see citing works

The Use of Model-Based Compartmental Analysis to Study Vitamin A Metabolism in a Non-Steady State

Green, M. H., & Green, J. B. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-9019-8_11 · Cited by 10 · see citing works

Introduction to Retinoids

O’Byrne, S. M., & Blaner, W. S. (2005) · AOCS Publishing eBooks · doi:10.1201/9781439822371.ch1 · Cited by 9 · see citing works

Transport of esterified retinol in fasting human blood.

Schindler, R., & Klopp, A. H. (1986) · PubMed · Cited by 8 · see citing works

Nongenomic Actions of Retinoids: Role of Nur77 and RXR in the Regulation of Apoptosis and Inflammation

Zeng, J.-Z., & Zhang, X.-K. (2007) · Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry · doi:10.2174/187152307783220022 · Cited by 4 · see citing works

Biological properties of extracellular vesicles and their physiological functions

Yáñez‐Mó, M., Siljander, P. R. ‐., Andreu, Z., Bedina Zavec, A., Borràs, F. E., Buzas, E. I., Buzas, K., Casal, E., Cappello, F., Carvalho, J., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.27066 · Cited by 5,926 · see citing works

A knowledge graph to interpret clinical proteomics data

Santos, A., Colaço, A. R., Nielsen, A. B., Niu, L., Strauss, M. T., Geyer, P. E., Coscia, F., Albrechtsen, N. J. W., Mundt, F. O., Jensen, L. J., et al. (2022) · Nature Biotechnology · doi:10.1038/s41587-021-01145-6 · Cited by 345 · see citing works

Metabolic Hallmarks of Hepatic Stellate Cells in Liver Fibrosis

Khomich, O. A., Ivanov, A. V., & Bartosch, B. (2019) · Cells · doi:10.3390/cells9010024 · Cited by 227 · see citing works

Update on hepatic stellate cells: pathogenic role in liver fibrosis and novel isolation techniques

Tacke, F., & Weiskirchen, R. (2011) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.11.92 · Cited by 206 · see citing works

Biological Functions of RBP4 and Its Relevance for Human Diseases

Steinhoff, J. S., Lass, A., & Schupp, M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.659977 · Cited by 182 · see citing works

The exposome and liver disease - how environmental factors affect liver health

Barouki, R., Samson, M., Blanc, É., Colombo, M. G., Zucman‐Rossi, J., Lazaridis, K. N., Miller, G. W., & Coumoul, X. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.02.034 · Cited by 176 · see citing works

Single-cell RNA sequencing of human liver reveals hepatic stellate cell heterogeneity

Payen, V. L., Lavergne, A., Alevra Sarika, N., Colonval, M., Karim, L., Deckers, M., Najimi, M., Coppieters, W., Charloteaux, B., Sokal, E. M., et al. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100278 · Cited by 160 · see citing works

Metabolic Effects of Inflammation on Vitamin A and Carotenoids in Humans and Animal Models.

Rubin, L., Ross, A., Stephensen, C., Bohn, T., & Tanumihardjo, S. (2017) · Advances in Nutrition · doi:10.3945/an.116.014167 · Cited by 138 · see citing works

Liver Retinol Transporter and Receptor for Serum Retinol-binding Protein (RBP4)

Alapatt, P., Guo, F., Komanetsky, S. M., Wang, S., Cai, J., Sargsyan, A., Rodríguez Díaz, E., Bacon, B. T., Aryal, P., & Graham, T. E. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.369132 · Cited by 150 · see citing works

Structure of the STRA6 receptor for retinol uptake

Chen, Y., Clarke, O. B., Kim, J., Stowe, S., Kim, Y.-K., Assur, Z., Cavalier, M., Godoy-Ruiz, R., von Alpen, D. C., Manzini, C., et al. (2016) · Science · doi:10.1126/science.aad8266 · Cited by 148 · see citing works

Lipopolysaccharide mediates hepatic stellate cell activation by regulating autophagy and retinoic acid signaling

Chen, M., Liu, J., Yang, W., & Ling, W. (2017) · Autophagy · doi:10.1080/15548627.2017.1356550 · Cited by 135 · see citing works

Hepatic Stellate Cell Activation and Inactivation in NASH-Fibrosis—Roles as Putative Treatment Targets?

Zisser, A., Ipsen, D. H., & Tveden‐Nyborg, P. (2021) · Biomedicines · doi:10.3390/biomedicines9040365 · Cited by 110 · see citing works

The adverse effects of alcohol on vitamin A metabolism

Clugston, R. D., & Blaner, W. S. (2012) · Nutrients · doi:10.3390/nu4050356 · Cited by 105 · see citing works

Retinol-Binding Protein 4 and Its Membrane Receptor STRA6 Control Adipogenesis by Regulating Cellular Retinoid Homeostasis and Retinoic Acid Receptor α Activity

Muenzner, M., Tuvia, N., Deutschmann, C., Witte, N., Tolkachov, A., Valai, A., Henze, A., Sander, L. E., Raila, J., & Schupp, M. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00221-13 · Cited by 96 · see citing works

Senescence in hepatic stellate cells as a mechanism of liver fibrosis reversal: a putative synergy between retinoic acid and PPAR-gamma signalings

Panebianco, C., Oben, J. A., Vinciguerra, M., & Pazienza, V. (2016) · Clinical and Experimental Medicine · doi:10.1007/s10238-016-0438-x · Cited by 97 · see citing works

Mechanisms of Transport and Delivery of Vitamin A and Carotenoids to the Retinal Pigment Epithelium

Harrison, E. H. (2019) · Molecular Nutrition &amp; Food Research · doi:10.1002/mnfr.201801046 · Cited by 97 · see citing works

Biological Role of Aldo–Keto Reductases in Retinoic Acid Biosynthesis and Signaling

Ruiz, F. X., Porté, S., Parés, X., & Farrés, J. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00058 · Cited by 88 · see citing works

Retinoids: Potent regulators of metabolism

Brun, P., Yang, K. J. Z., Lee, S., Yuen, J. J., & Blaner, W. S. (2012) · BioFactors · doi:10.1002/biof.1056 · Cited by 84 · see citing works

Metabolic Signature of Hepatic Fibrosis: From Individual Pathways to Systems Biology

Chang, M.-L., & Yang, S.-S. (2019) · Cells · doi:10.3390/cells8111423 · Cited by 81 · see citing works

Genome-wide analysis of FoxO1 binding in hepatic chromatin: Potential involvement of FoxO1 in linking retinoid signaling to hepatic gluconeogenesis

Shin, D.-J., Joshi, P., Hong, S.-H., Mosure, K. W., Shin, D.-G., & Osborne, T. F. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks932 · Cited by 78 · see citing works

Carotenoids and fatty liver disease: Current knowledge and research gaps

Clugston, R. D. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.158597 · Cited by 77 · see citing works

Molecular Mechanism and Treatment of Viral Hepatitis-Related Liver Fibrosis

Su, T., Kao, J., & Liu, C. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150610578 · Cited by 77 · see citing works

Serum biomarker panel for the diagnosis of rheumatoid arthritis

Mun, S., Lee, J., Park, M., Shin, J., Lim, M., & Kang, H. (2021) · Arthritis Research & Therapy · doi:10.1186/s13075-020-02405-7 · Cited by 76 · see citing works

Altered hepatic genes related to retinol metabolism and plasma retinol in patients with non-alcoholic fatty liver disease

Pettinelli, P., Arendt, B. M., Teterina, A. A., McGilvray, I. D., Comelli, E. M., Fung, S. K., Fischer, S. E., & Allard, J. P. (2018) · PLoS ONE · doi:10.1371/journal.pone.0205747 · Cited by 73 · see citing works

Metabolic Reprogramming of Liver Fibrosis

Delgado, M. E., Cárdenas, B., Farran, N., & Fernández, M. (2021) · Cells · doi:10.3390/cells10123604 · Cited by 73 · see citing works

Retinoid Homeostasis and Beyond: How Retinol Binding Protein 4 Contributes to Health and Disease

Steinhoff, J. S., Lass, A., & Schupp, M. (2022) · Nutrients · doi:10.3390/nu14061236 · Cited by 73 · see citing works

Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-κB and TGF-β1/Smad3 pathways

Feng, J., Chen, K., Xia, Y., Wu, L., Li, J., Li, S., Wang, W., Lu, X., Liu, T., & Guo, C.-Y. (2018) · Drug Design Development and Therapy · doi:10.2147/dddt.s162950 · Cited by 72 · see citing works

Vitamin A in health care: Suppression of growth and induction of differentiation in cancer cells by vitamin A and its derivatives and their mechanisms of action

Takahashi, N. K., Saito, D., Hasegawa, S., Yamasaki, M., & Imai, M. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107942 · Cited by 70 · see citing works

New insights and changing paradigms in the regulation of vitamin A metabolism in development

Shannon, S. R., Moise, A. R., & Trainor, P. A. (2017) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.264 · Cited by 63 · see citing works

Vitamin A Deficiency and Alterations in the Extracellular Matrix

Barber, T., Esteban-Pretel, G., Marín, M., & Timoneda, J. (2014) · Nutrients · doi:10.3390/nu6114984 · Cited by 63 · see citing works

Genome-Wide Transcriptional Reorganization Associated with Senescence-to-Immortality Switch during Human Hepatocellular Carcinogenesis

Yıldız, G., Arslan-Ergül, A., Baǧışlar, S., Konu, Ö., Yuzugullu, H., Gürsoy-Yüzügüllü, Ö., Öztürk, N., Özen, Ç., Özdağ, H., Erdal, E., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064016 · Cited by 60 · see citing works

Characterization of Vitamin A Metabolome in Human Livers With and Without Nonalcoholic Fatty Liver Disease

Zhong, G. G., Kirkwood, J. S., Won, K., Tjota, N., Jeong, H., & Isoherranen, N. (2019) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.119.258517 · Cited by 62 · see citing works

Nutrition in alcohol-related liver disease: Physiopathology and management

Kamran, U., Towey, J., Khanna, A., Chauhan, A., Rajoriya, N., & Holt, A. P. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i22.2916 · Cited by 61 · see citing works

Extracellular Vesicles in the Development of Cancer Therapeutics

Sun, H., Burrola, S., Wu, J., & Ding, W. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176097 · Cited by 62 · see citing works

Liver extracellular vesicles in health and disease

Royo, F., & Falcón‐Pérez, J. M. (2012) · Journal of Extracellular Vesicles · doi:10.3402/jev.v1i0.18825 · Cited by 60 · see citing works

Transcriptional Regulation of CYP2D6 Expression

Pan, X., Ning, M., & Jeong, H. (2016) · Drug Metabolism and Disposition · doi:10.1124/dmd.116.072249 · Cited by 60 · see citing works

Clinical Knowledge Graph Integrates Proteomics Data into Clinical Decision-MakingPreprint

Santos, A., Colaço, A. R., Nielsen, A. B., Niu, L., Geyer, P. E., Coscia, F., Albrechtsen, N. J. W., Mundt, F. O., Jensen, L. J., & Mann, M. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.09.084897 · Cited by 59 · see citing works

Vitamin A Transporters in Visual Function: A Mini Review on Membrane Receptors for Dietary Vitamin A Uptake, Storage, and Transport to the Eye

Martin Ask, N., Leung, M., Radhakrishnan, R., & Lobo, G. P. (2021) · Nutrients · doi:10.3390/nu13113987 · Cited by 52 · see citing works

Gulf War Illness: Unifying Hypothesis for a Continuing Health Problem

Mawson, A. R., & Croft, A. M. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16010111 · Cited by 56 · see citing works

The apelin–APJ axis: A novel potential therapeutic target for organ fibrosis

Huang, S., Chen, L., Lu, L., & Li, L. (2016) · Clinica Chimica Acta · doi:10.1016/j.cca.2016.02.025 · Cited by 54 · see citing works

Apigenin Alleviates Liver Fibrosis by Inhibiting Hepatic Stellate Cell Activation and Autophagy via TGF-β1/Smad3 and p38/PPARα Pathways

Ji, J., Yu, Q., Dai, W., Wu, L., Feng, J., Zheng, Y., Li, Y., & Guo, C. (2021) · PPAR Research · doi:10.1155/2021/6651839 · Cited by 54 · see citing works

Adipose triglyceride lipase is involved in the mobilization of triglyceride and retinoid stores of hepatic stellate cells

Taschler, U., Schreiber, R., Chitraju, C., Grabner, G. F., Romauch, M., Wolinski, H., Haemmerle, G., Breinbauer, R., Zechner, R., Lass, A., et al. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2015.02.017 · Cited by 53 · see citing works

Guidelines for the Use of Acitretin in Psoriasis

Carretero, G., Ribera, M., Belinchón, I., Carrascosa, J. M., Puig, L., Ferrándiz, C., Dehesa, L. A., Vidal, D., Peral, F., Jorquera, E., et al. (2013) · Actas Dermo-Sifiliográficas · doi:10.1016/j.adengl.2013.01.001 · Cited by 53 · see citing works

All-trans Retinoic Acid as a Versatile Cytosolic Signal Modulator Mediated by CRABP1

Nagpal, I., & Wei, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153610 · Cited by 51 · see citing works

Liver immune responses to inflammatory stimuli in a diet-induced obesity model of zebrafish

Forn‐Cuní, G., Varela, M., Fernández‐Rodríguez, C., Figueras, A. J., & Novoa, B. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0398 · Cited by 50 · see citing works

Silencing Retinoid X Receptor Alpha Expression Enhances Early-Stage Hepatitis B Virus Infection In Cell Cultures

Song, M. L., Sun, Y., Tian, J., He, W., Xu, G., Jing, Z., & Li, W. (2018) · Journal of Virology · doi:10.1128/jvi.01771-17 · Cited by 49 · see citing works

Food and Nutrition in the Pathogenesis of Liver Damage

Mega, A., Marzi, L., Kob, M., Piccin, A., & Floreani, A. (2021) · Nutrients · doi:10.3390/nu13041326 · Cited by 48 · see citing works

Acitretina: guía de uso en psoriasis

Carretero, G., Ribera, M., Belinchón, I., Carrascosa, J. M., Puig, L., Ferrándiz, C., Dehesa, L. A., Vidal, D., Peral, F., Jorquera, E., et al. (2013) · Actas Dermo-Sifiliográficas · doi:10.1016/j.ad.2013.01.003 · Cited by 48 · see citing works

Nuclear and extranuclear effects of vitamin A

Iskakova, M., Karbyshev, M. S., Piskunov, A., & Rochette‐Egly, C. (2015) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2014-0522 · Cited by 44 · see citing works

ATGL and CGI-58 are lipid droplet proteins of the hepatic stellate cell line HSC-T6

Eichmann, T. O., Grumet, L., Taschler, U., Hartler, J., Heier, C., Woblistin, A., Pajed, L., Kollroser, M., Rechberger, G. N., Thallinger, G., et al. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m062372 · Cited by 44 · see citing works

Vitamin A (retinoid) metabolism and actions: What we know and what we need to know about amphibians

Clugston, R. D., & Blaner, W. S. (2014) · Zoo Biology · doi:10.1002/zoo.21140 · Cited by 42 · see citing works

Hepatic stellate cells – from past till present: morphology, human markers, human cell lines, behavior in normal and liver pathology

Suflețel, R. T., Melincovici, C. S., Gheban, B., Zaharie, T., & Mihu, C. M. (2021) · Romanian Journal of Morphology and Embryology · doi:10.47162/rjme.61.3.01 · Cited by 45 · see citing works

Carcinogenic Risk of 2,6-Di-tert-Butylphenol and Its Quinone Metabolite 2,6-DTBQ Through Their Interruption of RARβ: In Vivo, In Vitro, and In Silico Investigations

Cui, S., Yang, Y., Zhan, T., Gao, Y., Zhang, J., Zhang, L., Ge, Z., Liu, W., Zhang, C., & Zhuang, S. (2021) · Environmental Science & Technology · doi:10.1021/acs.est.1c06866 · Cited by 40 · see citing works

Re-adaption on Earth after Spaceflights Affects the Mouse Liver Proteome

Anselm, V., Novikova, S. E., & Zgoda, V. G. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081763 · Cited by 38 · see citing works

Hepatic Retinyl Ester Hydrolases and the Mobilization of Retinyl Ester Stores

Grumet, L., Taschler, U., & Lass, A. (2016) · Nutrients · doi:10.3390/nu9010013 · Cited by 39 · see citing works

Vitamin A and retinoid signaling in the kidneys

DiKun, K. M., & Gudas, L. J. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108481 · Cited by 38 · see citing works

Raman spectroscopic studies of vitamin A content in the liver: a biomarker of healthy liver

Kochan, K., Marzec, K. M., Maślak, E., Chłopicki, S., & Barańśka, M. (2014) · The Analyst · doi:10.1039/c4an01878h · Cited by 36 · see citing works

High dietary fat–induced obesity in Wistar rats and type 2 diabetes in nonobese Goto-Kakizaki rats differentially affect retinol binding protein 4 expression and vitamin A metabolism

Shirai, T., Shichi, Y., Sato, M., Tanioka, Y., Furusho, T., Ota, T., Tadokoro, T., Suzuki, T., Kobayashi, K., & Yamamoto, Y. (2015) · Nutrition Research · doi:10.1016/j.nutres.2015.11.018 · Cited by 38 · see citing works

Retinoids in the Pathogenesis and Treatment of Liver Diseases

Melis, M., Tang, X., Trasino, S. E., & Gudas, L. J. (2022) · Nutrients · doi:10.3390/nu14071456 · Cited by 36 · see citing works

Retinol binding protein 4 and type 2 diabetes: from insulin resistance to pancreatic β-cell function

Fan, J., & Hu, J. (2024) · Endocrine · doi:10.1007/s12020-024-03777-5 · Cited by 36 · see citing works

Hepatic stellate cells retain retinoid-laden lipid droplets after cellular transdifferentiation into activated myofibroblasts

Jophlin, L., Koutalos, Y., Chen, C., Shah, V. H., & Rockey, D. C. (2018) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00251.2017 · Cited by 33 · see citing works

The retinoic acid hydroxylase Cyp26a1 has minor effects on postnatal vitamin A homeostasis, but is required for exogenous atRA clearance

Zhong, G. G., Hogarth, C. A., Snyder, J. M., Palau, L., Topping, T., Huang, W., Czuba, L. C., LaFrance, J., Ghiaur, G., & Isoherranen, N. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.009023 · Cited by 33 · see citing works

Retinoid roles in blocking hepatocellular carcinoma.

Shirakami, Y., Sakai, H., & Shimizu, M. (2015) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2304-3881.2015.05.01 · Cited by 33 · see citing works

The impact of retinol loading and surface charge on the hepatic delivery of lipid nanoparticles

Pan, T., Wang, P., Hung, C., Aljuffali, I. A., Dai, Y.-S., & Fang, J. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2016.02.029 · Cited by 33 · see citing works

Breastfeeding, retinoids, and postpartum depression: A new theory

Mawson, A. R., & Xue-yuan, W. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.05.038 · Cited by 32 · see citing works

The potential of retinoids for combination therapy of lung cancer: Updates and future directions

Tripathi, S. K., Pandey, K., Panda, M., Spinella, M. J., Rengasamy, K. R. R., & Biswal, B. K. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104331 · Cited by 32 · see citing works

Capsaicin induces de-differentiation of activated hepatic stellate cell

Bitencourt, S., de Mesquita, F. C., Caberlon, E., Haute, G. V., Basso, B. D. S., Ferreira, G. A., & de Oliveira, J. R. (2012) · Biochemistry and Cell Biology · doi:10.1139/o2012-026 · Cited by 32 · see citing works

An integrated approach to identify environmental modulators of genetic risk factors for complex traits

Balliu, B., Carcamo‐Orive, I., Gloudemans, M. J., Nachun, D. C., Durrant, M. G., Gazal, S., Park, C. Y., Knowles, D. A., Wabitsch, M., Quertermous, T., et al. (2021) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2021.08.014 · Cited by 32 · see citing works

The immunomodulatory role of all-trans retinoic acid in tumor microenvironment

Bi, G.-S., Liang, J.-Q., Bian, Y.-Y., Shan, G., Besskaya, V., Wang, Q., & Zhan, C. (2022) · Clinical and Experimental Medicine (Testo stampato) · doi:10.1007/s10238-022-00860-x · Cited by 27 · see citing works

Structural basis of lipid-droplet localization of 17-beta-hydroxysteroid dehydrogenase 13

(2023) · doi:10.1038/s41467-023-40766-0 · Cited by 29 · see citing works

Intact vitamin A transport is critical for cold-mediated adipose tissue browning and thermogenesis

Fenzl, A., Kulterer, O. C., Spirk, K., Mitulović, G., Marculescu, R., Bilban, M., Baumgartner-Parzer, S. M., Kautzky‐Willer, A., Kenner, L., Plutzky, J., et al. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101088 · Cited by 29 · see citing works

Preventive Effects of β-Cryptoxanthin, a Potent Antioxidant and Provitamin A Carotenoid, on Lifestyle-Related Diseases—A Central Focus on Its Effects on Non-Alcoholic Fatty Liver Disease (NAFLD)

Nishino, A., Maoka, T., & Yasui, H. (2021) · Antioxidants · doi:10.3390/antiox11010043 · Cited by 29 · see citing works

Genetically personalised organ-specific metabolic models in health and disease

Foguet, C., Xu, Y., Ritchie, S. C., Lambert, S. A., Persyn, E., Nath, A. P., Davenport, E. E., Roberts, D. J., Paul, D. S., Angelantonio, E. D., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35017-7 · Cited by 27 · see citing works

Female obesity: Association with endocrine disruption and reproductive dysfunction

Baraskar, K., Thakur, P., Shrivastava, R., & Shrivastava, V. K. (2021) · Obesity Medicine · doi:10.1016/j.obmed.2021.100375 · Cited by 27 · see citing works

High-fat diet enhanced retinal dehydrogenase activity, but suppressed retinol dehydrogenase activity in liver of rats

Zhang, M., Liu, C., Hu, M., Zhang, J., Xu, P., Li, F., Zhong, Z., Liu, L., & Liu, X. (2015) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2015.03.001 · Cited by 26 · see citing works

Alterations in vitamin A/retinoic acid homeostasis in diet-induced obesity and insulin resistance

Mody, N. (2017) · Proceedings of The Nutrition Society · doi:10.1017/s0029665117001069 · Cited by 26 · see citing works

Altered AKAP12 expression in portal fibroblasts and liver sinusoids mediates transition from hepatic fibrogenesis to fibrosis resolution

Lee, H. S., Choi, J. H., Son, T., Wee, H., Bae, S., Seo, J. H., Park, J. H., Ryu, S. H., Lee, D., Jang, M. K., et al. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0074-5 · Cited by 26 · see citing works

Chronic alcohol consumption has a biphasic effect on hepatic retinoid loss

Clugston, R. D., Huang, L., & Blaner, W. S. (2015) · The FASEB Journal · doi:10.1096/fj.14-266296 · Cited by 25 · see citing works

Microbiome-liver crosstalk: A multihit therapeutic target for liver disease

Kirundi, J., Moghadamrad, S., & Urbaniak, C. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i11.1651 · Cited by 24 · see citing works

Acyclic retinoid in chemoprevention of hepatocellular carcinoma: Targeting phosphorylated retinoid X receptor-α for prevention of liver carcinogenesis

Shimizu, M., Imai, K., Moriwaki, H., Shirakami, Y., & Takai, K. (2012) · Journal of Carcinogenesis · doi:10.4103/1477-3163.100398 · Cited by 24 · see citing works

Roles of Vitamin A Metabolism in the Development of Hepatic Insulin Resistance

Chen, G. (2013) · ISRN Hepatology · doi:10.1155/2013/534972 · Cited by 23 · see citing works

Gender and Single Nucleotide Polymorphisms inMTHFR,BHMT,SPTLC1,CRBP2,CETP, andSCARB1Are Significant Predictors of Plasma Homocysteine Normalized by RBC Folate in Healthy Adult

Clifford, A. J., Chen, K., McWade, L., Rincón, G., Kim, S., Holstege, D. M., Owens, J. E., Liu, B., Müller, H., Medrano, J. F. F., et al. (2012) · Journal of Nutrition · doi:10.3945/jn.112.160333 · Cited by 22 · see citing works

Digestion and Intestinal Absorption of Dietary Carotenoids and Vitamin A ☆

Harrison, E. H., & Kopec, R. E. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809954-4.00050-5 · Cited by 21 · see citing works

Altered hepatic retinyl ester concentration and acyl composition in response to alcohol consumption

Clugston, R. D., Jiang, H., Lee, M. X., Berk, P. D., Goldberg, I. J., Huang, L., & Blaner, W. S. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.04.006 · Cited by 21 · see citing works

Altered global microRNA expression in hepatic stellate cells LX-2 by angiotensin-(1–7) and miRNA-1914-5p identification as regulator of pro-fibrogenic elements and lipid metabolism

da Silva, B. D. O., Alberici, L. C., Ramos, L. F., da Silva, C. M., da Silveira, M. B., Dechandt, C. R. P., Friedman, S. L., Sakane, K. K., Gonçalves, L. R., & Moraes, K. C. M. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2018.02.018 · Cited by 21 · see citing works

Alcohol induced hepatic retinoid depletion is associated with the induction of multiple retinoid catabolizing cytochrome P450 enzymes

Ferdouse, A., Agrawal, R. R., Gao, M. A., Jiang, H., Blaner, W. S., & Clugston, R. D. (2022) · PLoS ONE · doi:10.1371/journal.pone.0261675 · Cited by 20 · see citing works

Plasma retinol and total carotenes and fracture risk after long-term supplementation with high doses of retinol

Ambrosini, G. L., Alfonso, H. S., Reid, A., Mackerras, D., Bremner, A., Beilby, J. P., Olsen, N. J., Musk, A. W., & de Klerk, N. H. (2013) · Nutrition · doi:10.1016/j.nut.2013.10.007 · Cited by 20 · see citing works

Non-coding RNA crosstalk with nuclear receptors in liver disease

Wu, J., Nagy, L. E., Liangpunsakul, S., & Wang, L. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166083 · Cited by 20 · see citing works

Role of aryl hydrocarbon receptor (AHR) in overall retinoid metabolism: Response comparisons to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure between wild-type and AHR knockout mice

Esteban, J., Sánchez-Pérez, I., Hamscher, G., Miettinen, H. M., Korkalainen, M., Viluksela, M., Pohjanvirta, R., & Håkansson, H. (2021) · Reproductive Toxicology · doi:10.1016/j.reprotox.2021.02.004 · Cited by 20 · see citing works

Retinol Binding Protein 4 and Fatty Liver: A Direct Link?

Maher, J. J. (2013) · Hepatology · doi:10.1002/hep.26507 · Cited by 19 · see citing works

RXRα modulates hepatic stellate cell activation and liver fibrosis by targeting CaMKKβ–AMPKα axis

Cai, L., Yin, M., Peng, S., Fen, L., Lai, L., Zhang, X., Xie, L., Wang, C., Zhou, H., Zhan, Y., et al. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.05.023 · Cited by 19 · see citing works

Strategies to Detect Hepatic Myofibroblasts in Liver Cirrhosis of Different Etiologies

Iwaisako, K., Taura, K., Koyama, Y., Takemoto, K., & Asagiri, M. (2014) · Current Pathobiology Reports · doi:10.1007/s40139-014-0057-8 · Cited by 19 · see citing works

Effects of all-trans and 9-cis retinoic acid on differentiating human neural stem cells in vitro

Kubíčková, B., Martinkova, S., Bohačiaková, D., Nezvedová, M., Liu, R., Brózman, O., Spáčil, Z., & Hilscherová, K. (2023) · Toxicology · doi:10.1016/j.tox.2023.153461 · Cited by 18 · see citing works

β-Carotene supplementation ameliorates experimental liver fibrogenesis via restoring antioxidant status and hepatic stellate cells activity

Latief, U., Husain, H., & Ahmad, R. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.08.027 · Cited by 18 · see citing works

Prediagnostic dietary intakes of vitamin A and β-carotene are associated with hepatocellular-carcinoma survival

Zhang, D., Luo, Y., Yishake, D., Liu, Z., He, T., Luo, Y., Zhang, Y., Fang, A., & Zhu, H. (2019) · Food & Function · doi:10.1039/c9fo02468a · Cited by 18 · see citing works

Highlighting the gaps in hazard and risk assessment of unregulated Endocrine Active Substances in surface waters: retinoids as a European case study

Kubíčková, B., Ramwell, C., Hilscherová, K., & Jacobs, M. N. (2021) · Environmental Sciences Europe · doi:10.1186/s12302-020-00428-0 · Cited by 19 · see citing works

CYP26B1 as regulator of retinoic acid in vascular cells and atherosclerotic lesions

Elmabsout, A. A. (2012) · Cited by 17 · see citing works

Factors Affecting Insulin-Regulated Hepatic Gene Expression

Guan, H.-P., & Chen, G. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-800101-1.00006-5 · Cited by 15 · see citing works

Compartmental modeling of whole-body vitamin A kinetics in unsupplemented and vitamin A-retinoic acid-supplemented neonatal rats

Tan, L., Wray, A. E., Green, M. H., & Ross, A. C. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m050518 · Cited by 15 · see citing works

Effects of methylmercury and retinol palmitate co-administration in rats during pregnancy and breastfeeding: Metabolic and redox parameters in dams and their offspring

Espitia-Pérez, P., Albino, S. M., da Rosa, H. T., Silveira, A. K., Espitia-Pérez, L., Brango, H., de Moraes, D. P., Hermann, P. R. S., Mingori, M. R., Barreto, F., et al. (2018) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2018.06.093 · Cited by 14 · see citing works

Retinoids in Liver Function

Shiota, G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804274-8.00050-3 · Cited by 2 · see citing works

Retinoic acids and hepatic stellate cells in liver disease

Lee, Y., & Jeong, W. (2012) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2011.07007.x · Cited by 119 · see citing works

Retinoids in health and disease: A role for hepatic stellate cells in affecting retinoid levels

Haaker, M. W., Vaandrager, A. B., & Helms, J. B. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2020.158674 · Cited by 84 · see citing works

Carotenoid and retinoid metabolism in hepatic stellate cells (HSCs) and their relationship to hepatic disease

Blaner, W. S., & Shmarakov, I. O. (2011) · Acta Biologica Cracoviensia. Series Zoologia

An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro

Vogel, S., Piantedosi, R., Frank, J., Lalazar, A., Rockey, D. C., Friedman, S. L., & Blaner, W. S. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32030-7 · Cited by 283 · see citing works