βKlotho Is Required for Fibroblast Growth Factor (FGF) 21 Signaling through FGF Receptor (FGFR) 1c and FGFR3c

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837

FGF-21 as a novel metabolic regulator

Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125

Fibroblast growth factors.

Ornitz, D. M., & Itoh, N. (2001) · Genome biology · doi:10.1186/gb-2001-2-3-reviews3005 · Cited by 1,985

Cellular signaling by fibroblast growth factor receptors

Eswarakumar, V. P., Lax, I., & Schlessinger, J. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.01.001 · Cited by 1,923

Receptor Specificity of the Fibroblast Growth Factor Family

Ornitz, D. M., Xu, J., Colvin, J. S., McEwen, D. G., MacArthur, C. A., Coulier, F., Gao, G., & Goldfarb, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.25.15292 · Cited by 1,871

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C. L., McDonald, J. G., Luo, G., Jones, S. A., Goodwin, B., Richardson, J. A., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.001 · Cited by 1,865

Klotho converts canonical FGF receptor into a specific receptor for FGF23

Urakawa, I., Yamazaki, Y., Shimada, T., Iijima, K., Hasegawa, H., Okawa, K., Fujita, T., Fukumoto, S., & Yamashita, T. (2006) · Nature · doi:10.1038/nature05315 · Cited by 1,865

Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21

Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.003 · Cited by 1,504

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism.

Shimada, T., Kakitani, M., Yamazaki, Y., Hasegawa, H., Takeuchi, Y., Fujita, T., Fukumoto, S., Tomizuka, K., & Yamashita, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19081 · Cited by 1,503

Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States

Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., & Maratos-Flier, E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.002 · Cited by 1,495

Klotho protein: Its role in aging and central nervous system pathology

Бокша, И. С., Prokhorova, T. A., Savushkina, O. K., & Терешкина, Е. Б. (2017) · Biochemistry (Moscow) · doi:10.1134/s0006297917090024 · Cited by 27

Exercise Is Medicine for Nonalcoholic Fatty Liver Disease: Exploration of Putative Mechanisms

Heinle, J. W., DiJoseph, K., Sabag, A., Oh, S., Kimball, S. R., Keating, S., & Stine, J. G. (2023) · Nutrients · doi:10.3390/nu15112452 · Cited by 26

Fibroblast Growth Factor 21 Facilitates the Homeostatic Control of Feeding Behavior

Wu, C.-T., CHAFFIN, A. T. B., & Ryan, K. K. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11030580 · Cited by 24

Sulfated Glycosaminoglycans Are Required for Specific and Sensitive Fibroblast Growth Factor (FGF) 19 Signaling via FGF Receptor 4 and betaKlotho

Nakamura, M., Uehara, Y., Asada, M., Honda, E., Nagai, N., Kimata, K., Suzuki, M., & Imamura, T. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.251140 · Cited by 25

A novel regulatory mechanism for Fgf18 signaling involving cysteine-rich FGF receptor (Cfr) and delta-like protein (Dlk)

Miyaoka, Y., Tanaka, M., Imamura, T., Takada, S., & Miyajima, A. (2009) · Development · doi:10.1242/dev.041574 · Cited by 27

mTOR and regulation of energy homeostasis in humans

Mannaa, M., Krämer, S., Boschmann, M., & Gollasch, M. (2013) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1057-6 · Cited by 25

Involvement of heparan sulfate 6-O-sulfation in the regulation of energy metabolism and the alteration of thyroid hormone levels in male mice

Nagai, N., Habuchi, H., Sugaya, N., Nakamura, M., Imamura, T., Watanabe, H., & Kimata, K. (2013) · Glycobiology · doi:10.1093/glycob/cwt037 · Cited by 25

Role of fibroblast growth factor 21 in gestational diabetes mellitus: A mini‐review

Yuan, D., Wu, B. J., Henry, A., Rye, K., & Ong, K. L. (2018) · Clinical Endocrinology · doi:10.1111/cen.13881 · Cited by 26

The cell adhesion molecule L1 regulates the expression of FGF21 and enhances neurite outgrowth

Huang, X., Hu, J., Li, Y., Yang, Z. Z., Zhu, H., Zhou, L., Ma, K., Schachner, M., Xiao, Z., & Li, Y. (2013) · Brain Research · doi:10.1016/j.brainres.2013.07.043 · Cited by 24

Fasting decreases plasma FGF21 in obese subjects and the expression of FGF21 receptors in adipose tissue in both lean and obese subjects

Nygaard, E. B., Ørskov, C., Almdal, T., Vestergaard, H., & Andersen, B. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0002 · Cited by 24

A Land of Controversy: Fibroblast Growth Factor-23 and Uremic Cardiac Hypertrophy

Bao, J., Hu, P., She, Q.-Y., & Li, A. (2020) · Journal of the American Society of Nephrology · doi:10.1681/asn.2020010081 · Cited by 27

Dynamic folding modulation generates FGF21 variant against diabetes

Zhu, L., Zhao, H., Liu, J., Cai, H., Wu, B., Liu, Z., Zhou, S., Liu, Q., Li, X., Bao, B., et al. (2020) · EMBO Reports · doi:10.15252/embr.202051352 · Cited by 23

Therapeutic utilities of fibroblast growth factor 19

Wu, X., & Li, Y. (2011) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2011.624514 · Cited by 23

Increased glycolysis in skeletal muscle coordinates with adipose tissue in systemic metabolic homeostasis

Xiang, C., Zhang, Y., Chen, Q., Sun, A., Peng, Y., Zhang, G., Zhou, D., Xie, Y., Hou, X., Zheng, F., et al. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16698 · Cited by 23

Autocrine FGF1 signaling promotes glucose uptake in adipocytes

Nies, V. J. M., Struik, D., Liu, S., Liu, W., Kruit, J. K., Downes, M., van Zutphen, T., Verkade, H. J., Evans, R. M., & Jonker, J. W. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2122382119 · Cited by 23

Metabolic Effects of FGF-21: Thermoregulation and Beyond

Ni, B., Farrar, J. S., Vaitkus, J. A., & Celi, F. S. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00148 · Cited by 23

Endoplasmic reticulum stress induces up-regulation of hepatic β-Klotho expression through ATF4 signaling pathway

Dong, K., Li, H., Zhang, M., Jiang, S., Chen, S., Zhou, J., Dai, Z., Fang, Q., & Jia, W. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.02.104 · Cited by 23

N-3 polyunsaturated fatty acids increase hepatic fibroblast growth factor 21 sensitivity via a PPAR-γ-β-klotho pathway

Yang, W., Chen, X., Liu, Y., Chen, M., Jiang, X., Shen, T., Li, Q., Yang, Y., & Ling, W. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201601075 · Cited by 25

Differential receptor selectivity of the FGF15/FGF19 orthologues determines distinct metabolic activities in db/db mice

Hansen, A. M. K., Vienberg, S. G., Lykkegaard, K., Zhao, X., Tingqing, G., Han, D., Zhang, X., Thøgersen, H., Sass‐Ørum, K., Tagmose, T. M., et al. (2018) · Biochemical Journal · doi:10.1042/bcj20180555 · Cited by 23

Impaired function of fibroblast growth factor 23 / Klotho protein axis in prediabetes and diabetes mellitus: Promising predictor of cardiovascular risk

Berezin, A. Е., & Berezin, A. A. (2019) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2019.07.018 · Cited by 24

N‐acetyl‐seryl‐aspartyl‐lysyl‐proline is a valuable endogenous antifibrotic peptide for kidney fibrosis in diabetes: An update and translational aspects

Kanasaki, K. (2020) · Journal of Diabetes Investigation · doi:10.1111/jdi.13219 · Cited by 23

The autocrine role of FGF21 in cultured adipocytes

Justesen, S., Haugegaard, K. V., Hansen, J. B., Hansen, H. S., & Andersen, B. (2020) · Biochemical Journal · doi:10.1042/bcj20200220 · Cited by 25

Long-Term Dietary Taurine Lowers Plasma Levels of Cholesterol and Bile Acids

Tagawa, R., Kobayashi, M., Sakurai, M., Yoshida, M., Kaneko, H., Mizunoe, Y., Nozaki, Y., Okita, N., Sudo, Y., & Higami, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031793 · Cited by 22

FGF21 regulates melanogenesis in alpaca melanocytes via ERK1/2-mediated MITF downregulation

Wang, R., Chen, T., Zhao, B., Fan, R., Ji, K., Yu, X., Wang, X., & Dong, C. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.06.064 · Cited by 22

Whole-body and adipose tissue-specific mechanisms underlying the metabolic effects of fibroblast growth factor 21 in the Siberian hamster

Lewis, J. E., Monnier, C., Marshall, H. J., Fowler, M. J., Green, R., Cooper, S., Chiotellis, A., Luckett, J., Perkins, A. C., Coşkun, T., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.10.009 · Cited by 25

Relationship between FGF21 and drug or nondrug therapy of type 2 diabetes mellitus

Guo, C. Y., Zhao, L., Li, Y., Deng, X., & Yuan, G. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29879 · Cited by 21

Understanding the Structure-Function Relationship between FGF19 and Its Mitogenic and Metabolic Activities

Wu, X., & Li, Y. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0887-1_13 · Cited by 21

Long-Term Administration of Fibroblast Growth Factor 21 Prevents Chemically-Induced Hepatocarcinogenesis in Mice

Xu, P., Zhang, Y., Wang, W., Yuan, Q., Liu, Z., Rasoul, L. M., Wu, Q., Liu, M., Ye, X., Li, D., et al. (2015) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-3711-z · Cited by 20

Hepatocyte-specific GDF15 overexpression improves high-fat diet-induced obesity and hepatic steatosis in mice via hepatic FGF21 induction

Takeuchi, K., Yamaguchi, K., Takahashi, Y., Yano, K., Okishio, S., Ishiba, H., Tochiki, N., Kataoka, S., Fujii, H., Iwai, N., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-75107-8 · Cited by 21

Cholic Acid Supplementation of a High-Fat Obesogenic Diet Suppresses Hepatic Triacylglycerol Accumulation in Mice via a Fibroblast Growth Factor 21–Dependent Mechanism

Ippagunta, S. M., Kharitonenkov, A., Adams, A. C., & Hillgartner, F. B. (2018) · Journal of Nutrition · doi:10.1093/jn/nxy022 · Cited by 21

Current understanding and controversies on the clinical implications of fibroblast growth factor 21

Badakhshi, Y., & Jin, T. (2020) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2020.1864278 · Cited by 20

Non-alcoholic fatty liver disease promotes breast cancer progression through upregulated hepatic fibroblast growth factor 21

Sui, Y., Liu, Q., Xu, C., Ganesan, K., Ye, Z., Li, Y., Wu, J., Du, B., Gao, F., Song, C., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-023-06386-8 · Cited by 19

Insulin sensitizes FGF21 in glucose and lipid metabolisms via activating common AKT pathway

Yu, D., Ye, X., Wu, Q., Li, S., Yang, Y., He, J., Liu, Y., Zhang, X., Yuan, Q., Liu, M., et al. (2015) · Endocrine · doi:10.1007/s12020-015-0801-9 · Cited by 19

Fibroblast Growth Factor 21 Promotes C2C12 Cells Myogenic Differentiation by Enhancing Cell Cycle Exit

Liu, X., Wang, Y., Zhao, S., & Li, X. (2017) · BioMed Research International · doi:10.1155/2017/1648715 · Cited by 19

The FGFR D3 Domain Determines Receptor Selectivity For Fibroblast Growth Factor 21

Gupte, J., Li, Y., Wu, X., Weiszmann, J., Hecht, R. I., Lemon, B. D., Lindberg, R. A., Wang, Z., & Li, Y. (2011) · Journal of Molecular Biology · doi:10.1016/j.jmb.2011.03.003 · Cited by 18

Fibroblast growth factor 21, fibroblast growth factor receptor 1, and β-Klotho expression in bovine growth hormone transgenic and growth hormone receptor knockout mice

Brooks, N. E., Hjortebjerg, R., Henry, B. E., List, E. O., Kopchick, J. J., & Berryman, D. E. (2016) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2016.08.003 · Cited by 18

The Role of Clinical Proteomics, Lipidomics, and Genomics in the Diagnosis of Alzheimer’s Disease

Martins, I. J. (2016) · Proteomes · doi:10.3390/proteomes4020014 · Cited by 19

Spatial distribution of beta‐klotho mRNA in the mouse hypothalamus, hippocampal region, subiculum, and amygdala

Bono, B. S. M., Ly, N. K. K., Miller, P. A., Williams-Ikhenoba, J. G., Dumiaty, Y., & Chee, M. J. S. (2022) · The Journal of Comparative Neurology · doi:10.1002/cne.25306 · Cited by 19

Fibroblast growth factor 21 reverses high‐fat diet‐induced impairment of vascular function via the anti‐oxidative pathway in ApoE knockout mice

Huang, W., Chen, C., Lin, T., Kuo, C., Huang, H., Huang, P., & Lin, S. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17273 · Cited by 18

Alteration in serum concentrations of FGF19, FGF21, and FGF23 in patients with urothelial carcinoma

Li, J., Chiu, K., Ou, Y., Wang, S., Chen, C., Yang, C., Ho, H., Cheng, C., Yang, C., Chen, C., et al. (2018) · BioFactors · doi:10.1002/biof.1460 · Cited by 17

Roles for fibroblast growth factor-23 and α-Klotho in acute kidney injury

Hu, P., Bao, J., & Li, A. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154435 · Cited by 17

Fibroblast growth factor 21 in dairy cows: current knowledge and potential relevance

Eder, K., Geßner, D. K., & Ringseis, R. (2021) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-021-00621-y · Cited by 18

Expression profile and overexpression outcome indicate a role for βKlotho in skeletal muscle fibro/adipogenesis

Phelps, M., Stuelsatz, P., & Yablonka‐Reuveni, Z. (2016) · FEBS Journal · doi:10.1111/febs.13682 · Cited by 17

BMP2/Smad signaling pathway is involved in the inhibition function of fibroblast growth factor 21 on vascular calcification

Liu, X., Cao, F., Liu, S., Mi, Y., & Liu, J. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.06.098 · Cited by 17

The Fibroblast Growth Factor (FGF) Signaling Complex

McKeehan, W. L., Wang, F., & Luo, Y. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00038-3 · Cited by 17

Fibroblast growth factor 23 and acute kidney injury

Neyra, J. A., Moe, O. W., & Hu, M. C. (2014) · Pediatric Nephrology · doi:10.1007/s00467-014-3006-1 · Cited by 17

Novel Sandwich Immunoassays for The Measurement of Total and Active Fgf21

Umberger, T. S., Sloan, J. H., Chen, J., Cheng, C., Siegel, R. W., Qian, Y., Troutt, J. S., & Konrad, R. J. (2014) · Bioanalysis · doi:10.4155/bio.14.241 · Cited by 16

Identification and characterization of adipose surface epitopes

Onogi, Y., Khalil, A., & Ussar, S. (2020) · Biochemical Journal · doi:10.1042/bcj20190462 · Cited by 16

Fibroblast growth factor 21

Trusz, G. J. (2024) · Differentiation · doi:10.1016/j.diff.2024.100793 · Cited by 15

Discovery of an artificial peptide agonist to the fibroblast growth factor receptor 1c/βKlotho complex from random peptide T7 phage display

Sakamoto, K., Kawata, Y., Masuda, Y., Umemoto, T., Ito, T., Asami, T., Takekawa, S., Ohtaki, T., & Inooka, H. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.10.009 · Cited by 15

The metabolic hormone FGF21 is associated with endothelial dysfunction in hemodialysis patients

Rusu, C. C., Racasan, S., Kacsó, I. M., Moldovan, D. T., Potra, A. R., Tirinescu, D. C., Budurea, C., Orasan, R. A., Pațiu, I. M., Bondor, C. I., et al. (2016) · International Urology and Nephrology · doi:10.1007/s11255-016-1474-x · Cited by 15

Fgf21 regulates T-cell development in the neonatal and juvenile thymus

Nakayama, Y., Masuda, Y., Ohta, H., Tanaka, T., Washida, M., Nabeshima, Y., Miyake, A., Itoh, N., & Konishi, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-00349-8 · Cited by 15

βklotho is essential for the anti‐endothelial mesenchymal transition effects of N‐acetyl‐seryl‐aspartyl‐lysyl‐proline

Gao, R., Kanasaki, K., Li, J., Kitada, M., Okazaki, T., & Koya, D. (2019) · FEBS Open Bio · doi:10.1002/2211-5463.12638 · Cited by 14

Fibroblast growth factor-21 as a novel metabolic factor for regulating thrombotic homeostasis

Li, S., Jia, H., Liu, Z., Wang, N., Guo, X., Cao, M., Fang, F., Yang, J., Li, J., He, Q., et al. (2022) · Scientific Reports · doi:10.1038/s41598-021-00906-2 · Cited by 14

Evaluation of fibroblast growth factor activity exerted by placental extract used as a cosmetic ingredient

Ito, K., Yamada, R., Matsumoto, N., & Imamura, T. (2017) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.12434 · Cited by 14

Molecular Control of Phosphorus Homeostasis and Precision Treatment of Hypophosphatemic Disorders

Weber, T. J., & Quarles, L. D. (2019) · Current Molecular Biology Reports · doi:10.1007/s40610-019-0118-1 · Cited by 15

Anti-Aging β-Klotho Gene-Activated Scaffold Promotes Rejuvenative Wound Healing Response in Human Adipose-Derived Stem Cells

Laiva, A. L., O’Brien, F. J., & Keogh, M. B. (2021) · Pharmaceuticals · doi:10.3390/ph14111168 · Cited by 14

Fibroblast growth factor 21 secretion enhances glucose uptake in mono(2-ethylhexyl)phthalate-treated adipocytes

Hsu, J., Yeh, S., Tsai, F., Chen, H., & Tsou, T. (2019) · Toxicology in Vitro · doi:10.1016/j.tiv.2019.04.021 · Cited by 15

Letter to the Editor: Parameters, Characteristics, and Criteria for Defining the Term “FGF21 Resistance”

Tanajak, P. (2017) · Endocrinology · doi:10.1210/en.2017-00056 · Cited by 13

β-Klotho as novel therapeutic target in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A narrative review

Meroni, M., Dongiovanni, P., Tiano, F., Piciotti, R., Alisi, A., & Panera, N. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117608 · Cited by 13

Identification of Sp1 as a Transcription Activator to Regulate Fibroblast Growth Factor 21 Gene Expression

Chen, S., Li, H., Zhang, J., Jiang, S., Zhang, M., Xu, Y., Dong, K., Yang, Y., Fang, Q., & Jia, W. (2017) · BioMed Research International · doi:10.1155/2017/8402035 · Cited by 12

Efficacy of a combination of high and low dosage of PEGylated FGF-21 in treatment of diabetes in db/db mice

Xu, P., Zhang, Y., Song, L., Khoso, M. H., Li, J., Jiang, X., He, J., Li, J., Ma, X., Ren, G., et al. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.09.019 · Cited by 12

KLOTHO, FGF21 AND FGF23: NOVEL PATHWAYS TO MUSCULOSKELETAL HEALTH?

Bartali, B., Semba, R. D., & de Araújo, A. B. (2013) · The Journal of Frailty & Aging · doi:10.14283/jfa.2013.26 · Cited by 12

Combined docosahexaenoic acid and thyroid hormone supplementation as a protocol supporting energy supply to precondition and afford protection against metabolic stress situations

Videla, L. A. (2019) · IUBMB Life · doi:10.1002/iub.2067 · Cited by 13

Investigating Anti-Obesity Effects by Oral Administration of Aloe vera Gel Extract (AVGE): Possible Involvement in Activation of Brown Adipose Tissue (BAT)

Tada, A., Misawa, E., Tanaka, M., Saito, M., Nabeshima, K., Yamauchi, K., Abe, F., Goto, T., & Kawada, T. (2020) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.66.176 · Cited by 12

Sex Dimorphism in the Fgf21 Gene Expression in Liver and Adipose Tissues is Dependent on the Metabolic Condition

Бажан, Н. М., Jakovleva, T., Balybina, N., Dubinina, A., Denisova, E. I., Feofanova, N. A., & En, M. (2019) · OnLine Journal of Biological Sciences · doi:10.3844/ojbsci.2019.28.36 · Cited by 11

Dapagliflozin promotes browning of white adipose tissue through the FGFR1-LKB1-AMPK signaling pathway

Lv, Y., Zhao, C., Jiang, Q., Rong, Y., Ma, M., Liang, L., Li, W., Zhang, J., Xu, N., & Wu, H. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09540-3 · Cited by 10

Development of Zalfermin, a Long-Acting Proteolytically Stabilized FGF21 Analog

Sass‐Ørum, K., Tagmose, T. M., Olsen, J., Sjölander, A., Wahlund, P., Han, D., Vegge, A., Reedtz‐Runge, S., Wang, Z., Gao, X., et al. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c00391 · Cited by 11

Heating-mediated purification of active FGF21 and structure-based design of its variant with enhanced potency

Jung, Y., Lee, K. W., Cho, J. H., Bae, D., Jeong, B.-G., Jung, Y.-J., Park, S., An, Y. J., Kim, K., Lee, G. S., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-27717-x · Cited by 11

Mapping the response of human fibroblast growth factor 21 (FGF21) promoter to serum availability and lipoic acid in HepG2 hepatoma cells

Xia, M., Erickson, A., Yi, X., & Moreau, R. F. (2015) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2015.12.004 · Cited by 10

Highly Selective and Sensitive Measurement of Active forms of FGF21 Using Novel Immunocapture Enrichment with LC–MS/MS

Zhao, Y., Liu, G., Kwok, S., Jones, B. R., Liu, J., Marchisin, D., Joyce, P., Peterson, J. E., & Shen, J. X. (2017) · Bioanalysis · doi:10.4155/bio-2017-0208 · Cited by 10

Research progress on the role of FGF21 in insulin resistance

Zhang, H., Zhu, R., Sun, Q., & Du, L. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1619462 · Cited by 10

Th2 Cytokines Increase the Expression of Fibroblast Growth Factor 21 in the Liver

Kang, S., Lee, S. E., Choi, M., Chang, J.-Y., Kim, J.-T., Zhang, B., Kang, Y.-E., Lee, J. H., Yi, H., & Shong, M. (2021) · Cells · doi:10.3390/cells10061298 · Cited by 9

Design of a Dual Agonist of Exendin-4 and FGF21 as a Potential Treatment for Type 2 Diabetes Mellitus and Obesity

Zhang, C., Gao, G., Li, Y., Ying, J., Li, J., & Hu, S. (2023) · Iranian journal of pharmaceutical research · doi:10.5812/ijpr-131015 · Cited by 8

Heart‐derived factors and organ cross‐talk in settings of health and disease: new knowledge and clinical opportunities for multimorbidity

Sen, M. G., Chooi, R., & McMullen, J. R. (2025) · The Journal of Physiology · doi:10.1113/jp287400 · Cited by 8

A comparative genomic study across 396 liver biopsies provides deep insight into FGF21 mode of action as a therapeutic agent in metabolic dysfunction‐associated steatotic liver disease

Tang, S., & Borlak, J. T. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70218 · Cited by 8

Plasma FGF21 concentrations, adipose fibroblast growth factor receptor-1 and β-klotho expression decrease with fasting in northern elephant seals

Suzuki, M., Lee, A. Y., Vázquez‐Medina, J. P., Viscarra, J. A., Crocker, D. E., & Ortiz, R. M. (2015) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2015.03.009 · Cited by 8

Acute Deletion of the FOXO1-dependent Hepatokine FGF21 Does not Alter Basal Glucose Homeostasis or Lipolysis in Mice

Sostre‐Colón, J., Gavin, M. J., Santoleri, D., & Titchenell, P. M. (2022) · Endocrinology · doi:10.1210/endocr/bqac035 · Cited by 7

A combined docosahexaenoic acid–thyroid hormone protocol upregulates rat liver β-Klotho expression and downstream components of FGF21 signaling as a potential novel approach to metabolic stress conditions

Vargas, R., Riquelme, B., Fernández, J., & Videla, L. A. (2017) · Food & Function · doi:10.1039/c7fo00923b · Cited by 8

Circulating factors that influence the central nervous system remyelination

Saitoh, S. S., Tanabe, S., & Muramatsu, R. (2022) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2021.12.001 · Cited by 8

Change of Fibroblast Growth Factor 21 Level Correlates with the Severity of Diabetic Sensory Polyneuropathy after Six-Week Physical Activity

Molnár, Á., Szentpéteri, A., Lőrincz, H., Seres, I., Harangi, M., Balogh, Z., Kempler, P., Paragh, G., & Sztanek, F. (2022) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2305160 · Cited by 7

Polyguluronate sulfate and its oligosaccharides but not heparin promotes FGF19/FGFR1c signaling

Lan, Y., Zeng, X., Guo, Z., Zeng, P., Hao, C., Zhao, X., Yu, G., & Zhang, L. (2017) · Journal of Ocean University of China · doi:10.1007/s11802-017-3195-x · Cited by 7

Editorial: FGF21 as a therapeutic target for obesity and insulin resistance: from rodent models to humans

Sousa‐Coelho, A. L. D., Rodríguez‐Rodríguez, R., Softic, S., Jonker, J. W., & Relat, J. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1253675 · Cited by 7

Effects of central FGF21 infusion on the glucose homeostasis in rats (brain–pancreas axis)

Tanbek, K., Yılmaz, Ü., Gül, M., Koç, A., & Sandal, S. (2023) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2023.2166964 · Cited by 6

Sulfated Glycosaminoglycan-Assisted Receptor Specificity of Human Fibroblast Growth Factor (FGF) 19 Signaling in a Mouse System Is Different from That in a Human System

Nakamura, M., Uehara, Y., Asada, M., Suzuki, M., & Imamura, T. (2012) · SLAS DISCOVERY · doi:10.1177/1087057112463820 · Cited by 6

Development of FGF21 Mutant with Potent Cardioprotective Effects in T2D Mice via FGFR1–AMPK-Mediated Inhibition of Oxidative Stress

Peng, Z., Gao, L., Zhang, L., Yao, R., Li, X., Deng, L. J., Fan, J., Ying, L., & Wang, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26146577 · Cited by 5

Association of NAFLD with FGF21 Polygenic Hazard Score, and Its Interaction with Protein Intake Level in Korean Adults

Lee, H. J., Shon, J., & Park, Y. J. (2023) · Nutrients · doi:10.3390/nu15102385 · Cited by 5

Secreted proteins in treating metabolic dysfunction-associated steatotic liver disease: from bench towards bedside

Huang, Y., Liu, B., Hu, C., & Lu, Y. (2025) · Protein & Cell · doi:10.1093/procel/pwaf027 · Cited by 4

UPRmt-regulated mitokines: novel strategies for myocardial injury repair

Gao, W., Liu, J., Zhang, W., Liu, B., & Shen, L. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1652353 · Cited by 4

Exercise-induced myokines in metabolic regulation: mechanisms, mimetics, and translational potential

Aslam, M. A., Lee, J., Bowen, T. S., & Huh, J. Y. (2026) · Archives of Pharmacal Research · doi:10.1007/s12272-026-01624-x · Cited by 7

Circulating FGF-21 as a Disease-Modifying Factor Associated with Distinct Symptoms and Cognitive Profiles in Myalgic Encephalomyelitis and Fibromyalgia

Azimi, G., Elremaly, W., Elbakry, M., Franco, A., Godbout, C., & Moreau, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26167670 · Cited by 4

An epidermis‐permeable dipeptide is a potential cosmetic ingredient with partial agonist/antagonist activity toward fibroblast growth factor receptors

Yamada, R., Fukumoto, R., Noyama, C., Fujisawa, A., Oka, S., & Imamura, T. (2019) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.12997 · Cited by 5

Fibroblast growth factor 21 and its influence on metabolic processes in the human body

Proshchai, G. A., Ворохобина, Н. В., Zagarskikh, E. Y., Александрович, П. С., & Partsernyak, A. S. (2018) · Vestnik of Saint Petersburg University Medicine · doi:10.21638/11701/spbu11.2018.104 · Cited by 4

Fibroblast growth factor 19 stimulates water intake

Bedoya, J. U., Chavey, C., Desandré, G., Meunier, L., Dupuy, A., Dopeso‐Reyes, I. G., Tordjmann, T., Assénat, E., Hibner, U., & Grégoire, D. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101483 · Cited by 5

Beta-Klotho Protein Expression in Healthy Human Tissues and Liver Biopsies From Patients With MASLD or MASH

Aaldijk, A. S., Struik, D., Driessen, S., Verzijl, C. R. C., Verheij, J., Nieuwdorp, M., Eilers, R. E., Wolters, J. C., Holleboom, A. G., & Jonker, J. W. (2025) · Gastro Hep Advances · doi:10.1016/j.gastha.2025.100745 · Cited by 3

The combination of zalfermin and semaglutide has additive therapeutic effects in a diet-induced obese and biopsy-confirmed mouse model of MASH

Norlin, J., Dermit, M., Sidiropoulos, N., Galsgaard, E. D., Hansen, H. H., Feigh, M., Veidal, S. S., Latta, M. R., Henriksson, E., & Andersen, B. (2025) · PLoS ONE · doi:10.1371/journal.pone.0331665 · Cited by 3

Role of the Klotho Gene in Bone and Mineral Metabolism

Riancho, J. A. (2008) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-008-9016-4 · Cited by 3

Pharmacological administration of FGF21 reverses obesity through a parabrachial-projecting neuron population in the hindbrain

Lin, Y., Claflin, K. E., Aklan, İ., Morgan, D. A., Sullivan, A. I., Rudolph, M. C., Rahmouni, K., & Potthoff, M. J. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117093 · Cited by 3

FGF Signaling: A Key Pathway During Skeletal Development

Fayad, C., & Legeai‐Mallet, L. (2024) · Biology of extracellular matrix · doi:10.1007/978-3-031-70835-0_8 · Cited by 2

High-Fat Diet Differentially Regulates Fibroblast Growth Factor Expression in Metabolic Tissues of Young and Aged Male Mice

Lin, Q., Hui, X., Gu, C., Min, K., Xiong, L., Zhou, W., Xu, J. J., Watson, S. E., Wintergerst, K. A., Cai, L., et al. (2025) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaf096 · Cited by 2

βKlotho is required for metabolic activity of fibroblast growth factor 21

Ogawa, Y., Kurosu, H., Yamamoto, M., Nandi, A., Rosenblatt, K. P., Goetz, R., Eliseenkova, A. V., Mohammadi, M., & Kuro-o, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701600104 · Cited by 617

FGF‐21/FGF‐21 receptor interaction and activation is determined by βKlotho

Kharitonenkov, A., Dunbar, J. D., Bina, H. A., Bright, S. W., Moyers, J. S., Zhang, C., Ding, L., Micanovic, R., Mehrbod, S. F., Knierman, M. D., et al. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21357 · Cited by 333

A Unique FGF23 with the Ability to Activate FGFR Signaling through Both αKlotho and βKlotho

Wu, X., Weiszmann, J., Ge, H., Baribault, H., Stevens, J. L., Hawkins, N., Vonderfecht, S. L., Gardner, J., Gupte, J., Sheng, J., et al. (2012) · Journal of Molecular Biology · doi:10.1016/j.jmb.2012.02.027 · Cited by 17

βKlotho Is Required for Fibroblast Growth Factor 21 Effects on Growth and Metabolism

Ding, X., Boney-Montoya, J., Owen, B. M., Bookout, A. L., Coate, K. C., Mangelsdorf, D. J., & Kliewer, S. A. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.08.002 · Cited by 403

Tissue-specific Expression of βKlotho and Fibroblast Growth Factor (FGF) Receptor Isoforms Determines Metabolic Activity of FGF19 and FGF21

Kurosu, H., Choi, M., Ogawa, Y., Dickson, A. S., Goetz, R., Eliseenkova, A. V., Mohammadi, M., Rosenblatt, K. P., Kliewer, S. A., & Kuro-o, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704165200 · Cited by 748