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Role of the GATA Family of Transcription Factors in Endocrine Development, Function, and Disease
Open accessAbstract
The WGATAR motif is a common nucleotide sequence found in the transcriptional regulatory regions of numerous genes. In vertebrates, these motifs are bound by one of six factors (GATA1 to GATA6) that constitute the GATA family of transcriptional regulatory proteins. Although originally considered for their roles in hematopoietic cells and the heart, GATA factors are now known to be expressed in a wide variety of tissues where they act as critical regulators of cell-specific gene expression. This includes multiple endocrine organs such as the pituitary, pancreas, adrenals, and especially the gonads. Insights into the functional roles played by GATA factors in adult organ systems have been hampered by the early embryonic lethality associated with the different Gata-null mice. This is now being overcome with the generation of tissue-specific knockout models and other knockdown strategies. These approaches, together with the increasing number of human GATA-related pathologies have greatly broadened the scope of GATA-dependent genes and, importantly, have shown that GATA action is not necessarily limited to early development. This has been particularly evident in endocrine organs where GATA factors appear to contribute to the transcription of multiple hormone-encoding genes. This review provides an overview of the GATA family of transcription factors as they relate to endocrine function and disease.
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“GATA4 is a zinc finger transcription factor essential for the development of various organs, including heart, testis, foregut, liver, and ventral pancreas (37).”
From The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. (2015) · cites this paper as [37]
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Tremblay, J. (2015) · Steroids · doi:10.1016/j.steroids.2015.08.001 · Cited by 198
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“Several non-finger omains of GATA2 have been described: two transactivation omains (TAD), located in the N- and C-terminal regions; nuclear localization signal (NLS); a negative regulatory omain (NRD); and regions that appear to be important for ts degradation [66,67].”
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Włodarski, M. W., Collin, M. P., & Horwitz, M. S. (2017) · Seminars in Hematology · doi:10.1053/j.seminhematol.2017.05.002 · Cited by 171
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“Introduction Transcription factor GATA4 has been implicated in the development and function of the mammalian testis (Viger et al., 2008).”
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How trophoblasts fuse: an in-depth look into placental syncytiotrophoblast formation
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Fletcher, P. A., Smiljanić, K., Prévide, R. M., Iben, J., Li, T., Rokic, M. B., Sherman, A., Coon, S. L., & Stojilković, S. S. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00623 · Cited by 101
“Gata2 is well-established to be critical in the development of T (together with Pou1f1) and G (without Pou1f1) (74).”
BackgroundInfluentialMutation update for the NR5A1 gene involved in DSD and infertility
Fabbri‐Scallet, H., de Sousa, L. M., Maciel‐Guerra, A. T., Guerra‐Júnior, G., & de Mello, M. P. (2019) · Human Mutation · doi:10.1002/humu.23916 · Cited by 98
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“…genes (e.g., Mis/Amh (Viger et al., 1998; Watanabe et al., 2000), Sf1 and aromatase (Cyp19a1) (Tremblay and Viger, 1999), Inha (Ketola et al., 1999), StAR (Nishida et al., 2008; Silverman et al., 2006) and Rhox5 (Bhardwaj et al., 2008); see (Lavoie and King, 2009; Viger et al., 2008) for review).”
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“Multiple signaling pathways also control GATA4 generation and activity in gonadal cells (reviewed in (176)).”
Taieb, J., Grynberg, M., Pierre, A., Arouche, N., Massart, P., Belville, C., Hesters, L., Frydman, R., Catteau-Jonard, S., Fanchin, R. R. F., et al. (2011) · Molecular Endocrinology · doi:10.1210/me.2010-0297 · Cited by 83
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Self-citationLung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition
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“Other candidates are GATA4 and GATA6, as they are expressed at high levels in Sertoli cells (Viger et al. 2008).”
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“In mice, in which GATA6 has been further studied, expression-based analyses suggest that GATA6 could play a role in very early pancreas specification [6–8].”
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“This transcription factor is mainly expressed in Sertoli and Leydig cells and has been implicated in the development and function of the mammalian testis, particularly in the regulation of gene expression and cell differentiation.(47,48) In the current study, 5-10% of the SCs in the transition region did not express G…”
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Kyrönlahti, A., Vetter, M., Euler, R., Bielińska, M., Jay, P. Y., Anttonen, M., Heikinheimo, M., & Wilson, D. B. (2011) · Biology of Reproduction · doi:10.1095/biolreprod.110.086850 · Cited by 63
Self-citationGATA4 Regulates Estrogen Receptor-α-Mediated Osteoblast Transcription
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“GATA4 plays a key role in normal granulosa cell function [23,24] and GCTs [25–27]; high GATA4 immunoreactivity denotes a more aggressive human GCT with increased recurrence risk [25].”
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Jia, W., Wu, W., Yang, D., Xiao, C., Huang, M., Long, F., Su, Z., Qin, M., Liu, X., & Zhu, Y. Z. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0570-5 · Cited by 61
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“GATA6, a marker of primitive endoderm, also widely expressed in endocrine tissues [37], was robustly expressed in placental/HLA-G+ cells (Fig.”
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“In the postnatal ovary, GATA4 and GATA6 are present in granulosa cells where they (directly or indirectly) regulate expression of numerous genes [2, 3].”
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Lee, A. W., Templeman, C. E., Stram, D. A., Beesley, J., Tyrer, J. P., Berchuck, A., Pharoah, P. D. P., Chenevix‐Trench, G., Pearce, C. L., Ness, R. B., et al. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.09.023 · Cited by 55
“In addition, rs1333052 lies within a binding site for GATA2, one of six factors that constitute the GATA family of transcriptional regulatory proteins which has been shown to play a role in ovarian function; it was identified by genome-wide ChIP-sequencing (30).”
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“The mouse and human ortholog of Gaf1, GATA6, is involved in differentiation, stem cell maintenance, and cancer (Viger et al., 2008; Wamaitha et al., 2015; Zhong et al., 2011).”
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“The GATA motifs, particularly GATA-1, -2, and -3, are involved in the regulation of hematopoiesis [39], suggesting this as a potential function altered by fadrozole exposure.”
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“GATA6 encodes a highly conserved zinc-finger transcription factor that recognizes and binds the (A/T)GATA(A/G) regulatory motif, two of which are located in the mouse Pdx1 and human PDX1 promoters (Carrasco et al., 2012; Lentjes et al., 2016; Patient and McGhee, 2002; Viger et al., 2008; Xuan et al., 2012).”
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“Expression of Gata6 is significantly depressed in most human adrenocortical tumors [46,47] and it has been hypothesized that decreased expression of Gata6 may be an important event for the escape of tumor cells from normal control mechanisms [48].”
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“GATA6 acts in synergy with SF1 and other transcription factors to enhance the expression of genes involved in adrenal steroid biosynthesis (20, 23).”
BackgroundSelf-citationGATA6 Is a Crucial Regulator of Shh in the Limb Bud
Kozhemyakina, E. A., Ionescu, A. M., & Lassar, A. B. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004072 · Cited by 50
“[51]), it seems plausible that both GATA4 and GATA6, which are”
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GATA4 Is a Key Regulator of Steroidogenesis and Glycolysis in Mouse Leydig Cells
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“In a variety of cell types, GATA4 is known for its involvement in cell fate decisions and it also appears to be involved in the process of cell migration (Molkentin, 2000; Viger et al., 2008).”
BackgroundSelf-citationDubé, C., Bergeron, F., Vaillant, M.-J., Robert, N. M., Brousseau, C., & Tremblay, J. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.10.008 · Cited by 49
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“These are intriguing findings, because the expression of AMH has been shown to be stimulated by GATA4 (20).”
BackgroundMurayama, C., Miyazaki, H., Miyamoto, A., & Shimizu, T. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.11.014 · Cited by 47
“The studies have reported that GATA-4 is essential for the gonadal function (Viger et al., 2008).”
SOX Genes and Their Role in Disorders of Sex Development
Sreenivasan, R., Gonen, N., & Sinclair, A. (2022) · Sexual Development · doi:10.1159/000524453 · Cited by 37
“An additional factor, GATA binding protein 4 (GATA4), interacts with SF-1 and zinc finger protein FOG family member 2 (FOG2/ZFPM2) to regulate the expression of SRY and SOX9 [Miyamoto et al., 2008; Viger et al., 2008].”
BackgroundGene Mutations Associated with Anomalies of Human Gonad Formation
Bashamboo, A., & McElreavey, K. (2012) · Sexual Development · doi:10.1159/000342188 · Cited by 45
“GATA4 cooperatively interacts with several proteins including NR5A1 to regulate the expression of critical genes known to be involved in testis determination and differentiation (SRY, SOX9, AMH, STAR, CYP19A1, INHA, HSD3B2) [Viger et al., 2008].”
BackgroundQin, F., Zhang, J., Zan, L., Guo, W., Wang, J., Chen, L., Cao, Y., Shen, O., & Tong, J. (2015) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2015.07.009 · Cited by 42
“Several studies have indicated that GATA-4 regulates the promoters of SF-1 (NR5A1) (Viger et al., 2008), StAR (Silverman et al., 2006), HSD17β1 (Piao et al., 1997), Cyp19 (Cai et al., 2007), human HSD3β1 (Peng et al., 2004), Cyp17 (Flück and Miller, 2004), and Cyp11A (Shih et al., 2011) (Tremblay and Viger, 2001).”
BackgroundGATA3 inhibits GCM1 activity and trophoblast cell invasion
Chiu, Y.-H., & Chen, H. (2016) · Scientific Reports · doi:10.1038/srep21630 · Cited by 43
de la Piscina, I. M., Mingo, C. D., Riedl, S., Rodriguez, A., Pandey, A. V., Fernández‐Cancio, M., Camats, N., Sinclair, A. H., Castaño, L. A., Audı́, L., et al. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00142 · Cited by 41
“Moreover, GATA4 functionally interacts with NR5A1 in Sertoli cell cultures to positively regulate the expression of AMH, and therefore, it has been reported that mutations in NR5A1 may cause 46,XY DSD due to lack of interaction with GATA (15).”
BackgroundBianco, S., Bellefleur, A., Beaulieu, É., Beauparlant, C. J., Bertolin, K., Droit, A., Schoonjans, K., Murphy, B. D., & Gévry, N. Y. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.088 · Cited by 42
Functional Cooperation Between GATA Factors and cJUN on the Star Promoter in MA‐10 Leydig Cells
Martin, L. J., Bergeron, F., Viger, R. S., & Tremblay, J. (2011) · Journal of Andrology · doi:10.2164/jandrol.110.012039 · Cited by 41
Self-citationThe Essential Role of GATA6 in the Activation of Estrogen Synthesis in Endometriosis
Bernardi, L. A., Dyson, M. T., Tokunaga, H., Sison, C., Oral, M., Robins, J. C., & Bulun, S. E. (2019) · Reproductive Sciences · doi:10.1177/1933719118756751 · Cited by 40
“The NR5A1 is a nuclear receptor important for sexual development and differentiation of steroidogenic tissues and has been established as a key factor regulating steroidogenesis.8,9 The NR5A1 is expressed in steroidogenic tissues, specifically the adrenal cortex and gonads,8 and coordinates the expression of multiple…”
BackgroundInfluentialRecent advances in senescence-associated secretory phenotype and osteoporosis
Fan, H., Qiao, Z., Li, J., Shang, G., Shang, C., Chen, S., Leng, Z., Su, H., Kou, H., & Liu, H. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e25538 · Cited by 42
“GATA factors are a set of transcription regulators that are ubiquitous in eukaryotic cells and regulate development and differentiation [48].”
BackgroundMolecular basis of crosstalk between oncogenic Ras and the master regulator of hematopoiesis GATA‐2
Katsumura, K. R., Yang, C., Boyer, M. E., Li, L., & Bresnick, E. H. (2014) · EMBO Reports · doi:10.15252/embr.201438808 · Cited by 38
“As GATA transcription factors control genetic networks in diverse contexts [1 – 3], and pathological GATA factor mutants have been described [4, 5], it is instructive to consider the consequences of such mutations.”
Wang, J., Wan, C. C., Shuju, Z., Yang, Z., Celi, P., Ding, X., Bai, S., Zeng, Q., Mao, X., Xu, S., et al. (2020) · Poultry Science · doi:10.1016/j.psj.2020.10.024 · Cited by 38
“(Viger et al., 2008), mediate the stimulatory effects of FSH on several ovarian genes (Lavoie, 2003), and increase StAR promoter activity (Gillio-Meina, 2002; Lavoie, 2003).”
BackgroundGenetic Mutations of Pancreatic Cancer and Genetically Engineered Mouse Models
Saiki, Y., Jiang, C., Ohmuraya, M., & Furukawa, T. (2021) · Cancers · doi:10.3390/cancers14010071 · Cited by 38
Taniguchi, H., Komiyama, J., Viger, R. S., & Okuda, K. (2009) · Molecular Reproduction and Development · doi:10.1002/mrd.21054 · Cited by 37
“A large number of in vitro studies have suggested that GATA4 is essential for the gonadal function (Viger et al., 2008).”
BackgroundInfluentialSelf-citationYorifuji, T., Kawakita, R., Hosokawa, Y., Fujimaru, R., Yamaguchi, E., & Tamagawa, N. (2012) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2012-101161 · Cited by 37
“GATA6 is a member of a GATA family of zinc-finger transcriptional regulators, which bind to the common WGATAR motif in the regulatory regions of many genes.(6) Although GATA6 is expressed during the embryogenesis of a variety of endodermally derived organs, including the heart, pancreas, ovary, lung, and liver, its mu…”
BackgroundGATA4 knockdown in MA-10 Leydig cells identifies multiple target genes in the steroidogenic pathway
Bergeron, F., Nadeau, G., & Viger, R. S. (2014) · Reproduction · doi:10.1530/rep-14-0369 · Cited by 36
“Following gonadal differentiation, GATA4 remains highly expressed in all gonadal somatic lineages of both sexes throughout ontogeny (reviewed in LaVoie (2003), Viger et al. (2004, 2008) and Zaytouni et al. (2011)).”
BackgroundInfluentialSelf-citationChen, H., Libertini, S. J., George, M. D., Dandekar, S., Tepper, C. G., Al-Bataina, B., Kung, H.-J., Ghosh, P., & Mudryj, M. M. (2010) · Endocrine Related Cancer · doi:10.1677/erc-10-0081 · Cited by 36
“GATA proteins have been proposed to play major roles in endocrine function and disease (Viger et al. 2008).”
BackgroundCurrent Knowledge on Endometriosis Etiology: A Systematic Review of Literature
Михалева, Л. М., Radzinsky, V. E., Orazov, M. R., Николаевна, Х. Т., Sorokina, A. V., Александрович, М. С., Владимировна, В. С., Shustova, V. B., & Sinelnikov, M. Y. (2021) · International Journal of Women s Health · doi:10.2147/ijwh.s306135 · Cited by 37
Notch signaling represses GATA4-induced expression of genes involved in steroid biosynthesis
George, R. M., Hahn, K. L., Rawls, A., Viger, R. S., & Wilson‐Rawls, J. (2015) · Reproduction · doi:10.1530/rep-15-0226 · Cited by 36
“Steroidogenesis genes have well-studied promoters that are transactivated by GATA4 (Tremblay & Viger 2001a,b, Tremblay et al. 2002, Viger et al. 2004, 2008, Bergeron et al. 2015, Schrade et al. 2015).”
Self-citationDaems, C., Di‐Luoffo, M., Paradis, E., & Tremblay, J. (2015) · Endocrinology · doi:10.1210/en.2014-1964 · Cited by 39
“Although 2 GATA factors (GATA4 and GATA6) have been identified in Leydig cells, GATA4 is the predominant member present in these cells (reviewed in Viger et al [47]).”
BackgroundCell Type-Specific Sexual Dimorphism in Rat Pituitary Gene Expression During Maturation1
Bjelobaba, I. M., Janjic, M. M., Kučka, M., & Stojilković, S. S. (2015) · Biology of Reproduction · doi:10.1095/biolreprod.115.129320 · Cited by 35
“The hormone-secreting anterior pituitary cells differentiate in a temporal- and spatial-specific fashion as three separate lineages under the influence of various transcriptional factors [20–22].”
BackgroundWatanabe, M., Yasuoka, Y., Mawaribuchi, S., Kuretani, A., Ito, M., Kondo, M., Ochi, H., Ogino, H., Fukui, A., Taira, M., et al. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.09.017 · Cited by 35
Deng, S., Zhang, Y., Yu, K., Wang, X., Chen, S., Han, D., Cheng, C. Y., Lian, Z., & Liu, Y. (2017) · Oncotarget · doi:10.18632/oncotarget.22855 · Cited by 32
“However, in steroidogenic cells, not all cAMP-regulated genes, such as StAR, have a consensus cAMP response element (CRE), but many of them have a regulatory sequence recognized by a GATA family transcription factor [69].”
BackgroundInfluentialGATA transcription factors regulate LHβ gene expression
Lo, A., Zheng, W., Gong, Y., Crochet, J. R., & Halvorson, L. M. (2011) · Journal of Molecular Endocrinology · doi:10.1530/jme-10-0137 · Cited by 34
Koster, R., Mitra, N., D'Andrea, K. P., Vardhanabhuti, S., Chung, C. C., Wang, Z., Erickson, R. L., Vaughn, D. J., Litchfield, K., Rahman, N., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu305 · Cited by 33
GATA4 protects granulosa cell tumors from TRAIL-induced apoptosis
Kyrönlahti, A., Kauppinen, M., Lind, E., Unkila‐Kallio, L., Bützow, R. C., Klefström, J. T., Wilson, D. B., Anttonen, M., & Heikinheimo, M. (2010) · Endocrine Related Cancer · doi:10.1677/erc-10-0041 · Cited by 33
“Recently, GATA4 has emerged as an important factor in the development and function of endocrine tissues (Viger et al. 2008).”
BackgroundSelf-citationGenetic regulation of RNA splicing in human pancreatic islets
Atla, G., Bonàs‐Guarch, S., Cuenca-Ardura, M., Beucher, A., Crouch, D. J. M., García-Hurtado, J., Morán, I., Cnop, M., Eliasson, L., Esguerra, J. L. S., et al. (2022) · Genome biology · doi:10.1186/s13059-022-02757-0 · Cited by 31
Adrenal Development in Mice Requires GATA4 and GATA6 Transcription Factors
Tevosian, S. G., Jiménez, E., Hatch, H. M., Jiang, T., Morse, D. A., Fox, S. C., & Padua, M. B. (2015) · Endocrinology · doi:10.1210/en.2014-1815 · Cited by 39
Wu, C., Wei, K., Chou, J., Lu, C., Hsieh, C., Lin, J. M. J., Deng, Y.-F., Hsu, W.-T., Wang, H.-M., Leung, C., et al. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17091467 · Cited by 31
“In humans, GATA1/2/3 are expressed in hematopoietic cells, whereas GATA4/5/6 are expressed in the cardiovascular system and endoderm-derived tissue, including the liver, lung, and pancreas [7].”
BackgroundTransgenic mouse models in the study of reproduction: insights into GATA protein function
Tevosian, S. G. (2014) · Reproduction · doi:10.1530/rep-14-0086 · Cited by 30
“In the postnatal ovaries, GATA4 is abundantly expressed in the granulosa cells of primary, preantral, and antral follicles as well as in endocrine theca cells, but not in primordial follicles or luteal cells (Viger et al. 2008).”
BackgroundFunctions of PIT1 in GATA2-dependent transactivation of the thyrotropin β promoter
Kashiwabara, Y., Sasaki, S., Matsushita, A., Nagayama, K., Ohba, K., Iwaki, H., Matsunaga, H., Suzuki, S., Misawa, H., Ishizuka, K., et al. (2008) · Journal of Molecular Endocrinology · doi:10.1677/jme-08-0099 · Cited by 31
“The Zn finger domain of GATA2 (GATA2-Zf) has high homology with that of GATA1 and 3, while the amino acid sequences of N- and C-terminal regions show diversity (Viger et al. 2008).”
BackgroundThurisch, B., Liang, S. Y., Sarioglu, N. M. E., Schomburg, L., Bungert, J., & Dame, C. (2009) · Journal of Molecular Endocrinology · doi:10.1677/jme-09-0030 · Cited by 30
“Although various putative GATA4 target genes have been identified in the testis and ovary by means of in vitro studies (for review see (Viger et al. 2008)), to our knowledge no in vivo genetic model is currently available that elucidates GATA4 function in the ovary.”
BackgroundHu, S., Yang, S., Lu, Y., Deng, Y., Li, L., Zhu, J., Zhang, Y., Hu, B., Hu, J., Xia, L., et al. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00196 · Cited by 29
Eisermann, K., Tandon, S., Bazarov, A., Brett, A., Fraizer, G. C., & Piontkivska, H. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-337 · Cited by 29
“bind the WGATAR consensus motif and are expressed in multiple tissues, including endocrine glands [50-52].”
BackgroundYau, D., Franco, E. D., Flanagan, S. E., Ellard, S., Blumenkrantz, M., & Mitchell, J. J. (2017) · Diagnostic Pathology · doi:10.1186/s13000-016-0592-1 · Cited by 28
“GATA6 is one of a family of evolutionarily conserved transcription factors recognizing the A/T-GATA-A/G consensus sequence, with key roles in the development and differentiation of multiple cell lineages and tissues [17, 18].”
BackgroundKouri, C., Sommer, G., & Flück, C. E. (2021) · Hormone Research in Paediatrics · doi:10.1159/000519691 · Cited by 29
“It interacts with several proteins including ZFPM2, SF-1, and WT1 to regulate the expression of sex determining genes SRY, SOX9, and AMH, as well as genes involved in sex differentiation including STAR, CYP17A1, CYP19A1, INHA, and HSD3B2 [38–42].”
BackgroundInfluentialGATA4 regulates osteoblastic differentiation and bone remodeling via p38-mediated signaling
Zhou, T., Guo, S., Zhang, Y., Weng, Y., Wang, L. Q., & Ma, J. (2017) · Journal of Molecular Histology · doi:10.1007/s10735-017-9719-2 · Cited by 28
“GATA4, a transcription factor, has been reported to regulate transcription in many organs (Mazaud et al. 2007; Molkentin et al. 1998; Viger et al. 2008).”
BackgroundGATA6+ Peritoneal Resident Macrophage: The Immune Custodian in the Peritoneal Cavity
Jayakumar, P., Laganson, A., & Deng, M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.866993 · Cited by 29
Metadata
- Authors
- Viger, R. S., Guittot, S. M., Anttonen, M., Wilson, D. B., & Heikinheimo, M.
- Affiliations
- Centre hospitalier universitaire de Québec (CA)
- Ontogeny-Reproduction Research Unit (R.S.V., S.M.G.), CHUQ Research Centre, Quebec City, Canada G1V 4G2
- Department of Obstetrics and Gynecology and Women’s Health Research Program (M.A.), FI-00014 Helsinki, Finland
- St. Louis Children's Hospital (US)
- Corresponding author
- Viger, Robert S
- Heikinheimo, Markku
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2008-04-01
- Volume
- 22
- Issue
- 4
- Pages
- 781-798
- ISSN
- 0888-8809 (ISSN-L)
- 1944-9917
- PMC
- PMC2276466
- OpenAlex
- W2013216633
- Cited by
- 270
- References
- 235
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 12 · 2023: 10 · 2022: 15 · 2021: 21 · 2020: 12 · 2019: 15 · 2018: 12 · 2017: 11 · 2016: 19 · 2015: 21 · 2014: 24 · 2013: 13 · 2012: 16
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Molecular Endocrinology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Helsingin Yliopisto
- Turun Yliopisto
- National Institutes of Health
- Canadian Institutes of Health Research
- National Institute of Diabetes and Digestive and Kidney Diseases (DK075618, R01DK075618)
- Institute of Gender and Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- GATA transcription factors, GATA-1, GATA2, GATA3, GATA4, GATA5, GATA6, endocrine development, endocrine function, gonads, pituitary gland, pancreas, adrenal gland, tissue-specific knockout mice
- MeSH terms
- Animals, Endocrine System Diseases, Endocrine System, Humans, Models, Biological, Transcription, Genetic, Protein Isoforms, GATA Transcription Factors
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