The DOI matches its Crossref record; 227 of the 235 references it cites were found in a registry or an index.
Role of the GATA Family of Transcription Factors in Endocrine Development, Function, and Disease
Open accessAbstract
The WGATAR motif is a common nucleotide sequence found in the transcriptional regulatory regions of numerous genes. In vertebrates, these motifs are bound by one of six factors (GATA1 to GATA6) that constitute the GATA family of transcriptional regulatory proteins. Although originally considered for their roles in hematopoietic cells and the heart, GATA factors are now known to be expressed in a wide variety of tissues where they act as critical regulators of cell-specific gene expression. This includes multiple endocrine organs such as the pituitary, pancreas, adrenals, and especially the gonads. Insights into the functional roles played by GATA factors in adult organ systems have been hampered by the early embryonic lethality associated with the different Gata-null mice. This is now being overcome with the generation of tissue-specific knockout models and other knockdown strategies. These approaches, together with the increasing number of human GATA-related pathologies have greatly broadened the scope of GATA-dependent genes and, importantly, have shown that GATA action is not necessarily limited to early development. This has been particularly evident in endocrine organs where GATA factors appear to contribute to the transcription of multiple hormone-encoding genes. This review provides an overview of the GATA family of transcription factors as they relate to endocrine function and disease.
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“GATA4 is a zinc finger transcription factor essential for the development of various organs, including heart, testis, foregut, liver, and ventral pancreas (37).”
From The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. (2015) · cites this paper as [37]
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Cites
Initial and cyclic recruitment of ovarian follicles
McGee, E. A., & Hsueh, A. J. W. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.2.0394 · Cited by 1,771
An early haematopoietic defect in mice lacking the transcription factor GATA-2
Tsai, F., Keller, G. M., Kuo, F. C., Weiss, M. J., Chen, J., Rosenblatt, M., Alt, F. W., & Orkin, S. H. (1994) · Nature · doi:10.1038/371221a0 · Cited by 1,447
Pevny, L., Simon, M. C., Robertson, E., Klein, W. H., Tsai, S.-F., D'Agati, V., Orkin, S. H., & Costantini, F. (1991) · Nature · doi:10.1038/349257a0 · Cited by 1,308
GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5
Garg, V., Kathiriya, I. S., Barnes, R., Schluterman, M. K., King, I. N., Butler, C. A., Rothrock, C. R., Eapen, R. S., Hirayama‐Yamada, K., Joo, K., et al. (2003) · Nature · doi:10.1038/nature01827 · Cited by 1,236
Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.Preprint
Molkentin, J. D., Lin, Q., Duncan, S. A., & Olson, E. N. (1997) · Genes & Development · doi:10.1101/gad.11.8.1061 · Cited by 1,137
GATA4 transcription factor is required for ventral morphogenesis and heart tube formation.Preprint
Kuo, C. T., Morrisey, E. E., Anandappa, R. T., Sigrist, K. S., Lu, M. M., Parmacek, M. S., Soudais, C., & Leiden, J. M. (1997) · Genes & Development · doi:10.1101/gad.11.8.1048 · Cited by 1,029
The Zinc Finger-containing Transcription Factors GATA-4, -5, and -6
Molkentin, J. D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.r000029200 · Cited by 880
Tsang, A. P., Visvader, J. E., Turner, C. A., Fujiwara, Y., Yu, C., Weiss, M. J., Crossley, M., & Orkin, S. H. (1997) · Cell · doi:10.1016/s0092-8674(00)80318-9 · Cited by 712
Achermann, J. C., Ito, M., Ito, M., Hindmarsh, P. C., & Jameson, J. L. (1999) · Nature Genetics · doi:10.1038/9629 · Cited by 709
Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis
Siciński, P., Donaher, J. L., Geng, Y., Parker, S. B., Gardner, H., Park, M. Y., Robker, R. L., Richards, J. S., McGinnis, L. K., Biggers, J. D., et al. (1996) · Nature · doi:10.1038/384470a0 · Cited by 697
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The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
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Decreased expression of synapse-related genes and loss of synapses in major depressive disorder
Kang, H. J., Voleti, B., Hajszan, T., Rajkowska, G., Stockmeier, C. A., Licznerski, P., Lepack, A., Majik, M. S., Jeong, L. S., Banasr, M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2886 · Cited by 808
The Emerging Field of Human Social Genomics
Slavich, G. M., & Cole, S. W. (2013) · Clinical Psychological Science · doi:10.1177/2167702613478594 · Cited by 523
Volkmar, M., Dedeurwaerder, S., Cunha, D. A., Ndlovu, M. N., Defrance, M., Deplus, R., Calonne, E., Volkmar, U., Igoillo‐Esteve, M., Naamane, N., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2011.503 · Cited by 420
“Interestingly, the GATA transcription factor family members are critical regulators in endocrine development, function and pathologies (Viger et al , 2008).”
Anjali, Kumar, S., Korra, T., Thakur, R., Arutselvan, R., Kashyap, A. S., Nehela, Y., Chaplygin, V. A., Minkina, T., & Keswani, C. (2023) · Plant Stress · doi:10.1016/j.stress.2023.100154 · Cited by 390
Metadata
- Authors
- Viger, R. S., Guittot, S. M., Anttonen, M., Wilson, D. B., & Heikinheimo, M.
- Affiliations
- Centre hospitalier universitaire de Québec (CA)
- Ontogeny-Reproduction Research Unit (R.S.V., S.M.G.), CHUQ Research Centre, Quebec City, Canada G1V 4G2
- Department of Obstetrics and Gynecology and Women’s Health Research Program (M.A.), FI-00014 Helsinki, Finland
- St. Louis Children's Hospital (US)
- Corresponding author
- Viger, Robert S
- Heikinheimo, Markku
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2008-04-01
- Volume
- 22
- Issue
- 4
- Pages
- 781-798
- ISSN
- 0888-8809 (ISSN-L)
- 1944-9917
- PMC
- PMC2276466
- OpenAlex
- W2013216633
- Cited by
- 270
- References
- 235
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 12 · 2023: 10 · 2022: 15 · 2021: 21 · 2020: 12 · 2019: 15 · 2018: 12 · 2017: 11 · 2016: 19 · 2015: 21 · 2014: 24 · 2013: 13 · 2012: 16
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Molecular Endocrinology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Helsingin Yliopisto
- Turun Yliopisto
- National Institutes of Health
- Canadian Institutes of Health Research
- National Institute of Diabetes and Digestive and Kidney Diseases (DK075618, R01DK075618)
- Institute of Gender and Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- GATA transcription factors, GATA-1, GATA2, GATA3, GATA4, GATA5, GATA6, endocrine development, endocrine function, gonads, pituitary gland, pancreas, adrenal gland, tissue-specific knockout mice
- MeSH terms
- Animals, Endocrine System Diseases, Endocrine System, Humans, Models, Biological, Transcription, Genetic, Protein Isoforms, GATA Transcription Factors
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