Cited by 270Genomics and Chromatin DynamicsDevelopmental Biology and Gene RegulationEstrogen and related hormone effects

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Role of the GATA Family of Transcription Factors in Endocrine Development, Function, and Disease

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Viger, Robert S, Guittot, Séverine Mazaud, Anttonen, Mikko, Wilson, David B, Heikinheimo, Markku·2008·Molecular Endocrinology

DOI 10.1210/me.2007-0513PMC PMC2276466

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Abstract

The WGATAR motif is a common nucleotide sequence found in the transcriptional regulatory regions of numerous genes. In vertebrates, these motifs are bound by one of six factors (GATA1 to GATA6) that constitute the GATA family of transcriptional regulatory proteins. Although originally considered for their roles in hematopoietic cells and the heart, GATA factors are now known to be expressed in a wide variety of tissues where they act as critical regulators of cell-specific gene expression. This includes multiple endocrine organs such as the pituitary, pancreas, adrenals, and especially the gonads. Insights into the functional roles played by GATA factors in adult organ systems have been hampered by the early embryonic lethality associated with the different Gata-null mice. This is now being overcome with the generation of tissue-specific knockout models and other knockdown strategies. These approaches, together with the increasing number of human GATA-related pathologies have greatly broadened the scope of GATA-dependent genes and, importantly, have shown that GATA action is not necessarily limited to early development. This has been particularly evident in endocrine organs where GATA factors appear to contribute to the transcription of multiple hormone-encoding genes. This review provides an overview of the GATA family of transcription factors as they relate to endocrine function and disease.

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The Effect of a Sertoli Cell-Selective Knockout of the Androgen Receptor on Testicular Gene Expression in Prepubertal Mice
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Functional interaction of GATA1 with erythroid Kruppel-like factor and Sp1 at defined erythroid promoters
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GATA factor activity is required for the trophoblast-specific transcriptional regulation of the mouse placental lactogen I gene
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The molecular signature of polycystic ovary syndrome (PCOS) theca cells defined by gene expression profiling
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Abnormalities of the Genitourinary Tract in Female Mice Lacking GATA5
Molkentin, J. D., Tymitz, K. M., Richardson, J. A., & Olson, E. N. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.14.5256-5260.2000 · Cited by 128
GATA-4 and GATA-6 modulate tissue-specific transcription of the human gene for P450c17 by direct interaction with Sp1
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Transcription Factors GATA-4 and GATA-6 and a GATA Family Cofactor, FOG-2, Are Expressed in Human Ovary and Sex Cord-Derived Ovarian Tumors
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Expression Profiles for Steroidogenic Enzymes in Adrenocortical Disease
Bassett, M. H., Mayhew, B. A., Rehman, K. S., White, P. C., Mantero, F., Arnaldi, G., Stewart, P. M., Bujalska, I. J., & Rainey, W. E. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0836 · Cited by 125
Protein-Protein Interaction between Fli-1 and GATA-1 Mediates Synergistic Expression of Megakaryocyte-Specific Genes through Cooperative DNA Binding
Eisbacher, M., Holmes, M. L., Newton, A., Hogg, P. J., Khachigian, L. M., Crossley, M., & Chong, B. H. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.10.3427-3441.2003 · Cited by 125
Gata6 is an important regulator of mouse pancreas development.
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Acetylation of GATA‐3 affects T‐cell survival and homing to secondary lymphoid organs
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Novel Combinatorial Interactions of GATA-1, PU.1, and C/EBPε Isoforms Regulate Transcription of the Gene Encoding Eosinophil Granule Major Basic Protein
Du, J., Stankiewicz, M. J., Liu, Y., Xi, Q., Schmitz, J. E., Lekstrom-Himes, J. A., & Ackerman, S. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204777200 · Cited by 120
A Functionally Conserved N-terminal Domain of the Friend of GATA-2 (FOG-2) Protein Represses GATA4-Dependent Transcription
Svensson, E. C., Huggins, G. S., Dardik, F. B., Polk, C. E., & Leiden, J. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001522200 · Cited by 119
Expression of Transcription Factor GATA-4 during Human Testicular Development and Disease
Ketola, I., Pentikäinen, V., Vaskivuo, T. E., Ilvesmäki, V., Herva, R., Dunkel, L., Tapanainen, J. S., Toppari, J., & Heikinheimo, M. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.10.6900 · Cited by 119
Hepatocyte Growth Factor Induces GATA-4 Phosphorylation and Cell Survival in Cardiac Muscle Cells
Kitta, K., Day, R. M., Kim, Y., Torregroza, I., Evans, T., & Suzuki, Y. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211616200 · Cited by 118
Transcription factor GATA4 regulates cardiac BCL2 gene expression in vitro and in vivo
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GATA-6 Induces p21Cip1 Expression and G1Cell Cycle Arrest
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Protein Kinase A-Dependent Cooperation between GATA and CCAAT/Enhancer-Binding Protein Transcription Factors Regulates Steroidogenic Acute Regulatory Protein Promoter Activity
Tremblay, J., Hamel, F., & Viger, R. S. (2002) · Endocrinology · doi:10.1210/en.2002-220413 · Cited by 114
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Differential activation of intestinal gene promoters: functional interactions between GATA-5 and HNF-1α
Krasinski, S. D., van Wering, H. M., Tannemaat, M. R., & Grand, R. J. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.1.g69 · Cited by 114
Small Ubiquitin-Like Modifier 1 (SUMO-1) Modification of the Synergy Control Motif of Ad4 Binding Protein/Steroidogenic Factor 1 (Ad4BP/SF-1) Regulates Synergistic Transcription between Ad4BP/SF-1 and Sox9
Komatsu, T., Mizusaki, H., Mukai, T., Ogawa, H., Baba, D., Shirakawa, M., Hatakeyama, S., Nakayama, K. I., Yamamoto, H., Kikuchi, A., et al. (2004) · Molecular Endocrinology · doi:10.1210/me.2004-0173 · Cited by 113
Embryonic expression of the human GATA-3 gene
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Developmentally regulated expression of adrenal 17 alpha-hydroxylase cytochrome P450 in the mouse embryo
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Regulation of eosinophil‐specific gene expression by a C/EBP–Ets complex and GATA‐1
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Histone modifications silence the GATA transcription factor genes in ovarian cancer
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GATA-6 is expressed in the human adrenal and regulates transcription of genes required for adrenal androgen biosynthesis
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Phosphorylation of the erythroid transcription factor GATA-1
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Rho/ROCK Pathway Contributes to the Activation of Extracellular Signal-regulated Kinase/GATA-4 during Myocardial Cell Hypertrophy
Yanazume, T., Hasegawa, K., Wada, H., Morimoto, T., Abe, M., Kawamura, T., & Sasayama, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107924200 · Cited by 106
Acetylation and MAPK phosphorylation cooperate to regulate the degradation of active GATA‐1
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Steroidogenic Factor-1 Influences Protein-Deoxyribonucleic Acid Interactions within the Cyclic Adenosine 3',5'-Monophosphate-Responsive Regions of the Murine Steroidogenic Acute Regulatory Protein Gene
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GATA-6 Activates Transcription of Thyroid Transcription Factor-1
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Phosphorylation of GATA2 by Akt Increases Adipose Tissue Differentiation and Reduces Adipose Tissue–Related Inflammation
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Mitogen-activated Protein Kinases p38 and ERK 1/2 Mediate the Wall Stress-induced Activation of GATA-4 Binding in Adult Heart
Tenhunen, O., Sármán, B., Kerkelä, R., Szokodi, I., Papp, L., Tóth, M., & Ruskoaho, H. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314317200 · Cited by 103
Genetic analysis of adrenal absence: agenesis and aplasia
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Temporal and Spatial Changes in Transcription Factor Binding and Histone Modifications at the Steroidogenic Acute Regulatory Protein (StAR) Locus Associated withStARTranscription
Hiroi, H., Christenson, L. K., Chang, L., Sammel, M. D., Berger, S. L., & Strauss, J. F. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0305 · Cited by 103
Functional regulation of GATA-2 by acetylation
Hayakawa, F., Towatari, M., Ozawa, Y., Tomita, A., Privalsky, M. L., & Saito, H. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603389 · Cited by 103
SUMO-1 Modification Activated GATA4-dependent Cardiogenic Gene Activity
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hFOG-2, a Novel Zinc Finger Protein, Binds the Co-repressor mCtBP2 and Modulates GATA-mediated Activation
Holmes, M. L., Turner, J. J. O., Fox, A. H., Chisholm, O., Crossley, M., & Chong, B. H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.33.23491 · Cited by 102
Correct dosage of Fog2 and Gata4 transcription factors is critical for fetal testis development in mice
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Gonadectomy-induced Adrenocortical Neoplasia in the Domestic Ferret ( Mustela putorius furo ) and Laboratory Mouse
Bielińska, M., Kiiveri, S., Parviainen, H., Mannisto, S., Heikinheimo, M., & Wilson, D. B. (2006) · Veterinary Pathology · doi:10.1354/vp.43-2-97 · Cited by 102
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Gonadectomy permits adrenocortical tumorigenesis in mice transgenic for the mouse inhibin alpha-subunit promoter/simian virus 40 T-antigen fusion gene: evidence for negative autoregulation of the inhibin alpha- subunit gene
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Regulation of GATA-2 Phosphorylation by Mitogen-activated Protein Kinase and Interleukin-3
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Physical and Functional Interaction between GATA-3 and Smad3 Allows TGF-β Regulation of GATA Target Genes
Blokzijl, A., ten Dijke, P., & Ibáñez, C. F. (2002) · Current Biology · doi:10.1016/s0960-9822(01)00623-6 · Cited by 101
FOG-2 and GATA-4 Are Coexpressed in the Mouse Ovary and Can Modulate Mullerian-Inhibiting Substance Expression1
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Transcription factor GATA-6 is expressed in the endocrine and GATA-4 in the exocrine pancreas.
Ketola, I., Otonkoski, T., Pulkkinen, M.-A., Niemi, H., Palgi, J., Jacobsen, C., Wilson, D., & Heikinheimo, M. (2004) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2004.06.007 · Cited by 100
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Transcription Factor GATA-4 Is Activated by Phosphorylation of Serine 261 via the cAMP/Protein Kinase A Signaling Pathway in Gonadal Cells
Tremblay, J., & Viger, R. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m213149200 · Cited by 98
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Novel roles for GATA transcription factors in the regulation of steroidogenesis
Tremblay, J., & Viger, R. S. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00211-5 · Cited by 95
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Reciprocal Changes in the Expression of Transcription Factors GATA-4 and GATA-6 Accompany Adrenocortical Tumorigenesis in Mice and Humans
Kiiveri, S., Siltanen, S., Rahman, N. A., Bielińska, M., Lehto, V., Huhtaniemi, I. T., Muglia, L. J., Wilson, D. B., & Heikinheimo, M. (1999) · Molecular Medicine · doi:10.1007/bf03403542 · Cited by 88
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Anomalous expression of epithelial differentiation-determining GATA factors in ovarian tumorigenesis.
Capo‐chichi, C. D., Roland, I. H., Vanderveer, L., Bao, R., Yamagata, T., Hirai, H., Cohen, C., Hamilton, T. C., Godwin, A. K., & Xu, X. (2003) · PubMed · Cited by 87
GATA Factors and the Nuclear Receptors, Steroidogenic Factor 1/Liver Receptor Homolog 1, Are Key Mutual Partners in the Regulation of the Human 3β-Hydroxysteroid Dehydrogenase Type 2 Promoter
Martin, L. J., Taniguchi, H., Robert, N. M., Simard, J., Tremblay, J., & Viger, R. S. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0257 · Cited by 84
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Differential Expression of GATA-4 and GATA-6 in Fetal and Adult Mouse and Human Adrenal Tissue
Kiiveri, S., Liu, J., Westerholm‐Ormio, M., Narita, N., Wilson, D. B., Voutilainen, R., & Heikinheimo, M. (2002) · Endocrinology · doi:10.1210/endo.143.8.8939 · Cited by 84
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Survival of Human Ovarian Follicles from Fetal to Adult Life: Apoptosis, Apoptosis-Related Proteins, and Transcription Factor GATA-4
Vaskivuo, T. E. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.7.3421 · Cited by 84
Androgens and Postmeiotic Germ Cells Regulate Claudin-11 Expression in Rat Sertoli Cells
Florin, A., Maire, M., Bözec, A., Hellani, A. A., Chater, S., Bars, R., Chuzel, F., & Benahmed, M. (2005) · Endocrinology · doi:10.1210/en.2004-0834 · Cited by 83
Signalling pathways in the molecular pathogenesis of ovarian granulosa cell tumours
Fuller, P. J., & Chu, S. (2004) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2004.02.005 · Cited by 80
GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo
Zhang, Y., Rath, N., Hannenhalli, S. S., Wang, Z., Cappola, T. P., Kimura, S., Atochina‐Vasserman, E. N., Lu, M. M., Beers, M. F., & Morrisey, E. E. (2006) · Development · doi:10.1242/dev.02720 · Cited by 80
A Naturally Occurring Steroidogenic Factor-1 Mutation Exhibits Differential Binding and Activation of Target Genes
Ito, M., Achermann, J. C., & Jameson, J. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002892200 · Cited by 80
Stromal Cells of the Human Postmenopausal Ovary Display a Distinctive Biochemical and Molecular Phenotype
Jabara, S. I., Christenson, L. K., Wang, C. Y., McAllister, J. M., Javitt, N. B., Dunaif, A. E., & Strauss, J. F. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021274 · Cited by 79
Mouse Strain Susceptibility to Gonadectomy-Induced Adrenocortical Tumor Formation Correlates with the Expression of GATA-4 and Luteinizing Hormone Receptor
Bielińska, M., Parviainen, H., Porter-Tinge, S. B., Kiiveri, S., Genova, E. C., Rahman, N. A., Huhtaniemi, I. T., Muglia, L. J., Heikinheimo, M., & Wilson, D. B. (2003) · Endocrinology · doi:10.1210/en.2003-0126 · Cited by 79
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Friend of GATA (FOG)-1 and FOG-2 Differentially Repress the GATA-Dependent Activity of Multiple Gonadal Promoters
Robert, N. M., Tremblay, J., & Viger, R. S. (2002) · Endocrinology · doi:10.1210/en.2002-220280 · Cited by 78
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Developmental expression and spermatogenic stage specificity of transcription factors GATA-1 and GATA-4 and their cofactors FOG-1 and FOG-2 in the mouse testis
Ketola, I., Anttonen, M., Vaskivuo, T. E., Tapanainen, J. S., Toppari, J., & Heikinheimo, M. (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1470397 · Cited by 78
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Dynamics of Ovarian Development in the FORKO Immature Mouse: Structural and Functional Implications for Ovarian Reserve
Balla, A. (2003) · Biology of Reproduction · doi:10.1095/biolreprod.103.015552 · Cited by 77
Modification of GATA-2 Transcriptional Activity in Endothelial Cells by the SUMO E3 Ligase PIASy
Chun, T., Itoh, H., Subramanian, L., Iñiguez-Lluhı́, J. A., & Nakao, K. (2003) · Circulation Research · doi:10.1161/01.res.0000076893.70898.36 · Cited by 76
In Vivo Regulation of Grp78/BiP Transcription in the Embryonic Heart
Mao, C., Tai, W.-C., Bai, Y. Q., Poizat, C. I., & Lee, A. S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m505784200 · Cited by 75
GATA-4 and GATA-6 Transcription Factors: Expression, Immunohistochemical Localization, and Possible Function in the Porcine Ovary1
Gillio‐Meina, C., Hui, Y. Y., & LaVoie, H. A. (2003) · Biology of Reproduction · doi:10.1095/biolreprod.102.009092 · Cited by 74
Activation of GATA-4 by Serotonin in Pulmonary Artery Smooth Muscle Cells
Suzuki, Y., Day, R. M., Tan, C. C., Sandven, T. H., Liang, Q., Molkentin, J. D., & Fanburg, B. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210465200 · Cited by 71
Modulation of Endogenous GATA-4 Activity Reveals Its Dual Contribution to Mullerian Inhibiting Substance Gene Transcription in Sertoli Cells
Tremblay, J., Robert, N. M., & Viger, R. S. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.9.0692 · Cited by 71
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Transcriptional Regulation of the Cholesterol Side Chain Cleavage Cytochrome P450 Gene (CYP11A1) Revisited: Binding of GATA, Cyclic Adenosine 3′,5′-Monophosphate Response Element-Binding Protein and Activating Protein (AP)-1 Proteins to a Distal Novel Cluster ofcis-Regulatory Elements Potentiates AP-2 and Steroidogenic Factor-1-Dependent Gene Expression in the Rodent Placenta and Ovary
Sher, N., Yivgi-Ohana, N., & Orly, J. (2007) · Molecular Endocrinology · doi:10.1210/me.2006-0226 · Cited by 71
GATA‐4 is required for sex steroidogenic cell development in the fetal mouse
Bielińska, M., Seehra, A., Toppari, J., Heikinheimo, M., & Wilson, D. B. (2006) · Developmental Dynamics · doi:10.1002/dvdy.21004 · Cited by 70
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High GATA-4 Expression Associates with Aggressive Behavior, whereas Low Anti-Müllerian Hormone Expression Associates with Growth Potential of Ovarian Granulosa Cell Tumors
Anttonen, M., Unkila‐Kallio, L., Leminen, A., Bützow, R. C., & Heikinheimo, M. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0921 · Cited by 70
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Comparison of Serous and Mucinous Ovarian Carcinomas: Distinct Pattern of Allelic Loss at Distal 8p and Expression of Transcription Factor GATA-4
Lassus, H. J., Laitinen, M., Anttonen, M., Heikinheimo, M., Aaltonen, L. A., Ritvos, O., & Bützow, R. C. (2001) · Laboratory Investigation · doi:10.1038/labinvest.3780260 · Cited by 69
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Convergence of Protein Kinase C and JAK-STAT Signaling on Transcription Factor GATA-4
Wang, J., Paradis, P., Aries, A., Komati, H., Lefèbvre, C., Wang, H., & Nemer, M. J. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.22.9829-9844.2005 · Cited by 68
Modification of the erythroid transcription factor GATA-1 by SUMO-1
Collavin, L., Gostissa, M., Avolio, F., Secco, P., Ronchi, A. E., Santoro, C., & Sal, G. D. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308605101 · Cited by 68
A tissue-specific knockout reveals that Gata1 is not essential for Sertoli cell function in the mouse
Lindeboom, F. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg723 · Cited by 67
Temporal and Spatial Localization Patterns of Gata4 During Porcine Gonadogenesis1
McCoard, S. A., Wise, T. H., Fahrenkrug, S. C., & Ford, J. J. (2001) · Biology of Reproduction · doi:10.1095/biolreprod65.2.366 · Cited by 66
A Mutated Form of Steroidogenic Factor 1 (SF-1 G35E) That Causes Sex Reversal in Humans Fails to Synergize with Transcription Factor GATA-4
Tremblay, J., & Viger, R. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305485200 · Cited by 65
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Functional Analysis of a Novel GATA3 Mutation in a Family with the Hypoparathyroidism, Deafness, and Renal Dysplasia Syndrome
Zahirieh, A., Nesbit, M. A., Ali, A., Wang, K., He, N., Stangou, M. J., Bamichas, G., SOMBOLOS, K. I., Thakker, R. V., & Pei, Y. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1969 · Cited by 64
Transcriptional activation of the steroidogenic acute regulatory protein (StAR) gene: GATA-4 and CCAAT/enhancer-binding protein β confer synergistic responsiveness in hormone-treated rat granulosa and HEK293 cell models
Silverman, E., Yivgi-Ohana, N., Sher, N., Bell, M., Eimerl, S., & Orly, J. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.03.008 · Cited by 64
Follicle-Stimulating Hormone-Induced Activation of Gata4 Contributes in the Up-Regulation of Cyp19 Expression in Rat Granulosa Cells
Kwintkiewicz, J., Cai, Z., & Stocco, C. O. (2007) · Molecular Endocrinology · doi:10.1210/me.2006-0446 · Cited by 64
Partially overlapping expression of Gata2 and Gata3 during inner ear development
Lilleväli, K., Matilainen, T., Karis, A., & Salminen, M. (2004) · Developmental Dynamics · doi:10.1002/dvdy.20185 · Cited by 62
The regulation of Sox9 gene expression by the GATA4/FOG2 transcriptional complex in dominant XX sex reversal mouse models
Manuylov, N. L., Fujiwara, Y., Adameyko, I. I., Poulat, F., & Tevosian, S. G. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.04.040 · Cited by 62
Gata4 Regulates Testis Expression of Dmrt1
Lei, N., & Heckert, L. L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.24.1.377-388.2004 · Cited by 62
Protein Kinase A-Dependent Synergism between GATA Factors and the Nuclear Receptor, Liver Receptor Homolog-1, Regulates Human Aromatase (CYP19) PII Promoter Activity in Breast Cancer Cells
Bouchard, M. F., Taniguchi, H., & Viger, R. S. (2005) · Endocrinology · doi:10.1210/en.2005-0187 · Cited by 62
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GATA-1 and GATA-4 Transactivate Inhibin/Activin -B-Subunit Gene Transcription in Testicular Cells
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Steroid Sulfotransferase 2A1 Gene Transcription Is Regulated by Steroidogenic Factor 1 and GATA-6 in the Human Adrenal
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“Interestingly, the GATA transcription factor family members are critical regulators in endocrine development, function and pathologies (Viger et al , 2008).”
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Authors: Viger, R. S., Guittot, S. M., Anttonen, M., Wilson, D. B., & Heikinheimo, M.
Affiliations: Centre hospitalier universitaire de Québec (CA)
Ontogeny-Reproduction Research Unit (R.S.V., S.M.G.), CHUQ Research Centre, Quebec City, Canada G1V 4G2
Department of Obstetrics and Gynecology and Women’s Health Research Program (M.A.), FI-00014 Helsinki, Finland
St. Louis Children's Hospital (US)
Corresponding author: Viger, Robert S
Heikinheimo, Markku
ORCID: Viger, Robert S
Anttonen, Mikko
Wilson, David B
Heikinheimo, Markku
Venue: Molecular Endocrinology
Publisher: The Endocrine Society
Published: 2008-04-01
Volume: 22
Issue: 4
Pages: 781-798
ISSN: 0888-8809 (ISSN-L)
1944-9917
DOI: 10.1210/me.2007-0513
PMC: PMC2276466
OpenAlex: W2013216633
Cited by: 270
References: 235
Citations by year: 2026: 3 · 2025: 11 · 2024: 12 · 2023: 10 · 2022: 15 · 2021: 21 · 2020: 12 · 2019: 15 · 2018: 12 · 2017: 11 · 2016: 19 · 2015: 21 · 2014: 24 · 2013: 13 · 2012: 16
FWCI: 1.42
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Molecular Endocrinology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: Helsingin Yliopisto
Turun Yliopisto
National Institutes of Health
Canadian Institutes of Health Research
National Institute of Diabetes and Digestive and Kidney Diseases (DK075618, R01DK075618)
Institute of Gender and Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords: GATA transcription factors, GATA-1, GATA2, GATA3, GATA4, GATA5, GATA6, endocrine development, endocrine function, gonads, pituitary gland, pancreas, adrenal gland, tissue-specific knockout mice
MeSH terms: Animals, Endocrine System Diseases, Endocrine System, Humans, Models, Biological, Transcription, Genetic, Protein Isoforms, GATA Transcription Factors

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Role of the GATA Family of Transcription Factors in Endocrine Development, Function, and Disease

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