The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Adipokines and the Peripheral and Neural Control of Energy Balance
Open accessAbstract
Adipokines are secreted by adipose tissue and control various physiological systems. Low leptin levels during fasting stimulate feeding, reduce energy expenditure, and modulate neuroendocrine and immune function to conserve energy stores. On the other hand, rising leptin levels in the overfed state prevent weight gain by inhibiting food intake and increasing energy expenditure. These actions are mediated by neuronal circuits in the hypothalamus and brainstem. Leptin also controls glucose and lipid metabolism by targeting enzymes such as AMP-activated protein kinase and stearoyl-coenzyme A desaturase-1 in liver and muscle. Likewise, adiponectin and resistin control energy balance and insulin sensitivity via central and peripheral targets. As highlighted in this review, there are distinct as well as common signaling pathways for adipokines. Understanding adipokine signaling in the brain and other organs will provide insights into the pathogenesis and treatment of obesity, diabetes and various metabolic disorders.
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Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
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Obesity-induced inflammatory changes in adipose tissue
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The role of neuropeptide Y in the antiobesity action of the obese gene product
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Cited by
Adipose tissue inflammation and metabolic dysfunction in obesity
Kawai, T., Autieri, M. V., & Scalia, R. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00379.2020 · Cited by 1,947
Chait, A., & den Hartigh, L. J. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00022 · Cited by 1,529
Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores.
Zechner, R., Kienesberger, P. C., Haemmerle, G., Zimmermann, R., & Lass, A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800031-jlr200 · Cited by 576
Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production
Mehran, A. E., Templeman, N. M., Brigidi, G. S., Lim, G. E., Chu, K.-Y., Hu, X., Botezelli, J. D., Asadi, A., Hoffman, B. G., Kieffer, T. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.10.019 · Cited by 498
Kupffer cells in non-alcoholic fatty liver disease: The emerging view
Baffy, G. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.03.008 · Cited by 473
Metadata
- Authors
- Ahima, R. S., & Lazar, M. A.
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2008-05
- Volume
- 22
- Issue
- 5
- Pages
- 1023-1031
- ISSN
- 0888-8809 (ISSN-L)
- 1944-9917
- OpenAlex
- W2036519287
- Cited by
- 315
- References
- 30
- FWCI
- 13.13
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
