Cited by 298Estrogen and related hormone effectsProstate Cancer Treatment and ResearchBreast Cancer Treatment Studies

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Minireview: The Androgen Receptor in Breast Tissues: Growth Inhibitor, Tumor Suppressor, Oncogene?

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Hickey, T. E., Robinson, J. L. L., Carroll, J. S., Tilley, W. D.·2012·Molecular Endocrinology

DOI 10.1210/me.2012-1107PMC PMC3404296

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Abstract

Androgen receptor (AR) signaling exerts an antiestrogenic, growth-inhibitory influence in normal breast tissue, and this role may be sustained in estrogen receptor α (ERα)-positive luminal breast cancers. Conversely, AR signaling may promote growth of a subset of ERα-negative, AR-positive breast cancers with a molecular apocrine phenotype. Understanding the molecular mechanisms whereby androgens can elicit distinct gene expression programs and opposing proliferative responses in these two breast cancer phenotypes is critical to the development of new therapeutic strategies to target the AR in breast cancer.

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Authors: Hickey, T. E., Robinson, J. L. L., Carroll, J. S., & Tilley, W. D.
Affiliations: Hanson Institute (AU)
University of Cambridge (GB)
Corresponding author: Tilley, W. D.
ORCID: Hickey, T. E.
Robinson, J. L. L.
Carroll, J. S.
Tilley, W. D.
Venue: Molecular Endocrinology
Publisher: The Endocrine Society
Published: 2012-08-01
Volume: 26
Issue: 8
Pages: 1252-1267
ISSN: 0888-8809 (ISSN-L)
1944-9917
DOI: 10.1210/me.2012-1107
PMC: PMC3404296
OpenAlex: W1974738527
Cited by: 289
References: 152
Citations by year: 2026: 10 · 2025: 12 · 2024: 15 · 2023: 11 · 2022: 15 · 2021: 40 · 2020: 16 · 2019: 19 · 2018: 27 · 2017: 18 · 2016: 29 · 2015: 22 · 2014: 30 · 2013: 24 · 2012: 1
FWCI: 3.06
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Molecular Endocrinology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Funders: U.S. Department of Defense (W81XWH-11-1-, W81XWH)
European Molecular Biology Organization
Cancer Research UK
University of Cambridge
National Breast Cancer Foundation
Medical Research Council
National Health and Medical Research Council (1008349)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
Keywords: androgen receptor, breast cancer, estrogen receptor alpha, luminal breast cancer, apocrine breast cancer, tumor suppressor, oncogenes, androgen signaling, transcriptional programs, therapeutic targeting
MeSH terms: Androgens, Animals, Breast Neoplasms, Female, Growth Inhibitors, Humans, Oncogenes, Receptors, Androgen, Signal Transduction, Genes, Tumor Suppressor, Mammary Glands, Human, Estrogen Receptor alpha

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Minireview: The Androgen Receptor in Breast Tissues: Growth Inhibitor, Tumor Suppressor, Oncogene?

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