The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Human Transforming Growth Factor- β3: Recombinant Expression, Purification, and Biological Activities in Comparison with Transforming Growth Factors-β 1 and -β2
Abstract
Recent cDNA characterization has predicted the existence of a new member of the transforming growth factor family, transforming growth factor-beta 3 (TGF beta 3). However, nothing is known about the biological activities of the TGF beta 3 protein, since it has not been purified from any natural sources. We report here the recombinant expression in mammalian cells and the purification to apparent homogeneity of human TGF beta 3. The TGF beta 3 was evaluated in comparison with purified TGF beta 1 and TGF beta 2 in several assays for its effects on stimulation or inhibition of proliferation of mammalian cells. These analyses revealed that TGF beta 3 exerts activities similar to the two other TGF beta species, but that there are distinct differences in potencies between the different TGF beta forms depending on the cell type and assay used.
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The scanning model for translation: an update.
Kozak, M. (1989) · The Journal of cell biology · doi:10.1083/jcb.108.2.229 · Cited by 3,486
Some recent advances in the chemistry and biology of transforming growth factor-beta.
Sporn, M. B., Roberts, A. B., Wakefield, L. M., & de Crombrugghe, B. (1987) · The Journal of cell biology · doi:10.1083/jcb.105.3.1039 · Cited by 1,279
Complete nucleotide sequence of SV40 DNA
Fiers, W., Contreras, R., Haegeman, G., Rogiers, R., Van de Voorde, A., Van Heuverswyn, H., Van Herreweghe, J., Volckaert, G., & Ysebaert, M. (1978) · Nature · doi:10.1038/273113a0 · Cited by 1,010
Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium.
Lyons, R. M., Keski-Oja, J., & Moses, H. L. (1988) · The Journal of cell biology · doi:10.1083/jcb.106.5.1659 · Cited by 963
Self-citationRoberts, A. B., Anzano, M. A., Lamb, L. C., Smith, J. M., & Sporn, M. B. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.9.5339 · Cited by 919
ZOLLER, M. J., & SMITH, M. (1984) · DNA · doi:10.1089/dna.1.1984.3.479 · Cited by 886
Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity
Urlaub, G., & Chasin, L. A. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.7.4216 · Cited by 876
Miyazono, K., Hellman, U., Wernstedt, C., & Heldin, C. H. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68800-3 · Cited by 637
Transforming growth factor production by chemically transformed cells.
Moses, H. L., Branum, E. L., Proper, J. A., & Robinson, R. A. (1981) · PubMed · Cited by 497
Self-citationCell adhesion protein receptors as targets for transforming growth factor-$beta; action
IGNOTZ, R. (1987) · Cell · doi:10.1016/0092-8674(87)90146-2 · Cited by 485
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PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing
Barrientos, S., Stojadinovic, O., Golinko, M. S., Brem, H., & Tomic‐Canic, M. (2008) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2008.00410.x · Cited by 3,583
Induction and molecular signature of pathogenic TH17 cells
Lee, Y., Awasthi, A., Yosef, N., Quintana, F. J., Xiao, S., Peters, A., Wu, C., Kleinewietfeld, M., Kunder, S., Hafler, D. A., et al. (2012) · Nature Immunology · doi:10.1038/ni.2416 · Cited by 1,174
Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice
Dickson, M. C., Martin, J. S., Cousins, F. M., Kulkarni, A. B., Karlsson, S., & Akhurst, R. J. (1995) · Development · doi:10.1242/dev.121.6.1845 · Cited by 1,029
Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription
Zhang, Y., Feng, X.-H., & Derynck, R. (1998) · Nature · doi:10.1038/29814 · Cited by 809
Self-citationAlliston, T., Choy, L., Ducy, P., Karsenty, G., & Derynck, R. (2001) · The EMBO Journal · doi:10.1093/emboj/20.9.2254 · Cited by 526
Self-citation
Metadata
- Authors
- Graycar, J. L., Miller, D. A., Arrick, B. A., Lyons, R. M., Moses, H. L., & Derynck, R.
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1989-12
- Volume
- 3
- Issue
- 12
- Pages
- 1977-1986
- ISSN
- 0888-8809 (ISSN-L)
- 1944-9917
- OpenAlex
- W1989897445
- Cited by
- 272
- References
- 26
- FWCI
- 9.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Human Transforming Growth Factor- β3: Recombinant Expression, Purification, and Biological Activities in Comparison with Transforming Growth Factors-β 1 and -β2. https://app.cochat.ai/papers/10.1210/mend-3-12-1977
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- Graycar, J. L., Miller, D. A., Arrick, B. A., Lyons, R. M., Moses, H. L., & Derynck, R. (1989). Human Transforming Growth Factor- β3: Recombinant Expression, Purification, and Biological Activities in Comparison with Transforming Growth Factors-β 1 and -β2. Molecular Endocrinology. https://doi.org/10.1210/mend-3-12-1977
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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