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Bone-Inducing Activity of Mature BMP-2b Produced from a Hybrid BMP-2a/2b Precursor
Open accessAbstract
The human osteoinductive proteins BMP-2a and BMP-2b have been cloned and expressed in mammalian cells. In order to improve expression levels we examined the role of the proregion in assembly and export. Use of the BMP-2a proregion combined with the mature region of BMP-2b leads to dramatically improved expression of mature BMP-2b. Mature BMP-2b has been purified to near homogeneity from the BMP-2a/2b hybrid, and its structural properties and biological activity determined. Recombinant mature BMP-2b homodimer elicits bone formation in vivo.
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Citations
Cited by
Nakashima, M. (1994) · Journal of Dental Research · doi:10.1177/00220345940730090601 · Cited by 275
Cunningham, N. S., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., Reddi, A. H., & Lee, S.-J. (1995) · Growth Factors · doi:10.3109/08977199509028956 · Cited by 104
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Metadata
- Authors
- Hammonds, R. G., Schwall, R., Dudley, A., Berkemeier, L., Lai, C., Lee, J., Cunningham, N., Reddi, A. H., Wood, W. I., & Mason, A. J.
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1991-01
- Volume
- 5
- Issue
- 1
- Pages
- 149-155
- ISSN
- 0888-8809 (ISSN-L)
- 1944-9917
- OpenAlex
- W1982607227
- Cited by
- 170
- References
- 0
- FWCI
- 5.83
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Bone-Inducing Activity of Mature BMP-2b Produced from a Hybrid BMP-2a/2b Precursor. https://app.cochat.ai/papers/10.1210/mend-5-1-149
- The paper
- Hammonds, R. G., Schwall, R., Dudley, A., Berkemeier, L., Lai, C., Lee, J., Cunningham, N., Reddi, A. H., Wood, W. I., & Mason, A. J. (1991). Bone-Inducing Activity of Mature BMP-2b Produced from a Hybrid BMP-2a/2b Precursor. Molecular Endocrinology. https://doi.org/10.1210/mend-5-1-149
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
