Cited by 258Estrogen and related hormone effectsGenomics and Chromatin DynamicsOvarian function and disorders

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Tissue-Specific Promoters Regulate Aromatase Cytochrome P450 Gene Expression in Human Ovary and Fetal Tissues

Means, Gary D., Kilgore, Michael W., Mahendroo, Mala S., Mendelson, Carole R., Simpson, Evan R.·1991·Molecular Endocrinology

DOI 10.1210/mend-5-12-2005

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Abstract

The formation of estrogens from C19 steroids is catalyzed by a specific form of cytochrome P450, aromatase cytochrome P450 (P450AROM; the product of the CYP19 gene). Previous studies have demonstrated that aromatase activity in human adipose and ovarian granulosa cells is subject to complex multifactorial regulation and that changes in activity are correlated with changes in the levels of mRNA encoding P450AROM. We have previously isolated the human CYP19 gene. Two unique untranslated first exons (exons I.1 and I.2) have been identified in mRNA specific for P450AROM in human placenta. Although the proportion of transcripts encoding exon I.2 is very small, genomic clones encoding the sequences of both exons I.1 and I.2 have recently been isolated. The corpus luteum of human ovary differs in that promoters I.1 and I.2 are completely inactive. Sequence analysis of the DNA immediately 5' of exon II (which contains the start site of translation) demonstrates the presence of a TATAA sequence beginning 149 basepairs 5' of the ATG initiation codon identified in placental exon II. Using a combination of primer extension and S1 nuclease protection analysis, it appears that the initiation site of ovarian P450AROM transcripts aligns 26 basepairs down-stream of the sequence TATAA. It appears, therefore, that the expression of P450AROM-specific mRNA in corpus luteum is regulated by an additional promoter (promoter II), which is located just 5' of exon II. Consistent with these observations, Northern analysis of poly(A)+ RNA isolated from placenta and corpus luteum demonstrates that the major promoter of placental P450AROM is promoter I.1, while the major promoter in the corpus luteum is promoter II.(ABSTRACT TRUNCATED AT 250 WORDS)

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Detection of specific sequences among DNA fragments separated by gel electrophoresis
Southern, E. M. (1975) · Journal of Molecular Biology · doi:10.1016/s0022-2836(75)80083-0 · Cited by 32,245
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
Chirgwin, J. M., Przybyla, A., MacDonald, R. J., & Rutter, W. J. (1979) · Biochemistry · doi:10.1021/bi00591a005 · Cited by 21,460
Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., & Erlich, H. A. (1988) · Science · doi:10.1126/science.2448875 · Cited by 17,719
Source of Estrogen Production in Postmenopausal Women1
GRODIN, J. M., SIITERI, P. K., & MACDONALD, P. C. (1973) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-36-2-207 · Cited by 959
MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer
Lassar, A. B., Buskin, J. N., Lockshon, D., Davis, R. L., Apone, S., Hauschka, S. D., & Weintraub, H. M. (1989) · Cell · doi:10.1016/0092-8674(89)90935-5 · Cited by 817
The human c-myc oncogene: Structural consequences of translocation into the igh locus in Burkitt lymphoma
Battey, J., Moulding, C. T., Taub, R. A., Murphy, W., Stewart, T. A., Potter, H., Lenoir, G., & Leder, P. (1983) · Cell · doi:10.1016/0092-8674(83)90534-2 · Cited by 714
The P450 Superfamily: Updated Listing of All Genes and Recommended Nomenclature for the Chromosomal Loci
Nebert, D. W., Nelson, D. R., Adesnik, M., Coon, M. J., Estabrook, R. W., Gonzalez, F. J., Guengerich, F. P., GUNSALUS, I. C., Johnson, E. F., KEMPER, B. W., et al. (1989) · DNA · doi:10.1089/dna.1.1989.8.1 · Cited by 606
Biological Aromatization of Steroids
Ryan, K. J. (1959) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)70286-x · Cited by 595
TGF-β1 inhibition of transin/stromelysin gene expression is mediated through a fos binding sequence
Kerr, L. D., Miller, D. B., & Matrisian, L. M. (1990) · Cell · doi:10.1016/0092-8674(90)90807-q · Cited by 437
Distribution and regulation of aromatase activity in the rat hypothalamus and limbic system
ROSELLI, C. E., HORTON, L. E., & RESKO, J. A. (1985) · Endocrinology · doi:10.1210/endo-117-6-2471 · Cited by 415

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Androgen excess in women – A health hazard?
Rosmond, R. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2005.09.057 · Cited by 11
17α-Hydroxylase gene expression in the bovine ovary: Mechanisms regulating expression differ from those in adrenal cells
Demeter, M., Michael, M. D., Kilgore, M. W., & Simpson, E. R. (1996) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(96)00088-x · Cited by 11
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Choi, H., Roh, S., Kim, H. G., Han, E. H., Jeong, H. G., & Kang, K. W. (2008) · Endocrine Related Cancer · doi:10.1677/erc-07-0192 · Cited by 10
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Costanzo, M., Garcia-Feyling, J., Saraco, N. I., Marino, R. M., Garrido, N. P., Touzón, M. S., Viterbo, G. L., Lazzati, J. M., Patiño, H. C., Mattone, C., et al. (2018) · Hormone Research in Paediatrics · doi:10.1159/000492128 · Cited by 10
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Yoshida, Y., & Aoyama, Y. (1994) · Stem Cells · doi:10.1002/stem.5530120710 · Cited by 8
Diverse Molecular Mechanisms Regulate the Expression of Steroid Hydroxylase Genes Required for Production of Ligands for Nuclear Receptors
Waterman, M. R., & Keeney, D. S. (1996) · Advances in molecular and cell biology · doi:10.1016/s1569-2558(08)60341-0 · Cited by 8
Presence of exon I.4 mRNA from CYP19 gene in human granulosa cells
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Prescott, J. S. (1995) · Louisiana State University · doi:10.31390/gradschool_disstheses.6045
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Rajapaksha, W. R. A. K. J. S. (1998) · Enlighten: Theses (The University of Glasgow)
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Authors: Means, G. D., Kilgore, M. W., Mahendroo, M. S., Mendelson, C. R., & Simpson, E. R.
Affiliations: The University of Texas Southwestern Medical Center (US)
ORCID: Mahendroo, Mala S.
Mendelson, Carole R.
Venue: Molecular Endocrinology
Publisher: The Endocrine Society
Published: 1991-12
Volume: 5
Issue: 12
Pages: 2005-2013
ISSN: 0888-8809 (ISSN-L)
1944-9917
DOI: 10.1210/mend-5-12-2005
OpenAlex: W2095719571
Cited by: 258
References: 40
Citations by year: 2026: 1 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 1 · 2015: 4 · 2014: 11 · 2013: 5 · 2012: 2
FWCI: 5.56
Type: journal article
Language: en
Open access: closed
Locations: Molecular Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (AM-31206)
National Institute on Aging (AG-08174)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD007190, 5-T32 HD07190)
Army Research Office
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Keywords: aromatase, P450arom, tissue-specific promoters, promoter analysis, corpus luteum, placenta, granulosa cells, translation initiation sites, estrogen synthesis, gene expression regulation
MeSH terms: Amino Acid Sequence, Aromatase, Base Sequence, DNA, Exons, Female, Fetus, Humans, Molecular Sequence Data, Ovary, Placenta, Pregnancy, Promoter Regions, Genetic, RNA, RNA, Messenger, Transcription, Genetic, Protein Biosynthesis, Gene Expression, Polymerase Chain Reaction, TATA Box

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Tissue-Specific Promoters Regulate Aromatase Cytochrome P450 Gene Expression in Human Ovary and Fetal Tissues

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