Cited by 258Estrogen and related hormone effectsGenomics and Chromatin DynamicsOvarian function and disorders

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Tissue-Specific Promoters Regulate Aromatase Cytochrome P450 Gene Expression in Human Ovary and Fetal Tissues

Means, Gary D., Kilgore, Michael W., Mahendroo, Mala S., Mendelson, Carole R., Simpson, Evan R.·1991·Molecular Endocrinology

DOI 10.1210/mend-5-12-2005

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Abstract

The formation of estrogens from C19 steroids is catalyzed by a specific form of cytochrome P450, aromatase cytochrome P450 (P450AROM; the product of the CYP19 gene). Previous studies have demonstrated that aromatase activity in human adipose and ovarian granulosa cells is subject to complex multifactorial regulation and that changes in activity are correlated with changes in the levels of mRNA encoding P450AROM. We have previously isolated the human CYP19 gene. Two unique untranslated first exons (exons I.1 and I.2) have been identified in mRNA specific for P450AROM in human placenta. Although the proportion of transcripts encoding exon I.2 is very small, genomic clones encoding the sequences of both exons I.1 and I.2 have recently been isolated. The corpus luteum of human ovary differs in that promoters I.1 and I.2 are completely inactive. Sequence analysis of the DNA immediately 5' of exon II (which contains the start site of translation) demonstrates the presence of a TATAA sequence beginning 149 basepairs 5' of the ATG initiation codon identified in placental exon II. Using a combination of primer extension and S1 nuclease protection analysis, it appears that the initiation site of ovarian P450AROM transcripts aligns 26 basepairs down-stream of the sequence TATAA. It appears, therefore, that the expression of P450AROM-specific mRNA in corpus luteum is regulated by an additional promoter (promoter II), which is located just 5' of exon II. Consistent with these observations, Northern analysis of poly(A)+ RNA isolated from placenta and corpus luteum demonstrates that the major promoter of placental P450AROM is promoter I.1, while the major promoter in the corpus luteum is promoter II.(ABSTRACT TRUNCATED AT 250 WORDS)

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Detection of specific sequences among DNA fragments separated by gel electrophoresis
Southern, E. M. (1975) · Journal of Molecular Biology · doi:10.1016/s0022-2836(75)80083-0 · Cited by 32,245
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
Chirgwin, J. M., Przybyla, A., MacDonald, R. J., & Rutter, W. J. (1979) · Biochemistry · doi:10.1021/bi00591a005 · Cited by 21,460
Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., & Erlich, H. A. (1988) · Science · doi:10.1126/science.2448875 · Cited by 17,719
Source of Estrogen Production in Postmenopausal Women1
GRODIN, J. M., SIITERI, P. K., & MACDONALD, P. C. (1973) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-36-2-207 · Cited by 959
MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer
Lassar, A. B., Buskin, J. N., Lockshon, D., Davis, R. L., Apone, S., Hauschka, S. D., & Weintraub, H. M. (1989) · Cell · doi:10.1016/0092-8674(89)90935-5 · Cited by 817
The human c-myc oncogene: Structural consequences of translocation into the igh locus in Burkitt lymphoma
Battey, J., Moulding, C. T., Taub, R. A., Murphy, W., Stewart, T. A., Potter, H., Lenoir, G., & Leder, P. (1983) · Cell · doi:10.1016/0092-8674(83)90534-2 · Cited by 714
The P450 Superfamily: Updated Listing of All Genes and Recommended Nomenclature for the Chromosomal Loci
Nebert, D. W., Nelson, D. R., Adesnik, M., Coon, M. J., Estabrook, R. W., Gonzalez, F. J., Guengerich, F. P., GUNSALUS, I. C., Johnson, E. F., KEMPER, B. W., et al. (1989) · DNA · doi:10.1089/dna.1.1989.8.1 · Cited by 606
Biological Aromatization of Steroids
Ryan, K. J. (1959) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)70286-x · Cited by 595
TGF-β1 inhibition of transin/stromelysin gene expression is mediated through a fos binding sequence
Kerr, L. D., Miller, D. B., & Matrisian, L. M. (1990) · Cell · doi:10.1016/0092-8674(90)90807-q · Cited by 437
Distribution and regulation of aromatase activity in the rat hypothalamus and limbic system
ROSELLI, C. E., HORTON, L. E., & RESKO, J. A. (1985) · Endocrinology · doi:10.1210/endo-117-6-2471 · Cited by 415

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Toda, K., & Shizuta, Y. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb17772.x · Cited by 51
Aromatase and the breast: Regulation and clinical aspects
Miller, W. R. (2006) · Maturitas · doi:10.1016/j.maturitas.2006.04.020 · Cited by 49
Potential for Estrogen Synthesis and Action in Human Normal and Neoplastic Thyroid Tissues1
Valle, L. D., Ramina, A., Vianello, S., Fassina, A., Belvedere, P., & Colombo, L. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.10.5170 · Cited by 49
Aromatase Messenger RNA Is Derived from the Proximal Promoter of the Aromatase Gene in Leydig, Sertoli, and Germ Cells of the Rat Testis1
Lanzino, M., Catalano, S., Genissel, C., Andò, S., Carreau, S., Hamra, K., & McPhaul, M. J. (2001) · Biology of Reproduction · doi:10.1095/biolreprod64.5.1439 · Cited by 49
Gene Regulation Studies of Aromatase Expression in Breast Cancer and Adipose Stromal Cells
Zhou, D., Zhou, C., & Chen, S. (1997) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(97)80023-4 · Cited by 48
Aromatase inhibitors in ovarian cancer: is there a role?
Li, Y. F., Hu, W., Fu, S., Li, J., LIU, J. H., & Kavanagh, J. J. (2007) · International Journal of Gynecological Cancer · doi:10.1111/j.1525-1438.2007.01075.x · Cited by 51
Identification of a Promoter That Controls Aromatase Expression in Human Breast Cancer and Adipose Stromal Cells
Zhou, D., Clarke, P., Wang, J., & Chen, S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.25.15194 · Cited by 46
The promoter(s) of the aromatase gene in male testicular cells.
Carreau, S., Bourguiba, S., Lambard, S., Silandre, D., & Delalande, C. (2004) · PubMed · Cited by 45
Transcriptional control of local estrogen formation by aromatase in the breast
To, S. Q., Knower, K. C., Cheung, V., Simpson, E. R., & Clyne, C. D. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.05.004 · Cited by 44
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Boerboom, D., Kerban, A., & Sirois, J. (1999) · Endocrinology · doi:10.1210/endo.140.9.6951 · Cited by 43
Expression of the aromatase cytochrome P450 encoding gene in cattle and sheep
Vanselow, J., Fürbaß, R., Zsolnai, A., Kalbe, C., Said, H. M., & Schwerin, M. (2001) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(01)00144-3 · Cited by 43
Aromatase inhibitors for the treatment of breast cancer: An overview (2019–2023)
Bhatia, N. S., & Thareja, S. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107607 · Cited by 42
Aromatase inhibitors for ovulation induction and ovarian stimulation
Lee, V. C. Y., & Ledger, W. J. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04006.x · Cited by 42
Potential role of UGT pharmacogenetics in cancer treatment and prevention: focus on tamoxifen and aromatase inhibitors
Lazarus, P. J., & Sun, D. (2009) · Drug Metabolism Reviews · doi:10.3109/03602530903208652 · Cited by 42
Retinoic acids promote the action of aromatase and 17beta-hydroxysteroid dehydrogenase type 1 on the biosynthesis of 17beta-estradiol in placental cells
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Genetic Diseases of Steroid Metabolism
White, P. C. (1994) · Vitamins and hormones · doi:10.1016/s0083-6729(08)61147-4 · Cited by 43
Down-regulation of promoter 1.3 activity of the human aromatase gene in breast tissue by zinc-finger protein, snail (SnaH).
Okubo, T., Truong, T. K., Yu, B., Itoh, T., Zhao, J., Grube, B., Zhou, D., & Chen, S. (2001) · PubMed · Cited by 42
Estrogen Biosynthesis in THP1 Cells Is Regulated by Promoter Switching of the Aromatase (CYP19) Gene
Shozu, M., Zhao, Y., & Simpson, E. R. (1997) · Endocrinology · doi:10.1210/endo.138.12.5562 · Cited by 43
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An aromatase pseudogene is transcribed in the bovine placenta
Fürbaβ, R., & Vanselow, J. (1995) · Gene · doi:10.1016/0378-1119(94)00754-g · Cited by 40
Regulation of aromatase promoter activity in human breast tissue by nuclear receptors
Yang, C., Yu, B., Zhou, D., & Chen, S. (2002) · Oncogene · doi:10.1038/sj.onc.1205386 · Cited by 40
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Marino, R. M., Garrido, N. P., Costanzo, M., Guercio, G., Juanes, M., Rocco, C. A., Ramírez, P., Warman, D. M., Ciaccio, M., Pena, G., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2967 · Cited by 38
Unique regulation of expression of human aromatase in the placenta
Harada, N., Yoshimura, N., & Honda, S. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00375-3 · Cited by 38
Physiology of Testicular Steroidogenesis
Stocco, D. M., & McPhaul, M. J. (2006) · Elsevier eBooks · doi:10.1016/b978-012515400-0/50025-7 · Cited by 38
Potential for Estrogen Synthesis and Action in Human Normal and Neoplastic Thyroid Tissues
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Functional characterization of the rat gamma-glutamyl transpeptidase promoter that is expressed and regulated in the liver and hepatoma cells.
Brouillet, A., Darbouy, M., Okamoto, T., Chobert, M.-N., Lahuna, O., Garlatti, M., Goodspeed, D. C., & Laperche, Y. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36547-x · Cited by 37
Structure of Aromatase mRNA in the Rat Brain
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Androstenedione up-regulation of endometrial aromatase expression via local conversion to estrogen: potential relevance to the pathogenesis of endometriosis.
Bukulmez, O., Hardy, D., Carr, B. R., Auchus, R., Toloubeydokhti, T., Word, R., & Mendelson, C. R. (2008) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2008-0248 · Cited by 40
Self-citation
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Keeney, D. S., & Waterman, M. R. (1993) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(93)90026-a · Cited by 35
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Zhou, D., & Chen, S. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0641 · Cited by 35
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Quignot, N., Desmots, S., Barouki, R., & Lemazurier, E. (2011) · Toxicology in Vitro · doi:10.1016/j.tiv.2011.11.004 · Cited by 33
Modulation of estradiol synthesis and aromatase activity in human choriocarcinoma JEG-3 cells exposed to tetrabromobisphenol A
Honkisz-Orzechowska, E., & Wójtowicz, A. K. (2014) · Toxicology in Vitro · doi:10.1016/j.tiv.2014.09.003 · Cited by 33
Characterization of a novel silencer element in the human aromatase gene PII promoter
Jin, T., Zhang, X., Li, H., & Goss, P. E. (2000) · Breast Cancer Research and Treatment · doi:10.1023/a:1006481228794 · Cited by 33
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Sasano, H., Kaga, K., Sato, S., Yajima, A., Nagura, H., & Harada, N. (1996) · British Journal of Cancer · doi:10.1038/bjc.1996.586 · Cited by 32
Existence and expression of the untranslated first exon of aromatase mRNA in the rat brain
Yamada-Mouri, N., Hirata, S., & Kato, J. (1996) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(96)00022-2 · Cited by 32
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Jakob, F. J., Homann, D., Seufert, J., Schneider, D., & Köhrle, J. (1995) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(95)03512-6 · Cited by 32
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Callard, G. V., Kruger, A., & Betka, M. (1995) · Environmental Health Perspectives · doi:10.1289/ehp.95103s751 · Cited by 32
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Bourguiba, S., Chater, S., Delalande, C., Benahmed, M., & Carreau, S. (2003) · Biology of Reproduction · doi:10.1095/biolreprod.102.013961 · Cited by 32
Excessive levels of diverse phytoestrogens can modulate steroidogenesis and cell migration of KGN human granulosa-derived tumor cells
Solak, K. A., Wijnolts, F. M. J., Nijmeijer, S. M., Blaauboer, B. J., van den Berg, M., & van Duursen, M. B. M. (2014) · Toxicology Reports · doi:10.1016/j.toxrep.2014.06.006 · Cited by 30
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Post‐translational dual regulation of cytochrome P450 aromatase at the catalytic and protein levels by phosphorylation/dephosphorylation
Hayashi, T., & Harada, N. (2014) · FEBS Journal · doi:10.1111/febs.13021 · Cited by 31
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Toda, K., Nomoto, S., & Shizuta, Y. (1996) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00232-4 · Cited by 31
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Yamada-Mouri, N., Hirata, S., Hayashi, M., & Kato, J. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00157-u · Cited by 31
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Lenz, S., Pöhland, R., Becker, F. O., & Vanselow, J. (2004) · Molecular Reproduction and Development · doi:10.1002/mrd.20000 · Cited by 29
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Nordman, I. C., & Dalley, D. N. (2008) · The Breast Journal · doi:10.1111/j.1524-4741.2008.00648.x · Cited by 29
Cattle and sheep use different promoters to direct the expression of the aromatase cytochrome P450 encoding gene, Cyp19, during pregnancy
Vanselow, J., Fürbaß, R., Rehbock, F., Klautschek, G., & Schwerin, M. (2004) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2004.01.008 · Cited by 29
3.11. Reproductive and Developmental Toxicity
Bremer, S., Cortvrindt, R. G., Daston, G. P., Eletti, B., Mantovani, A., Maranghi, F., Pelkonen, O., Ruhdel, I., & Spielmann, H. (2005) · Alternatives to Laboratory Animals · doi:10.1177/026119290503301s17 · Cited by 28
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Yue, W., Berstein, L. M., Wang, J., Clark, G. M., Hamilton, C., Demers, L. M., & Santen, R. J. (2001) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(01)00154-6 · Cited by 28
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Zhang, Z., Yamashita, H., Toyama, T., Omoto, Y., Sugiura, H., Hara, Y., Wu, X., Kobayashi, S., & Iwase, H. (2003) · Breast Cancer Research · doi:10.1186/bcr657 · Cited by 28
RegulatedCYP19Aromatase Transcription in Breast Stromal Fibroblasts1
Pauley, R. J., Santner, S. J., Tait, L. R., Bright, R. K., & Santen, R. J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.2.6345 · Cited by 28
Leptin induces CREB-dependent aromatase activation through COX-2 expression in breast cancer cells
Kim, H. G., Jin, S. W., Kim, Y.-A., Khanal, T., Lee, G. H., Kim, S., Rhee, S. D., Chung, Y., Hwang, Y. J., Jeong, T. C., et al. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.05.058 · Cited by 27
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Kimura, R., Yoshii, H., Nomura, M., Kotomura, N., Mukai, T., Ishihara, S., Ohba, K., Yanase, T., Gotoh, O., Nawata, H., et al. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3774 · Cited by 26
Aromatase and Intracrinology of Estrogen in Hormone-Dependent Tumors
Harada, N. (1999) · Oncology · doi:10.1159/000055270 · Cited by 27
Evidence That Increased Ovarian Aromatase Activity and Expression Account for Higher Estradiol Levels in African American Compared With Caucasian Women
Shaw, N. D., Srouji, S. S., Welt, C. K., Cox, K., Fox, J. H., Adams, J. M., Sluss, P. M., & Hall, J. E. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2398 · Cited by 26
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Han, E. H., Kim, H. G., Hwang, Y. P., Choi, J. H., Im, J. H., Park, B., Yang, J. H., Jeong, T. C., & Jeong, H. G. (2010) · Toxicology Letters · doi:10.1016/j.toxlet.2010.07.015 · Cited by 26
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McInnes, K. J., Brown, K. A., Knower, K. C., Chand, A. L., Clyne, C. D., & Simpson, E. R. (2008) · Breast Cancer Research and Treatment · doi:10.1007/s10549-007-9883-2 · Cited by 26
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Characterization of aromatase cytochrome P-450 mRNA in rat perinatal brain, ovary and a Leydig tumor cell line: evidence for the existence of brain specific aromatase transcripts
Lephart, E. D., Herbst, M. A., & McPhaul, M. J. (1995) · Endocrine · doi:10.1007/bf02917445 · Cited by 26
Regulation of Aromatase Expression in Human Ovarian Surface Epithelial Cells1
Okubo, T., Mok, S. C., & Chen, S. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.12.7067 · Cited by 25
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Stocco, C. O., Kwintkiewicz, J., & Cai, Z. (2007) · Journal of Molecular Endocrinology · doi:10.1677/jme-07-0026 · Cited by 24
Transcriptional regulation of the human aromatase cytochrome P450 gene expression in human placental cells
Toda, K., Yang, L.-X., & Shizuta, Y. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00032-u · Cited by 24
The 5'-Flanking Region of the Ovarian Promoter of the Bovine CYP19 Gene Contains a Deletion in a Cyclic Adenosine 3',5'-Monophosphate-Like Responsive Sequence
Hinshelwood, M. M., Michael, M. D., & Simpson, E. R. (1997) · Endocrinology · doi:10.1210/endo.138.9.5317 · Cited by 24
Self-citation
The inducible isoform of CREM (inducible cAMP early repressor, ICER) is a repressor of CYP19 rat ovarian promoter
Morales, V., González, I., Hernández, I., Quintana, J., Santana, M., de Galarreta, C. R., & Fanjul, L. F. (2003) · Journal of Endocrinology · doi:10.1677/joe.0.1790417 · Cited by 23
Expression and distribution of cortical type aromatase mRNA variant in the adult rat brain
Yamada-Mouri, N., Hirata, S., Kato, J., & Hoshi, K. (1997) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(96)00222-1 · Cited by 23
Time required for temperature-induced changes in gonadal aromatase activity and related gonadal structure in turtle embryos
Desvages, G., & Pieau, C. (1992) · Differentiation · doi:10.1111/j.1432-0436.1992.tb00495.x · Cited by 23
Molecular analysis of aberrant expression of aromatase in breast cancer tissues
Harada, N., & Honda, S. (1998) · Breast Cancer Research and Treatment · doi:10.1023/a:1006076101178 · Cited by 23
Regulation of Steroidogenic and Related P450s
Kagawa, N., & Waterman, M. R. (1995) · Springer eBooks · doi:10.1007/978-1-4757-2391-5_12 · Cited by 23
Novel activator protein‐2α splice‐variants function as transactivators of the ovine placental lactogen gene
Limesand, S. W., & Anthony, R. V. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02124.x · Cited by 22
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Lee, S., Kim, W., Choi, J., Lee, S. S., & Shin, J. (2010) · Journal of Human Genetics · doi:10.1038/jhg.2010.6 · Cited by 22
Expression of Genes Encoding Steroidogenic Enzymes in the Ovary
Hinshelwood, M. M., Demeter, M., Means, G., & Simpson, E. R. (1994) · Elsevier eBooks · doi:10.1016/b978-0-08-091819-8.50010-2 · Cited by 22
Self-citation
Expression of two aromatase cDNAs in various rabbit tissues
Delarue, B., Bréard, E., Mittre, H., & Leymarie, P. (1998) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(97)00152-0 · Cited by 22
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Alternative splicing within the human cytochrome P450 superfamily with an emphasis on the brain: the convolution continues
Turman, C. M., Hatley, J. M., Ryder, D. J., Ravindranath, V., & Strobel, H. W. (2006) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2.3.399 · Cited by 20
Factors regulating the bovine, caprine, rat and human ovarian aromatase promoters in a bovine granulosa cell model
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Authors: Means, G. D., Kilgore, M. W., Mahendroo, M. S., Mendelson, C. R., & Simpson, E. R.
Affiliations: The University of Texas Southwestern Medical Center (US)
ORCID: Mahendroo, Mala S.
Mendelson, Carole R.
Venue: Molecular Endocrinology
Publisher: The Endocrine Society
Published: 1991-12
Volume: 5
Issue: 12
Pages: 2005-2013
ISSN: 0888-8809 (ISSN-L)
1944-9917
DOI: 10.1210/mend-5-12-2005
OpenAlex: W2095719571
Cited by: 258
References: 40
Citations by year: 2026: 1 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 1 · 2015: 4 · 2014: 11 · 2013: 5 · 2012: 2
FWCI: 5.56
Type: journal article
Language: en
Open access: closed
Locations: Molecular Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (AM-31206)
National Institute on Aging (AG-08174)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD007190, 5-T32 HD07190)
Army Research Office
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Keywords: aromatase, P450arom, tissue-specific promoters, promoter analysis, corpus luteum, placenta, granulosa cells, translation initiation sites, estrogen synthesis, gene expression regulation
MeSH terms: Amino Acid Sequence, Aromatase, Base Sequence, DNA, Exons, Female, Fetus, Humans, Molecular Sequence Data, Ovary, Placenta, Pregnancy, Promoter Regions, Genetic, RNA, RNA, Messenger, Transcription, Genetic, Protein Biosynthesis, Gene Expression, Polymerase Chain Reaction, TATA Box

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Tissue-Specific Promoters Regulate Aromatase Cytochrome P450 Gene Expression in Human Ovary and Fetal Tissues

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