Cited by 169Growth Hormone and Insulin-like Growth FactorsHypothalamic control of reproductive hormonesRegulation of Appetite and Obesity

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Somatostatin receptor subtype 2 knockout mice are refractory to growth hormone-negative feedback on arcuate neurons.

Open access

Zheng, Hui, Bailey, Alex, Jiang, Ming-Hao, Honda, Kazufumi, Chen, Howard Y., Trumbauer, Myrna E., Van der Ploeg, Lex H.T., Schaeffer, James M., Leng, Gareth, Smith, Roy G.·1997·Molecular Endocrinology

DOI 10.1210/mend.11.11.0016

Open this paper in CoChat — free account Open PDF

Abstract

The pulsatile nature of GH release is apparently regulated by alternating sequential changes in two hypothalamic hormones, GH releasing hormone (GHRH) and somatostatin. Entrainment of this pulsatility appears to involve GH-mediated negative feedback. Recently a new receptor involved in GH release was cloned. Activation of this receptor by GH-releasing peptides and MK-0677 initiates and amplifies GH pulsatility and is associated with increased Fos immunoreactivity and electrical activity in GHRH containing arcuate neurons. We show that pretreating mice with GH blocks activation of these neurons by MK-0677. Similarly, octreotide inhibited the action of MK-0677. To determine whether this GH-mediated negative feedback on GHRH neurons was direct, or by GH stimulation of somatostatin release from periventricular neurons, we selectively inactivated the gene for one of the five specific somatostatin receptor subtypes (subtype 2). In the knockout mice, both GH and octreotide failed to inhibit MK-0677 activation of arcuate neurons. GH did, however, increase Fos immunoreactivity in the periventricular nucleus, consistent with GH stimulation of somatostatin release from periventricular neurons. Thus, GH-mediated negative feedback involves signaling between periventricular and arcuate neurons with the signal being transduced specifically through somatostatin subtype 2 receptors.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1210/mend.11.11.0016

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release
Howard, A., Feighner, S., Cully, D., Arena, J. P., Liberator, P., Rosenblum, C., Hamelin, M., Hreniuk, D. L., Palyha, O., Anderson, J., et al. (1996) · Science · doi:10.1126/science.273.5277.974 · Cited by 2,106
Self-citation
Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues.
Guan, X.-M., Yu, H., Palyha, O., McKee, K., Feighner, S., Sirinathsinghji, D., Smith, R. G., van der Ploeg, L., & Howard, A. (1997) · Brain Research. Molecular Brain Research · doi:10.1016/s0169-328x(97)00071-5 · Cited by 1,185
Self-citation
Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.
Yamada, Y., Post, S. R., Wang, K., Tager, H. S., Bell, G. I., & Seino, S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.1.251 · Cited by 753
Sexual Dimorphism in the Control of Growth Hormone Secretion*
Jansson, J., Edén, S., & Isaksson, O. G. P. (1985) · Endocrine Reviews · doi:10.1210/edrv-6-2-128 · Cited by 746
Molecular Biology of Somatostatin Receptors*
Reisine, T., & Bell, G. I. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-4-427 · Cited by 661
On thein Vitroandin VivoActivity of a New Synthetic Hexapeptide that Acts on the Pituitary to Specifically Release Growth Hormone*
Bowers, C. Y., Momany, F. A., Reynolds, G. A., & Hong, A. L. (1984) · Endocrinology · doi:10.1210/endo-114-5-1537 · Cited by 653
Transcriptional autoregulation of the proto-oncogene fos
Sassone‐Corsi, P., Sisson, J. C., & Verma, I. M. (1988) · Nature · doi:10.1038/334314a0 · Cited by 611
The somatostatin receptor family
Patel, Y., Greenwood, M. T., Panetta, R., Demchyshyn, L. L., Niznik, H. B., & Srikant, C. B. (1995) · Life Sciences · doi:10.1016/0024-3205(95)02082-t · Cited by 366
Molecular Analysis of Rat Pituitary and Hypothalamic Growth Hormone Secretagogue Receptors
McKee, K. K., Palyha, O. C., Feighner, S. D., Hreniuk, D. L., Tan, C. P., Phillips, M. S., Smith, R. G., der Ploeg, L. H. T. V., & Howard, A. D. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.4.9908 · Cited by 358
Self-citation
A Nonpeptidyl Growth Hormone Secretagogue
Smith, R. G., Cheng, K., Schoen, W. R., Pong, S., Hickey, G. J., Jacks, T., Butler, B., CHAN, W. W.-S., Chaung, L. Y., Judith, F. R., et al. (1993) · Science · doi:10.1126/science.8503009 · Cited by 341
Self-citation

Show all 35 references

Sorted by citations

Somatostatin and Its Receptor Family
Patel, Y. (1999) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1999.0183 · Cited by 1,670
Somatostatin Inhibits Insulin and Glucagon Secretion via Two Receptor Subtypes: An in Vitro Study of Pancreatic Islets from Somatostatin Receptor 2 Knockout Mice
Strowski, M. Z., Parmar, R. M., Blake, A. D., & Schaeffer, J. M. (2000) · Endocrinology · doi:10.1210/endo.141.1.7263 · Cited by 358
Self-citation
Mutant G-protein-coupled receptors as a cause of human diseases
Schöneberg, T., Schulz, A. M., Biebermann, H., Hermsdorf, T., Römpler, H., & Sangkuhl, K. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.08.008 · Cited by 343
Regulation and function of somatostatin receptors
Olias, G., Viollet, C., Kusserow, H., Epelbaum, J., & Meyerhof, W. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02402.x · Cited by 322
Somatostatin receptors
Møller, L. N., Stidsen, C. E., Hartmann, B., & Holst, J. J. (2003) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(03)00235-9 · Cited by 310
International Union of Basic and Clinical Pharmacology. CV. Somatostatin Receptors: Structure, Function, Ligands, and New Nomenclature
Günther, T., Tulipano, G., Dournaud, P., Bousquet, C., Csaba, Z., Kreienkamp, H., Lupp, A., Korbonits, M., Castano, J. P., Wester, H., et al. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.015388 · Cited by 264
Somatotropic and Gonadotropic Axes Linkages in Infancy, Childhood, and the Puberty-Adult Transition
Veldhuis, J. D., Roemmich, J. N., Richmond, E. J., & Bowers, C. Y. (2006) · Endocrine Reviews · doi:10.1210/er.2005-0006 · Cited by 236
Somatostatinergic systems in brain: Networks and functions
Viollet, C., Lepousez, G., Loudes, C., Videau, C., Simon, A., & Epelbaum, J. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.09.007 · Cited by 195
Development of Growth Hormone Secretagogues
Smith, R. G. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0019 · Cited by 168
Self-citation
Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth.
Low, M. J., Otero-Corchon, V., Parlow, A. F., Ramirez, J. L., Kumar, U., Patel, Y. C., & Rubinstein, M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11941 · Cited by 163
Central and peripheral actions of somatostatin on the growth hormone–IGF-I axis
Murray, R. D., Kim, K., Ren, S.-G., Chelly, M. R., Umehara, Y., & Melmed, S. K. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19933 · Cited by 162
Somatostatin Signaling in Neuronal Cilia Is Criticalfor Object Recognition Memory
Einstein, E. B., Patterson, C. A., Hon, B. J., Regan, K. A., Reddi, J., Melnikoff, D. E., Mateer, M. J., Schulz, S., Johnson, B. N., & Tallent, M. K. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5295-09.2010 · Cited by 129
Somatostatin Receptor Subtype 5 Regulates Insulin Secretion and Glucose Homeostasis
Strowski, M. Z., Köhler, M. G., Chen, H. Y., Trumbauer, M. E., Li, Z., Szalkowski, D., Gopal-Truter, S., Fisher, J. K., Schaeffer, J. M., Blake, A. D., et al. (2003) · Molecular Endocrinology · doi:10.1210/me.2001-0035 · Cited by 130
Self-citation
Molecular Endocrinology and Physiology of the Aging Central Nervous System
Smith, R. G., Betancourt, L., & Sun, Y. (2005) · Endocrine Reviews · doi:10.1210/er.2002-0017 · Cited by 129
Self-citation
sst2 Somatostatin Receptor Inhibits Cell Proliferation through Ras-, Rap1-, and B-Raf-dependent ERK2 Activation
Lahlou, H., Saint‐Laurent, N., Estève, J., Eychène, A., Pradayrol, L., Pyronnet, S., & Susini, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304524200 · Cited by 126
High basal gastric acid secretion in somatostatin receptor subtype 2 knockout mice
Martı́nez, V., Curi, A. P., Torkian, B., Schaeffer, J. M., Wilkinson, H. A., Walsh, J. H., & Taché, Y. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70417-2 · Cited by 126
Self-citation
Sleep in mice with nonfunctional growth hormone-releasing hormone receptors
Obál, F., Alt, J. A., Taishi, P., Gardi, J., & Krueger, J. M. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00361.2002 · Cited by 124
Elevated Fasting Plasma Ghrelin in Prader-Willi Syndrome Adults Is Not Solely Explained by Their Reduced Visceral Adiposity and Insulin Resistance
Goldstone, A. P., Thomas, E. L., Brynes, A. E., Castroman, G., Edwards, R., Ghatei, M. A., Frost, G. S., Holland, A. J., Grossman, A. B., Korbonits, M., et al. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031118 · Cited by 113
Involvement of sst2 somatostatin receptor in locomotor, exploratory activity and emotional reactivity in mice
Viollet, C., Vaillend, C., Videau, C., Bluet‐Pajot, M., Ungerer, A., L’Héritier, A., Kopp, C., Potier, B., Billard, J., Schaeffer, J. M., et al. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00249.x · Cited by 114
Self-citation
Central and Peripheral Roles of Ghrelin on Glucose Homeostasis
Sun, Y., Asnicar, M., & Smith, R. G. (2007) · Neuroendocrinology · doi:10.1159/000109094 · Cited by 102
Self-citation
Function and expression of somatostatin receptors of the endocrine pancreas
Strowski, M. Z., & Blake, A. D. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.02.007 · Cited by 101
Advances in understanding neuronal somatostatin receptors
Selmer, I.-S., Schindler, M., Allen, J. P., Humphrey, P. P. A., & Emson, P. C. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00108-7 · Cited by 99
Somatostatin receptor subtype 1 modulates basal inhibition of growth hormone release in somatotrophs
Kreienkamp, H., Akgün, E., Baumeister, H., Meyerhof, W., & Richter, D. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01582-3 · Cited by 94
Factors Regulating Growth Hormone Secretion in Humans
Goldenberg, N., & Barkan, A. L. (2007) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2006.11.003 · Cited by 93
Somatostatin receptor subtypes 2 and 4 affect seizure susceptibility and hippocampal excitatory neurotransmission in mice
Moneta, D., Richichi, C., Aliprandi, M., Dournaud, P., Dutar, P., Billard, J., Carlo, A.-S., Viollet, C., Hannon, J. P., Fehlmann, D., et al. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02146.x · Cited by 88
Neurophysiological regulation andtarget-tissue impact of the pulsatile mode of growth hormone secretion in the human
Veldhuis, J. D., Anderson, S. M., Shah, N., Bray, M., Vick, T. M., Gentili, A., Mulligan, T., Johnson, M. L., WELTMAN, A. L., Evans, W. S., et al. (2001) · Growth Hormone & IGF Research · doi:10.1016/s1096-6374(01)80005-8 · Cited by 79
Somatostatin stimulates ductal bile absorption and inhibits ductal bile secretion in mice via SSTR2 on cholangiocytes
Gong, A., Tietz, P. S., Muff, M. A., Splinter, P. L., Huebert, R. C., Strowski, M. Z., Chen, X., & LaRusso, N. F. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00313.2002 · Cited by 79
Growth Hormone Releasing Substances: Types and Their Receptors
Smith, R. G., Palyha, O. C., Feighner, S. D., Tan, C. P., McKee, K., Hreniuk, D. L., Yang, L., Morriello, G., Nargund, R. P., Patchett, A., et al. (1999) · Hormone Research in Paediatrics · doi:10.1159/000044375 · Cited by 78
Self-citation
Somatostatin receptor 2 knockout/lacZ knockin mice show impaired motor coordination and reveal sites of somatostatin action within the striatum
Allen, J. P., Hathway, G. J., Clarke, N. J., Jowett, M. I., Topps, S., Kendrick, K. M., Humphrey, P. P. A., Wilkinson, L. S., & Emson, P. C. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02629.x · Cited by 75
Somatostatin system: molecular mechanisms regulating anterior pituitary hormones
Eigler, T., & Ben-Shlomo, A. (2014) · Journal of Molecular Endocrinology · doi:10.1530/jme-14-0034 · Cited by 75
Disrupted hippocampal growth hormone secretagogue receptor 1α interaction with dopamine receptor D1 plays a role in Alzheimer′s disease
Tian, J., Guo, L., Sui, S., Driskill, C., Phensy, A., Wang, Q., Gauba, E., Zigman, J. M., Swerdlow, R. H., Kroener, S., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aav6278 · Cited by 72
A New Orphan Receptor Involved in Pulsatile Growth Hormone Release
Smith, R. G., Feighner, S. D., Prendergast, K., Guan, X.-M., & Howard, A. (1999) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(98)00132-5 · Cited by 72
Self-citation
A construct of interactive feedback control of the GH axis in the male
Farhy, L. S., Straume, M., Johnson, M. L., Kovatchev, B. P., & Veldhuis, J. D. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.1.r38 · Cited by 70
Crucial role for somatostatin receptor subtype 2 in determining the uptake of [111In-DTPA-D-Phe1]octreotide in somatostatin receptor-positive organs.
Hofland, L. J., Lamberts, S. W. J., van Hagen, P. M., Reubi, J., Schaeffer, J. M., Waaijers, M., van Koetsveld, P. M., Srinivasan, A., Krenning, E. P., & Breeman, W. A. P. (2003) · PubMed · Cited by 69
Self-citation
MOLECULAR EVOLUTION OF GPCRS: Somatostatin/urotensin II receptors
Tostivint, H., Daza, D. O., Bergqvist, C. A., Quan, F. B., Bougerol, M., Lihrmann, I., & Larhammar, D. (2014) · Journal of Molecular Endocrinology · doi:10.1530/jme-13-0274 · Cited by 66
Spatial learning and synaptic hippocampal plasticity in type 2 somatostatin receptor knock-out mice
Dutar, P., Vaillend, C., Viollet, C., Billard, J., Potier, B., Carlo, A.-S., Ungerer, A., & Epelbaum, J. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00074-x · Cited by 65
Adenosine: A Partial Agonist of the Growth Hormone Secretagogue Receptor
Smith, R. G., Griffin, P. R., Xu, Y., Smith, A., Liu, K., Calacay, J., Feighner, S. D., Pong, C., Leong, D. A., Pomés, A., et al. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3610 · Cited by 65
Self-citation
Roles of Hippocampal Somatostatin Receptor Subtypes in Stress Response and Emotionality
Prévot, T. D., Gastambide, F., Viollet, C., Henkous, N., Martel, G., Epelbaum, J., Béracochéa, D., & Guillou, J. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.281 · Cited by 67
Insights into the Regulation of Gastric Acid Secretion Through Analysis of Genetically Engineered Mice
Samuelson, L. C., & Hinkle, K. L. (2003) · Annual Review of Physiology · doi:10.1146/annurev.physiol.65.092101.142213 · Cited by 61
Growth Hormone Secretagogue Activation of the Arcuate Nucleus and Brainstem Occurs Via a Non‐Noradrenergic Pathway
Bailey, Englehardt, V., Leng, G., Smith, & Dickson, S. L. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00398.x · Cited by 61
Self-citation
Somatostatin Receptor Type 5 Modulates Somatostatin Receptor Type 2 Regulation of Adrenocorticotropin Secretion
Ben-Shlomo, A., Wawrowsky, K., Proekt, I., Wolkenfeld, N. M., Ren, S.-G., Taylor, J., Culler, M. D., & Melmed, S. K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501998200 · Cited by 60
Somatostatin sst2 receptor knock-out mice: localisation of sst1–5 receptor mRNA and binding in mouse brain by semi-quantitative RT–PCR, in situ hybridisation histochemistry and receptor autoradiography
Hannon, J. P., Petrucci, C., Fehlmann, D., Viollet, C., Epelbaum, J., & Hoyer, D. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(01)00186-1 · Cited by 56
Characterisation of [125I]-TyroDTrp8-somatostatin binding in sst1- to sst4- and SRIF-gene-invalidated mouse brain
Videau, C., Hochgeschwender, U., Kreienkamp, H., Brennan, M. B., Viollet, C., Richter, D., & Epelbaum, J. (2003) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-003-0758-8 · Cited by 58
Somatostatin (SRIF) and SRIF receptors in the mouse retina
Cristiani, R., Petrucci, C., Monte, M. D., & Bagnoli, P. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02450-2 · Cited by 57
Somatostatin in the dentate gyrus
Tallent, M. K. (2007) · Progress in brain research · doi:10.1016/s0079-6123(07)63016-7 · Cited by 54
Involvement of the Sst1 Somatostatin Receptor Subtype in the Intrahypothalamic Neuronal Network Regulating Growth Hormone Secretion: Anin Vitroandin VivoAntisense Study1
Lanneau, C., Bluet‐Pajot, M., Zizzari, P., Csaba, Z., Dournaud, P., Helboe, L., Hoyer, D., Pellegrini, E., Tannenbaum, G. S., Epelbaum, J., et al. (2000) · Endocrinology · doi:10.1210/endo.141.3.7349 · Cited by 55
Somatostatin is a selective chemoattractant for primitive (CD34+) hematopoietic progenitor cells
Oomen, S. P. M. A., van Hennik, P. B., Antonissen, C., Lichtenauer-Kaligis, E. G. R., Hofland, L. J., Lamberts, S. W. J., Löwenberg, B., & Touw, I. P. (2002) · Experimental Hematology · doi:10.1016/s0301-472x(01)00772-x · Cited by 54
The somatostatin sst1 receptor: an autoreceptor for somatostatin in brain and retina?
Thermos, K., Bagnoli, P., Epelbaum, J., & Hoyer, D. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.09.003 · Cited by 53
Calcium and other signalling pathways in neuroendocrine regulation of somatotroph functions
Chang, J. P., Habibi, H. R., Yu, Y., Moussavi, M., Grey, C. L., & Pemberton, J. G. (2011) · Cell Calcium · doi:10.1016/j.ceca.2011.11.001 · Cited by 52
Selective somatostatin sst2 receptor blockade with the novel cyclic octapeptide, CYN-154806
Feniuk, W., Jarvie, E. M., Luo, J., & Humphrey, P. P. A. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00035-6 · Cited by 52
Growth Hormone Secretagogues and Hypothalamic Networks
Bluet‐Pajot, M., Tolle, V., Zizzari, P., Robert, C., Hammond, C., Mitchell, V. A., Beauvillain, J., Viollet, C., Epelbaum, J., & Kordon, C. (2001) · Endocrine · doi:10.1385/endo:14:1:001 · Cited by 52
Somatostatins and their receptors in fish
Lin, X., & Peter, R. E. (2001) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/s1096-4959(01)00362-1 · Cited by 51
Somatostatin Is Essential for the Sexual Dimorphism of GH Secretion, Corticosteroid-Binding Globulin Production, and Corticosterone Levels in Mice
Adams, J. M., Otero-Corchón, V., Hammond, G. L., Veldhuis, J. D., Qi, N., & Low, M. J. (2014) · Endocrinology · doi:10.1210/en.2014-1429 · Cited by 51
Hippocampal SSTR4 somatostatin receptors control the selection of memory strategies
Gastambide, F., Viollet, C., Lepousez, G., Epelbaum, J., & Guillou, J. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1204-x · Cited by 49
Unequal autonegative feedback by GH models the sexual dimorphism in GH secretory dynamics
Farhy, L. S., Straume, M., Johnson, M. L., Kovatchev, B. P., & Veldhuis, J. D. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00407.2001 · Cited by 49
Functional aspects of the somatostatinergic system in the retina and the potential therapeutic role of somatostatin in retinal disease.
Casini, G., Catalani, E., Monte, M. D., & Bagnoli, P. (2005) · PubMed · doi:10.14670/hh-20.615 · Cited by 48
Somatostatin Contributes toIn VivoGamma Oscillation Modulation and Odor Discrimination in the Olfactory Bulb
Lepousez, G., Mouret, A., Loudes, C., Epelbaum, J., & Viollet, C. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4958-09.2010 · Cited by 46
Changes in neuronal response to ischemia in retinas with genetic alterations of somatostatin receptor expression
Catalani, E., Cervia, D., Martini, D., Bagnoli, P., Simonetti, E., Timperio, A. M., & Casini, G. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05419.x · Cited by 46
Role of endogenous somatostatin in regulating GH output under basal conditions and in response to metabolic extremes
Luque, R. M., Park, S., & Kineman, R. D. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.12.005 · Cited by 49
Growth hormone-releasing hormone activates sleep regulatory neurons of the rat preoptic hypothalamus
Peterfi, Z., McGinty, D., Sarai, E., & Szymusiak, R. S. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00494.2009 · Cited by 45
Genetic deletion of somatostatin receptor 1 alters somatostatinergic transmission in the mouse retina
Monte, M. D., Petrucci, C., Vasilaki, A., Cervia, D., Grouselle, D., Epelbaum, J., Kreienkamp, H., Richter, D., Hoyer, D., & Bagnoli, P. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00296-x · Cited by 45
Dissociation between tumor shrinkage and hormonal response during somatostatin analog treatment in an acromegalic patient: Preferential expression of somatostatin receptor subtype 3
Casarini, A., Pinto, E. M., Jallad, R. S., Giorgi, R. R., Giannella‐Neto, D., & Bronstein, M. D. (2006) · Journal of Endocrinological Investigation · doi:10.1007/bf03347378 · Cited by 44
Gender-Dependent Role of Endogenous Somatostatin in Regulating Growth Hormone-Axis Function in Mice
Luque, R. M., & Kineman, R. D. (2007) · Endocrinology · doi:10.1210/en.2007-0946 · Cited by 43
Somatostatin Receptor Subtype-2-Deficient Mice with Diet-Induced Obesity Have Hyperglycemia, Nonfasting Hyperglucagonemia, and Decreased Hepatic Glycogen Deposition
Singh, V., Grötzinger, C., Nowak, K. W., Zacharias, S., Göncz, E., Pleß, G., Sauer, I. M., Eichhorn, I., Pfeiffer-Guglielmi, B., Hamprecht, B., et al. (2007) · Endocrinology · doi:10.1210/en.2006-1659 · Cited by 46
Sustained alterations of hypothalamic tanycytes during posttraumatic hypopituitarism in male mice
Osterstock, G., El Yandouzi, T., Romanò, N., Carmignac, D., Langlet, F., Coutry, N., Guillou, A., Schaeffer, M., Chauvet, N., Vanacker, C., et al. (2014) · Endocrinology · doi:10.1210/en.2013-1336 · Cited by 43
Somatostatin receptors differentially affect spontaneous epileptiform activity in mouse hippocampal slices
Cammalleri, M., Cervia, D., Langenegger, D., Liu, Y., Monte, M. D., Hoyer, D., & Bagnoli, P. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03741.x · Cited by 40
Model-projected mechanistic bases for sex differences in growth hormone regulation in humans
Farhy, L. S., Bowers, C. Y., & Veldhuis, J. D. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00584.2006 · Cited by 37
Treatment with the Oral Growth Hormone Secretagogue MK-677 Increases Markers of Bone Formation and Bone Resorption in Obese Young Males
Svensson, J., Ohlsson, C., Jansson, J., Murphy, G. M., Wyss, D., Krupa, D. A., Cerchio, K., Polvino, W. J., Gertz, B., Baylink, D. J., et al. (1998) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1998.13.7.1158 · Cited by 40
The GLP1R Agonist Liraglutide Reduces Hyperglucagonemia Induced by the SGLT2 Inhibitor Dapagliflozin via Somatostatin Release
Saponaro, C., Gmyr, V., Thévenet, J., Moerman, E., Delalleau, N., Pasquetti, G., Coddeville, A., Quenon, A., Daoudi, M., Hübert, T., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.009 · Cited by 39
Somatostatin modulates generation of inspiratory rhythms and determines asphyxia survival
Ramírez‐Jarquín, J. O., Lara-Hernández, S., López-Guerrero, J. J., Aguileta, M. A., Rivera‐Angulo, A., Sampieri, A., Vaca, L. A., Ordaz, B., & Peña‐Ortega, F. (2012) · Peptides · doi:10.1016/j.peptides.2012.02.011 · Cited by 33
Modelling the Hypothalamic Control of Growth Hormone Secretion
MacGregor, D. J., & Leng, G. (2005) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2005.01370.x · Cited by 33
Self-citation
Cooperation between hippocampal somatostatin receptor subtypes 4 and 2: Functional relevance in interactive memory systems
Gastambide, F., Lepousez, G., Viollet, C., Loudes, C., Epelbaum, J., & Guillou, J. (2009) · Hippocampus · doi:10.1002/hipo.20680 · Cited by 34
Constitutive Somatostatin Receptor Activity Determines Tonic Pituitary Cell Response
Ben-Shlomo, A., Zhou, C., Pichurin, O., Chesnokova, V., Liu, N., Culler, M. D., & Melmed, S. K. (2009) · Molecular Endocrinology · doi:10.1210/me.2008-0361 · Cited by 33
Somatostatin and somatostatin receptors: implications for neoplastic growth and cancer biology
Msaouel, P., Galanis, E., & Koutsilieris, M. (2009) · Expert Opinion on Investigational Drugs · doi:10.1517/13543780903176399 · Cited by 31
Targeting sst2A Receptor-Expressing Cells in the Rat Hypothalamus through in Vivo Agonist Stimulation: Neuroanatomical Evidence for a Major Role of this Subtype in Mediating Somatostatin Functions
Csaba, Z., Simon, A., Helboe, L., Epelbaum, J., & Dournaud, P. (2003) · Endocrinology · doi:10.1210/en.2002-221090 · Cited by 31
Galanin inhibits gastric acid secretion through a somatostatin-independent mechanism in mice
Piqueras, L., Taché, Y., & Martı́nez, V. (2004) · Peptides · doi:10.1016/j.peptides.2004.06.003 · Cited by 31
Peripheral GABAB agonists stimulate gastric acid secretion in mice
Piqueras, L., & Martı́nez, V. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705876 · Cited by 31
Somatostatin and Cognitive Function in Neurodegenerative Disorders
Tuboly, G., & Vécsei, L. (2012) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955713804484794 · Cited by 32
Somatostatin Receptor type 2 Mediates Bombesin‐Induced Inhibition of Gastric Acid Secretion in Mice
Piqueras, L., Taché, Y., & Martı́nez, V. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.039750 · Cited by 30
Pattern-Dependent Suppression of Growth Hormone (GH) Pulsatility by Ghrelin and GH-Releasing Peptide-6 in Moderately GH-Deficient Rats
Thompson, N. M., Davies, J. S., Mode, A., Houston, P. A., & Wells, T. (2003) · Endocrinology · doi:10.1210/en.2003-0423 · Cited by 30
Peripheral PACAP inhibits gastric acid secretion through somatostatin release in mice
Piqueras, L., Taché, Y., & Martı́nez, V. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705739 · Cited by 29
Role of somatostatin receptors on gastric acid secretion in wild-type and somatostatin receptor type 2 knockout mice
Piqueras, L., & Mart�nez, V. (2004) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-004-0992-8 · Cited by 28
Subcellular Dynamics of Somatostatin Receptor Subtype 1 in the Rat Arcuate Nucleus: Receptor Localization and Synaptic Connectivity Vary in Parallel with the Ultradian Rhythm of Growth Hormone Secretion
Stroh, T., van Schouwenburg, M. R., Beaudet, A., & Tannenbaum, G. S. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0336-09.2009 · Cited by 30
Control of Gastric Acid Secretion in Somatostatin Receptor 2 Deficient Mice: Shift from Endocrine/Paracrine to Neurocrine Pathways
Zhao, C., Martı́nez, V., Piqueras, L., Wang, L., Taché, Y., & Chen, D. (2007) · Endocrinology · doi:10.1210/en.2007-0238 · Cited by 27
Null mutant mouse models of somatostatin and cortistatin, and their receptors
Zeyda, T., & Hochgeschwender, U. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.11.029 · Cited by 28
Involvement of the Sst1 Somatostatin Receptor Subtype in the Intrahypothalamic Neuronal Network Regulating Growth Hormone Secretion: An in Vitro and in Vivo Antisense Study
Lanneau, C. (2000) · Endocrinology · doi:10.1210/en.141.3.967 · Cited by 27
Interleukin‐1β Stimulates Growth Hormone‐Releasing Hormone Receptor mRNA Expression in the Rat Hypothalamus In Vitro and In Vivo
Taishi, P., de, A. R., Alt, J. A., Gardi, J., Obál, F., & Krueger, J. M. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.0953-8194.2004.01138.x · Cited by 25
An exercise “sweet spot” reverses cognitive deficits of aging by growth-hormone-induced neurogenesis
Blackmore, D. G., Steyn, F. J., Carlisle, A., O’Keeffe, I., Vien, K.-Y., Zhou, X. A., Leiter, O., Jhaveri, D. J., Vukovic, J., Waters, M. J., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103275 · Cited by 26
Somatostatin binds to murine macrophages through two distinct subsets of receptors
Perez, J., Viollet, C., Doublier, S., Videau, C., Epelbaum, J., & Baud, L. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(03)00094-8 · Cited by 25
Antidiabetic Activity of a Highly Potent and Selective Nonpeptide Somatostatin Receptor Subtype-2 Agonist
Strowski, M. Z., Cashen, D. E., Birzin, E. T., Yang, L., Singh, V., Jacks, T. M., Nowak, K. W., Rohrer, S. P., Patchett, A. A., Smith, R. G., et al. (2006) · Endocrinology · doi:10.1210/en.2006-0274 · Cited by 24
Self-citation
Sexually Dimorphic Distribution of sst2A Somatostatin Receptors on Growth Hormone-Releasing Hormone Neurons in Mice
Bouyer, K., Loudes, C., Robinson, I. C. A. F., Epelbaum, J., & Faivre‐Bauman, A. (2006) · Endocrinology · doi:10.1210/en.2005-1462 · Cited by 26
Neuroendocrine Control of Growth Hormone Secretion
Jansson, J., & Dickson, S. L. (1999) · Endocrine updates · doi:10.1007/978-1-4615-5163-8_1 · Cited by 24
Alterations in glucose homeostasis in SSTR1 gene-ablated mice
Wang, X. P., Norman, M. A., Yang, J., Magnusson, J., Kreienkamp, H.-J., Richter, D., DeMayo, F. J., & Brunicardi, F. C. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.11.002 · Cited by 23
Actions of neuropeptide Y and growth hormone secretagogues in the arcuate nucleus and ventromedial hypothalamic nucleus
Kumarnsit, E., Johnstone, L. E., & Leng, G. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02521.x · Cited by 23
Self-citation
Different brain structures mediate drinking and sleep suppression elicited by the somatostatin analog, octreotide, in rats
Hajdu, I., Szentirmai, É., Obál, F., & Krueger, J. M. (2003) · Brain Research · doi:10.1016/j.brainres.2003.09.029 · Cited by 23
Identification of transcriptional regulatory elements in the human somatostatin receptor sst2 promoter and regions including estrogen response element half-site for estrogen activation
Kimura, N., Takamatsu, N., Yaoita, Y., OSAMURA, R. Y., & Kimura, N. (2007) · Journal of Molecular Endocrinology · doi:10.1677/jme-07-0108 · Cited by 22
Molecular Biology of the Receptors for Somatostatin and Cortistatin
Kreienkamp, H. (1999) · Results and problems in cell differentiation · doi:10.1007/978-3-540-49421-8_10 · Cited by 22
Determinants of dual secretagogue drive of burst-like growth hormone secretion in premenopausal women studied under a selective estradiol clamp
Erickson, D., Keenan, D. M., Farhy, L., Mielke, K., Bowers, C. Y., & Veldhuis, J. D. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1621 · Cited by 21
Hypothalamic Regulation of Anterior Pituitary Function
Ben-Shlomo, A., & Melmed, S. K. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-380926-1.10002-1 · Cited by 22
Mammalian G-protein function in vivo: New insights through altered gene expression
Offermanns, S. (2006) · Springer eBooks · doi:10.1007/bfb0035551 · Cited by 21

Authors: Zheng, H., Bailey, A., Jiang, M.-H., Honda, K., Chen, H. Y., Trumbauer, M. E., Van der Ploeg, L. H. T., Schaeffer, J. M., Leng, G., & Smith, R. G.
Affiliations: Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
University of Edinburgh (GB)
ORCID: Zheng, Hui
Leng, Gareth
Venue: Molecular Endocrinology
Publisher: The Endocrine Society
Published: 1997-10
Volume: 11
Issue: 11
Pages: 1709-1717
ISSN: 0888-8809 (ISSN-L)
1944-9917
DOI: 10.1210/mend.11.11.0016
OpenAlex: W2036239129
Semantic Scholar: a3cb0d5444d5295da89c93a95ccdf0ac5396679b
Cited by: 169
References: 35
Citations by year: 2026: 1 · 2025: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2019: 4 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 6 · 2013: 3 · 2012: 4
FWCI: 6.89
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Molecular Endocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: somatostatin receptor 2, growth hormone-releasing hormone, pulsatile growth hormone secretion, octreotide, Fos-like immunoreactivity, hypothalamic regulation of growth hormone, knockout mice
MeSH terms: Animals, Arcuate Nucleus of Hypothalamus, Feedback, Gene Expression Regulation, Hypothalamus, Posterior, Indoles, Secretory Rate, Somatostatin, Growth Hormone, Growth Hormone-Releasing Hormone, Spiro Compounds, Octreotide, Signal Transduction, Proto-Oncogene Proteins c-fos, Receptors, Somatostatin, Mice, Knockout, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Somatostatin receptor subtype 2 knockout mice are refractory to growth hormone-negative feedback on arcuate neurons.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks