Zheng, Hui

Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice

Cherny, R. A., Atwood, C. S., Xilinas, M. E., Gray, D. N., Jones, W. D., McLean, C. A., Barnham, K. J., Volitakis, I., Fraser, F. W., Kim, Y.-S., et al. (2001) · Neuron

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NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer’s Disease

Lian, H., Yang, L., Cole, A., Sun, L., Chiang, A. C.-A., Fowler, S. W., Shim, D. J., Rodriguez-Rivera, J., Taglialatela, G., Jankowsky, J. L., et al. (2015) · Neuron

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

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Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease

Lian, H., Litvinchuk, A., Chiang, A. C.-A., Aithmitti, N., Jankowsky, J. L., & Zheng, H. (2016) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

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Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease

Roy, E. R., Wang, B., Wan, Y.-W., Chiu, G., Cole, A., Yin, Z., Propson, N. E., Xu, Y., Jankowsky, J. L., Liu, Z., et al. (2020) · Journal of Clinical Investigation

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

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Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease

Litvinchuk, A., Wan, Y.-W., Swartzlander, D. B., Chen, F., Cole, A., Propson, N. E., Wang, Q., Zhang, B., Liu, Z., & Zheng, H. (2018) · Neuron

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

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Practical considerations for choosing a mouse model of Alzheimer’s disease

Jankowsky, J. L., & Zheng, H. (2017) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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The Autophagy–Lysosomal Pathway in Neurodegeneration: A TFEB Perspective

Martini-Stoica, H., Xu, Y., Ballabio, A., & Zheng, H. (2016) · Trends in Neurosciences

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

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Meta-Analysis of the Alzheimer’s Disease Human Brain Transcriptome and Functional Dissection in Mouse Models

Wan, Y.-W., Al-Ouran, R., Mangleburg, C. G., Perumal, T. M., Lee, T. V., Allison, K., Swarup, V., Funk, C. C., Gaiteri, C., Allen, M., et al. (2020) · Cell Reports

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Defective Neuromuscular Synapses in Mice Lacking Amyloid Precursor Protein (APP) and APP-Like Protein 2

Wang, P., Yang, G., Mosier, D. R., Chang, P., Zaidi, T., Gong, Y.-D., Zhao, N.-M., Dominguez, B., Lee, K.-F., Gan, W.-B., et al. (2005) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

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Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging

Propson, N. E., Roy, E. R., Litvinchuk, A., Köhl, J., & Zheng, H. (2021) · Journal of Clinical Investigation

Barrier Structure and Function StudiesComplement system in diseases

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TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading

Martini-Stoica, H., Cole, A. L., Swartzlander, D. B., Chen, F., Wan, Y.-W., Bajaj, L., Bader, D. A., Lee, V. M. Y., Trojanowski, J. Q., Liu, Z., et al. (2018) · Journal of Experimental Medicine

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

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Presynaptic and Postsynaptic Interaction of the Amyloid Precursor Protein Promotes Peripheral and Central Synaptogenesis

Wang, Z., Wang, B., Yang, L., Guo, Q., Aithmitti, N., Songyang, Z., & Zheng, H. (2009) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

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Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques

Roy, E. R., Chiu, G., Li, S., Propson, N. E., Kanchi, R., Wang, B., Coarfa, C., Zheng, H., & Cao, W. (2022) · Immunity

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

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Peripheral immune system in aging and Alzheimer’s disease

Cao, W., & Zheng, H. (2018) · Molecular Neurodegeneration

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

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Accelerated Plaque Accumulation, Associative Learning Deficits, and Up-regulation of α7 Nicotinic Receptor Protein in Transgenic Mice Co-expressing Mutant Human Presenilin 1 and Amyloid Precursor Proteins

Dineley, K. T., Xia, X., Bui, D., Sweatt, J. D., & Zheng, H. (2002) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

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Loss of α7 Nicotinic Receptors Enhances β-Amyloid Oligomer Accumulation, Exacerbating Early-Stage Cognitive Decline and Septohippocampal Pathology in a Mouse Model of Alzheimer's Disease

Hernandez, C. M., Kayed, R., Zheng, H., Sweatt, J. D., & Dineley, K. T. (2010) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsNicotinic Acetylcholine Receptors Study

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IL‐6 and IL‐1β in Fever: Studies Using Cytokine‐Deficient (Knockout) Mice a

KOZAK, W., KLUGER, M. J., SOSZYNSKI, D., CONN, C. A., RUDOLPH, K., LEON, L. R., & ZHENG, H. (1998) · Annals of the New York Academy of Sciences

Thermal Regulation in MedicineInflammasome and immune disorders

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Genetic Suppression of Transgenic APP Rescues Hypersynchronous Network Activity in a Mouse Model of Alzeimer's Disease

Born, H. A., Kim, J.-Y., Savjani, R. R., Das, P., Dabaghian, Y. A., Guo, Q., Yoo, J. W., Schuler, D. R., Cirrito, J. R., Zheng, H., et al. (2014) · The Journal of Neuroscience

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Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading

Xu, Y., Propson, N. E., Du, S., Xiong, W., & Zheng, H. (2021) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

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Somatostatin receptor subtype 2 knockout mice are refractory to growth hormone-negative feedback on arcuate neurons.

Zheng, H., Bailey, A., Jiang, M.-H., Honda, K., Chen, H. Y., Trumbauer, M. E., Van der Ploeg, L. H. T., Schaeffer, J. M., Leng, G., & Smith, R. G. (1997) · Molecular Endocrinology

Growth Hormone and Insulin-like Growth FactorsHypothalamic control of reproductive hormones

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Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits

Wu, Y., Du, S., Johnson, J. L., Tung, H.-Y., Landers, C. T., Liu, Y., Seman, B. G., Wheeler, R. T., Costa-Mattioli, M., Kheradmand, F., et al. (2019) · Nature Communications

Antifungal resistance and susceptibilityNeuroinflammation and Neurodegeneration Mechanisms

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A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer’s disease

Zhao, P., Xu, Y., Jiang, L., Fan, X., Li, L., Li, X., Arase, H., Zhao, Y., Cao, W., Zheng, H., et al. (2022) · Science Translational Medicine

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

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Intraperitoneal injection of the pancreatic peptide amylin potently reduces behavioral impairment and brain amyloid pathology in murine models of Alzheimer’s disease

Zhu, H., Wang, X., Wallack, M., Li, H., Carreras, I., Dedeoglu, A., Hur, J.-Y., Zheng, H., Li, H., Fine, R., et al. (2015) · Molecular Psychiatry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Amyloid, tau, pathogen infection and antimicrobial protection in Alzheimer’s disease –conformist, nonconformist, and realistic prospects for AD pathogenesis

Li, H., Liu, C.-C., Zheng, H., & Huang, T. Y. (2018) · Translational Neurodegeneration

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

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