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Radiotherapy enhancement with gold nanoparticles
Abstract
Gold is an excellent absorber of X-rays. If tumours could be loaded with gold, this would lead to a higher dose to the cancerous tissue compared with the dose received by normal tissue during a radiotherapy treatment. Calculations indicate that this dose enhancement can be significant, even 200% or greater. In this paper, the physical and biological parameters affecting this enhancement are discussed. Gold nanoparticles have shown therapeutic efficacy in animal trials and these results are reviewed. Some 86% long-term (>1 year) cures of EMT-6 mouse mammary subcutaneous tumours was achieved with an intravenous injection of gold nanoparticles before irradiation with 250-kVp photons, whereas only 20% were cured with radiation alone. The clinical potential of this approach is also discussed.
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Cited by
Gold nanoparticles for cancer radiotherapy: a review
Haume, K., Rosa, S., Grellet, S., Śmiałek, M. A., Butterworth, K. T., Solov’yov, A. V., Prise, K. M., Golding, J., & Mason, N. J. (2016) · Cancer Nanotechnology · doi:10.1186/s12645-016-0021-x · Cited by 445
Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles
McMahon, S. J., Hyland, W. B., Muir, M. F., Coulter, J. A., Jain, S., Butterworth, K. T., Schettino, G., Dickson, G. R., Hounsell, A. R., O'Sullivan, J. M., et al. (2011) · Scientific Reports · doi:10.1038/srep00018 · Cited by 429
Generation of reactive oxygen species induced by gold nanoparticles under x-ray and UV Irradiations
Misawa, M., & Takahashi, J. (2011) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2011.01.014 · Cited by 342
Recent advances in metal nanoparticles in cancer therapy
Sharma, A., Goyal, A. K., & Rath, G. (2018) · Journal of Drug Targeting · doi:10.1080/1061186x.2017.1400553 · Cited by 341
Ni, K., Lan, G., Chan, C., Quigley, B., Lu, K., Aung, T., Guo, N., La Riviere, P., Weichselbaum, R. R., & Lin, W. (2018) · Nature Communications · doi:10.1038/s41467-018-04703-w · Cited by 336
Metadata
- Authors
- Hainfeld, J. F., Dilmanian, F. A., Slatkin, D. N., & Smilowitz, H. M.
- Venue
- Journal of Pharmacy and Pharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-08-01
- Volume
- 60
- Issue
- 8
- Pages
- 977-985
- ISSN
- 0022-3573 (ISSN-L)
- 2042-7158
- OpenAlex
- W2115712044
- Cited by
- 733
- References
- 0
- FWCI
- 14.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Radiotherapy enhancement with gold nanoparticles. https://app.cochat.ai/papers/10.1211/jpp.60.8.0005
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- Hainfeld, J. F., Dilmanian, F. A., Slatkin, D. N., & Smilowitz, H. M. (2008). Radiotherapy enhancement with gold nanoparticles. Journal of Pharmacy and Pharmacology. https://doi.org/10.1211/jpp.60.8.0005
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
