The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles
Open accessAbstract
Gold nanoparticles (GNPs) are being proposed as contrast agents to enhance X-ray imaging and radiotherapy, seeking to take advantage of the increased X-ray absorption of gold compared to soft tissue. However, there is a great discrepancy between physically predicted increases in X-ray energy deposition and experimentally observed increases in cell killing. In this work, we present the first calculations which take into account the structure of energy deposition in the nanoscale vicinity of GNPs and relate this to biological outcomes, and show for the first time good agreement with experimentally observed cell killing by the combination of X-rays and GNPs. These results are not only relevant to radiotherapy, but also have implications for applications of heavy atom nanoparticles in biological settings or where human exposure is possible because the localised energy deposition high-lighted by these results may cause complex DNA damage, leading to mutation and carcinogenesis.
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DNA-Programmable Nanoparticle Crystallization*
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Gold nanoparticles for applications in cancer radiotherapy: Mechanisms and recent advancements
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Physical basis and biological mechanisms of gold nanoparticle radiosensitization
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Metadata
- Authors
- McMahon, S. J., Hyland, W. B., Muir, M. F., Coulter, J. A., Jain, S., Butterworth, K. T., Schettino, G., Dickson, G. R., Hounsell, A. R., O'Sullivan, J. M., Prise, K. M., Hirst, D. G., & Currell, F. J.
- Venue
- Scientific Reports
- Published
- 2011-06-20
- Volume
- 1
- Issue
- 1
- Pages
- 18-18
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2171351334
- Cited by
- 429
- References
- 28
- FWCI
- 18.06
- Type
- journal article
- Language
- en
- Open access
- gold
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- McMahon, S. J., Hyland, W. B., Muir, M. F., Coulter, J. A., Jain, S., Butterworth, K. T., Schettino, G., Dickson, G. R., Hounsell, A. R., O'Sullivan, J. M., Prise, K. M., Hirst, D. G., & Currell, F. J. (2011). Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles. Scientific Reports. https://doi.org/10.1038/srep00018
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