Hydrogen sulfide protects from intestinal ischaemia–reperfusion injury in rats
Abstract
OBJECTIVES: Hydrogen sulfide (H2S) is an endogenously gaseous mediator, regulating many pathophysiological functions in mammalian cells. H2S has been shown to inhibit myocardial ischaemia-reperfusion (I/R) injury. However, little is known about whether H2S could modulate intestinal I/R injury. This study aimed to investigate the effect of H2S on intestinal I/R injury and potential mechanism(s) underlying the action of H2S in regulating the development of intestinal I/R injury in rats. METHODS: Following surgical induction of intestinal I/R injury for 1 h, groups of Sprague-Dawley rats were treated with, or without, tetramethylpyrazine (8 mg/kg), or sodium hydrosulfide (NaHS, an H2S donor at 7 or 14 micromol/kg) 30 min after occlusion. All rats were sacrificed immediately after the reperfusion. Their intestinal injury, together with that of sham-control rats, was histologically examined and their sera and intestinal malondialdehyde (MDA), superoxide dismutase (SOD), peroxidase (GSH-Px) activities were characterized by biochemical analysis. KEY FINDINGS: The results showed that NaHS significantly reduced intestinal I/R injury and the levels of sera and intestinal MDA activity, and dramatically increased the levels of serum and intestinal SOD and GSH-Px activity. CONCLUSIONS: The results suggest that H2S protects from intestinal I/R injury in rats, which is associated with increase in the activity of antioxidant enzymes.
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Lower concentrations of endogenously derived H2S exert beneficial cytoprotective, antioxidant and anti-inflammatory actions.
“On one hand, it appears that lower concentrations of endogenously derived H2S exert beneficial cytoprotective, antioxidant and anti-inflammatory actions[344,348–351]”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [348]
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- Authors
- Liu, H., Bai, X.-B., Shi, S., & Cao, Y.-X.
- Affiliations
- Department of General Surgery, the First Affiliated Hospital , Shaanxi,
- Xi'an Jiaotong University (CN)
- Corresponding author
- Cao, Yong-Xiao
- Venue
- Journal of Pharmacy and Pharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-02-01
- Volume
- 61
- Issue
- 2
- Pages
- 207-212
- ISSN
- 0022-3573 (ISSN-L)
- 2042-7158
- OpenAlex
- W2000904326
- Cited by
- 65
- References
- 30
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 5 · 2015: 8 · 2014: 3 · 2013: 6 · 2012: 6
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Journal of Pharmacy and Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Health Sciences › Medicine › Surgery › Hydrogen's biological and therapeutic effects
- Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
- Keywords
- hydrogen sulfide, intestinal ischemia-reperfusion injury, sodium hydrosulfide, antioxidant enzymes, superoxide dismutase, glutathione peroxidase, malondialdehyde, oxidative stress, intestinal protection
- MeSH terms
- Animals, Antioxidants, Disease Models, Animal, Glutathione Peroxidase, Hydrogen Sulfide, Intestinal Diseases, Male, Malondialdehyde, Mesenteric Vascular Occlusion, Sulfides, Superoxide Dismutase, Reperfusion Injury, Rats
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