Antiulcerogenic and anti-inflammatory activities of the essential oil from Pterodon emarginatus seeds
Abstract
The objective of this work was to investigate the antiulcerogenic and anti-inflammatory activities of the essential oil from Pterodon emarginatus seeds.The following tests were used: ulcers induced by ethanol, indometacin and HCl/ethanol, and pleurisy induced by carrageenan in Swiss albino rats. The rats were treated by the oral route with essential oil of P. emarginatus seeds.The essential oil at 100, 300 and 500 mg/kg exhibited significant protection against ulcers induced by ethanol, indometacin and HCl/ethanol (P < 0.001). The essential oil caused a marked reduction in the exudate volume and inhibited leucocyte and neutrophil influx (P < 0.05) in carrageenan-induced pleurisy. Moreover, the essential oil significantly decreased nitric oxide (NO) and interleukin-1 (IL-1) levels, without affecting tumour necrosis factor-alpha production.The results demonstrated the marked antiulcerogenic and anti-inflammatory effects of the essential oil from P. emarginatus, which are, at least in part, a consequence of NO and IL-1 modulation. P. emarginatus or its constituents might represent new therapeutic options to treat gastric ulcers and inflammatory diseases.
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Mice pretreated with Pterodon emarginatus oil show marked reduction of IL-1 and TNF-α levels after a single intrapleural injection of carrageenan.
“Animals (mice) pretreated with Pterodon emarginatus Vogel. oil presented a marked reduction of IL-1 and TNF-α levels after submitted to a single intrapleural injection of carrageenan [123].”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [123]
The inhibitory effect of some essential oils on pro-inflammatory cytokine production seems to be mediated by suppressing gene expression of these cytokines, mainly at the transcriptional level.
“The inhibitory effect of some of the essential oils on the production of pro-inflammatory cytokines reported in this chapter seems to be mediated by suppressing gene expression of these cytokines. Such was described by some authors because they found that the essential oils studied significantly suppressed the protein and mRNA expression of the cytokines in stimulated cells, assuming therefore,”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [123]
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“Furthermore, mice that were pre-treated with Pterodon emargina oil exhibited a reduction of (IL-1) and (TNF-α) levels after the intrapleural injection of carrageenan, and germacreneD was identified as the major compound of the oil [42].”
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Self-citationApplication of essential oils as antioxidant agents
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- Authors
- Dutra, R. C., Fava, M. B., Alves, C. C. S., Ferreira, A. P., & Barbosa, N. R.
- Affiliations
- Universidade Federal de Juiz de Fora (BR)
- Venue
- Journal of Pharmacy and Pharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-02-01
- Volume
- 61
- Issue
- 2
- Pages
- 243-250
- ISSN
- 0022-3573 (ISSN-L)
- OpenAlex
- W4240751835
- Cited by
- 12
- References
- 0
- Citations by year
- 2024: 1 · 2023: 2 · 2021: 2 · 2020: 1 · 2017: 1 · 2016: 1 · 2014: 1 · 2012: 1
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pharmacy and Pharmacology (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry Medicinal Plant Applications
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Keywords
- Pterodon emarginatus, seed essential oil, antiulcer activity, anti-inflammatory activity, ethanol-induced gastric injury, indomethacin-induced ulcer, carrageenan-induced pleurisy, nitric oxide, interleukin-1, TNF-α, neutrophil infiltration, gastric ulcer
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