The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Medication adherence among HIV+ adults: Effects of cognitive dysfunction and regimen complexity
Open accessAbstract
BACKGROUND: Although the use of highly active antiretroviral therapy in the treatment of HIV infection has led to considerable improvement in morbidity and mortality, unless patients are adherent to their drug regimen (i.e., at least 90 to 95% of doses taken), viral replication may ensue and drug-resistant strains of the virus may emerge. METHODS: The authors studied the extent to which neuropsychological compromise and medication regimen complexity are predictive of poor adherence in a convenience sample of 137 HIV-infected adults. Medication adherence was tracked through the use of electronic monitoring technology (MEMS caps). RESULTS: Two-way analysis of variance revealed that neurocognitive compromise as well as complex medication regimens were associated with significantly lower adherence rates. Cognitively compromised participants on more complex regimens had the greatest difficulty with adherence. Deficits in executive function, memory, and attention were associated with poor adherence. Logistic regression analysis demonstrated that neuropsychological compromise was associated with a 2.3 times greater risk of adherence failure. Older age (>50 years) was also found to be associated with significantly better adherence. CONCLUSIONS: HIV-infected adults with significant neurocognitive compromise are at risk for poor medication adherence, particularly if they have been prescribed a complex dosing regimen. As such, simpler dosing schedules for more cognitively impaired patients might improve adherence.
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Adherence to Protease Inhibitor Therapy and Outcomes in Patients with HIV Infection
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Structured Clinical Interview for DSM-III-R Personality Disorders
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Hirsch, M. S., Brun-Vézinet, F., D'Aquila, R. T., Hammer, S. M., Johnson, V. A., Kuritzkes, D. R., Loveday, C., Mellors, J. W., Clotet, B., Conway, B., et al. (2000) · JAMA · doi:10.1001/jama.283.18.2417 · Cited by 766
A Comparison Study of Multiple Measures of Adherence to HIV Protease Inhibitors
Liu, H., Golin, C. E., Miller, L. G., Hays, R. D., Beck, C. K., Sanandaji, S., Christian, J., Maldonado, T., Duran, D., Kaplan, A. H., et al. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-10-200105150-00011 · Cited by 758
Cited by
An information-motivation-behavioral skills model of adherence to antiretroviral therapy.
Fisher, J. D., Fisher, W. A., Amico, K. R., & Harman, J. J. (2006) · Health Psychology · doi:10.1037/0278-6133.25.4.462 · Cited by 696
Cognitive Neuropsychology of HIV-Associated Neurocognitive Disorders
Woods, S. P., Moore, D. J., Weber, E., & Grant, I. (2009) · Neuropsychology Review · doi:10.1007/s11065-009-9102-5 · Cited by 573
Neurological complications of HIV infection
McArthur, J. C., Brew, B. J., & Nath, A. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70165-4 · Cited by 554
Executive Function, Working Memory, and Medication Adherence Among Older Adults
Insel, K., Morrow, D., Brewer, B., & Figueredo, A. (2006) · The Journals of Gerontology Series B: Psychological Sciences and Social Sciences · doi:10.1093/geronb/61.2.p102 · Cited by 343
Drug Use and Medication Adherence among HIV-1 Infected Individuals
Hinkin, C. H., Barclay, T. R., Castellon, S. A., Levine, A. J., Durvasula, R. S., Marion, S. D., Myers, H. F., & Longshore, D. (2007) · AIDS and Behavior · doi:10.1007/s10461-006-9152-0 · Cited by 305
Self-citation
Metadata
- Authors
- Hinkin, C. H., Castellon, S. A., Durvasula, R. S., Hardy, D. J., Lam, M. N., Mason, K. I., Thrasher, D., Goetz, M. B., & Stefaniak, M.
- Venue
- Neurology
- Published
- 2002-12-24
- Volume
- 59
- Issue
- 12
- Pages
- 1944-1950
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2109188618
- Cited by
- 455
- References
- 44
- FWCI
- 8.28
- Type
- journal article
- Language
- en
- Open access
- green
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- Hinkin, C. H., Castellon, S. A., Durvasula, R. S., Hardy, D. J., Lam, M. N., Mason, K. I., Thrasher, D., Goetz, M. B., & Stefaniak, M. (2002). Medication adherence among HIV+ adults: Effects of cognitive dysfunction and regimen complexity. Neurology. https://doi.org/10.1212/01.wnl.0000038347.48137.67
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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