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Cited by 46Amyotrophic Lateral Sclerosis ResearchCervical and Thoracic MyelopathyNeurogenetic and Muscular Disorders Research

An exploratory case-control study on spinal and bulbar forms of amyotrophic lateral sclerosis in the province of Rome

Binazzi, Alessandra, Belli, Stefano, Uccelli, Raffaella, Desiato, Maria Teresa, Talamanca, Irene Figa, Antonini, Giovanni, Corsi, Fabio, Scoppetta, Ciriaco +4 more·2008·Amyotrophic Lateral Sclerosis
DOI 10.1080/17482960802382313
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Abstract

Several environmental and life-style factors reported as possibly associated with ALS have been analysed in the present study, focusing on the two clinical onsets of ALS. A case-control study (77 cases and 185 controls) has been performed in the province of Rome in the period 2005-2006. Increased risks were observed in bulbar cases for former smokers (OR: 4.55, 90% CI 1.72-12.08) and more than 24 pack-years, compared with spinal cases for employment in the construction sector and professional exposure to building materials (OR: 5.27, 90% CI 1.15-24.12) and metals (OR: 2.94, 90% CI 1.20-7.21). Overall and bulbar cases showed an increased risk for consumption of cold cuts and a decreased risk for vegetables intake. Regarding head injuries, differences were observed if the last injury occurred in the age range of 30-40 years, among all (OR: 14.2, 90% CI 1.04-194.42) and bulbar (OR: 17.4, 90% CI 1.70-178.5) cases, and less than 30 years among spinal cases (OR: 7.13, 90% CI 1.34-37.94). Moreover, a risk for a time period of 11-30 years since the last head injury suffered was found in bulbar cases (OR: 3.51, 90% CI 1.03-11.95). Some of the hypothesized risk factors for ALS have been found positively associated in this study, with different patterns between bulbar and spinal ALS.

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  • Head injuries have previously been associated with ALS risk.

    “and head injuries (14;20–22).”

    From Association of ALS with head injury, cigarette smoking and APOE genotypes (2010) · cites this paper as [22]

  • An Italian case-control study not included in the meta-analysis reported an increased risk of ALS when the last head injury occurred at an older age and closer to the time of diagnosis.

    “An Italian case-control study, which was not included in this meta-analysis, also reported an increased risk of ALS when the last head injury occurred at an older age and closer to the time of diagnosis (22).”

    From Association of ALS with head injury, cigarette smoking and APOE genotypes (2010) · cites this paper as [22]

  • Some studies have reported that multiple head injuries and age at first head injury were associated with ALS, which is consistent with the findings we observed in our study.

    “Some studies have reported that multiple head injuries and age at first head injury were associated with ALS, which is also consistent with the findings we observed in our study [18,20,61,62].”

    From Head Injury and Amyotrophic Lateral Sclerosis: Population-Based Study from the National ALS Registry (2025) · cites this paper as [62]

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Authors
Binazzi, A., Belli, S., Uccelli, R., Desiato, M. T., Talamanca, I. F., Antonini, G., Corsi, F., Scoppetta, C., Inghilleri, M., Pontieri, F., Vanacore, N., & ALS ROME GROUP
Affiliations
  • Istituto Superiore di Sanità (IT)
  • National Agency for New Technologies, Energy and Sustainable Economic Development (IT)
  • Sapienza University of Rome (IT)
  • São Camilo Hospital (BR)
  • Policlinico Umberto I (IT)
Corresponding author
Binazzi, Alessandra
ORCID
Venue
Amyotrophic Lateral Sclerosis
Publisher
Informa UK Limited
Published
2008
Volume
10
Issue
5-6
Pages
1-10
ISSN
  • 1471-180X (ISSN-L)
  • 1748-2968
DOI
10.1080/17482960802382313
OpenAlex
W2084330862
Cited by
46
References
53
Citations by year
2026: 1 · 2025: 1 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 6 · 2014: 4 · 2013: 1 · 2012: 7
FWCI
1.74
Type
journal article
Language
en
Open access
closed
Locations
  • Amyotrophic Lateral Sclerosis (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
  • Health Sciences › Medicine › Surgery › Cervical and Thoracic Myelopathy
  • Health Sciences › Medicine › Genetics › Neurogenetic and Muscular Disorders Research
Keywords
bulbar onset, spinal onset, risk factors, smoking, construction workers, metal exposure, vegetable consumption, traumatic brain injury, Rome province
MeSH terms
Adolescent, Adult, Aged, Amyotrophic Lateral Sclerosis, Female, Craniocerebral Trauma, Humans, Male, Middle Aged, Risk Factors, Rome, Smoking, Case-Control Studies, Occupational Exposure, Age of Onset, Young Adult

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