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Head trauma preceding PD: A case-control study

Bower, J. H., Maraganore, D. M., Peterson, B. J., McDonnell, S. K., Ahlskog, J. E., Rocca, W. A.·2003·Neurology
DOI 10.1212/01.wnl.0000068008.78394.2c
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Abstract

Objective To investigate the association of PD with preceding head trauma using a case-control study design. Methods The medical records-linkage system of the Rochester Epidemiology Project was used to identify 196 subjects who developed PD in Olmsted County, MN, from 1976 through 1995. Each incident case was matched by age (+/-1 year) and sex to a general population control. The complete medical records of cases and controls in the system were reviewed to detect preceding episodes of head trauma. Results The frequency of head trauma overall was significantly higher in cases than in controls (odds ratio [OR] = 4.3; 95% CI = 1.2 to 15.2). Compared with subjects who never experienced a trauma, subjects who experienced a mild head trauma with only amnesia had no increased risk; however, subjects who experienced a mild head trauma with loss of consciousness or a more severe trauma had an OR of 11.0 (95% CI = 1.4 to 85.2). Although not significant, head trauma resulting in hospitalization was more frequent in cases than in control subjects (OR = 8.0; 95% CI = 1.0 to 64.0). Whereas the OR was higher for men than women and for patients with later onset of PD than for patients with earlier onset, these differences were not significant. Conclusions These results suggest an association between head trauma and the later development of PD that varies with severity. Although the OR is high (4.3), the population attributable risk is only 5% because head trauma is a relatively rare event.

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Crossref · 10.1212/01.wnl.0000068008.78394.2c

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5 of 5 references verified0 citation errors · 0 not checkable

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  • In a population-based study of PD, an OR of 4.3 (95% CI 1.2-15.2) was reported for head injuries leading to loss of consciousness or hospitalization.

    “In a population-based study of PD, an OR of 4.3 (95% CI 1.2–15.2) was reported for head injuries leading to loss of consciousness or hospitalization, as documented in medical records (55).”

    From Association of ALS with head injury, cigarette smoking and APOE genotypes (2010) · cites this paper as [55]

  • The study data support the existence of a relatively long period of latency between injury and ALS onset, since head injuries up to 15 years before the reference date contributed to the observed increased odds of ALS.

    “Consistent with previous epidemiologic studies of head injury in PD (55;56) and ALS (21), our data also support the existence of a relatively long period of latency between injury and ALS onset, since head injuries up to 15 years before the reference date contributed to the observed increased odds of ALS.”

    From Association of ALS with head injury, cigarette smoking and APOE genotypes (2010) · cites this paper as [55]

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Authors
Bower, J. H., Maraganore, D. M., Peterson, B. J., McDonnell, S. K., Ahlskog, J. E., & Rocca, W. A.
Affiliations
From the Departments of Neurology (Drs. Bower, Maraganore, Ahlskog, and Rocca) and Health Sciences Research (Dr. Rocca, B.J. Peterson and S.K. McDonnell), Mayo Foundation, Rochester, MN.
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2003-05-27
Volume
60
Issue
10
Pages
1610-1615
ISSN
  • 0028-3878
  • 1526-632X
DOI
10.1212/01.wnl.0000068008.78394.2c
Cited by
166
References
5
Language
en

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