Cited by 355Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration MechanismsNuclear Receptors and Signaling

Neuroinflammation mediated by IL-1β increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease

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Koprich, James B, Reske-Nielsen, Casper, Mithal, Prabhakar, Isacson, Ole·2008·Journal of Neuroinflammation

Abstract

Background: The etiology of Parkinson's disease (PD) remains elusive despite identification of several genetic mutations. It is more likely that multiple factors converge to give rise to PD than any single cause. Here we report that inflammation can trigger degeneration of dopamine (DA) neurons in an animal model of Parkinson's disease. Methods: We examined the effects of inflammation on the progressive 6-OHDA rat model of Parkinson's disease using immunohistochemistry, multiplex ELISA, and cell counting stereology. Results: We show that a non-toxic dose of lipopolysaccharide (LPS) induced secretion of cytokines and predisposed DA neurons to be more vulnerable to a subsequent low dose of 6-hydroxydopamine. Alterations in cytokines, prominently an increase in interleukin-1beta (IL-1β), were identified as being potential mediators of this effect that was associated with activation of microglia. Administration of an interleukin-1 receptor antagonist resulted in significant reductions in tumor necrosis factor-α and interferon-γ and attenuated the augmented loss of DA neurons caused by the LPS-induced sensitization to dopaminergic degeneration. Conclusion: These data provide insight into the etiology of PD and support a role for inflammation as a risk factor for the development of neurodegenerative disease.

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  • In a different PD mouse model, blocking IL-1β signaling using an IL-1 receptor antagonist significantly attenuated neurodegeneration.

    “In a different PD mouse model, blocking IL-1β signaling using an IL-1 receptor antagonist also significantly attenuated neurodegeneration.362,363”

    From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [362]

    The Results section reports significantly less dopamine-neuron cell loss with IL-1 receptor antagonist than with vehicle after LPS and 6-OHDA treatment (p < 0.05). However, the Background identifies the model as a rat model of Parkinson’s disease, not a mouse model. (LLM, conf=0.91)

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Authors
Koprich, J. B., Reske-Nielsen, C., Mithal, P., & Isacson, O.
Affiliations
Harvard University (US)
Venue
Journal of Neuroinflammation
Published
2008-02-27
Volume
5
Issue
1
Pages
8-8
ISSN
1742-2094 (ISSN-L)
OpenAlex
W1990872391
Cited by
355
References
86
Citations by year
2026: 14 · 2025: 15 · 2024: 27 · 2023: 18 · 2022: 30 · 2021: 24 · 2020: 22 · 2019: 15 · 2018: 21 · 2017: 15 · 2016: 21 · 2015: 22 · 2014: 16 · 2013: 19 · 2012: 14
FWCI
13.05
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Journal of Neuroinflammation (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
National Institute of Neurological Disorders and Stroke (P50NS039793, NS-39793)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
Keywords
Parkinson's disease, neuroinflammation, IL-1β, dopaminergic neurons, dopaminergic neuron loss, lipopolysaccharide, 6-hydroxydopamine, microglial activation, interleukin-1 receptor antagonist, TNF-α, interferon-gamma, neurodegeneration, Parkinson's disease model
MeSH terms
Animals, Disease Models, Animal, Disease Susceptibility, Dopamine, Female, Lipopolysaccharides, Nerve Degeneration, Neuritis, Risk Factors, Substantia Nigra, Sympatholytics, Neuroimmunomodulation, Oxidopamine, Rats, Sprague-Dawley, Microglia, Antirheumatic Agents, Parkinsonian Disorders, Rats, Interleukin-1beta, Interleukin 1 Receptor Antagonist Protein

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