The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Fatigue in MS is related to sympathetic vasomotor dysfunction
Abstract
The authors studied standard autonomic function tests and measures of heart rate variability in 60 patients with multiple sclerosis (MS) and correlated results with the Fatigue Severity Scale and the Modified Fatigue Impact Scale. The authors found that autonomic responses correlated with fatigue resembling a hypoadrenergic orthostatic response, possibly due to a sympathetic vasomotor lesion with intact vagal heart control. Treatments to control sympathetic dysfunction for MS-associated fatigue deserve further study.
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“Specifically, in MS patients, various measures of autonomic dysfunction correlate strongly with individual fatigue levels (Flachenecker et al., 2003; Cortez et al., 2015).”
From Allostatic Self-efficacy: A Metacognitive Theory of Dyshomeostasis-Induced Fatigue and Depression (2016) · cites this paper as Flachenecker et al., 2003
Citations
Cites
Assessment of autonomic function in humans by heart rate spectral analysis
Pomeranz, B., Macaulay, R. J., Caudill, M. A., Kutz, I., Adam, D., Gordon, D., Kilborn, K. M., Barger, A. C., Shannon, D. C., Cohen, R. J., et al. (1985) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1985.248.1.h151 · Cited by 2,876
Flachenecker, P., Kümpfel, T., Kallmann, B. A., Gottschalk, M., Grauer, O. M., Rieckmann, P., Trenkwalder, C., & Toyka, K. V. (2002) · Multiple Sclerosis Journal · doi:10.1191/1352458502ms839oa · Cited by 635
Self-citationFatigue in multiple sclerosis: current understanding and future directions.
Schwid, S. R., Covington, M., Segal, B. M., & Goodman, A. D. (2002) · PubMed · Cited by 225
Mathias, C. J., Mallipeddi, R., & Bleasdale-Barr, K. (1999) · Journal of Neurology · doi:10.1007/s004150050479 · Cited by 178
Cardiovascular autonomic dysfunction in multiple sclerosis: correlation with orthostatic intolerance
Flachenecker, P., Wolf, A., Krauser, M., Hartung, H., & Reiners, K. (1999) · Journal of Neurology · doi:10.1007/s004150050407 · Cited by 112
Self-citationCardiovascular autonomic dysregulation and fatigue in multiple sclerosis
Merkelbach, S., Dillmann, U., Kölmel, C., Holz, J., & Müller, M. (2001) · Multiple Sclerosis Journal · doi:10.1177/135245850100700508 · Cited by 63
Is fatigue in patients with multiple sclerosis related to autonomic dysfunction?
Keselbrener, L., AKSELROD, S., Ahiron, A., Eldar, M., Barak, Y., & Rotstein, Z. (2000) · Clinical Autonomic Research · doi:10.1007/bf02291352 · Cited by 58
Egg, R., Högl, B., Glatzl, S., Beer, R., & Berger, T. (2002) · Multiple Sclerosis Journal · doi:10.1191/1352458502ms793oa · Cited by 27
Research works printed but not linked: 2
- Therapeutics and Technology Assessment Subcommittee. Clinical autonomic testing. Neurology . 1996; 46: 873–880.
- Wieling W Karemaker JM. Measurement of heart rate and blood pressure to evaluate disturbances in neurocardiovascular control. In: Mathias CJ Bannister R eds. Autonomic failure. A textbook of clinical disorders of the autonomic nervous system. 4th ed. New York: Oxford University Press 1999: 196–210.
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Kontaxis, S., Laporta, E., Pagès, E. G., Guerrero, A. I., Zabalza, A., Martinis, M., Lucia, R., Simblett, S. K., Weyer, J., Hotopf, M. H., et al. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1145818 · Cited by 2
Martinez-Assucena, A., Marnetoft, S., Roig-Rovira, T., Miguel, H. S., Bernabeu, M., & Gispert-Saúch, M. M. (2010) · Critical Reviews in Physical and Rehabilitation Medicine · doi:10.1615/critrevphysrehabilmed.v22.i1-4.90 · Cited by 2
Delva, I. I. (2022) · Eastern Ukrainian Medical Journal · doi:10.21272/eumj.2022;10(4):309-317 · Cited by 2
Health, Wellness, and the Effect of Comorbidities on the Multiple Sclerosis Disease Course
Conway, D. S., Sullivan, A. B., & Rensel, M. R. (2023) · Neurologic Clinics · doi:10.1016/j.ncl.2023.06.007 · Cited by 2
An unusual cause of subacute intestinal obstruction: Figure 1
Cheung, F. K. Y., Siu, W. T., Chiu, P. W. Y., & Ng, E. K. W. (2006) · Gut · doi:10.1136/gut.2005.076554 · Cited by 2
Cohen, J. A., & Rudick, R. A. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9781139023986.054 · Cited by 3
BAROREFLEX SENSITIVITY IN MULTIPLE SCLEROSIS
Konečný, L., Pospíšil, P., Anbais, F. H., Fišer, B., Pohanka, M., Siègelovà, J., & Dobšák, P. (2008) · Cited by 1
Fatigue in multiple sclerosis: a short clinical update
Zarei, H. (2007) · Cited by 1
Gastrointestinal Autonomic Disorders
Bassi, A., Bossa, M., D’Alba, L., Greco, C., Casini, A., Pellicano, C., Simonelli, M., & Zampatti, S. (2023) · Springer eBooks · doi:10.1007/978-3-031-43036-7_8 · Cited by 1
Analysis and Validation for Kinematic and Physiological Data of VR Training System
Chen, S., Ben, H., Gao, Y., Liu, Y., Liao, Z., Li, J., & Hao, A. (2021) · IEEE International Symposium on Mixed and Augmented Reality Adjunct (ISMAR-Adjunct) · doi:10.1109/ismar-adjunct54149.2021.00040 · Cited by 1
Test Battery for Evaluating Fatigue in Multiple Sclerosis Patients
Graham, J. E., Fisher, N. M., Granger, C. V., & Tomita, M. (2007) · International Journal of MS Care · doi:10.7224/1537-2073-9.3.118 · Cited by 1
Multiple Sclerosis related Fatigue and the Hypothalamic-Pituitary-Adrenal Axis
Nawrath, L. M. (2010)
Die Neuro-Endokrino-Immunologie der Multiplen Sklerose
Paur, R., & Schmidbauer, M. (2009) · Psychopraxis · doi:10.1007/s00739-009-0153-4
Vermoeidheid – concepten voor behandeling en meting in de fysiotherapie
O’Connell, C., & Stokes, E. (2008) · Stimulus · doi:10.1007/bf03077608
Pharmacological and drug-free Interventions for Fatigue in Multiple Sclerosis
Penner, I. (2013) · Neurodegenerative Disease Management · doi:10.2217/nmt.12.80
Davis, W. H. W. (2013) · SUNScholar (Stellenbosch University)
Response to Flachenecker et al.
Sanya, E. O., Tutaj, M., Brown, C., Goel, N., Neundörfer, B., & Hilz, M. J. (2005) · Clinical Autonomic Research · doi:10.1007/s10286-005-0316-1
Gene Expression and Variation in Multiple Sclerosis
Szvetko, A. L. (2009) · Griffith Research Online · doi:10.25904/1912/1563
フィリピンにおける地域医療従事者確保の斬新な取り組み : 国立フィリピン大学健康科学部の紹介(〈特集〉地域医療)
雄一, 千., 尚子, 林., Salvador, I. B. D., Siega-Sur, J. L. J., Labarda, M. D. P., & 修二, 大. (2013) · Dokkyo journal of medical sciences
Bhise, V. V., & Krupp, L. (2015) · Neuropsychiatric symptoms of neurological disease · doi:10.1007/978-3-319-18464-7_11
Definitions, Epidemiology, and Etiological Factors
Flachenecker, P. (2023) · Springer eBooks · doi:10.1007/978-3-031-13498-2_2 · Cited by 2
Self-citationYang, L., Li, W., Xie, Y., Ma, S., Zhou, X., Huang, X., & Tan, S. (2023) · Figshare · doi:10.6084/m9.figshare.22625642
Physiopathologie et traitement de la fatigue dans la sclérose en plaques
Chalah, M. A. (2019) · theses.fr (ABES) · doi:10.70675/9be71a74z7578z4637za069zf44a656eb777
Metadata
- Authors
- Flachenecker, P., Rufer, A., Bihler, I., Hippel, C., Reiners, K., Toyka, K. V., & Kesselring, J.
- Affiliations
- University of Würzburg (DE)
- Venue
- Neurology
- Published
- 2003-09-23
- Volume
- 61
- Issue
- 6
- Pages
- 851-853
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1970120310
- Cited by
- 125
- References
- 8
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 11 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 6 · 2018: 2 · 2017: 8 · 2016: 5 · 2015: 10 · 2014: 4 · 2013: 6 · 2012: 8
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
- Keywords
- multiple sclerosis, fatigue, autonomic dysfunction, sympathetic nervous system, vasomotor dysfunction, heart rate variability, orthostatic response, Fatigue Severity Scale, Modified Fatigue Impact Scale
- MeSH terms
- Adult, Aged, Blood Pressure, Electrocardiography, Fatigue, Female, Fourier Analysis, Heart Rate, Humans, Hypotension, Orthostatic, Male, Middle Aged, Multiple Sclerosis, Posture, Surveys and Questionnaires, Severity of Illness Index, Sympathetic Nervous System, Vagus Nerve, Valsalva Maneuver, Vasomotor System, Hand Strength
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