The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Depression but not seizure frequency predicts quality of life in treatment-resistant epilepsy
Abstract
BACKGROUND: The two-thirds of patients with epilepsy who become seizure-free have a quality of life (QOL) similar to the general population. The major treatment challenge is patients with refractory epilepsy. Whereas neurologists typically focus on seizure reduction in the treatment of these patients, results of studies relating seizure frequency to QOL are conflicting. As depression is associated with reduced QOL in epilepsy and antiepileptic medications (AEDs) can cause depression, it is important to determine the relative roles of depression and seizure frequency in QOL in refractory epilepsy. METHODS: Prospective evaluation was conducted of patients with refractory epilepsy being admitted to an inpatient video-EEG monitoring unit. The impact of clinical variables (age, sex, marital status, seizure frequency, duration and type of seizure disorder, seizure localization, number of AEDs, depression) on QOL was analyzed. RESULTS: Depression was a powerful predictor of QOL (n = 122, beta = -35.8, p < 0.0001). No other variable predicted QOL. Depression was common (54%), severe (19% with suicidal thoughts), underdiagnosed (37%), and largely untreated (17% on antidepressants). CONCLUSIONS: Treatment of depression may be inadequately prioritized in the management of intractable epilepsy.
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Cites
Psychometric properties of the Beck Depression Inventory: Twenty-five years of evaluation
Beck, A. T., Steer, R. A., & Carbin, M. G. (1988) · Clinical Psychology Review · doi:10.1016/0272-7358(88)90050-5 · Cited by 11,696
Development and cross-cultural translations of a 31-item quality of life in epilepsy inventory
Cramer, J. A., Perrine, K., Devinsky, O., Bryant‐Comstock, L., Meador, K., & Hermann, B. (1998) · Epilepsia · doi:10.1111/j.1528-1157.1998.tb01278.x · Cited by 782
Development of the Quality of Life in Epilepsy Inventory
Devinsky, O., Vickrey, B. G., Cramer, J., Perrine, K., Hermann, B., Meador, K., & Hays, R. D. (1995) · Epilepsia · doi:10.1111/j.1528-1157.1995.tb00467.x · Cited by 634
Self-citation
Cited by
Rapid detection of major depression in epilepsy: a multicentre study
Gilliam, F. G., Barry, J. J., Hermann, B. P., Meador, K. J., Vahle, V., & Kanner, A. M. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70415-x · Cited by 712
Epilepsy, suicidality, and psychiatric disorders: a bidirectional association
Hesdorffer, D. C., Ishihara, L., Mynepalli, L., Webb, D. J., Weil, J., & Hauser, W. A. (2012) · Annals of Neurology · doi:10.1002/ana.23601 · Cited by 610
Alper, K., Schwartz, K. A., Kolts, R. L., & Khan, A. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.023 · Cited by 522
Descriptive Epidemiology of Major Depression in Canada
Patten, S. B., Wang, J. L., Williams, J. V., Currie, S., Beck, C. A., Maxwell, C. J., & el-Guebaly, N. (2006) · The Canadian Journal of Psychiatry · doi:10.1177/070674370605100204 · Cited by 443
Micoulaud-Franchi, J.-A., Lagarde, S., Barkate, G., Dufournet, B., Besancon, C., Trébuchon-Da Fonseca, A., Gavaret, M., Bartolomei, F., Bonini, F., & McGonigal, A. (2016) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2016.02.015 · Cited by 251
Metadata
- Authors
- Boylan, L. S., Flint, L. A., Labovitz, D. L., Jackson, S. C., Starner, K., & Devinsky, O.
- Venue
- Neurology
- Published
- 2004-01-27
- Volume
- 62
- Issue
- 2
- Pages
- 258-261
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2035998652
- Cited by
- 644
- References
- 3
- FWCI
- 15.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Boylan, L. S., Flint, L. A., Labovitz, D. L., Jackson, S. C., Starner, K., & Devinsky, O. (2004). Depression but not seizure frequency predicts quality of life in treatment-resistant epilepsy. Neurology. https://doi.org/10.1212/01.wnl.0000103282.62353.85
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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