Cerebral glucose metabolism in patients with AD and different APOE genotypes
Abstract
Objective To examine the influence of the APOE epsilon4 allele on cerebral glucose metabolism in a large series of patients with Alzheimer disease (AD). Methods Eighty-three patients (41 APOE epsilon4 positive and 42 epsilon4 negative) were selected from a pre-existing databank of patients with AD (n > 1,000). The patients were carefully matched for age, age at onset, approximate disease duration, educational level, and overall degree of cognitive impairment. Cerebral [18F]fluorodeoxyglucose PET imaging was performed in all patients by a standardized protocol. Statistical comparison of patient PET data vs a healthy control population was performed as well as an analysis of differences between groups (SPM99; Wellcome Department of Cognitive Imaging, London, UK). Results A similar pattern of cerebral hypometabolism was detected in the epsilon4-positive and -negative patient groups vs healthy volunteers in regions typically affected by AD (bilateral temporal, parietal, posterior cingulate, and prefrontal cortical areas). The comparison between epsilon4-positive and -negative patients additionally revealed stronger abnormalities in epsilon4 carriers in parietal, temporal, and posterior cingulate cortical regions. Conclusions A generally similar pattern of cerebral hypometabolism was detected in APOE epsilon4-positive and -negative patients with Alzheimer disease. However, in direct comparison of the two matched groups, the abnormalities in the epsilon4-positive group were demonst…
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Brain metabolic changes can be influenced by APOE genetic variation.
“These changes in brain metabolism can be influenced by APOE genetic variation [12][13][14] .”
From APOE4-drives brain bioenergetic shifts independent of Alzheimer’s disease pathology (2026) · cites this paper as [14]
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APOE4-drives brain bioenergetic shifts independent of Alzheimer’s disease pathology
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- Authors
- Drzezga, A., Riemenschneider, M., Strassner, B., Grimmer, T., Peller, M., Knoll, A., Wagenpfeil, S., Minoshima, S., Schwaiger, M., & Kurz, A.
- Affiliations
- University of Washington (US)
- Venue
- Neurology
- Published
- 2005-01-11
- Volume
- 64
- Issue
- 1
- Pages
- 102-107
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2164277022
- Cited by
- 116
- References
- 3
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 5
- FWCI
- 5.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- Alzheimer's disease, APOE ε4, brain glucose metabolism, brain hypometabolism, 18F-FDG PET, genetic risk factors, posterior cingulate cortex, parietal cortex, temporal cortex, prefrontal cortex
- MeSH terms
- Aged, Alzheimer Disease, Apolipoproteins E, Cerebral Cortex, Female, Genotype, Glucose, Humans, Male, Middle Aged, Fluorodeoxyglucose F18, Positron-Emission Tomography, Apolipoprotein E4
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