Cited by 27Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Alzheimer's disease biomarkers: correspondence between human studies and animal models

Open access
Sabbagh, Jonathan J., Kinney, Jefferson W., Cummings, Jeffrey L.·2013·Neurobiology of Disease

Abstract

Alzheimer's disease (AD) represents an escalating global threat as life expectancy and disease prevalence continue to increase. There is a considerable need for earlier diagnoses to improve clinical outcomes. Fluid biomarkers measured from cerebrospinal fluid (CSF) and blood, or imaging biomarkers have considerable potential to assist in the diagnosis and management of AD. An additional important utility of biomarkers is in novel therapeutic development and clinical trials to assess efficacy and side effects of therapeutic interventions. Because many biomarkers are initially examined in animal models, the extent to which markers translate from animals to humans is an important issue. The current review highlights many existing and pipeline biomarker approaches, focusing on the degree of correspondence between AD patients and animal models. The review also highlights the need for greater translational correspondence between human and animal biomarkers.

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Crossref · 10.1016/j.nbd.2013.04.010

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  • A number of clinical studies using DTI have observed increased MD and reduced FA in the white matter of the brains of AD patients compared to healthy controls.

    “A number of clinical studies using DTI have observed increased MD and reduced FA in the white matter of the brains of AD patients when compared to healthy controls (Jack, 2012, Sabbagh et al., 2013).”

    From In vivo imaging of tau pathology using multi-parametric quantitative MRI (2015) · cites this paper as Sabbagh et al., 2013

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Authors
Sabbagh, J. J., Kinney, J. W., & Cummings, J. L.
Affiliations
  • University of Nevada, Las Vegas (US)
  • Cleveland Clinic (US)
Corresponding author
Kinney, Jefferson W.
Venue
Neurobiology of Disease
Publisher
Elsevier BV
Published
2013-08
Volume
56
Pages
116-130
ISSN
0969-9961 (ISSN-L)
OpenAlex
W2011018734
Cited by
27
References
284
Citations by year
2026: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 4 · 2019: 1 · 2017: 5 · 2016: 1 · 2015: 3 · 2014: 6 · 2013: 1
FWCI
0.40
Type
journal article
Language
en
Open access
Licence
cc-by-sa
Locations
  • Neurobiology of Disease (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
Alzheimer's disease, biomarkers, animal models, translational research, cerebrospinal fluid biomarkers, blood biomarkers, imaging biomarkers, early diagnosis, treatment development, clinical trials
MeSH terms
Alzheimer Disease, Animals, Electroencephalography, Humans, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Biomarkers, Early Diagnosis, Positron-Emission Tomography

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