Differences in neuropathologic characteristics across the Lewy body dementia spectrum
Open accessAbstract
BACKGROUND: The objective of this comparative neuropathologic study was to determine the extent to which dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD) are distinct entities or part of a continuum with respect to the duration of parkinsonism. METHODS: We evaluated the relationship between cortical alpha-synuclein pathology, plaques (Consortium to Establish a Registry for Alzheimer's Disease [CERAD]), tangles (Braak staging), and cholinergic deficits (choline acetyltransferase in temporal cortex) in 57 prospectively assessed patients (29 DLB, 28 PDD), confirmed at autopsy. The PDD group was divided according to the median duration of parkinsonism prior to dementia. RESULTS: There was an association between longer duration of parkinsonism prior to dementia and less severe cortical alpha-synuclein pathology (chi(2) 10.4, df 2, p = 0.006) and lower CERAD plaque scores (chi(2) 26.6, df 9, p = 0.002), but not Braak staging. These findings were confirmed in a further correlation analysis, which also identified an unexpected correlation between more pronounced cortical cholinergic deficits and longer duration of parkinsonism prior to dementia (R = -0.37, p = 0.04). CONCLUSION: While there is a clear relationship between the duration of Parkinson disease prior to the onset of dementia and key neuropathologic and neurochemical characteristics, there is a gradation of these differences across the dementia with Lewy bodies/Parkinson disease dementia spectrum and the findings do not support an arbitrary cut-off between the two disorders.
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Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works
Parkinsonism: onset, progression, and mortality
Hoehn, M. M., & Yahr, M. D. (1967) · Neurology · doi:10.1212/wnl.17.5.427 · Cited by 12,107 · see citing works
Staging of brain pathology related to sporadic Parkinson’s disease
Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777 · see citing works
Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium
McKeith, I. G., Dickson, D. W., Lowe, J., Emre, M., O'Brien, J. T., Feldman, H., Cummings, J., Duda, J. E., Lippa, C., Perry, E. K., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000187889.17253.b1 · Cited by 5,069 · see citing works
Self-citationMirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961 · see citing works
McKeith, I. G., Galasko, D., Kosaka, K., Perry, E. K., Dickson, D. W., Hansen, L. A., Salmon, D. P., Lowe, J., Mirra, S. S., Byrne, E. J., et al. (1996) · Neurology · doi:10.1212/wnl.47.5.1113 · Cited by 3,960 · see citing works
Self-citationDiagnostic Criteria for Parkinson Disease
Gelb, D. J., Oliver, E., & Gilman, S. (1999) · Archives of Neurology · doi:10.1001/archneur.56.1.33 · Cited by 2,822 · see citing works
Cholinergic dysfunction in diseases with Lewy bodies
Dodel, R. C., Du, Y.-S., Bales, K., Gao, F., Eastwood, B., Glazier, B., Zimmer, R., Cordell, B., Hake, A., Evans, R., et al. (2000) · Neurology · doi:10.1212/wnl.54.2.407 · Cited by 972 · see citing works
Visual hallucinations in Lewy body disease relate to Lewy bodies in the temporal lobe
Harding, A., Broe, G. A., & Halliday, G. M. (2002) · Brain · doi:10.1093/brain/awf033 · Cited by 608 · see citing works
Senile dementia of Lewy body type
Perry, R. H., Irving, D., Blessed, G., FAIRBAIRN, A. F., & Perry, E. K. (1990) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(90)90236-g · Cited by 573 · see citing works
Self-citationParkinson Disease Neuropathology
Apaydın, H., Ahlskog, J. E., Parisi, J. E., Boeve, B. F., & Dickson, D. W. (2002) · Archives of Neurology · doi:10.1001/archneur.59.1.102 · Cited by 397 · see citing works
Neuropathology of dementia in Parkinson's disease: A prospective, community‐based study
Aarsland, D., Perry, R., Brown, A. D., Larsen, J. O., & Ballard, C. G. (2005) · Annals of Neurology · doi:10.1002/ana.20635 · Cited by 347 · see citing works
Self-citationShimura, H., Hattori, N., Kubo, S., Yoshikawa, M., Kitada, T., Matsumine, H., Asakawa, S., Minoshima, S., Yamamura, Y., Shimizu, N., et al. (1999) · Annals of Neurology · doi:10.1002/1531-8249(199905)45:5 · Cited by 282 · see citing works
Frequency of Dementia in Parkinson Disease
Aarsland, D., Tandberg, E., Larsen, J. O., & Cummings, J. L. (1996) · Archives of Neurology · doi:10.1001/archneur.1996.00550060082020 · Cited by 276 · see citing works
Self-citationCholinergic Transmitter and Neurotrophic Activities in Lewy Body Dementia
Perry, E. K., Irving, D., Kerwin, J. M., McKeith, I. G., Thompson, P., Collerton, D., FAIRBAIRN, A. F., Ince, P. G., Morris, C. M., Cheng, A. V., et al. (1993) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199307020-00002 · Cited by 213 · see citing works
Self-citationTam, C. W. C., Burton, E. J., McKeith, I. G., Burn, D. J., & O’Brien, J. T. (2005) · Neurology · doi:10.1212/01.wnl.0000153070.82309.d4 · Cited by 209 · see citing works
Self-citationAre Parkinson’s Disease with dementia and Dementia with lewy Bodies the Same Entity?
Aarsland, D., Ballard, C. G., & Halliday, G. M. (2004) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988704267470 · Cited by 204 · see citing works
Self-citationLarsen, J. O., Dupont, E., & Tandberg, E. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1994.tb01674.x · Cited by 176 · see citing works
Self-citationDementia with Lewy bodies and Parkinson's disease with dementia: Are they different?
Tsuboi, Y., & Dickson, D. W. (2005) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2004.10.014 · Cited by 154 · see citing works
Ouchi, Y., Yoshikawa, E., Okada, H., Futatsubashi, M., Sekine, Y., Iyo, M., & Sakamoto, M. (1999) · PubMed · Cited by 145 · see citing works
Katsuse, O., Iseki, E., Marui, W., & Kosaka, K. (2003) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(03)00037-6 · Cited by 96 · see citing works
A paced visual serial addition test for fMRI
Lazeron, R. H. C., Rombouts, S. A. R. B., de Sonneville, L. M. J., Barkhof, F., & Scheltens, P. (2003) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(03)00144-8 · Cited by 90 · see citing works
The present state of people who survived the holocaust as children
Robinson, S., Rapaport‐Bar‐Sever, M., & Rapaport, J. (1994) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1994.tb01508.x · Cited by 87 · see citing works
Parkinson's disease and dementia with Lewy bodies: One disease or two?
Richard, I. H., Papka, M., Rubio, A. I., & Kurlan, R. (2002) · Movement Disorders · doi:10.1002/mds.10274 · Cited by 65 · see citing works
Iseki, E. (2004) · Neuropathology · doi:10.1111/j.1440-1789.2003.00530.x · Cited by 54 · see citing works
Non‐uniformity in the regional pattern of Lewy pathology in brains of dementia with Lewy bodies
Yamamoto, R., Iseki, E., Marui, W., Togo, T., Katsuse, O., Kato, M., Isojima, D., Akatsu, H., Kosaka, K., & Arai, H. (2005) · Neuropathology · doi:10.1111/j.1440-1789.2005.00627.x · Cited by 31 · see citing works
Rodrigo, J., Fernández, A. P., Bentura, M. L., de Velasco, J. M., Serrano, J., UTTENTHAL, L. O., & Martínez‐Murillo, R. (1998) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(98)00016-7 · Cited by 29 · see citing works
Torres, E. M., Rogers, D. C., Annett, L. E., SIRINATHSINGHJI, D. J. S., & Dunnett, S. B. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90100-y · Cited by 20 · see citing works
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Clinical diagnostic criteria for dementia associated with Parkinson’s disease
Emre, M., Aarsland, D., Brown, R., Burn, D. J., Duyckaerts, C., Mizuno, Y., Broe, G. A., Cummings, J., Dickson, D. W., Gauthier, S., et al. (2007) · Movement Disorders · doi:10.1002/mds.21507 · Cited by 3,027 · see citing works
Self-citationLees, A. J., Hardy, J., & Revesz, T. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60492-x · Cited by 1,956 · see citing works
Cognitive decline in Parkinson disease
Aarsland, D., Creese, B., Politis, M., Chaudhuri, K. R., ffytche, D. H., Weintraub, D., & Ballard, C. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.27 · Cited by 1,027 · see citing works
Self-citationNeuropathological assessment of Parkinson’s disease: refining the diagnostic criteria
Dickson, D. W., Braak, H., Duda, J. E., Duyckaerts, C., Gasser, T., Halliday, G. M., Hardy, J., Leverenz, J. B., Del Tredici, K., Wszolek, Z. K., et al. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70238-8 · Cited by 972 · see citing works
Kehagia, A. A., Barker, R. A., & Robbins, T. W. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70212-x · Cited by 883 · see citing works
Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies
Irwin, D. J., Lee, V. M. ‐., & Trojanowski, J. Q. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3549 · Cited by 875 · see citing works
Irwin, D. J., Grossman, M., Weintraub, D. A., Hurtig, H. I., Duda, J. E., Xie, S. X., Lee, E. B., Deerlin, V. M. V., López, O. L., Kofler, J., et al. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30291-5 · Cited by 588 · see citing works
Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important?
Compta, Y., Parkkinen, L., O’Sullivan, S. S., Vandrovcová, J., Holton, J. L., Collins, C., Lashley, T., Kallis, C., Williams, D. R., de Silva, R., et al. (2011) · Brain · doi:10.1093/brain/awr031 · Cited by 585 · see citing works
The epidemiology of dementia associated with Parkinson disease
Aarsland, D., & Kurz, M. W. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.08.034 · Cited by 572 · see citing works
Self-citationNeuropathologic substrates of Parkinson disease dementia
Irwin, D. J., White, M. T., Toledo, J. B., Xie, S. X., Robinson, J. L., Van Deerlin, V., Lee, V. M. ‐., Leverenz, J. B., Montine, T. J., Duda, J. E., et al. (2012) · Annals of Neurology · doi:10.1002/ana.23659 · Cited by 518 · see citing works
Cognitive impairment in patients with Parkinson's disease: diagnosis, biomarkers, and treatment
Svenningsson, P., Westman, E., Ballard, C. G., & Aarsland, D. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70152-7 · Cited by 497 · see citing works
Self-citationAmyloid biomarkers in Alzheimer's disease
Blennow, K., Mattsson, N., Schöll, M., Hansson, O., & Zetterberg, H. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.03.002 · Cited by 470 · see citing works
Neuropathology of sporadic Parkinson's disease: Evaluation and changes of concepts
Jellinger, K. A. (2011) · Movement Disorders · doi:10.1002/mds.23795 · Cited by 448 · see citing works
Edison, P., Rowe, C. C., Rinne, J. O., Ng, S., Ahmed, I., Kemppainen, N. M., Villemagne, V. L., O'Keefe, G. J., Någren, K., Chaudhuri, К. R., et al. (2008) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2007.127878 · Cited by 422 · see citing works
Rolinski, M., Fox, C., Maidment, I., & McShane, R. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006504.pub2 · Cited by 418 · see citing works
Are dementia with Lewy bodies and Parkinson’s disease dementia the same disease?
Jellinger, K. A., & Korczyn, A. D. (2018) · BMC Medicine · doi:10.1186/s12916-018-1016-8 · Cited by 386 · see citing works
Alpha-synuclein biology in Lewy body diseases
Kim, W. S., Kågedal, K., & Halliday, G. M. (2014) · Alzheimer s Research & Therapy · doi:10.1186/s13195-014-0073-2 · Cited by 376 · see citing works
Neurotransmitter changes in dementia with Lewy bodies and Parkinson disease dementia in vivo
Klein, J. C., Eggers, C., Kalbe, E., Weisenbach, S., Hohmann, C., Vollmar, S., Baudrexel, S., Diederich, N. J., Heiß, W.-D., & Hilker, R. (2010) · Neurology · doi:10.1212/wnl.0b013e3181d55f61 · Cited by 355 · see citing works
The Epidemiology of Dementia Associated with Parkinson's Disease
Aarsland, D., & Kurz, M. W. (2010) · Brain Pathology · doi:10.1111/j.1750-3639.2009.00369.x · Cited by 340 · see citing works
Self-citationAlpha‐Synuclein as a Biomarker for Parkinson's Disease
Atik, A., Stewart, T., & Zhang, J. (2016) · Brain Pathology · doi:10.1111/bpa.12370 · Cited by 311 · see citing works
PIB is a non-specific imaging marker of amyloid-beta (A ) peptide-related cerebral amyloidosis
Lockhart, A., Lamb, J. R., Osredkar, T., Sue, L. I., Joyce, J. N., Ye, L., Libri, V., Leppert, D., & Beach, T. G. (2007) · Brain · doi:10.1093/brain/awm191 · Cited by 302 · see citing works
The progression of pathology in Parkinson's disease
Halliday, G. M., & McCann, H. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05118.x · Cited by 298 · see citing works
Dementia with Lewy bodies and Parkinson’s disease-dementia: current concepts and controversies
Jellinger, K. A. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-017-1821-9 · Cited by 265 · see citing works
Cognitive impairment and dementia in Parkinson's disease
Pagonabarraga, J., & Kulisevsky, J. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.03.029 · Cited by 257 · see citing works
Oliveira, A. M. D., Radanovic, M., Mello, P. C. H. D., Buchain, P. C., Vizzotto, A. D. B., Celestino, D. L., Stella, F., Piersol, C. V., & Forlenza, O. V. (2015) · BioMed Research International · doi:10.1155/2015/218980 · Cited by 247 · see citing works
The clinical characteristics of dementia with Lewy bodies and a consideration of prodromal diagnosis
Donaghy, P. C., & McKeith, I. G. (2014) · Alzheimer s Research & Therapy · doi:10.1186/alzrt274 · Cited by 249 · see citing works
Self-citationImaging biomarkers in Parkinson’s disease and Parkinsonian syndromes: current and emerging concepts
Saeed, U., Compagnone, J., Aviv, R. I., Strafella, A. P., Black, S. E., Lang, A. E., & Masellis, M. (2017) · Translational Neurodegeneration · doi:10.1186/s40035-017-0076-6 · Cited by 236 · see citing works
Alves, G. W., Brønnick, K., Aarsland, D., Blennow, K., Zetterberg, H., Ballard, C. G., Kurz, M. W., Andréasson, U., Tysnes, O., Larsen, J. O., et al. (2010) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2009.199950 · Cited by 221 · see citing works
Self-citationCerebrospinal fluid biomarkers in Parkinson disease
Parnetti, L., Castrioto, A., Chiasserini, D., Persichetti, E., Tambasco, N., El-Agnaf, O., & Calabresi, P. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.10 · Cited by 209 · see citing works
Parkinson Disease With Dementia
Sabbagh, M. N., Adler, C. H., Lahti, T., Connor, D. J., Vedders, L. J., Peterson, L. K., Caviness, J. N., Shill, H. A., Sue, L. I., Ziabreva, I., et al. (2009) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e31819c5ef4 · Cited by 209 · see citing works
Self-citationNon-motor dysfunction in Parkinson's disease
Ziemssen, T., & Reichmann, H. (2007) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2006.12.014 · Cited by 205 · see citing works
Cognitive status correlates with white matter alteration in Parkinson's disease
Hattori, T., Orimo, S., Aoki, S., Ito, K., Abe, O., Amano, A., Sato, R., Sakai, K., & Mizusawa, H. (2011) · Human Brain Mapping · doi:10.1002/hbm.21245 · Cited by 201 · see citing works
Smith, C., Malek, N., Grosset, K. A., Cullen, B., Gentleman, S., & Grosset, D. G. (2019) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2019-321111 · Cited by 201 · see citing works
Pathologic Accumulation of α-Synuclein and Aβ in Parkinson Disease Patients With Dementia
Kotzbauer, P. T., Cairns, N. J., Campbell, M. C., Willis, A. W., Racette, B. A., Tabbal, S. D., & Perlmutter, J. S. (2012) · Archives of Neurology · doi:10.1001/archneurol.2012.1608 · Cited by 197 · see citing works
Cerebrospinal Fluid Patterns and the Risk of Future Dementia in Early, Incident Parkinson Disease
Bäckström, D. C., Domellöf, M. E., Linder, J., Olsson, B., Öhrfelt, A., Trupp, M., Zetterberg, H., Blennow, K., & Forsgren, L. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.1449 · Cited by 197 · see citing works
Milestones in Parkinson's disease—Clinical and pathologic features
Halliday, G. M., Lees, A. J., & Stern, M. (2011) · Movement Disorders · doi:10.1002/mds.23669 · Cited by 197 · see citing works
Regional Multiple Pathology Scores Are Associated with Cognitive Decline in L ewy Body Dementias
Howlett, D. R., Whitfield, D., Johnson, M. A., Attems, J., O'Brien, J. T., Aarsland, D., Lai, M. K. P., Lee, J. H., Chen, C., Ballard, C. G., et al. (2014) · Brain Pathology · doi:10.1111/bpa.12182 · Cited by 196 · see citing works
Self-citationCortical thinning is associated with disease stages and dementia in Parkinson's disease
Zarei, M., Ibarretxe‐Bilbao, N., Compta, Y., Hough, M., Junqué, C., Bargalló, N., Tolosa, E., & Martí, M. J. (2013) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-304126 · Cited by 192 · see citing works
Cognitive impairment in Parkinson's disease: Tools for diagnosis and assessment
Kulisevsky, J., & Pagonabarraga, J. (2009) · Movement Disorders · doi:10.1002/mds.22506 · Cited by 188 · see citing works
Compta, Y., Martı́, M. J., Ibarretxe‐Bilbao, N., Junqué, C., Valldeoriola, F., Muñoz, E., Ezquerra, M., Ríos, J., & TOLOSA, E. S. (2009) · Movement Disorders · doi:10.1002/mds.22594 · Cited by 185 · see citing works
Gray matter atrophy in Parkinson disease with dementia and dementia with Lewy bodies
Beyer, M. K., Larsen, J. O., & Aarsland, D. (2007) · Neurology · doi:10.1212/01.wnl.0000269666.62598.1c · Cited by 172 · see citing works
Self-citationCerebrospinal Fluid Biomarkers in Parkinson's Disease with Dementia and Dementia with Lewy Bodies
Parnetti, L., Tiraboschi, P., Lanari, A., Peducci, M., Padiglioni, C., D’Amore, C., Pierguidi, L., Tambasco, N., Rossi, A., & Calabresi, P. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.02.016 · Cited by 173 · see citing works
Tröster, A. I. (2008) · Neuropsychology Review · doi:10.1007/s11065-008-9055-0 · Cited by 173 · see citing works
In vivo amyloid imaging in autopsy-confirmed Parkinson disease with dementia
Burack, M. A., Hartlein, J. M., Flores, H., Taylor-Reinwald, L., Perlmutter, J. S., & Cairns, N. J. (2009) · Neurology · doi:10.1212/wnl.0b013e3181c7da8e · Cited by 163 · see citing works
Irwin, D. J., & Hurtig, H. I. (2018) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.1000444 · Cited by 165 · see citing works
Walker, L., Stefanis, L., & Attems, J. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14698 · Cited by 158 · see citing works
A claims data-based comparison of comorbidity in individuals with and without dementia
Bauer, K., Schwarzkopf, L., Graessel, E., & Holle, R. (2014) · BMC Geriatrics · doi:10.1186/1471-2318-14-10 · Cited by 157 · see citing works
CSF Aβ 42 predicts early-onset dementia in Parkinson disease
Alves, G. W., Lange, J., Blennow, K., Zetterberg, H., Andréasson, U., Førland, M. G. G., Tysnes, O., Larsen, J. O., & Pedersen, K. F. (2014) · Neurology · doi:10.1212/wnl.0000000000000425 · Cited by 157 · see citing works
Self-citationDistribution and Load of Amyloid-β Pathology in Parkinson Disease and Dementia with Lewy Bodies
Hepp, D. H., Vergoossen, D. L. E., Huisman, E., Lemstra, A. W., Bank, N. B., Berendse, H. W., Rozemüller, A. J. M., Foncke, E. M. J., & van de Berg, W. D. J. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw070 · Cited by 155 · see citing works
PET imaging of brain amyloid in dementia: a review
Quigley, H., Colloby, S. J., & O'Brien, J. T. (2010) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2640 · Cited by 150 · see citing works
Self-citationThe pattern of cortical atrophy in patients with Parkinson's disease according to cognitive status
Song, S., Lee, J. E., Park, H., Sohn, Y. H., Lee, J. D., & Lee, P. H. (2011) · Movement Disorders · doi:10.1002/mds.23477 · Cited by 147 · see citing works
Amyloid imaging of Lewy body‐associated disorders
Foster, E. R., Campbell, M. C., Burack, M. A., Hartlein, J. M., Flores, H. P., Cairns, N. J., Hershey, T. G., & Perlmutter, J. S. (2010) · Movement Disorders · doi:10.1002/mds.23393 · Cited by 147 · see citing works
Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders
Coughlin, D. G., Xie, S. X., Liang, M., Williams, A., Peterson, C. S., Weintraub, D. A., McMillan, C. T., Wolk, D. A., Akhtar, R. S., Hurtig, H. I., et al. (2018) · Annals of Neurology · doi:10.1002/ana.25392 · Cited by 145 · see citing works
Lee, J. E., Cho, K. H., Song, S. K., Kim, H. J., Lee, H. S., Sohn, Y. H., & Lee, P. H. (2013) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2013-305062 · Cited by 144 · see citing works
Cholinesterase inhibitors for Parkinson's disease: a systematic review and meta-analysis
Pagano, G., Rengo, G., Pasqualetti, G., Femminella, G. D., Monzani, F., Ferrara, N., & Tagliati, M. (2014) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2014-308764 · Cited by 140 · see citing works
Hall, B., Mak, E., Cervenka, S., Aigbirhio, F. I., Rowe, J. B., & O’Brien, J. T. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.03.002 · Cited by 132 · see citing works
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Jellinger, K. A. (2008) · Neurodegenerative Diseases · doi:10.1159/000113679 · Cited by 137 · see citing works
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Pagonabarraga, J., Corcuera‐Solano, I., Vives‐Gilabert, Y., Llebaria, G., García‐Sánchez, C., Pascual‐Sedano, B., Delfino, M., Kulisevsky, J., & Gómez‐Ansón, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054980 · Cited by 138 · see citing works
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Marsh, S. E., & Blurton-Jones, M. M. (2012) · Alzheimer s Research & Therapy · doi:10.1186/alzrt109 · Cited by 138 · see citing works
Amyloid-β and Parkinson’s disease
Kings Parcog groupMDS Nonmotor study group, Lim, E. W., Aarsland, D., Ffytche, D. H., Taddei, R. N., van Wamelen, D. J., Wan, Y.-M., Tan, E. K., & Chaudhuri, К. R. (2018) · Journal of Neurology · doi:10.1007/s00415-018-9100-8 · Cited by 137 · see citing works
Self-citationChiasserini, D., Biscetti, L., Eusebi, P., Salvadori, N., Frattini, G., Simoni, S., Roeck, N. D., Tambasco, N., Stoops, E., Vanderstichele, H., et al. (2017) · Alzheimer s Research & Therapy · doi:10.1186/s13195-017-0276-4 · Cited by 138 · see citing works
Pathological Influences on Clinical Heterogeneity in Lewy Body Diseases
Coughlin, D. G., Hurtig, H. I., & Irwin, D. J. (2019) · Movement Disorders · doi:10.1002/mds.27867 · Cited by 130 · see citing works
Azam, S., Haque, M. E., Jakaria, M., Jo, S.-H., Kim, I., & Choi, D. (2020) · Cells · doi:10.3390/cells9020506 · Cited by 124 · see citing works
van Steenoven, I., Aarsland, D., Weintraub, D. A., Londos, E., Blanc, F., van der Flier, W. M., Teunissen, C. E., Mollenhauer, B., Fladby, T., Kramberger, M. G., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160322 · Cited by 122 · see citing works
Self-citationCognition, language, and clinical pathological features of non-Alzheimer's dementias: An overview
Reilly, J. J., Rodriguez, A. D., Lamy, M., & Neils‐Strunjas, J. (2010) · Journal of Communication Disorders · doi:10.1016/j.jcomdis.2010.04.011 · Cited by 120 · see citing works
Amyloid PET Imaging in Lewy Body Disorders
Donaghy, P. C., Thomas, A. J., & O'Brien, J. T. (2013) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2013.03.001 · Cited by 118 · see citing works
Self-citationÖhrfelt, A., Zetterberg, H., Andersson, K., Persson, R., Secic, D., Brinkmalm, G., Wallin, A., Mulugeta, E., Francis, P. T., Vanmechelen, E., et al. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0527-x · Cited by 109 · see citing works
Self-citationCholinesterase inhibitors and memantine for symptomatic treatment of dementia
Rodda, J. E., & Carter, J. (2012) · BMJ · doi:10.1136/bmj.e2986 · Cited by 105 · see citing works
Ferrer, I. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.02.004 · Cited by 105 · see citing works
Vitali, P., Migliaccio, R., Agosta, F., Rosen, H., & Geschwind, M. D. (2008) · Seminars in Neurology · doi:10.1055/s-0028-1083695 · Cited by 103 · see citing works
Aβ-amyloid deposition in patients with Parkinson disease at risk for development of dementia
Petrou, M., Bohnen, N. I., Müller, M. L. T. M., Koeppe, R. A., Albin, R. L., & Frey, K. A. (2012) · Neurology · doi:10.1212/wnl.0b013e3182698d4a · Cited by 101 · see citing works
Biomarkers in dementia with Lewy bodies: a review
Sinha, N., Firbank, M., & O'Brien, J. T. (2011) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2749 · Cited by 98 · see citing works
Self-citationUsing Pittsburgh Compound B for In Vivo PET Imaging of Fibrillar Amyloid-Beta
Cohen, A. D., Rabinovici, G. D., Mathis, C. A., Jagust, W. J., Klunk, W. E., & Ikonomović, M. D. (2012) · Advances in pharmacology · doi:10.1016/b978-0-12-394816-8.00002-7 · Cited by 99 · see citing works
Brooks, D. J. (2009) · Movement Disorders · doi:10.1002/mds.22581 · Cited by 97 · see citing works
Ruffmann, C., Calboli, F. C. F., Bravi, I., Gveric, D. O., Curry, L. K., de Smith, A. J., Pavlou, S., Buxton, J. L., Blakemore, A. I. F., Takousis, P., et al. (2015) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12294 · Cited by 96 · see citing works
Dementia in Parkinson's disease
Aarsland, D., Beyer, M. K., & Kurz, M. W. (2008) · Current Opinion in Neurology · doi:10.1097/wco.0b013e3283168df0 · Cited by 95 · see citing works
Self-citationα‐synuclein genetic variability: A biomarker for dementia in Parkinson disease
Guella, I., Evans, D. M., Szu‐Tu, C., Nosova, E., Bortnick, S., SNCA Cognition Study Group, Goldman, J. G., Dalrymple‐Alford, J. C., Geurtsen, G. J., Litvan, I., et al. (2016) · Annals of Neurology · doi:10.1002/ana.24664 · Cited by 94 · see citing works
Staffaroni, A., Elahi, F., McDermott, D., Marton, K., Karageorgiou, E., Sacco, S., Paoletti, M., Caverzasi, E., Hess, C., Rosen, H., et al. (2017) · Seminars in Neurology · doi:10.1055/s-0037-1608808 · Cited by 91 · see citing works
Dementia in Parkinson's disease is associated with enhanced mitochondrial complex I deficiency
Gatt, A. P., Duncan, O. F., Attems, J., Francis, P. T., Ballard, C. G., & Bateman, J. E. (2016) · Movement Disorders · doi:10.1002/mds.26513 · Cited by 91 · see citing works
Self-citationCerebrospinal fluid biomarkers in parkinsonian conditions: an update and future directions
Magdalinou, N. K., Lees, A. J., & Zetterberg, H. (2014) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2013-307539 · Cited by 93 · see citing works
Ye, L., Velasco, A. L., Fraser, G. M., Beach, T. G., Sue, L. I., Osredkar, T., Libri, V., Spillantini, M. G., Goedert, M., & Lockhart, A. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05245.x · Cited by 92 · see citing works
Dementia with Lewy bodies and Parkinson’s disease with dementia: where two worlds collide
McKeith, I. G. (2007) · Practical Neurology · doi:10.1136/jnnp.2007.134163 · Cited by 91 · see citing works
Self-citationMagnetic Resonance Imaging in Lewy Body Dementias
Watson, R., Blamire, A. M., & O'Brien, J. T. (2009) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000264614 · Cited by 90 · see citing works
Self-citationCSF tau and β-amyloid predict cerebral synucleinopathy in autopsied Lewy body disorders
Irwin, D. J., Xie, S. X., Coughlin, D. G., Nevler, N., Akhtar, R. S., McMillan, C. T., Lee, E. B., Wolk, D. A., Weintraub, D. A., Chen‐Plotkin, A. S., et al. (2018) · Neurology · doi:10.1212/wnl.0000000000005166 · Cited by 91 · see citing works
Predictors of Survival in Dementia with Lewy Bodies and Parkinson Dementia
Jellinger, K. A., Wenning, G. K., & Seppi, K. (2007) · Neurodegenerative Diseases · doi:10.1159/000107703 · Cited by 88 · see citing works
Ghebremedhin, E., Rosenberger, A., Rüb, U., Vukšić, M., Berhe, T., Bickeböller, H., de Vos, R. A. I., Thal, D. R., & Deller, T. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181d88e63 · Cited by 82 · see citing works
Metabolic connectomics targeting brain pathology in dementia with Lewy bodies
Caminiti, S. P., Tettamanti, M., Sala, A., Presotto, L., Iannaccone, S., Cappa, S. F., Magnani, G., Perani, D., & Initiative, A. D. N. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16654497 · Cited by 77 · see citing works
Laforce, R., & Rabinovici, G. D. (2011) · Alzheimer's Research & Therapy · doi:10.1186/alzrt93 · Cited by 79 · see citing works
Fujimi, K., Sasaki, K., Noda, K., Wakisaka, Y., Tanizaki, Y., Matsui, Y., Sekita, A., Iida, M., Kiyohara, Y., Kanba, S., et al. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00169.x · Cited by 79 · see citing works
Jellinger, K. A. (2007) · Springer eBooks · doi:10.1007/978-3-211-73574-9_12 · Cited by 78 · see citing works
Brønnick, K., Nordby, H., Larsen, J. P., & Aarsland, D. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.02.021 · Cited by 74 · see citing works
Self-citationMastenbroek, S. E., Vogel, J. W., Collij, L. E., Serrano, G. E., Tremblay, C., Young, A. L., Arce, R. A., Shill, H. A., Driver‐Dunckley, E. D., Mehta, S. H., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49402-x · Cited by 75 · see citing works
Shimizu, S., Hirao, K., Kanetaka, H., Namioka, N., Hatanaka, H., Hirose, D., Fukasawa, R., Umahara, T., Sakurai, H., & Hanyu, H. (2015) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-015-3146-y · Cited by 74 · see citing works
Significance of Brain Lesions in Parkinson Disease Dementia and Lewy Body Dementia
Jellinger, K. A. (2009) · Monographs in clinical neuroscience/Frontiers of neurology and neuroscience/Monographs in neural sciences · doi:10.1159/000197890 · Cited by 74 · see citing works
Evaluation of the Braak hypothesis: how far can it explain the pathogenesis of Parkinson's disease?
Halliday, G. M., McCann, H., & Shepherd, C. E. (2012) · Expert Review of Neurotherapeutics · doi:10.1586/ern.12.47 · Cited by 74 · see citing works
MRI and cognitive impairment in Parkinson's disease
Ibarretxe‐Bilbao, N., TOLOSA, E. S., Junqué, C., & Martı́, M. J. (2009) · Movement Disorders · doi:10.1002/mds.22670 · Cited by 74 · see citing works
Arguing against the proposed definition changes of PD
Boeve, B. F., Dickson, D. W., Duda, J. E., Ferman, T. J., Galasko, D. R., Galvin, J. E., Goldman, J. G., Growdon, J. H., Hurtig, H. I., Kaufer, D., et al. (2016) · Movement Disorders · doi:10.1002/mds.26721 · Cited by 73 · see citing works
Self-citationCorrelation between decreased CSF α-synuclein and Aβ1–42 in Parkinson disease
Buddhala, C., Campbell, M. C., Perlmutter, J. S., & Kotzbauer, P. T. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.07.043 · Cited by 72 · see citing works
Lee, J. E., Park, B., Song, S., Sohn, Y. H., Park, H., & Lee, P. H. (2009) · Movement Disorders · doi:10.1002/mds.22858 · Cited by 70 · see citing works
Default mode network differences between rigidity- and tremor-predominant Parkinson's disease
Karunanayaka, P., Lee, E.-Y., Lewis, M. M., Sen, S., Eslinger, P. J., Yang, Q. X., & Huang, X. (2016) · Cortex · doi:10.1016/j.cortex.2016.04.021 · Cited by 70 · see citing works
- Authors
- Ballard, C., Ziabreva, I., Perry, R., Larsen, J. P., O'Brien, J., McKeith, I., Perry, E., & Aarsland, D.
- Affiliations
- King's College London (GB)
- From the Wolfson Centre for Age-Related Diseases (C.B.), Wolfson Building, Guy's Campus, King's College London, UK; Institute of Ageing and Health (I.Z., R.P., J.O., I.M., E.P.), Newcastle General Hospital, Newcastle upon Tyne, UK; and Norwegian Center for Movement Disorders (J.P.L., D.A.), Stavanger University Hospital, Stavanger, Norway.
- Venue
- Neurology
- Published
- 2006-12-12
- Volume
- 67
- Issue
- 11
- Pages
- 1931-1934
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2107172544
- Cited by
- 335
- References
- 28
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 9 · 2023: 9 · 2022: 12 · 2021: 11 · 2020: 16 · 2019: 23 · 2018: 23 · 2017: 15 · 2016: 16 · 2015: 13 · 2014: 21 · 2013: 25 · 2012: 28
- FWCI
- 12.73
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- dementia with Lewy bodies, Parkinson's disease dementia, alpha-synuclein pathology, Braak staging, cholinergic deficit, choline acetyltransferase, differential diagnosis, neuropathology
- MeSH terms
- Aged, Aged, 80 and over, Choline O-Acetyltransferase, Female, Humans, Male, Parkinson Disease, Prospective Studies, Temporal Lobe, Time Factors, Neurofibrillary Tangles, Lewy Body Disease, alpha-Synuclein, Plaque, Amyloid
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