Cited by 1,007Parkinson's Disease Mechanisms and TreatmentsDementia and Cognitive Impairment ResearchDeep Brain Stimulation and Movement Disorders

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Cognitive profile of patients with newly diagnosed Parkinson disease

Muslimović, Dino, Post, Bart, Speelman, Johannes D., Schmand, Ben·2005·Neurology

DOI 10.1212/01.wnl.0000180516.69442.95

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Abstract

OBJECTIVE: To determine the frequency and pattern of cognitive dysfunction in patients with newly diagnosed Parkinson disease (PD) and to identify its demographic and clinical correlates. METHODS: A cohort of 115 consecutive patients with newly diagnosed PD and 70 healthy controls underwent a comprehensive neuropsychological assessment including tests of psychomotor speed, attention, language, memory, executive and visuospatial functions, as well as measures of affective status. Patients also received quantitative ratings of motor symptom severity and functional status. Neuropsychological performance of PD patients was compared with that of healthy controls and with available normative data. Independent demographic and clinical predictors of cognitive impairment were identified with multiple logistic regression analysis. RESULTS: Relative to controls, PD patients performed significantly worse on most cognitive measures. However, further analysis revealed that group differences in cognitive performance could mainly be explained by measures of immediate memory and executive function. Comparison with normative data showed that impairments were most frequent on measures of executive function, memory and psychomotor speed. In all, 24% of PD patients (4% of controls) displayed defective performance on at least three neuropsychological tests and were classified as cognitively impaired. Late onset of disease was an independent predictor of cognitive dysfunction in PD. CONCLUSION: Cognitive impairments are common even in newly diagnosed Parkinson disease patients, with deficits being most prominent in the domains of memory and executive functions. Older age at disease onset is likely to be an important determinant of cognitive dysfunction in Parkinson disease.

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Authors: Muslimović, D., Post, B., Speelman, J. D., & Schmand, B.
Affiliations: From the Department of Neurology, Academic Medical Center, University of Amsterdam, the Netherlands; and CARPA Study Group (Drs. Post and Speelman).
Amsterdam UMC Location University of Amsterdam (NL)
ORCID: Post, Bart
Schmand, Ben
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2005-10-25
Volume: 65
Issue: 8
Pages: 1239-1245
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/01.wnl.0000180516.69442.95
OpenAlex: W2131881760
Cited by: 1,007
References: 29
Citations by year: 2026: 18 · 2025: 35 · 2024: 30 · 2023: 31 · 2022: 48 · 2021: 58 · 2020: 48 · 2019: 57 · 2018: 57 · 2017: 58 · 2016: 54 · 2015: 67 · 2014: 71 · 2013: 82 · 2012: 62
FWCI: 16.66
Type: journal article
Language: en
Open access: closed
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
UvA-DARE (University of Amsterdam) (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Pure Amsterdam UMC (submittedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
Keywords: Parkinson's disease, cognitive impairment, executive function, memory impairment, psychomotor speed, age of onset, neuropsychological assessment, newly diagnosed patients
MeSH terms: Affective Symptoms, Aged, Cognition Disorders, Female, Humans, Language Disorders, Male, Memory Disorders, Middle Aged, Neuropsychological Tests, Parkinson Disease, Predictive Value of Tests, Psychomotor Performance, Cohort Studies, Comorbidity, Prevalence, Age of Onset

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Cognitive profile of patients with newly diagnosed Parkinson disease

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