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Cited by 1,007Parkinson's Disease Mechanisms and TreatmentsDementia and Cognitive Impairment ResearchDeep Brain Stimulation and Movement Disorders

The DOI matches its Crossref record; 28 of the 29 references it cites were found in a registry or an index.

Cognitive profile of patients with newly diagnosed Parkinson disease

Muslimović, Dino, Post, Bart, Speelman, Johannes D., Schmand, Ben·2005·Neurology
DOI 10.1212/01.wnl.0000180516.69442.95
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Abstract

OBJECTIVE: To determine the frequency and pattern of cognitive dysfunction in patients with newly diagnosed Parkinson disease (PD) and to identify its demographic and clinical correlates. METHODS: A cohort of 115 consecutive patients with newly diagnosed PD and 70 healthy controls underwent a comprehensive neuropsychological assessment including tests of psychomotor speed, attention, language, memory, executive and visuospatial functions, as well as measures of affective status. Patients also received quantitative ratings of motor symptom severity and functional status. Neuropsychological performance of PD patients was compared with that of healthy controls and with available normative data. Independent demographic and clinical predictors of cognitive impairment were identified with multiple logistic regression analysis. RESULTS: Relative to controls, PD patients performed significantly worse on most cognitive measures. However, further analysis revealed that group differences in cognitive performance could mainly be explained by measures of immediate memory and executive function. Comparison with normative data showed that impairments were most frequent on measures of executive function, memory and psychomotor speed. In all, 24% of PD patients (4% of controls) displayed defective performance on at least three neuropsychological tests and were classified as cognitively impaired. Late onset of disease was an independent predictor of cognitive dysfunction in PD. CONCLUSION: Cognitive impairments are common even in newly diagnosed Parkinson disease patients, with deficits being most prominent in the domains of memory and executive functions. Older age at disease onset is likely to be an important determinant of cognitive dysfunction in Parkinson disease.

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Research works printed but not linked: 9

  1. Growdon JH Corkin S Rosen TJ. Distinctive aspects of cognitive dysfunction in Parkinson’s disease. In: Streifler MB Korczyn AD Melamed E Youdim MBH eds. Parkinson’s Disease: Anatomy Pathology and Therapy. Advances in Neurology vol. 53. New York: Raven Press 1990:365-376.
  2. Fahn S Elton RI Members of the UPDRS Development Committee. In: Fahn S Marsden CD Calne DB Goldstein M eds. Recent development in Parkinson’s disease vol. 2. New York: Macmillan Health Care Information 1987:153-164.
  3. Schwab JF. Projection technique for evaluating surgery in Parkinson’s disease. In: Billingham FH Donaldson MC eds. Third symposium on Parkinson’s disease. Edinburgh: Livingstone 1969:152-157.
  4. Lezak MD ed. Neuropsychological assessment 4th ed. New York: Oxford University Press 2004.
  5. Lindeboom J, Matto D. Digit series and Knox cubes as concentration tests for elderly subjects. Tijdschr Gerontol Geriatr 1994;25:63–66.
  6. Wechsler D. Wechsler Memory Scale 3rd edition (WMS-III): Test Manual New York: Psychological Corporation 1997.
  7. Benton A Hamsher K Varney N Spreen O. Contributions to neuropsychological assessment –a clinical manual. New York: Oxford University Press 1983.
  8. Cohen J. Statistical power analysis for the behavioral sciences 2nd ed. New York: Academic Press 1988.
  9. Huber SJ, Christy JA, Paulson GW. Cognitive heterogeneity associated with clinical subtypes of Parkinson’s disease. Neuropsychiatry, Neuropsychology, and Behavioral Neurology 1991;4:147–157.

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Metadata

Authors
Muslimović, D., Post, B., Speelman, J. D., & Schmand, B.
Affiliations
  • From the Department of Neurology, Academic Medical Center, University of Amsterdam, the Netherlands; and CARPA Study Group (Drs. Post and Speelman).
  • Amsterdam UMC Location University of Amsterdam (NL)
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2005-10-25
Volume
65
Issue
8
Pages
1239-1245
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/01.wnl.0000180516.69442.95
OpenAlex
W2131881760
Cited by
1,007
References
29
Citations by year
2026: 18 · 2025: 35 · 2024: 30 · 2023: 31 · 2022: 48 · 2021: 58 · 2020: 48 · 2019: 57 · 2018: 57 · 2017: 58 · 2016: 54 · 2015: 67 · 2014: 71 · 2013: 82 · 2012: 62
FWCI
16.66
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • UvA-DARE (University of Amsterdam) (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
Keywords
Parkinson's disease, cognitive impairment, executive function, memory impairment, psychomotor speed, age of onset, neuropsychological assessment, newly diagnosed patients
MeSH terms
Affective Symptoms, Aged, Cognition Disorders, Female, Humans, Language Disorders, Male, Memory Disorders, Middle Aged, Neuropsychological Tests, Parkinson Disease, Predictive Value of Tests, Psychomotor Performance, Cohort Studies, Comorbidity, Prevalence, Age of Onset

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