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Cited by 313Genetic Neurodegenerative DiseasesMetabolism and Genetic DisordersBiochemical effects in animals

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2′dG

Hersch, S. M., Gevorkian, S., Marder, K., Moskowitz, C., Feigin, A., Cox, M., Como, P., Zimmerman, C., Lin, M., Zhang, L., Ulug, A. M., Beal, M. F., Matson, W., Bogdanov, M., Ebbel, E., Zaleta, A., Kaneko, Y., Jenkins, B., Hevelone, N., Zhang, H., Yu, H., Schoenfeld, D., Ferrante, R., Rosas, H. D.·2006·Neurology
DOI 10.1212/01.wnl.0000194318.74946.b6
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Abstract

In a randomized, double-blind, placebo-controlled study in 64 subjects with Huntington disease (HD), 8 g/day of creatine administered for 16 weeks was well tolerated and safe. Serum and brain creatine concentrations increased in the creatine-treated group and returned to baseline after washout. Serum 8-hydroxy-2'-deoxyguanosine (8OH2'dG) levels, an indicator of oxidative injury to DNA, were markedly elevated in HD and reduced by creatine treatment.

Overview

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Crossref · 10.1212/01.wnl.0000194318.74946.b6

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Metadata

Authors
Hersch, S. M., Gevorkian, S., Marder, K., Moskowitz, C., Feigin, A., Cox, M., Como, P., Zimmerman, C., Lin, M., Zhang, L., Ulug, A. M., Beal, M. F., Matson, W., Bogdanov, M., Ebbel, E., Zaleta, A., Kaneko, Y., Jenkins, B., Hevelone, N., Zhang, H., Yu, H., Schoenfeld, D., Ferrante, R., & Rosas, H. D.
Affiliations
  • Harvard University (US)
  • From the Departments of Neurology, (S.M.H., S.G., A.Z., N.H., H.Z., H.Y., H.D.R.) and Biostatistics (D.S.), MassGeneral Institute for Neurodegenerative Disease, MGH-NMR Center and Athinoula A. Martinos Center for Biomedical Imaging (A.Z., B.J., N.H., H.D.R.), Massachusetts General Hospital and Harvard Medical School, Charlestown, MA; Center for Parkinson's Disease and Other Movement Disorders (K.M., C.M.), Department of Neurology, Sergievsky Center and Taub Institute for Research on Alzheimer's...
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2006-01-24
Volume
66
Issue
2
Pages
250-252
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/01.wnl.0000194318.74946.b6
OpenAlex
W2163827910
Cited by
313
References
10
Citations by year
2026: 6 · 2025: 5 · 2024: 13 · 2023: 10 · 2022: 11 · 2021: 14 · 2020: 6 · 2019: 8 · 2018: 12 · 2017: 8 · 2016: 14 · 2015: 13 · 2014: 21 · 2013: 20 · 2012: 22
FWCI
8.98
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Neurological Disorders and Stroke (NS042861, NS 35255, R01NS035255)
  • National Center for Research Resources (M01RR001066, M01-RR01066, M01RR000645, M01 RR00645)
  • National Center for Complementary and Integrative Health (AT00613)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
  • Health Sciences › Medicine › Physiology (medical) › Biochemical effects in animals
Keywords
creatine, Huntington's disease, 8-hydroxy-2'-deoxyguanosine, oxidative DNA damage, drug safety and tolerability, neuroprotection
MeSH terms
8-Hydroxy-2'-Deoxyguanosine, Adult, Biological Availability, Brain, Creatine, Deoxyguanosine, Double-Blind Method, Female, Humans, Huntington Disease, Male, Middle Aged, Biomarkers

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